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17 - New Concepts in Targeting and Imaging Liver Cancer

from PART III - ORGAN-SPECIFIC CANCERS

Published online by Cambridge University Press:  18 May 2010

By
Eleni Liapi ,
Christos S. Georgiades ,
Kelvin Hong  and
Jean-Francois H. Geschwind
Edited by
Jean-François H. Geschwind  and
Michael C. Soulen
Eleni Liapi
Affiliation:
Postdoctoral Research Fellow, Department of Radiology and Radiological Science Division of Cardiovascular and Interventional Radiology Johns Hopkins University School of Medicine Baltimore, MD
Christos S. Georgiades
Affiliation:
Assistant Professor, Department of Radiology and Radiological Science Division of Cardiovascular and Interventional Radiology Johns Hopkins University School of Medicine Baltimore, MD
Kelvin Hong
Affiliation:
Assistant Professor, Department of Radiology and Radiological Science Division of Cardiovascular and Interventional Radiology Johns Hopkins University School of Medicine Baltimore, MD
Jean-Francois H. Geschwind
Affiliation:
Professor of Radiology, Department of Radiology and Radiological Science Johns Hopkins University School of Medicine Baltimore, MD
Jean-François H. Geschwind
Affiliation:
The Johns Hopkins University School of Medicine
Michael C. Soulen
Affiliation:
University of Pennsylvania School of Medicine
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Summary

Ongoing research in the discipline of image-guided interventional oncology for hepatic malignancies seeks to discover and implement novel and effective therapeutic approaches in order to benefit patients with unresectable liver cancer. Research in this area incorporates advancements in the knowledge of liver cancer biology, new concepts in targeting liver cancer, development of novel drugs, improvement of intra-arterial drug delivery and technological advances of imaging systems.

This chapter is an overview of the most recent knowledge in liver cancer biology, new locoregional therapies for liver cancer and new imaging concepts for monitoring locoregional treatment response.

NEW CONCEPTS IN TARGETING LIVER CANCER

Targeting Angiogenesis

The fundamental role of angiogenesis in tumor progression was first suggested by Folkman et al. in a classic study describing that tumors cannot grow beyond 1 mm or 2 mm without the formation of new blood vessels (1). This complex process facilitates tumor progression and, eventually, tumor metastatic spread (1, 2). Several factors, including tumor hypoxia, growth factors, cytokines, oncogene activation and other mutations interact to stimulate angiogenesis (2, 3). Therefore, targeted inhibition of angiogenesis can be achieved at any of the aforementioned different levels, with treatments including the neutralization of growth factors with monoclonal antibodies (mAbs), the inhibition of downstream signaling from tyrosine kinase receptors and interference with the interaction between proliferating endothelial cells and matrix components.

Hepatocellular carcinoma (HCC) is one of the most vascular solid cancers, associated with a high propensity for vascular invasion.

Type
Chapter
Information
Interventional Oncology
Principles and Practice
 , pp. 202 - 212
Publisher: Cambridge University Press
Print publication year: 2008

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  • New Concepts in Targeting and Imaging Liver Cancer
    • By Eleni Liapi, Postdoctoral Research Fellow, Department of Radiology and Radiological Science Division of Cardiovascular and Interventional Radiology Johns Hopkins University School of Medicine Baltimore, MD, Christos S. Georgiades, Assistant Professor, Department of Radiology and Radiological Science Division of Cardiovascular and Interventional Radiology Johns Hopkins University School of Medicine Baltimore, MD, Kelvin Hong, Assistant Professor, Department of Radiology and Radiological Science Division of Cardiovascular and Interventional Radiology Johns Hopkins University School of Medicine Baltimore, MD, Jean-Francois H. Geschwind, Professor of Radiology, Department of Radiology and Radiological Science Johns Hopkins University School of Medicine Baltimore, MD
  • Edited by Jean-François H. Geschwind, The Johns Hopkins University School of Medicine, Michael C. Soulen, University of Pennsylvania School of Medicine
  • Book: Interventional Oncology
  • Online publication: 18 May 2010
  • Chapter DOI: https://doi.org/10.1017/CBO9780511722226.018
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  • New Concepts in Targeting and Imaging Liver Cancer
    • By Eleni Liapi, Postdoctoral Research Fellow, Department of Radiology and Radiological Science Division of Cardiovascular and Interventional Radiology Johns Hopkins University School of Medicine Baltimore, MD, Christos S. Georgiades, Assistant Professor, Department of Radiology and Radiological Science Division of Cardiovascular and Interventional Radiology Johns Hopkins University School of Medicine Baltimore, MD, Kelvin Hong, Assistant Professor, Department of Radiology and Radiological Science Division of Cardiovascular and Interventional Radiology Johns Hopkins University School of Medicine Baltimore, MD, Jean-Francois H. Geschwind, Professor of Radiology, Department of Radiology and Radiological Science Johns Hopkins University School of Medicine Baltimore, MD
  • Edited by Jean-François H. Geschwind, The Johns Hopkins University School of Medicine, Michael C. Soulen, University of Pennsylvania School of Medicine
  • Book: Interventional Oncology
  • Online publication: 18 May 2010
  • Chapter DOI: https://doi.org/10.1017/CBO9780511722226.018
Available formats
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To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

  • New Concepts in Targeting and Imaging Liver Cancer
    • By Eleni Liapi, Postdoctoral Research Fellow, Department of Radiology and Radiological Science Division of Cardiovascular and Interventional Radiology Johns Hopkins University School of Medicine Baltimore, MD, Christos S. Georgiades, Assistant Professor, Department of Radiology and Radiological Science Division of Cardiovascular and Interventional Radiology Johns Hopkins University School of Medicine Baltimore, MD, Kelvin Hong, Assistant Professor, Department of Radiology and Radiological Science Division of Cardiovascular and Interventional Radiology Johns Hopkins University School of Medicine Baltimore, MD, Jean-Francois H. Geschwind, Professor of Radiology, Department of Radiology and Radiological Science Johns Hopkins University School of Medicine Baltimore, MD
  • Edited by Jean-François H. Geschwind, The Johns Hopkins University School of Medicine, Michael C. Soulen, University of Pennsylvania School of Medicine
  • Book: Interventional Oncology
  • Online publication: 18 May 2010
  • Chapter DOI: https://doi.org/10.1017/CBO9780511722226.018
Available formats
×