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4 - Evolutionary Biology of Malarial Parasites

Published online by Cambridge University Press:  10 August 2009

By
Ananias A. Escalante  and
Altaf A. Lal
Edited by
Krishna R. Dronamraju
Ananias A. Escalante
Affiliation:
Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, Atlanta, Georgia 30333
Altaf A. Lal
Affiliation:
U.S. Embassy, New Delhi, 110021, India
Krishna R. Dronamraju
Affiliation:
Foundation for Genetic Research, Houston, Texas
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Summary

INTRODUCTION

Analysis of Plasmodium spp. genome sequences would allow for the discovery of thousands of new genes and proteins, providing a unique opportunity for understanding the complex biology of malarial parasites. However, the identification of these new genes will be followed by the same old questions that researchers have faced for nearly three decades: how variable are the newly identified genes? How is such variation generated and maintained? How can this diversity affect intervention efforts?

Understanding the origin and extent of malarial parasites' genetic diversity, and the implications of these on the development of new intervention strategies, requires a close collaboration between biomedical researchers and evolutionary biologists. In the case of malaria research, as is the case in the study of many other infectious diseases, biomedical researchers/public health professionals and evolutionary biologists have traditionally worked in isolation.

Biomedical researchers and public health managers often seek answers to the following questions: What are the specific clinical end points in malaria? What level of efficacy can be expected from a multivalent vaccine? How does drug-resistance emerge? How quickly do drug-resistant parasites disperse? What is the impact of transmission pressure on the dispersal of drug-resistant parasites? Is it better to use one drug at a time or to use a “cocktail” before any of the drugs become ineffective? What is the impact of bed-nets on the selection of parasite lines?

Type
Chapter
Information
Infectious Disease and Host-Pathogen Evolution , pp. 75 - 112
Publisher: Cambridge University Press
Print publication year: 2004

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  • Evolutionary Biology of Malarial Parasites
    • By Ananias A. Escalante, Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, Atlanta, Georgia 30333, Altaf A. Lal, U.S. Embassy, New Delhi, 110021, India
  • Edited by Krishna R. Dronamraju, Foundation for Genetic Research, Houston, Texas
  • Book: Infectious Disease and Host-Pathogen Evolution
  • Online publication: 10 August 2009
  • Chapter DOI: https://doi.org/10.1017/CBO9780511546259.005
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  • Evolutionary Biology of Malarial Parasites
    • By Ananias A. Escalante, Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, Atlanta, Georgia 30333, Altaf A. Lal, U.S. Embassy, New Delhi, 110021, India
  • Edited by Krishna R. Dronamraju, Foundation for Genetic Research, Houston, Texas
  • Book: Infectious Disease and Host-Pathogen Evolution
  • Online publication: 10 August 2009
  • Chapter DOI: https://doi.org/10.1017/CBO9780511546259.005
Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

  • Evolutionary Biology of Malarial Parasites
    • By Ananias A. Escalante, Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, US Department of Health and Human Services, Atlanta, Georgia 30333, Altaf A. Lal, U.S. Embassy, New Delhi, 110021, India
  • Edited by Krishna R. Dronamraju, Foundation for Genetic Research, Houston, Texas
  • Book: Infectious Disease and Host-Pathogen Evolution
  • Online publication: 10 August 2009
  • Chapter DOI: https://doi.org/10.1017/CBO9780511546259.005
Available formats
×