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Chapter 4 - Individualized Luteal Phase Support

Published online by Cambridge University Press:  12 February 2021

By
Barbara Lawrenz  and
Human M. Fatemi
Edited by
Human M. Fatemi  and
Barbara Lawrenz
Human M. Fatemi
Affiliation:
IVI Middle East Fertility Clinic, Abu Dhabi, UAE
Barbara Lawrenz
Affiliation:
IVI Middle East Fertility Clinic, Abu Dhabi, UAE
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Summary

In ovarian stimulation cycles for IVF/ICSI, a defective luteal phase occurs in almost all patients as a result of the multifollicular development and supraphysiological hormonal levels, which inhibit the LH secretion by the pituitary via negative feedback actions at the level of the hypothalamic-pituitary axis. Progesterone is crucial to induce secretory transformation of the endometrium after previous estrogenization, a process which will finally result in a receptive endometrium. Consequently, luteal phase support (LPS) represents an essential part of ART treatment in case of a planned fresh embryo transfer, as it is crucial to counterbalance the luteal phase insufficiency.

Type
Chapter
Information
Individualized In-Vitro Fertilization
Delivering Precision Fertility Treatment
 , pp. 39 - 49
Publisher: Cambridge University Press
Print publication year: 2021

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