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36 - Levels of Analysis in Alzheimer’s Disease Research

from Section 12

Published online by Cambridge University Press:  02 April 2020

By
Stephan Heckers
Edited by
Kenneth S. Kendler ,
Josef Parnas  and
Peter Zachar
Kenneth S. Kendler
Affiliation:
Virginia Commonwealth University
Josef Parnas
Affiliation:
University of Copenhagen
Peter Zachar
Affiliation:
Auburn University, Montgomery
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Summary

Psychiatric disorders can be explained at various levels of analysis. Some models start out with first-person experience, some focus on psychological and sociological factors and some look for answers by studying the brain. These levels of analysis are often defined by subject matter (e.g., life events or brain changes), scientific methods (e.g., interview or brain scan), and claims of causality (e.g., weak environmental effects of life stressors or strong genetic effects in Mendelian disorders). Here I am reviewing progress in the scientific exploration of Alzheimer’s Disease at four levels: clinical phenotype, cognitive neuroscience of memory, pathological and biochemical analysis of post-mortem brain tissue, and genetic analysis of patients as well as genetic mouse models of Alzheimer’s disease. This review allows me to reflect on some important ideas in James Woodward’s essay "Levels: What Are They and What Are They Good for?"

Keywords

Dementiamemoryneuropathologyneurodegenerative disordermodels of psychiatric disorderlevels of analysis
Type
Chapter
Information
Levels of Analysis in Psychopathology
Cross-Disciplinary Perspectives
 , pp. 450 - 456
Publisher: Cambridge University Press
Print publication year: 2020

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References

Alzheimer, A. (1907) ‘Über eine eigenartige Erkrankung der Hirnrinde’, Allgemeine Zeitschrift für Psychiatrie, 64, 146–48.Google Scholar
Bekris, L. M., et al. (2010) ‘Genetics of Alzheimer disease’, Journal of Geriatric Psychiatry and Neurology, 23 (4), 213–27.Google ScholarPubMed
Braak, H. and Braak, E. (1991) ‘Neuropathological stageing of Alzheimer-related changes’, Acta Neuropathologica, 82 (4), 239–59.CrossRefGoogle ScholarPubMed
De Jager, P. L., Yang, H. S., and Bennett, D. A. (2018) ‘Deconstructing and targeting the genomic architecture of human neurodegeneration’, Nature Neuroscience, 21 (10), 1310–17.Google Scholar
Elahi, F. M. and Miller, B. L. (2017) ‘A clinicopathological approach to the diagnosis of dementia’, Nature Reviews Neurology, 13 (8), 457–76.CrossRefGoogle Scholar
Glenner, G. G. and Wong, C. W. (1984) ‘Alzheimer’s disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein’, Biochemical and Biophysical Research Communications, 120 (3), 885–90.CrossRefGoogle ScholarPubMed
Hampel, H., et al. (2017) ‘A Precision Medicine Initiative for Alzheimer’s disease: The road ahead to biomarker-guided integrative disease modeling’, Climacteric, 20 (2), 107–18.Google Scholar
Mehta, D., et al. (2017) ‘Why do trials for Alzheimer’s disease drugs keep failing? A discontinued drug perspective for 2010–2015’, Expert Opinion on Investigative Drugs, 26 (6), 735–39.CrossRefGoogle Scholar
Tanzi, R. E. (2012) ‘The genetics of Alzheimer disease’, Cold Spring Harbor Perspectives in Medicine, 2 (10), a006296. doi: 10.1101/cshperspect.a006296CrossRefGoogle ScholarPubMed
Vergallo, A., et al. (2018) ‘The cholinergic system in the pathophysiology and treatment of Alzheimer’s disease’, Brain, 141 (7), 1917–33.Google Scholar

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