Skip to main content Accessibility help
×
Hostname: page-component-586b7cd67f-t7czq Total loading time: 0 Render date: 2024-11-22T17:55:38.033Z Has data issue: false hasContentIssue false

Chapter 2 - Anatomy of the Insula

from Section 1 - The Human Insula from an Epileptological Standpoint

Published online by Cambridge University Press:  09 June 2022

Dang Nguyen
Affiliation:
Université de Montréal
Jean Isnard
Affiliation:
Claude Bernard University Lyon
Philippe Kahane
Affiliation:
Grenoble-Alpes University Hospital
Get access

Summary

In this chapter, the insula’s microanatomy, consisting of five main gyri – three anterior short and two posterior long gyri – is described and nomenclature differences from the nineteenth to twenty-first century tabulated to ease communication. The insula’s relationship to neighboring structures is highlighted, as these relationships are important for the exploration of the insula with depth electrodes as part of the presurgical investigation. Quantitative data on the insula’s features (i.e., volumes and extents) are summarized. The chapter finishes with a brief overview of the scarce data on neurotransmitter systems in the insula and the relevance of insular anatomy for the interpretation of functional imaging results with PET.

Type
Chapter
Information
Insular Epilepsies , pp. 11 - 25
Publisher: Cambridge University Press
Print publication year: 2022

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Vesalius, A., De humani corporis fabrica libri septem. 1543, Basilea: Ex officina I. Oporini. 659.Google Scholar
Reil, J.C., Die Sylvische Grube oder das Thal, das gestreifte grosse Hirnganglium, dessen Kapsel und die Seitentheile des grossen Gehirns. Arch Physiol, 1809. 9: pp. 195208.Google Scholar
Gray, H., Anatomy Descriptive and Surgical. 1858, London: John W. Parker and Son. 750.Google Scholar
Ono, M., Kubik, S., and Abernathey, C.D., Atlas of the Cerebral Sulci. 1990, Stuttgart and New York: Georg Thieme Verlag. 218.Google Scholar
Mutschler, I., et al., Functional organization of the human anterior insular cortex. Neurosci Lett, 2009. 457(2): pp. 6670.CrossRefGoogle Scholar
Kurth, F., et al., A link between the systems: functional differentiation and integration within the human insula revealed by meta-analysis. Brain Structure & Function, 2010. 214(5–6): pp. 519534.CrossRefGoogle ScholarPubMed
Nieuwenhuys, R., The insular cortex: A review. Prog Brain Res, 2012. 195: pp. 123163.CrossRefGoogle ScholarPubMed
Retzius, G., Das Menschenhirn: Studien in der makroskopischen Morphologie. 1896, Stockholm: P.A. Norstedt.Google Scholar
Cunningham, D.J., Development of the gyri and sulci on the surface of the island of Reil of the human brain. J Anat Physiol, 1891. 25(pt 3): pp. 338348.Google Scholar
Türe, U., et al., Topographic anatomy of the insular region. Journal of Neurosurgery, 1999. 90(4): pp. 720733.Google Scholar
Naidich, T.P., et al., The insula: Anatomic study and MR Imaging display at 1.5 T. American Journal of Neuroradiology, 2004. 25(2): pp. 222232.Google Scholar
Faillenot, I., et al., Macroanatomy and 3D probabilistic atlas of the human insula. Neuroimage, 2017. 150: pp. 8898.CrossRefGoogle ScholarPubMed
Afif, A., Becq, G., and Mertens, P., Definition of a stereotactic 3-dimensional magnetic resonance imaging template of the human insula. Neurosurgery, 2013. 72(1 Suppl Operative): pp. 3546; discussion 46.Google Scholar
Brodmann, K., Vergleichende Lokalisationslehre der Großhirnrinde in ihren Prinzipien dargestellt aufgrund des Zellenbaues. 1909, Leipzig: Barth, J.A.Google Scholar
Morel, A., et al., The human insula: Architectonic organization and postmortem MRI registration. Neuroscience, 2013. 236: pp. 117135.CrossRefGoogle ScholarPubMed
Jakab, A., et al., Connectivity-based parcellation reveals interhemispheric differences in the insula. Brain Topography, 2012. 25(3): pp. 264271.Google Scholar
Hammers, A., et al., Three-dimensional maximum probability atlas of the human brain, with particular reference to the temporal lobe. Hum Brain Mapp, 2003. 19: pp. 224247.CrossRefGoogle Scholar
Brockhaus, H., Die Cyto- und Myeloarchitektonik des Cortex claustralis und des Claustrum beim Menschen. J Psychol Neurol, 1940. 49: pp. 249348.Google Scholar
Good, C.D., et al., A voxel-based morphometric study of ageing in 465 normal adult human brains. Neuroimage, 2001. 14(pt 1): pp. 2136.CrossRefGoogle ScholarPubMed
Heckemann, R.A., et al., Improving intersubject image registration using tissue-class information benefits robustness and accuracy of multi-atlas based anatomical segmentation. Neuroimage, 2010 May 15;51(1):221227.Google Scholar
Stiles, J., Jernigan, T.L., The basics of brain development. Neuropsychol Rev, 2010. 20: pp. 327348.Google Scholar
Verburg, B.O., et al., New charts for ultrasound dating of pregnancy and assessment of fetal growth: longitudinal data from a population-based cohort study. Ultrasound Obstet Gynecol, 2008. 31(4): pp. 388396.Google Scholar
Hochstetter, F., Beiträge zur Entwicklungsgeschichte des menschlichen Gehirns. 1919, Wien and Leipzig: Franz Deuticke. 224.Google Scholar
Afif, A., et al., Development of the human fetal insular cortex: Study of the gyration from 13 to 28 gestational weeks. Brain Struct Funct, 2007. 212(3–4): pp. 335346.CrossRefGoogle ScholarPubMed
Streeter, G.L., The development of the nervous system, in Manual of Human Embyology, Keibel, F., Mall, F.P., Editor. 1912, Lippincott: Philadelphia and London. pp. 1156.Google Scholar
Chi, J.G., Dooling, E.C., Gilles, F.H., Gyral development of the human brain. Ann Neurol, 1977. 1: pp. 8693.Google Scholar
von Economo, C., and Koskinas, G.N., Die Cytoarchitektonik der Hirnrinde des erwachsenen Menschen. 1925, Berlin: Springer.Google Scholar
Rose, M., Die Inselrinde des Menschen und der Tiere. J Psychol Neurol, 1928. 37: pp. 467624.Google Scholar
Mesulam, M.M., Mufson, E.J., The insula of Reil in man and monkey, in Association and Auditory Cortices, Peters, J.E.G., Editor. 1985, Springer: Boston.Google Scholar
Kurth, F., et al., Cytoarchitecture and probabilistic maps of the human posterior insular cortex. Cereb Cortex, 2010. 20(6): pp. 14481461.Google Scholar
von Economo, C., Eine neue Art Spezialzellen des Lobus cinguli und Lobus insulae. Zeitschrift für die gesamte Neurologie und Psychiatrie, 1926. 100(1): pp. 706712.Google Scholar
Mazzola, L., et al., Spatial segregation of somato- sensory and pain activations in the human operculo-insular cortex. Neuroimage, 2012. 60(1): pp. 409418.Google Scholar
Glasser, M.F., et al., A multi-modal parcellation of human cerebral cortex. Nature, 2016. 536(7615): pp. 171178.Google Scholar
Kelly, C., et al., A convergent functional architecture of the insula emerges across imaging modalities. Neuroimage, 2012. 61(4): pp. 11291142.Google Scholar
Cerliani, L., et al., Probabilistic tractography recovers a rostrocaudal trajectory of connectivity variability in the human insular cortex. Hum Brain Mapp, 2012. 33(9): pp. 20052034.Google Scholar
Bishop, K.M., Rubenstein, J.L., and O’Leary, D.D., Distinct actions of Emx1, Emx2, and Pax6 in regulating the specification of areas in the developing neocortex. J Neurosci, 2002. 22(17): pp. 76277638.Google Scholar
Klingler, J., and Gloor, P., The connections of the amygdala and of the anterior temporal cortex in the human brain. J Comp Neurol, 1960. 115: pp. 333369.Google Scholar
Frot, M., Faillenot, I., and Mauguiere, F., Processing of nociceptive input from posterior to anterior insula in humans. Hum Brain Mapp, 2014. 35(11): pp. 54865499.Google Scholar
Rocher, A.B., et al., Resting-state brain glucose utilization as measured by PET is directly related to regional synaptophysin levels: a study in baboons. Neuroimage, 2003. 20(3): pp. 18941898.CrossRefGoogle Scholar
Sibson, N.R., et al., Stoichiometric coupling of brain glucose metabolism and glutamatergic neuronal activity. Proc Natl Acad Sci U S A, 1998. 95(1): pp. 316321.CrossRefGoogle ScholarPubMed
von Spiczak, S., et al., The role of opioids in restless legs syndrome: an [11C]diprenorphine PET study. Brain, 2005. 128(Pt 4): pp. 906917.Google Scholar
Hammers, A., and Lingford-Hughes, A., Opioid imaging. Neuroimaging Clin N Am, 2006. 16(4): pp. 529552.Google Scholar
Hammers, A., PET in MRI-negative refractory focal epilepsy, in MRI-Negative Epilepsy – Evaluation and Surgical Management, So, E.L., Ryvlin, P., Editors. 2015, Cambridge University Press: Cambridge. pp. 2837.Google Scholar
McGinnity, C.J., et al., Test-retest reproducibility of quantitative binding measures of [11C]Ro15-4513, a PET ligand for GABA(A) receptors containing alpha5 subunits. Neuroimage, 2017. 152: pp. 270282.Google Scholar
Picard, F., et al., High density of nicotinic receptors in the cingulo-insular network. Neuroimage, 2013. 79: pp. 4251.Google Scholar
Picard, F., et al., Alteration of the in vivo nicotinic receptor density in ADNFLE patients: a PET study. Brain, 2006. 129(pt 8): pp. 20472060.CrossRefGoogle ScholarPubMed
Nieuwenhuys, R., Chemoarchitecture of the Brain. 1985, Berlin Heidelberg: Springer. 246.Google Scholar
Counsell, S.J., et al., Fetal and neonatal neuroimaging. Handb Clin Neurol, 2019. 162: pp. 67103.Google Scholar

Save book to Kindle

To save this book to your Kindle, first ensure [email protected] is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Available formats
×

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

Available formats
×