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29 - Evolutionary Medicine and the Causes of Chronic Disease

Published online by Cambridge University Press:  05 August 2012

By
Paul W. Ewald
Edited by
Michael P. Muehlenbein
Michael P. Muehlenbein
Affiliation:
Indiana University, Bloomington
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Summary

The current integration of evolution with medicine is artificially narrow because it reflects the biases of medicine as a whole and the specializations of particular investigators. If evolutionary principles are to offer a fundamental framework for understanding medical issues they should help identify these biases and the areas over which integration needs to be broadened. The chapter discusses this problem as it relates to evolutionary interpretations of chronic diseases. It also illustrates how an evolutionary perspective can provide a broader framework for resolving the causes and control of chronic diseases, focusing on the greatest killers in prosperous societies – atherosclerosis and cancer.

OVERVIEW OF CHRONIC DISEASES

Chronic diseases account for about 70% of the mortality in the United States and other wealthy countries. Most of this disease-induced mortality is attributable to heart attacks, strokes, and cancer. In spite of this importance, the causes of chronic diseases remain largely unresolved. This situation represents a major short-coming of modern medicine because understanding the causes of disease enables prevention, and prevention is the most effective way of eliminating the damage inflicted by disease. We can therefore expect that a better understanding of the causes of chronic diseases will yield some of the most valuable contributions that any discipline can make to improvements in health.

Chronic diseases can be defined broadly as diseases that persist within individuals for a long time. The US National Center for Health Statistics considers “long” to mean persistence for at least three months.

Type
Chapter
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Human Evolutionary Biology , pp. 502 - 517
Publisher: Cambridge University Press
Print publication year: 2010

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References

Almog, Y., Novack, V., Eisinger, M., et al. (2007). The effect of statin therapy on infection-related mortality in patients with atherosclerotic diseases. Critical Care Medicine, 35, 1635–1636.CrossRefGoogle ScholarPubMed
Andersson, K., Waterboer, T., Kirnbauer, R., et al. (2008). Seroreactivity to cutaneous human papillomaviruses among patients with nonmelanoma skin cancer or benign skin lesions. Cancer Epidemiology, Biomarkers and Prevention, 17, 189–195.CrossRefGoogle ScholarPubMed
Austad, S. N. (1997). Why We Age. What Science is Discovering About the Body's Journey Through Life. New York: Wiley.Google Scholar
Austad, S. N. and Finch, C. E. (2008). The evolutionary context of human aging and degenerative disease. In Evolution in Health and Disease, Stearns, S. S. and Koella, J. C. (eds). New York: Oxford University Press, pp. 301–311.Google Scholar
Balin, B. J., Gerard, H. C., Arking, E. J., et al. (1998). Identification and localization of Chlamydia pneumoniae in the Alzheimer's brain. Medical Microbiology and Immunology, 187, 23–42.CrossRefGoogle ScholarPubMed
Berker, B., Soylemez, F., Cengiz, S. D., et al. (2003). Serologic assay of Helicobacter pylori infection. Is it useful in hyperemesis gravidarum? Journal of Reproductive Medicine, 48, 809–812.Google ScholarPubMed
Bonnet, M., Guinebretiere, J.-M., Kremmer, E., et al. (1999). Detection of Epstein–Barr virus in invasive breast cancers. Journal of the National Cancer Institute, 91, 1376–1381.CrossRefGoogle ScholarPubMed
Branca, M., Giorgi, C., Ciotti, M., et al. (2006). Down-regulated nucleoside diphosphate (NDP) kinase nm23-H1 expression is unrelated to high-risk human papillomavirus (HPV) but associated with progression of cin and unfavourable prognosis in cervical cancer. Journal of Clinical Pathology, 59, 1044–1051.CrossRefGoogle Scholar
Brown, A. S., Begg, M. D., Gravenstein, S., et al. (2004). Serologic evidence of prenatal influenza in the etiology of schizophrenia. Archives of General Psychiatry, 61, 774–780.CrossRefGoogle ScholarPubMed
Bruzzi, P., Negri, E., Vecchia, C., et al. (1988). Short term increase in risk of breast cancer after full term pregnancy. British Medical Journal, 297, 1096–1098.CrossRefGoogle ScholarPubMed
Cevrioglu, A. S., Altindis, M., Yilmazer, M., et al. (2004). Efficient and non-invasive method for investigating Helicobacter pylori in gravida with hyperemesis gravidarum: Helicobacter pylori stool antigen test. Journal of Obstetrics and Gynaecology Research, 30, 136–141.CrossRefGoogle ScholarPubMed
Cochran, G. M., Ewald, P. W. and Cochran, K. D. (2000). Infectious causation of disease: an evolutionary perspective. Perspectives in Biology and Medicine, 43, 406–448.CrossRefGoogle Scholar
Conde-Agudelo, A. and Belizan, J. M. (2000). Risk factors for preeclampsia in a large cohort of Latin American and Caribbean women. British Journal of Obstetrics and Gynaecology, 107, 75–83.CrossRefGoogle Scholar
Conde-Agudelo, A., Villar, J. and Lindheimer, M. (2008). Maternal infection and risk of preeclampsia: systematic review and metaanalysis. American Journal of Obstetrics and Gynecology, 198, 7–22.CrossRefGoogle ScholarPubMed
Corbo, R. M. and Scacchi, R. (1999). Apolipoprotein E (APOE) allele distribution in the world. Is APOE4 a “thrifty” allele? Annals of Human Genetics, 63, 301–310.CrossRefGoogle ScholarPubMed
Crespi, B. J. and Summers, K. (2005). Evolutionary biology of cancer. Trends in Ecology and Evolution, 20, 545–552.CrossRefGoogle ScholarPubMed
Crespi, B. J. and Summers, K. (2006). Positive selection in the evolution of cancer. Biological Reviews of the Cambridge Philosophical Society, 81, 407–424.CrossRefGoogle Scholar
Crespi, B. J., Summers, K. and Dorus, S. (2007). Adaptive evolution of genes underlying schizophrenia. Proceedings of the Royal Society of London. Series B, 274, 2801–2810.CrossRefGoogle ScholarPubMed
Crowther, M. A. (2005). Pathogenesis of atherosclerosis. Hematology. Education Program of the American Society of Hematology, 1, 436–441.Google Scholar
Damin, A., Karam, R., Zettler, C., et al. (2004). Evidence for an association of human papillomavirus and breast carcinomas. Breast Cancer Research and Treatment, 84, 131–137.CrossRefGoogle ScholarPubMed
Villiers, E.-M., Sandstrom, R., Zur Hausen, H., et al. (2005). Presence of papillomavirus sequences in condylomatous lesions of the mammillae and in invasive carcinoma of the breast. Breast Cancer Research, 7, R1–R11.CrossRefGoogle Scholar
Delport, W. and Merwe, S. W. (2007). The transmission of Helicobacter pylori: the effects of analysis method and study population on inference. Best Practice and Research: Clinical Gastroenterology, 21, 215–236.CrossRefGoogle ScholarPubMed
Diamond, J. (2005). Evolutionary biology: Geography and skin colour. Nature, 435, 283–284.CrossRefGoogle ScholarPubMed
Ding, L., Li, L., Yang, J., et al. (2007). Latent membrane protein 1 encoded by Epstein–Barr virus induces telomerase activity via p16INK4A/Rb/E2F1 and JNK signaling pathways. Journal of Medical Virology, 79, 1153–1163.CrossRefGoogle ScholarPubMed
Doyle, C., Swain Ewald, H. A. and Ewald, P. W. (2007). Premenstrual syndrome: an evolutionary perspective on its causes and treatment. Perspectives in Biology and Medicine, 50, 181–202.CrossRefGoogle ScholarPubMed
Doyle, C., Swain Ewald, H. A. and Ewald, P. W. (2008). An evolutionary perspective on premenstrual syndrome and its implications for investigating infectious causes of chronic disease. In Evolutionary Medicine and Health. New Perspectives, Trevathan, W. R., Smith, E. O. and Mckenna, J. J. (eds). New York: Oxford University Press, pp. 196–215.Google Scholar
Dupont, H. L. and Hornick, R. B. (1973). Adverse effect of Lomotil therapy in shigellosis. Journal of the American Medical Association, 226, 1525–1528.CrossRefGoogle ScholarPubMed
Eaton, S. B. and Eaton, S. B. I I I (1999). Breast cancer in evolutionary context. In Evolutionary Medicine, Trevathan, W. R., Smith, E. O. and Mckenna, J. J. (eds). New York: Oxford University Press, pp. 429–442.Google Scholar
Eaton, S. B., Shostak, M. and Konner, M. (1988). The Paleolithic Prescription. New York: Harper and Row.Google Scholar
Eaton, S. B., Pike, M. C., Short, R. V., et al. (1994). Women's reproductive cancers in evolutionary context. Quarterly Review of Biology, 69, 353–367.CrossRefGoogle ScholarPubMed
Ewald, P. W. (1980). Evolutionary biology and treatment of signs and symptoms of infectious disease. Journal of Theoretical Biology, 86, 169–176.CrossRefGoogle ScholarPubMed
Ewald, P. W. (1994). Evolution of Infectious Disease. New York: Oxford University Press.Google Scholar
Ewald, P. W. (2000). Plague Time. How Stealth Infections Cause Cancer, Heart Disease, and Other Deadly Ailments. New York: Free Press.Google Scholar
Ewald, P. W. (2008). An evolutionary perspective on the causes of chronic diseases: atherosclerosis as an illustration. In Evolutionary Medicine and Health. New Perspectives, Trevathan, W. R., Smith, E. O. and Mckenna, J. J. (eds). New York: Oxford University Press, pp. 350–367.Google Scholar
Ewald, P. W. (2009). An evolutionary perspective on parasitism as a cause of cancer. Advances in Parasitology, 61, 28–43.Google Scholar
Ewald, P. W. and Cochran, G. M. (2000). Chlamydia pneumoniae and cardiovascular disease: an evolutionary perspective on infectious causation and antibiotic treatment. Journal of Infectious Diseases, 181, S394–S401.CrossRefGoogle ScholarPubMed
Fina, F., Romain, S., Ouafik, L. H., et al. (2001). Frequency and genome load of Epstein–Barr virus in 509 breast cancers from different geographical areas. British Journal of Cancer, 84, 783–790.CrossRefGoogle ScholarPubMed
Finch, C. E. (2007). The Biology of Human Longevity: Inflammation, Nutrition, and Aging in the Evolution of Lifespans. Boston: Academic.Google Scholar
Finch, C. E. and Stanford, C. B. (2004). Meat-adaptive genes and the evolution of slower aging in humans. Quarterly Review of Biology, 79, 3–50.CrossRefGoogle ScholarPubMed
Flaxman, S. M. and Sherman, P. W. (2000). Morning sickness: a mechanism for protecting mother and embryo. Quarterly Review of Biology, 75, 113–148.CrossRefGoogle ScholarPubMed
Frank, S. A. (2007). Dynamics of Cancer. Incidence, Inheritance, and Evolution. Princeton: Princeton University Press.Google ScholarPubMed
Fujimoto, Y., Furusyo, N., Toyoda, K., et al. (2007). Intrafamilial transmission of Helicobacter pylori among the population of endemic areas in Japan. Helicobacter, 12, 170–176.CrossRefGoogle ScholarPubMed
Fullerton, S. M., Clark, A. G., Weiss, K. M., et al. (2000). Apolipoprotein E variation at the sequence haplotype level: implications for the origin and maintenance of a major human polymorphism. American Journal of Human Genetics, 67, 881–900.CrossRefGoogle ScholarPubMed
Gardner, C. D., Lawson, L. D., Block, E., et al. (2007). Effect of raw garlic vs. commercial garlic supplements on plasma lipid concentrations in adults with moderate hypercholesterolemia: a randomized clinical trial. Archives of Internal Medicine, 167, 346–353.CrossRefGoogle ScholarPubMed
Gérard, H. C., Wang, G. F., Balin, B. J., et al. (1999). Frequency of apolipoprotein E (APOE) allele types in patients with Chlamydia-associated arthritis and other arthritides. Microbial Pathogenesis, 26, 35–43.CrossRefGoogle ScholarPubMed
Gérard, H. C., Fomicheva, E., Whittum-Hudson, J. A., et al. (2008). Apolipoprotein E4 enhances attachment of Chlamydophila (Chlamydia) pneumoniae elementary bodies to host cells. Microbial Pathogenesis, 44, 279–285.CrossRefGoogle ScholarPubMed
Gerber, L. M. and Crews, D. E. (1999). Evolutionary perspectives on chronic degenerative diseases. In Evolutionary Medicine, Trevathan, W. R., Smith, E. O. and McKenna, J. J. (eds). New York: Oxford University Press, pp. 443–469.Google Scholar
Greaves, M. (2000). Cancer. The Evolutionary Legacy. Oxford: Oxford University Press.Google Scholar
Greaves, M. (2006). Infection, immune responses and the aetiology of childhood leukaemia. Nature Reviews Cancer, 3, 193–203.CrossRefGoogle Scholar
Greaves, M. (2008). Cancer: evolutionary origins of vulnerability. In Evolution in Health and Disease, Stearns, S. S. and Koella, J. C. (eds). New York: Oxford University Press, pp. 277–287.Google Scholar
Guasparri, I., Bubman, D. and Cesarman, E. (2008). EBV LMP2A affects LMP1-mediated NF-κB signaling and survival of lymphoma cells by regulating TRAF2 expression. Blood, 111, 3813–3820.CrossRefGoogle ScholarPubMed
Haig, D. (1993). Genetic conflicts in human pregnancy. Quarterly Review of Biology, 68, 495–532.CrossRefGoogle ScholarPubMed
Haig, D. (2008). Intimate relations: evolutionary conflicts of pregnancy and childhood. In Evolution in Health and Disease, Stearns, S. S. and Koella, J. C. (eds). New York: Oxford University Press, pp. 65–76.Google Scholar
Hino, R., Uozaki, H., Inoue, Y., et al. (2008). Survival advantage of EBV-associated gastric carcinoma: surviving up-regulation by viral latent membrane protein 2A. Cancer Research, 68, 1427–1435.CrossRefGoogle Scholar
Hinze-Selch, D., Däubener, W., Eggert, L., et al. (2007). A controlled prospective study of Toxoplasma gondii infection in individuals with schizophrenia: beyond seroprevalence. Schizophrenia Bulletin, 33, 782–788.CrossRefGoogle ScholarPubMed
Hook, E. B. (1976). Changes in tobacco smoking and ingestion of alcohol and caffeinated beverages during early pregnancy: are these consequences in part of feto-protective mechanisms diminishing maternal exposure to embryo toxins. In Birth Defects, Risks and Consequences, Kelly, S. (ed.). New York: Academic, pp. 173–183.Google Scholar
Ilveskoski, E., Perola, M., Lehtimaki, T., et al. (1999). Age-dependent association of apolipoprotein E genotype with coronary and aortic atherosclerosis in middle-aged men. An autopsy study. Circulation, 100, 608–613.CrossRefGoogle ScholarPubMed
Jacobson, G. F., Autry, A. M., Somer-Shely, T. L., et al. (2003). Helicobacter pylori seropositivity and hyperemesis gravidarum. Journal of Reproductive Medicine, 48, 578–582.Google ScholarPubMed
Jenson, A. B., Geyer, S., Sundberg, J. P., et al. (2001). Human papillomavirus and skin cancer. Journal of Investigative Dermatology Symposium Proceedings, 6, 203–206.CrossRefGoogle ScholarPubMed
Jerwood, S. and Cohen, J. (2008). Unexpected antimicrobial effect of statins. Journal of Antimicrobial Chemotherapy, 61, 362–364.CrossRefGoogle ScholarPubMed
Kan, C.-Y., Iacopetta, B., Lawson, J., et al. (2005). Identification of human papillomavirus DNA gene sequences in human breast cancer. British Journal of Cancer, 93, 946–948.CrossRefGoogle ScholarPubMed
Karaer, A., Ozkan, O., Ozer, S., et al. (2008). Gastrointestinal symptoms and Helicobacter pylori infection in early pregnancy. A seroepidemiologic study. Gynecologic and Obstetric Investigation, 66, 44–46.CrossRefGoogle ScholarPubMed
Karagas, M. R., Nelson, H. H., Sehr, P., et al. (2006). Human papillomavirus infection and incidence of squamous cell and basal cell carcinomas of the skin. Journal of the National Cancer Institute, 98, 1425–1426.CrossRefGoogle Scholar
Karagas, M. R., Nelson, H. H., Zens, M. S., et al. (2007). Squamous cell and basal cell carcinoma of the skin in relation to radiation therapy and potential modification of risk by sun exposure. Epidemiology, 18, 776–784.CrossRefGoogle ScholarPubMed
Katz, E., Lareef, M. H., Rassa, J. C., et al. (2005). MMTV Env encodes an ITAM responsible for transformation of mammary epithelial cells in three-dimensional culture. Journal of Experimental Medicine, 201, 431–439.CrossRefGoogle ScholarPubMed
Kazerooni, T., Taallom, M. and Ghaderi, A. A. (2002). Helicobacter pylori seropositivity in patients with hyperemesis gravidarum. International Journal of Gynaecology and Obstetrics, 79, 217–220.CrossRefGoogle ScholarPubMed
Key, T. J. A. and Pike, M. C. (1988). The role of oestrogens and progestagens in the epidemiology and prevention of breast cancer. European Journal of Cancer and Clinical Oncology, 24, 29–43.CrossRefGoogle ScholarPubMed
Kleer, C., Tseng, M., Gutsch, D., et al. (2002). Detection of Epstein–Barr virus in rapidly growing fibroadenomas of the breast in immunosuppressed hosts. Modern Pathology, 15, 759–764.CrossRefGoogle ScholarPubMed
Kleinsmith, L. J. (2005). Principles of Cancer Biology. San Francisco: Pearson/Benjamin Cummings.Google Scholar
Knight, J., Sharma, N. and Robertson, E. (2005). Epstein–Barr virus latent antigen 3C can mediate the degradation of the retinoblastoma protein through an SCF cellular ubiqitin ligase. Proceedings of the National Academy of Sciences of the United States of America, 102, 18562–18566.CrossRefGoogle Scholar
Koçak, I., Akcan, Y., Ustün, C., et al. (1999). Helicobacter pylori seropositivity in patients with hyperemesis gravidarum. International Journal of Gynaecology and Obstetrics, 66, 251–254.CrossRefGoogle ScholarPubMed
Komarova, N. L. and Wodarz, D. (2008). Cancer as a microevolutionary process. In Evolution in Health and Disease, Stearns, S. S. and Koella, J. C. (eds). New York: Oxford University Press, pp. 289–299.Google Scholar
Lambe, M., Hsieh, C., Trichopoulos, D., et al. (1994). Transient increase in risk of breast cancer after giving birth. New England Journal of Medicine, 331, 5–9.CrossRefGoogle ScholarPubMed
Lawson, J. S., Tran, D. and Rawlinson, W. D. (2001). From Bittner to Barr: a viral, diet and hormone breast cancer aetiology hypothesis. Breast Cancer Research, 3, 81–85.CrossRefGoogle ScholarPubMed
Ledgerwood, L. G., Ewald, P. W. and Cochran, G. M. (2003). Genes, germs, and schizophrenia: an evolutionary perspective. Perspectives in Biology and Medicine, 46, 317–348.CrossRefGoogle Scholar
Lee, R. H., Pan, V. L. and Wing, D. A. (2005). The prevalence of Helicobacter pylori in the Hispanic population affected by hyperemesis gravidarum. American Journal of Obstetrics Gynecology, 193, 1024–1027.CrossRefGoogle ScholarPubMed
Lencz, T., Morgan, T. V., Athanasiou, M., et al. (2007). Converging evidence for a pseudoautosomal cytokine receptor gene locus in schizophrenia. Molecular Psychiatry, 12, 572–580.CrossRefGoogle Scholar
Leonard, W. R. (2008). Lifestyle, diet, and disease: comparative perspectives on the determinants of chronic health risks. In Evolution in Health and Disease, Stearns, S. S. and Koella, J. C. (eds). New York: Oxford University Press, pp. 265–276.Google Scholar
Liu, W. K., Chu, Y. L., Zhang, F., et al. (2005). The relationship between HPV16 and expression of CD44v6, nm23H1 in esophageal squamous cell carcinoma. Archives of Virology, 150, 991–1001.CrossRefGoogle ScholarPubMed
Liu, X., Roberts, J., Dakic, A., et al. (2008). HPV E7 contributes to the telomerase activity of immortalized and tumorigenic cells and augments E6-induced hTERT promoter function. Virology, 375, 611–623.CrossRefGoogle ScholarPubMed
Mahley, R. W. and Huang, Y. D. (1999). Apolipoprotein E: from atherosclerosis to Alzheimer's disease and beyond. Current Opinion in Lipidology, 10, 207–217.CrossRefGoogle ScholarPubMed
Maula, S., Huuhtanen, R. L., Blomqvist, C. P., et al. (2001). The adhesion molecule CD44v6 is associated with a high risk for local recurrence in adult soft tissue sarcomas. British Journal of Cancer, 84, 244–252.CrossRefGoogle ScholarPubMed
Mays, M. E. and Dujovne, C. A. (2008). Pleiotropic effects: should statins be considered an essential component in the treatment of dyslipidemia?Current Atherosclerosis Reports, 10, 45–52.CrossRefGoogle ScholarPubMed
McKenna, D., Watson, P. and Dornan, J. (2003). Helicobacter pylori infection and dyspepsia in pregnancy. Obstetrics and Gynecology, 102, 845–849.Google ScholarPubMed
Merlo, L. M., Pepper, J. W., Reid, B. J., et al. (2006). Cancer as an evolutionary and ecological process. Nature Reviews Cancer, 6, 924–935.CrossRefGoogle ScholarPubMed
Mileo, A. M., Piombino, E., Severino, A., et al. (2006). Multiple interference of the human papillomavirus-16 E7 oncoprotein with the functional role of the metastasis suppressor Nm23-H1 protein. Journal of Bioenergetics and Biomembranes, 38, 215–225.CrossRefGoogle ScholarPubMed
Mortensen, P. B., Nørgaard-Pedersen, B., Waltoft, B. L., et al. (2007). Early infections of Toxoplasma gondii and the later development of schizophrenia. Schizophrenia Bulletin, 33, 741–744.CrossRefGoogle ScholarPubMed
Murakami, M., Lan, K., Subramanian, C., et al. (2005). Epstein–Barr virus nuclear antigen 1 interacts with Nm23-H1 in lymphoblastoid cell lines and inhibits its ability to suppress cell migration. Journal of Virology, 79, 1559–1568.CrossRefGoogle ScholarPubMed
Nesse, R. M. (2008). The importance of evolution for medicine. In Evolutionary Medicine and Health. New Perspectives, Trevathan, W. R., Smith, E. O. and Mckenna, J. J. (eds). New York: Oxford University Press, pp. 416–433.Google Scholar
Nesse, R. M. and Stearns, S. C. (2008). The great opportunity: evolutionary applications to medicine and public health. Evolutionary Applications, 1, 28–48.CrossRefGoogle ScholarPubMed
Nesse, R. M. and Williams, G. C. (1995). Why We Get Sick. The New Science of Darwinian Medicine. New York: Times Books.Google Scholar
Niebuhr, D. W., Millikan, A. M., Cowan, D. N., et al. (2008). Selected infectious agents and risk of schizophrenia among US military personnel. American Journal of Psychiatry, 165, 99–106.CrossRefGoogle ScholarPubMed
Noyan, V., Apan, T. Z., Yucel, A., et al. (2004). Cytotoxin associated gene A-positive Helicobacter pylori strains in dyspeptic pregnant women. European Journal of Obstetrics, Gynecology and Reproductive Biology, 116, 186–189.CrossRefGoogle ScholarPubMed
Ouatas, T., Clare, S. E., Hartsough, M. T., et al. (2002). MMTV-associated transcription factor binding sites increase nm23-H1 metastasis suppressor gene expression in human breast carcinoma cell lines. Clinical and Experimental Metastasis, 19, 35–42.CrossRefGoogle ScholarPubMed
Perry, S., Luz Sanchez, M., Yang, S., et al. (2006). Gastroenteritis and transmission of Helicobacter pylori infection in households. Emerging Infectious Diseases, 12, 1701–1708.CrossRefGoogle ScholarPubMed
Potten, C. S., Watson, R. J., Williams, G. T., et al. (1988). The effect of age and menstrual cycle upon proliferative activity in the normal human breast. British Journal of Cancer, 58, 163–170.CrossRefGoogle ScholarPubMed
Profet, M. (1992). Pregnancy sickness as adaptation: a deterrent to maternal ingestion of teratogens. In The Adapted Mind, Barkow, J. E., Cosmides, L., et al. (eds). New York: Oxford University Press, pp. 327–365.Google Scholar
Reeth, K. V., Brown, I., Essen, S., et al. (2004). Genetic relationships, serological cross-reaction and cross-protection between H1N2 and other influenza A virus subtypes endemic in European pigs. Virus Research, 103, 115–124.CrossRefGoogle ScholarPubMed
Reymunde, A., Santiago, N. and Perez, L. (2001). Helicobacter pylori and severe morning sickness. American Journal of Gastroenterology, 96, 2279–2280.CrossRefGoogle ScholarPubMed
Russo, J. (1992). Influence of age and parity on the development of the human breast. Breast Cancer Research and Treatment, 23, 211–218.CrossRefGoogle ScholarPubMed
Saal, L. H., Gruvberger-Saal, S. K., Persson, C., et al. (2008). Recurrent gross mutations of the PTEN tumor suppressor gene in breast cancers with deficient DSB repair. Nature Genetics, 40, 102–107.CrossRefGoogle ScholarPubMed
Sgouros, J., Galani, E., Gonos, E., et al. (2007). Correlation of nm23-H1 gene expression with clinical outcome in patients with advanced breast cancer. In Vivo, 21, 519–522.Google ScholarPubMed
Sherman, P. W. and Flaxman, S. M. (2002). Nausea and vomiting of pregnancy in an evolutionary perspective. American Journal of Obstetrics and Gynecology, 186, S190–S197.CrossRefGoogle Scholar
Shirin, H., Sadan, O., Shevah, O., et al. (2004). Positive serology for Helicobacter pylori and vomiting in the pregnancy. Archives of Gynecology and Obstetrics, 270, 10–14.CrossRefGoogle ScholarPubMed
Sinha, S. K., Martin, B., Gold, B. D., et al. (2004). The incidence of Helicobacter pylori acquisition in children of a Canadian First Nations community and the potential for parent-to-child transmission. Helicobacter, 9, 59–68.CrossRefGoogle ScholarPubMed
Siqueira, F. M., Cota, L. O., Costa, J. E., et al. (2008). Maternal periodontitis as a potential risk variable for preeclampsia: a case-control study. Journal of Periodontology, 79, 207–215.CrossRefGoogle ScholarPubMed
Stearns, , S. S. and Koella, J. C. (eds) (2008). Evolution in Health and Disease, 2nd edn. New York: Oxford University Press.
Stearns, S. C., Nesse, R. M. and Haig, D. (2008). Introducing evolutionary thinking for medicine. In Evolution in Health and Disease, Stearns, S. S. and Koella, J. C. (eds). New York: Oxford University Press, pp. 1–15.Google Scholar
Subramanian, C. and Robertson, E. S. (2002). The metastatic suppressor Nm23-H1 interacts with EBNA3C at sequences located between the glutamine- and proline-rich domains and can cooperate in activation of transcription. Journal of Virology, 76, 8702–8709.CrossRefGoogle ScholarPubMed
Taubes, G. (2008). What's cholesterol got to do with it? New York Times. January 27, p. 18.Google Scholar
Trevathan, W. R., Smith, E. O. and Mckenna, J. J. (2008). Background. In Evolutionary Medicine and Health. New Perspectives, Trevathan, W. R., Smith, E. O. and Mckenna, J. J. (eds). New York: Oxford University Press, pp. 1–54.Google Scholar
Trichopoulos, D., Li, F. and Hunter, D. (1996). What causes cancer?Scientific American, 275, 80–87.CrossRefGoogle ScholarPubMed
Tungteakkhun, S. S. and Duerksen-Hughes, P. J. (2008). Cellular binding partners of the human papillomavirus E6 protein. Archives of Virology, 153, 397–408.CrossRefGoogle ScholarPubMed
Wang, Y., Holland, J., Bleiweiss, I., et al. (1995). Detection of mammary tumor virus ENV gene-like sequences in human breast cancer. Cancer Research, 55, 5173–5179.Google ScholarPubMed
Weyermann, M., Brenner, H., Adler, G., et al. (2003). Helicobacter pylori infection and the occurrence and severity of gastrointestinal symptoms during pregnancy. American Journal of Obstetrics and Gynecology, 189, 526–531.CrossRefGoogle ScholarPubMed
Williams, E., Jones, L., Vessey, M., et al. (1990). Short term increase in risk of breast cancer associated with full term pregnancy. British Medical Journal, 300, 578–579.CrossRefGoogle ScholarPubMed
Williams, G. C. and Nesse, R. M. (1991). The dawn of Darwinian medicine. Quarterly Review of Biology, 66, 1–22.CrossRefGoogle ScholarPubMed
Wu, C. Y., Tseng, J. J., Chou, M. M., et al. (2000). Correlation between Helicobacter pylori infection and gastrointestinal symptoms in pregnancy. Advances in Therapy, 17, 152–158.CrossRefGoogle ScholarPubMed
Yang, Y. J., Sheu, B. S., Lee, S. C., et al. (2005). Children of Helicobacter pylori-infected dyspeptic mothers are predisposed to H. pylori acquisition with subsequent iron deficiency and growth retardation. Helicobacter, 10, 249–255.CrossRefGoogle Scholar

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