This chapter outlines the early development of UN CND and how it progressed towards its first new international treaty in 1948. Emerging from the tense post-war negotiations the key uncertainties for CND were: how it would operate in practice; how it would fit into broader UN and geopolitical streams; and whether it would function as a talking-shop or, as per the US vision, a tool to enforce regulations and publicly bludgeon member states as needed. The first three meetings of CND in 1946– 1948 would be pivotal. The first two served to sound out the political context within which CND would operate and how the structures would function in practice. Following this, a major political push occurred around the Third Session, first concluding a new Protocol and then spring boarding into discussions on a new production limitation convention and even advocating a new ‘single convention’ to unify all previous drug treaties.