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13 - LRRTM1:

a maternally suppressed genetic effect on handedness and schizophrenia

from Section 2 - Language lateralization and psychosis

Published online by Cambridge University Press:  10 December 2009

Iris E. C. Sommer
Affiliation:
Universiteit Utrecht, The Netherlands
René S. Kahn
Affiliation:
Universiteit Utrecht, The Netherlands
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Summary

This chapter describes how leucine-rich repeat transmembrane neuronal 1 (LRRTM1)'s involvement in handedness was discovered, and also the latest knowledge of its functions in brain development and disease. In searching for genetic effects on handedness and schizophrenia, it is therefore reasonable to approach complex and heterogeneous traits as multi-factorial, and to apply relatively model-free methods developed for human complex-trait genetics. Maximum likelihood variance-components modeling, with independent paternal and maternal quantitative-trait-locus (QTL) effects, also yielded an estimate of the paternal effect roughly five times that of the maternal effect at the peak of linkage. The single nucleotide polymorphisms (SNPs) were targeted within four positional and functional candidate genes on 2p12-p11 (LRRTM4, CTNNA2, LRRTM1, DNAH6). The chapter analyzes the SNPs rs1007371 and rs723524, which together can be used to construct a close proxy to the risk haplotype. The imprinting of LRRTM1 appears to be human or primate specific based on preliminary data.
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Publisher: Cambridge University Press
Print publication year: 2009

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  • LRRTM1:
  • Edited by Iris E. C. Sommer, Universiteit Utrecht, The Netherlands, René S. Kahn, Universiteit Utrecht, The Netherlands
  • Book: Language Lateralization and Psychosis
  • Online publication: 10 December 2009
  • Chapter DOI: https://doi.org/10.1017/CBO9780511576744.014
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  • LRRTM1:
  • Edited by Iris E. C. Sommer, Universiteit Utrecht, The Netherlands, René S. Kahn, Universiteit Utrecht, The Netherlands
  • Book: Language Lateralization and Psychosis
  • Online publication: 10 December 2009
  • Chapter DOI: https://doi.org/10.1017/CBO9780511576744.014
Available formats
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Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

  • LRRTM1:
  • Edited by Iris E. C. Sommer, Universiteit Utrecht, The Netherlands, René S. Kahn, Universiteit Utrecht, The Netherlands
  • Book: Language Lateralization and Psychosis
  • Online publication: 10 December 2009
  • Chapter DOI: https://doi.org/10.1017/CBO9780511576744.014
Available formats
×