This chapter suggests that the field of macro-finance is primed for a scientific revolution, or paradigm shift, in Kuhnian terms away from determinate modeling structures toward partially open ones that allow for novel Knightian uncertainty-related events, narrative dynamics, and the unanticipated structural change they engender. The chapter presents a discussion on recent developments representing aggregate behavior and outcomes in financial markets based on model ambiguity and intervallic change that is allowed to occur at times and in ways that would be difficult for any researcher to anticipate ex ante. The main findings of the preceding analyses of Chapters 4 through 12 will be woven into the discussion throughout. The modeling frameworks of Knightian Uncertainty Economics and Imperfect Knowledge Economics are discussed as potential approaches to be adopted in the post-paradigm shift in macro-finance.