This chapter examines the Eurasian Transformation as a catalyst for the rise of the Asian and Western empires that together reshaped Asia during the early modern period. Specifically, I aim to understand how the Eurasian Transformation made it possible for ‘barbarians’ to establish primacy over pre-existing international systems in South and East Asia, despite their limited numbers and stigmatised status. I begin by offering a synoptic overview of Eurasia at c. 1500. I next introduce the Eurasian Transformation, a unique conjunction of military, economic, cultural and administrative macro-processes that together made new forms of empire-building possible from this time on. I conclude by considering the Eurasian Transformation’s diverse impacts on Eurasia’s sedentary power centres, and on the liminal ‘barbarian’ actors populating Eurasia’s land and sea frontiers.