Book contents
- Levels of Analysis in Psychopathology
- Advance Praise for Levels of Analysis in Psychopathology
- Levels of Analysis in Psychopathology
- Copyright page
- Contents
- Figures
- Tables
- Contributors
- Preface
- General Introduction
- Part I Neuroscience, Mechanisms, and RDoC
- Section 1
- Section 2
- Section 3
- 7 Introduction
- 8 Tackling Hard Problems: Neuroscience, Treatment, and Anxiety
- 9 Commentary on Daniel S. Pine
- Part II Phenomenology, Biological Psychology, and the Mind–Body Problem
- Part III Taxonomy, Integration, and Multiple Levels of Explanation
- Index
- References
8 - Tackling Hard Problems: Neuroscience, Treatment, and Anxiety
from Section 3
Published online by Cambridge University Press: 02 April 2020
Book contents
- Levels of Analysis in Psychopathology
- Advance Praise for Levels of Analysis in Psychopathology
- Levels of Analysis in Psychopathology
- Copyright page
- Contents
- Figures
- Tables
- Contributors
- Preface
- General Introduction
- Part I Neuroscience, Mechanisms, and RDoC
- Section 1
- Section 2
- Section 3
- 7 Introduction
- 8 Tackling Hard Problems: Neuroscience, Treatment, and Anxiety
- 9 Commentary on Daniel S. Pine
- Part II Phenomenology, Biological Psychology, and the Mind–Body Problem
- Part III Taxonomy, Integration, and Multiple Levels of Explanation
- Index
- References
Summary
This chapter reviews efforts to use neuroscience to inform clinical practice for mental disorders, discussing anxiety disorders as an exemplary foundation for work on other mental illnesses. The chapter unfolds in four stages. The first portion provides an overview, focusing on three levels of inquiry: clinical state; psychological testing; and brain function, as revealed by functional magnetic resonance imaging. Next, the chapter describes research across these three levels for one narrow area of neuroscience, related to the orienting of attention, where progress in clinically relevant domains has been steady. The third section also focuses on the three levels to summarize work on appraisal, a process closely connected to consciousness, where research has yet to profoundly impact clinical thinking.Finally, the chapter concludes by summarizing problems confronting future attempts to establish a clinical neuroscience approach to mental disorders, problems which are difficult to solve due to unique aspects of human thought.
- Type
- Chapter
- Information
- Levels of Analysis in PsychopathologyCross-Disciplinary Perspectives, pp. 91 - 113Publisher: Cambridge University PressPrint publication year: 2020
References
Badura-Brack, A. S., Naim, R., Ryan, T. J., Levy, O., Abend, R., Khanna, M. M., … Bar-Haim, Y. (2015) ‘Effect of attention training on attention bias variability and PTSD symptoms: Randomized controlled trials in Israeli and U.S. combat veterans.’ American Journal of Psychiatry, 172(12), 1233–1241.CrossRefGoogle ScholarPubMed
Bar-Haim, Y., Lamy, D., Pergamin, L., Bakermans-Kranenburg, M. J., & van Ijzendoorn, M. H. (2007) ‘Threat-related attentional bias in anxious and nonanxious individuals: A meta-analytic study.’ Psychological Bulletin, 133(1), 1–24.CrossRefGoogle ScholarPubMed
Barberini, C. L., Morrison, S. E., Saez, A., Lau, B., & Salzman, C. D. (2012) ‘Complexity and competition in appetitive and aversive neural circuits.’ Frontiers in Neuroscience, 6, 170.CrossRefGoogle ScholarPubMed
Beesdo, K., Knappe, S., & Pine, D. S. (2009) ‘Anxiety and anxiety disorders in children and adolescents: Developmental issues and implications for DSM-V.’ Psychiatric Clinics of North America, 32(3), 483–524.Google Scholar
Briggs-Gowan, M. J., Grasso, D., Bar-Haim, Y., Voss, J., McCarthy, K. J., Pine, D. S., & Wakschlag, L. S. (2016) ‘Attention bias in the developmental unfolding of post-traumatic stress symptoms in young children at risk.’ Journal of Child Psychology and Psychiatry, 57(9), 1083–1091.Google Scholar
Britton, J. C., Suway, J. G., Clementi, M. A., Fox, N. A., Pine, D. S., & Bar-Haim, Y. (2015) ‘Neural changes with attention bias modification for anxiety: A randomized trial.’ Social Cognitive and Affective Neuroscience, 10(7), 913–920.Google Scholar
Corbetta, M., Patel, G., & Shulman, G. L. (2008) ‘The reorienting system of the human brain: From environment to theory of mind.’ Neuron, 58(3), 306–324.CrossRefGoogle ScholarPubMed
Cristea, I. A., Kok, R. N., & Cuijpers, P. (2015) ‘Efficacy of cognitive bias modification interventions in anxiety and depression: Meta-analysis.’ British Journal of Psychiatry, 206(1), 7–16.Google Scholar
Cuthbert, B. N., & Insel, T. R. (2013) ‘Toward the future of psychiatric diagnosis: The seven pillars of RDoC.’ BMC Medicine, 11, 126.CrossRefGoogle ScholarPubMed
Davis-Kean, P. E., Huesmann, L. R., Jager, J., Collins, W. A., Bates, J. E., & Lansford, J. E. (2008) ‘Changes in the relation of self-efficacy beliefs and behaviors across development.’ Child Development, 79(5), 1257–1269.CrossRefGoogle ScholarPubMed
Davis, M., Walker, D. L., Miles, L., & Grillon, C. (2010) ‘Phasic vs sustained fear in rats and humans: Role of the extended amygdala in fear vs anxiety.’ Neuropsychopharmacology, 35(1), 105–135.Google Scholar
Duits, P., Cath, D. C., Lissek, S., Hox, J. J., Hamm, A. O., Engelhard, I. M., … Baas, J. M. (2015) ‘Updated meta-analysis of classical fear conditioning in the anxiety disorders.’ Depression and Anxiety, 32(4), 239–253.CrossRefGoogle ScholarPubMed
Gold, A. L., Shechner, T., Farber, M. J., Spiro, C. N., Leibenluft, E., Pine, D. S., & Britton, J. C. (2016) ‘Amygdala–cortical connectivity: Associations with anxiety, development, and threat.’ Depression and Anxiety, 33(10), 917–926.CrossRefGoogle ScholarPubMed
Goodkind, M., Eickhoff, S. B., Oathes, D. J., Jiang, Y., Chang, A., Jones-Hagata, L. B., … Etkin, A. (2015) ‘Identification of a common neurobiological substrate for mental illness.’ JAMA Psychiatry, 72(4), 305–315.Google Scholar
Harter, S. (1992) ‘Visions of self: Beyond the me in the mirror.’ Nebraska Symposium on Motivation, 40, 99–144.Google ScholarPubMed
Harter, S., Bresnick, S., Bouchey, H. A., & Whitesell, N. R. (1997) ‘The development of multiple role-related selves during adolescence.’ Development and Psychopathology, 9(4), 835–853.Google Scholar
Insel, T. R. (2014) ‘The NIMH Research Domain Criteria (RDoC) project: Precision medicine for psychiatry.’ American Journal of Psychiatry, 171(4), 395–397.Google Scholar
Lau, J. Y., Britton, J. C., Nelson, E. E., Angold, A., Ernst, M., Goldwin, M., … Pine, D. S. (2011) ‘Distinct neural signatures of threat learning in adolescents and adults.’ Proceedings of the National Academy of the Sciences U S A, 108(11), 4500–4505.CrossRefGoogle ScholarPubMed
Lazarov, A., Marom, S., Yahalom, N., Pine, D. S., Hermesh, H., & Bar-Haim, Y. (2018) ‘Attention bias modification augments cognitive-behavioral group therapy for social anxiety disorder: A randomized controlled trial.’ Psychological Medicine, 48(13), 2177–2185.Google Scholar
Lazarov, A., Pine, D. S., & Bar-Haim, Y. (2017) ‘Gaze-contingent music reward therapy for social anxiety disorder: A randomized controlled trial.’ American Journal of Psychiatry, 174(7), 649–656.Google Scholar
LeDoux, J. E. (2014) ‘Coming to terms with fear.’ Proceedings of the National Academy of the Sciences U S A, 111(8), 2871–2878.CrossRefGoogle ScholarPubMed
LeDoux, J. E., & Brown, R. (2017) ‘A higher-order theory of emotional consciousness.’ Proceedings of the National Academy of the Sciences U S A, 114(10), E2016–E2025.CrossRefGoogle ScholarPubMed
LeDoux, J. E., & Pine, D. S. (2016) ‘Using neuroscience to help understand fear and anxiety: A two-system framework.’ American Journal of Psychiatry, 173(11), 1083–1093.CrossRefGoogle ScholarPubMed
McTeague, L. M., Huemer, J., Carreon, D. M., Jiang, Y., Eickhoff, S. B., & Etkin, A. (2017) ‘Identification of common neural circuit disruptions in cognitive control across psychiatric disorders.’ American Journal of Psychiatry, 174(7), 676–685.Google Scholar
Miyake, A., & Friedman, N. P. (2012) ‘The nature and organization of individual differences in executive functions: Four general conclusions.’ Current Directions in Psychological Science, 21(1), 8–14.CrossRefGoogle ScholarPubMed
Monk, C. S., Telzer, E. H., Mogg, K., Bradley, B. P., Mai, X., Louro, H. M., … Pine, D. S. (2008) ‘Amygdala and ventrolateral prefrontal cortex activation to masked angry faces in children and adolescents with generalized anxiety disorder.’ Archives of General Psychiatry, 65(5), 568–576.CrossRefGoogle ScholarPubMed
Moore, T., & Zirnsak, M. (2017) ‘Neural mechanisms of selective visual attention.’ Annual Review of Psychology, 68, 47–72.Google Scholar
Pine, D. S. (2013) ‘A 60-year climb on the mountain of nosology.’ Journal of the American Academy of Child and Adolescent Psychiatry, 52(12), 1251–1254.Google Scholar
Pine, D. S., & Fox, N. A. (2015) ‘Childhood antecedents and risk for adult mental disorders.’ Annual Review of Psychology, 66, 459–485.Google Scholar
Pine, D. S., & Leibenluft, E. (2015) ‘Biomarkers with a mechanistic focus.’ JAMA Psychiatry, 72(7), 633–634.CrossRefGoogle ScholarPubMed
Price, R. B., Wallace, M., Kuckertz, J. M., Amir, N., Graur, S., Cummings, L., … Bar-Haim, Y. (2016) ‘Pooled patient-level meta-analysis of children and adults completing a computer-based anxiety intervention targeting attentional bias.’ Clinical Psychology Review, 50, 37–49.CrossRefGoogle ScholarPubMed
Rappaport, B. I., Pagliaccio, D., Pine, D. S., Klein, D. N., & Jarcho, J. M. (2017) ‘Discriminant validity, diagnostic utility, and parent-child agreement on the Screen for Child Anxiety Related Emotional Disorders (SCARED) in treatment- and non-treatment-seeking youth.’ Journal of Anxiety Disorders, 51, 22–31.CrossRefGoogle ScholarPubMed
Shaffer, D., Fisher, P., Dulcan, M. K., Davies, M., Piacentini, J., Schwab-Stone, M. E., … Regier, D. A. (1996) ‘The NIMH Diagnostic Interview Schedule for Children Version 2.3 (DISC-2.3): Description, acceptability, prevalence rates, and performance in the MECA study. Methods for the epidemiology of child and adolescent mental disorders study.’ Journal of the American Academy of Child and Adolescent Psychiatry, 35(7), 865–877.CrossRefGoogle ScholarPubMed
Shaffer, D., Fisher, P., Lucas, C. P., Dulcan, M. K., & Schwab-Stone, M. E. (2000) ‘NIMH Diagnostic Interview Schedule for Children Version IV (NIMH DISC-IV): Description, differences from previous versions, and reliability of some common diagnoses.’ Journal of the American Academy of Child and Adolescent Psychiatry, 39(1), 28–38.Google Scholar
van Vugt, B., Dagnino, B., Vartak, D., Safaai, H., Panzeri, S., Dehaene, S., & Roelfsema, P. R. (2018) ‘The threshold for conscious report: Signal loss and response bias in visual and frontal cortex.’ Science, 360(6388), 537–542.CrossRefGoogle ScholarPubMed
Wald, I., Degnan, K. A., Gorodetsky, E., Charney, D. S., Fox, N. A., Fruchter, E., … Bar-Haim, Y. (2013) ‘Attention to threats and combat-related posttraumatic stress symptoms: Prospective associations and moderation by the serotonin transporter gene.’ JAMA Psychiatry, 70(4), 401–408.Google Scholar
Wald, I., Lubin, G., Holoshitz, Y., Muller, D., Fruchter, E., Pine, D. S., … Bar-Haim, Y. (2011) ‘Battlefield-like stress following simulated combat and suppression of attention bias to threat.’ Psychological Medicine, 41(4), 699–707.CrossRefGoogle ScholarPubMed
White, L. K., Degnan, K. A., Henderson, H. A., Perez-Edgar, K., Walker, O. L., Shechner, T., … Fox, N. A. (2017) ‘Developmental relations among behavioral inhibition, anxiety, and attention biases to threat and positive information.’ Child Development, 88(1), 141–155.CrossRefGoogle ScholarPubMed
White, L. K., Sequeira, S., Britton, J. C., Brotman, M. A., Gold, A. L., Berman, E., … Pine, D. S. (2017) ‘Complementary features of attention bias modification therapy and cognitive-behavioral therapy in pediatric anxiety disorders.’ American Journal of Psychiatry, 174(8), 775–784.CrossRefGoogle ScholarPubMed
- 1
- Cited by