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3 - Exposure–response functions for health impacts

Published online by Cambridge University Press:  05 July 2014

Ari Rabl
Affiliation:
Ecole des Mines, Paris
Joseph V. Spadaro
Affiliation:
Basque Centre for Climate Change, Bilbao, Spain
Mike Holland
Affiliation:
Ecometrics Research and Consulting (EMRC)
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Summary

Summary

This chapter is fairly long and detailed because health impacts weigh heavily in the estimation of damage costs. It begins with an overview of the health impacts of air pollution. It then describes the methods used for measuring the health impacts of pollution. The key ingredient in the calculation of damage costs is the exposure–response function (ERF), and we discuss its general features in Section 3.3. The rest of the chapter presents ERFs for specific pollutants and end points. Section 3.4 discusses mortality and life expectancy, and Section 3.5 presents morbidity impacts of the classical air pollutants. Finally, Section 3.6 addresses other pollutants, especially the toxic metals. A summary of the ERFs used by ExternE (2008) will be provided in Table 12.3 in Chapter 12.

A word of caution should be given in relation to the contents of this chapter. There is a great deal of research going on into the health effects of air pollution at the current time. The core position defined here reflects relatively recent consensus, but this will inevitably be revised as more evidence becomes available. The two areas where this is most likely to make a difference concern quantification of the long-term (chronic) effects of exposure to ozone, and the effects of exposure to NO2. For the latter, there are significant questions of causality being considered – are the effects linked to NO2 a true effect of the pollutant, or is the pollutant simply an indicator of other stresses? Readers should refer to the final reports of the REVIHAAP and HRAPIE studies led by WHO-Europe on behalf of the European Commission, once they become available, for an updated perspective. Whilst we accept that new findings will influence the choice of response functions, the principles described in this chapter are likely to remain robust.

Type
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Information
How Much Is Clean Air Worth?
Calculating the Benefits of Pollution Control
, pp. 63 - 130
Publisher: Cambridge University Press
Print publication year: 2014

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References

Abbey, D. E., Hwang, B. L., Burchette, R. J., Vancuren, T. and Mills, P. K. 1995. Estimated long-term ambient concentrations of PM10 and development of respiratory symptoms in a nonsmoking population. Arch Env Health 50: 139–152.CrossRefGoogle Scholar
Abbey, D. E., Nishino, N., McDonnell, W. F. et al. 1999. Long-term inhalable particles and other air pollutants related to mortality in nonsmokers. Am. J. Respir. Crit. Care Med 159, 373–382.CrossRefGoogle ScholarPubMed
Abt 2004. Power Plant Emissions: Particulate Matter-Related Health Damages and the Benefits of Alternative Emission Reduction Scenarios. Prepared for EPA by Abt Associates Inc. 4800 Montgomery Lane. Bethesda, MD20814–5341.Google Scholar
Anderson, H. R., Atkinson, R. W., Peacock, J. L., Marston, L. and Konstantinou, K. 2004. Meta-analysis of time-series studies and panel studies of particulate matter (PM) and ozone (O3). Report of a WHO task group. World Health Organization. (; accessed November 2004).
Armstrong, B. and Tremblay, C. 1994. Lung cancer mortality and polyaromatic hydrocarbons. American J Epidemiology 139 (3), 250–262.CrossRefGoogle Scholar
Axelrad, D. A., Bellinger, D. C., Ryan, L. M. and Woodruff, T. J. 2007. Dose-response relationship of prenatal mercury exposure and IQ: an integrative analysis of epidemiologic data. Environ Health Perspect 115(4): 609–615.CrossRefGoogle ScholarPubMed
Bobak, M. and Leon, D. A. 1999. The effect of air pollution on infant mortality appears specific for respiratory causes in the postneonatal period. Epidemiology 10(6), 666–670.CrossRefGoogle ScholarPubMed
Calabrese, E. J., Baldwin, L. A. and Holland, C. D. 1999. Hormesis: A highly generalizable and reproducible phenomenon with important implications for risk assessment. Risk Analysis 19 (2), pp. 261–281.CrossRefGoogle ScholarPubMed
Chen, H., Goldberg, M. S. and Villeneuve, P. J. 2008. A systematic review of the relation between long-term exposure to ambient air pollution and chronic diseases. Reviews On Environmental Health 23 (4), 243–297.Google ScholarPubMed
Clancy, L., Goodman, P., Sinclair, H. and Dockery, D. W. 2002. Effect of air-pollution control on death rates in Dublin, Ireland: an intervention study. Lancet 360, October 19.CrossRefGoogle ScholarPubMed
Crawford, M. and Wilson, R. 1996. Low-dose linearity: the rule or the exception?, Human and Ecological Risk Assessment 2, 305–330.CrossRefGoogle Scholar
Crouse, D. L., Peters, P. A., van Donkelaar, A. et al. 2012. Risk of non accidental and cardiovascular mortality in relation to long-term exposure to low concentrations of fine particulate matter: A Canadian national-level cohort study. Environ Health Perspect 120: 708–714.CrossRefGoogle Scholar
Crump, K. 1994. Risk of benzene induced leukemia: a sensitivity analysis of the pliofilm cohort with additional follow-up and new exposure estimates. J. Toxicology and Environmental Health 42, 219–242.CrossRefGoogle ScholarPubMed
Daniels, M. J., Dominici, F., Samet, J. M. and Zeger, S. L. 2000. Estimating particulate matter-mortality dose-response curves and threshold levels: an analysis of daily time-series for the 20 largest US cities. Am J Epidemiol 152(5): 397–406. See also Comment in: Am J Epidemiol 152(5): 407–412.CrossRefGoogle ScholarPubMed
Daniels, M. J., Dominici, F., Zeger, S. L. and Samet, J. M. 2004. The National Morbidity, Mortality, and Air Pollution Study, Part III: PM10 Concentration–Response Curves and Thresholds for the 20 Largest US Cities. Health Effects Institute Research Report Number 94, Part III, May 2004.
Declerq, C. and Macquet, V. 2000. Short-term effects of ozone on respiratory health of children in Armentieres, North of France. Rev Epidemiol Sante Publique 48 Suppl 2: 2S37–43.Google Scholar
Dockery, D. W., Pope, C. A., Xiping, Xu et al. 1993. An association between air pollution and mortality in six US cities. New England J of Medicine 329, 1753–1759 (Dec. 1993).CrossRefGoogle Scholar
Doll, R., Peto, R., Boreham, J. and Sutherland, I. 2004. Mortality in relation to smoking: 50 years’ observations on male British doctors. British Medical Journal 328(7455): 1519–1527.CrossRefGoogle ScholarPubMed
Donaldson, K. 2006. Lecture at COST633 conference on health effects of PM constituents, Vienna, 3–5 April 2006.
Dreicer, M., Tort, V. and Margerie, H. 1995. Nuclear fuel cycle: implementation in France. Final report for ExternE Program, contract EC DG12 JOU2-CT92-0236. CEPN, F-92263 Fontenay-aux-Roses. This report is included in Rabl et al. (1996).
ECRHS 1996. European Community Respiratory Health Survey: Variations in the prevalence of respiratory symptoms, self-reported asthma attacks, and use of asthma medication in the European Community Respiratory Health Survey (ECRHS). Eur Respir J 9: 687–695.CrossRefGoogle Scholar
EFSA 2010. Scientific Opinion on Lead in Food. EFSA Panel on Contaminants in the Food Chain (CONTAM), European Food Safety Authority (EFSA), Parma, Italy. EFSA Journal 2010; 8(4):1570.Google Scholar
Elliott, P., Shaddick, G., Wakefield, J. C., de Hoogh, C. and Briggs, D. J. 2007. Long-term associations of outdoor air pollution with mortality in Great Britain. Thorax 2007 (0), 1–8.Google ScholarPubMed
EPA 1994. Estimating exposure to dioxin-like compounds, and Health Assessment Document for 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) and Related Compounds. Report EPA/600/BP-92/001 a,b, and c. USEPA, Washington, DC.
EPA 2000. Exposure and Human Health Reassessment of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) and Related Compounds: Part III: Integrated Summary and Risk Characterization for 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) and Related Compounds. Report EPA/600/P-00/001Bg, September 2000. United States Environmental Protection Agency. Washington, DC 20460. Available at .
EPA 2001. Oral Reference Dose for Methylmercury. United States Environmental Protection Agency. Integrated Risk Information System (IRIS). Office of Research and Development, National Center for Environmental Assessment, Washington, DC.
EPA 2006. IRIS Database for Risk Assessment.
ExternE 1998. ExternE: Externalities of Energy. Vol.7: Methodology 1998 Update (EUR 19083); Vol.8: Global Warming (EUR 18836); Vol.9: Fuel Cycles for Emerging and End-Use Technologies, Transport and Waste (EUR 18887); Vol.10: National Implementation (EUR 18528). Published by European Commission, Directorate-General XII, Science Research and Development. Office for Official Publications of the European Communities, L-2920 Luxembourg. Results are also available at
ExternE 2000. External Costs of Energy Conversion – Improvement of the ExternE Methodology and Assessment of Energy-Related Transport Externalities. Final Report for Contract JOS3-CT97-0015, published as Environmental External Costs of Transport. Friedrich, R. & Bickel, P., eds. Springer Verlag Heidelberg 2001.Google Scholar
ExternE 2008. Results of the NEEDS phase of ExternE. Available at
Frith, C. H., Littlefield, N. A. and Umholtz, R. 1981. Incidence of pulmonary metastases for various neoplasms in BALB/cStCrlfC3H/Nctr female mice fed N-2-fluorenylacetamide. Journal of the National Cancer Institute 66, p. 703–712.Google ScholarPubMed
Gauderman, J. M., Avol, E., Gilliland, F. et al. The effect of air pollution on lung development from 10 to 18 years of age. N Engl J Med 351: 1057–1067.
Graves, P. E. and Krumm, R. J. 1981. Health and air quality: evaluating the effects of policy. Volume 322 of AEI Studies in economic policy. Enterprise Institute for Public Policy Research, 1981.
Graziano, J. H. and Blum, C. 1991. Lead exposure from lead crystal. Lancet 337 (8734), 141–142.CrossRefGoogle ScholarPubMed
Guo, Z., Mosley, R., McBrian, J. and Fortmann, R. 2000. Fine particulate matter emissions from candles, Engineering Solutions to Indoor Air Quality Problems Symposium, Air & Waste Management Association, VIP-98, pp. 211–225.
Hedley, A. J., Wong, C-M, Thach, T. Q. et al. 2002. Cardiorespiratory and all-cause mortality after restrictions on sulphur content of fuel in Hong Kong: an intervention study, Lancet 360, November 23.Google Scholar
HEI 2001. Airborne particles and health: HEI epidemiologic evidence. HEI Perspectives, June 2001. Health Effects Institute, Charlestown Navy Yard, 120 Second Avenue, Boston, MA 02129-4533. Available at
HEI 2003. Revised Analyses of Time-Series Studies of Air Pollution and Health. Special Report. Health Effects Institute, Boston MA.
Hiltermann, T. J. N., Stolk, J., Zee, S. C. et al. 1998. Asthma severity and susceptibility to air pollution. European Respiratory Journal 11: 686–693.Google ScholarPubMed
Hoek, G., Brunekreef, Bert, Goldbohm, Sandra, Fischer, Paul and van den Brandt, Piet A. 2002. Association between mortality and indicators of traffic-related air pollution in the Netherlands: a cohort study. Lancet 360 (Issue 9341, 19 October), 1203–1209. See also “Mortality and indicators of traffic-related air pollution”, Lancet 361, Issue 9355, 1 February 2003, Page 430.CrossRefGoogle ScholarPubMed
Hoek, G. and Brunekreef, B. 1995. Effect of photochemical air pollution on acute respiratory symptoms in children. Am J Respir Crit Care Med 151: 27–32.CrossRefGoogle ScholarPubMed
Hoek, G., Krishnan, R. M., Beelen, R. et al. 2013. Long-term air pollution exposure and cardio-respiratory mortality: a review. Environ Health 28;12(1): 43.CrossRefGoogle Scholar
Holland, M. 2013. Cost-benefit Analysis of Policy Scenarios for the Revision of the Thematic Strategy on Air Pollution: Version 1 Corresponding to IIASA TSAP Report #10, Version 1. March 2013. Contract report to European Commission DG Environment.
Holland, M., Hunt, A., Hurley, F., Navrud, S. and Watkiss, P. 2005. Methodology for the Cost-Benefit Analysis for CAFE: Volume 1: Overview of Methodology. Didcot. UK: AEA Technology Environment. Available: Google Scholar
Hurley, F., Archibald, R. McL., Colling, P. L. et al. 1983. The mortality of coke workers in Britain. Ann. J. Ind. Med 4, 691–704.CrossRefGoogle ScholarPubMed
Hurley, F., Hunt, A., Cowie, H. et al. 2005. Methodology for the Cost-Benefit Analysis for CAFE: Volume 2: Health Impact Assessment. Didcot, UK: AEA Technology Environment. Available: Google Scholar
IARC 1995. IARC Monographs on the Evaluation of Carcinogenic Risks of Chemicals to Humans. International Agency for Research on Cancer.
ICRP 1991. 1990 Recommendations of the International Commission on Radiological Protection. Publication ICRP 60.
ICRP 2007. The 2007 Recommendations of the International Commission on Radiological Protection. ICPR Publication 103. Elsevier.Google Scholar
ISAAC 1998. The International Study of Asthma and Allergies in Childhood Steering Committee. Worldwide variations in the prevalence of asthma symptoms: the international study of asthma and allergies in childhood (ISAAC). Eur Respir J 12: 315–335.CrossRefGoogle Scholar
Jerrett, M., Burnett, R. T., Pope, C. A. et al. 2009. Long-term ozone exposure and mortality. N Engl J Med 360(11): 1085–1095.CrossRefGoogle ScholarPubMed
Jetter, J. J., Guoa, Z., McBrian, J. A. and Flynn, M. R. 2002. Characterization of emissions from burning incense. Science of the Total Environment 295: 51–67.CrossRefGoogle ScholarPubMed
Katsouyanni, K., Touloumi, G., Samoli, E. et al. 2001. Confounding and effect modification in the short-term effects of ambient particles on total mortality: results from 29 European cities within the APHEA2 project. Epidemiology 12(5): 521–531.CrossRefGoogle ScholarPubMed
Katsouyanni, K., Touloumi, G., Spix, C. et al. 1997. Short-term effects of ambient sulphur dioxide and particulate matter on mortality in 12 European cities: Results from time series data from the APHEA project. British Med. J 314: 1658–1663.CrossRefGoogle ScholarPubMed
Krewski, D., Burnett, R. T., Goldberg, M. S. et al. 2000. Particle Epidemiology Reanalysis Project. Health Effects Institute, Cambridge MA. Available at .Google Scholar
Krewski, D., Jerrett, M., Burnett, R. T. et al. 2009. Extended Follow-Up and Spatial Analysis of the American Cancer Society Study Linking Particulate Air Pollution and Mortality. Report 140. Health Effects Institute, Charlestown Navy Yard, 120 Second Avenue, Boston, MA 02129–4533.
Krzyzanowski, M., Quackenboss, J. J, and Lebowitz, M, D. 1990. Chronic respiratory effects of indoor formaldehyde exposure. Environmental Research 52, 117–125.CrossRefGoogle ScholarPubMed
Kuenzli, N., Kaiser, R.Medina, S. et al. 2000. Public health impact of outdoor and traffic-related air pollution: a European assessment. Lancet 356 (Sept.), 795–801.CrossRefGoogle Scholar
Laden, F., Neas, L. M.Dockery, D. W. and Schwartz, J. 2000. Association of Fine Particulate Matter from Different Sources with Daily Mortality in Six U.S. Cities. Environmental Health Perspectives – New Series 108 – issue 10, 941–948.CrossRefGoogle ScholarPubMed
Lanphear, B. P., Dietrich, K., Auinger, P. and Cox, C. 2000. Cognitive deficits associated with blood lead concentrations <10 µg/dL in US children and adolescents. Public Health Reports 115(6), 521–529.CrossRefGoogle ScholarPubMed
Lanphear, B. P., Hornung, R., Khoury, J. et al. 2005. Low-level environmental lead exposure and children’s intellectual function: an international pooled analysis. Environ Health Perspect 2005 Jul; 113(7): 894–899.CrossRefGoogle ScholarPubMed
Lave, L. B. and Seskin, E. P. 1977. Air Pollution and Human Health. Republished in 2010 by Taylor & Francis.
Le Tetre, A., Medina, S., Samoli, E. et al. (2002). Short-term effects of particulate air pollution on cardiovascular diseases in eight European cities. J Epidemiology and Community Health 56: 773–779.CrossRefGoogle Scholar
Leksell, L. and Rabl, A. 2001. Air pollution and mortality: Quantification and valuation of years of life lost. Risk Analysis 21 (5): 843–857.CrossRefGoogle ScholarPubMed
Levy, J. I., Hammitt, J. K. and Spengler, J. D. 2000. Estimating the mortality impacts of particulate matter: What can be learned from between-study variability?Environ Health Perspect 108(2): 109–117.CrossRefGoogle ScholarPubMed
Levy, J. I., Hammitt, J. K., Yanagisawa, Y. and Spengler, J. D. 1999. Development of a new damage function model for power plants: methodology and applications. Environmental Science & Technology 33(24): 4364–4372.CrossRefGoogle Scholar
Lim, S. S., Vos, T., Flaxman, A. D. et al. 2012. A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet, 380(9859): 2224–2260.CrossRefGoogle ScholarPubMed
Lippmann, M., Ito, K., Hwang, J-S., Maciejczyk, P. and Chen, L-C. 2006. Cardiovascular effects of nickel in ambient air. Environmental Health Perspectives 114(11): 1662–1669.Google ScholarPubMed
Lippmann, M., Ito, K., Nádas, A. and Burnett, R. T. 2000. Association of Particulate Matter Components with Daily Mortality and Morbidity in Urban Populations. Research Report 95, Health Effects Institute. Cambridge, MA. Available at Google ScholarPubMed
Matus, K., Nam, K-M., Selin, N. E. et al. 2011. Health Damages from Air Pollution in China. Report No. 196, MIT Joint Program on the Science and Policy of Global Change. Massachusetts Institute of Technology, Cambridge, MA.Google Scholar
Medina, S., Plasència, A., Artazcoz, L. et al. 2002. APHEIS Health Impact Assessment of Air Pollution in 26 European Cities. Second year report, 2000–2001. Institut de Veille Sanitaire, Saint-Maurice, France.Google Scholar
NCHS 1999. National Center for Health Statistics, Hyattsville, Maryland. National Vital Statistics Reports, Vol. 47, No. 19, June 30, 1999.Google Scholar
NRC 2010. Hidden Costs of Energy: Unpriced Consequences of Energy Production and Use. National Research Council of the National Academies Press. National Academies Press, 500 Fifth Street, NW Washington, DC 20001.Google Scholar
ORNL/RFF 1994. External Costs and Benefits of Fuel Cycles. Prepared by Oak Ridge National Laboratory and Resources for the Future. Edited by Lee, Russell, Oak Ridge National Laboratory, Oak Ridge, TN 37831.
Ostro, B. D. 1987. Air Pollution and Morbidity Revisited: a Specification Test, J. Environ. Econ. Manage. 14: 87–98.CrossRefGoogle Scholar
Ostro, B. D. and Rothschild, S. 1989. Air pollution and acute respiratory morbidity; an observational study of multiple pollutants. Environmental Research 48: 238–247.CrossRefGoogle Scholar
Ott, W. 1995. Environmental Statistics and Data Analysis. Lewis Publishers. CRC Press LLC, 2000 N.W. Corporate Blvd., Boca Raton, FL 33431.Google Scholar
Pennington, D., Crettaz, P., Tauxe, A. et al. 2002. Assessing human health response in life cycle assessment using ED10s and DALYs: part 2 – noncancer effects. Risk Analysis 22 (5): 947–963.CrossRefGoogle ScholarPubMed
Pope, C. A. 1989. Respiratory disease associated with community air pollution and a steel mill, Utah Valley. Am J Public Health. May; 79(5): 623–628.CrossRefGoogle Scholar
Pope, C. A., Burnett, R. T., Thun, M. J. et al. 2002. Lung cancer, cardiopulmonary mortality, and long term exposure to fine particulate air pollution. J. Amer. Med. Assoc. 287(9): 1132–1141.CrossRefGoogle ScholarPubMed
Pope, C. A., Burnett, R. T., Krewski, D. et al. 2009. Cardiovascular mortality and exposure to airborne fine particulate matter and cigarette smoke: Shape of the exposure-response relationship. Circulation 120: 941–948.CrossRefGoogle ScholarPubMed
Pope, C. A., Burnett, R. T., Turner, M. C. et al. 2011. Lung cancer and cardiovascular disease mortality associated with ambient air pollution and cigarette smoke: shape of the exposure-response relationships. Environmental Health Perspectives, 119(11): 1616–1621.CrossRefGoogle ScholarPubMed
Pope, C. A., Hill, R. W. and Villegas, G. M. 1999. Particulate air pollution and daily mortality on Utah’s Wasatch Front. Environmental Health Perspectives 107(7): 567–573.CrossRefGoogle ScholarPubMed
Pope, C. A., Thun, M. J., Namboodri, M. M. et al. 1995. Particulate air pollution as a predictor of mortality in a prospective study of US adults. Amer. J. of Resp. Critical Care Med 151: 669–674.CrossRefGoogle Scholar
Puett, R. C., Hart, J. E., Yanosky, J. D. et al. 2009. Chronic fine and coarse particulate exposure, mortality, and coronary heart disease in the nurses’ health study. Environmental Health Perspectives 117 (11).CrossRefGoogle ScholarPubMed
Rabl, A. 1998. Mortality risks of air pollution: the role of exposure-response functions. Journal of Hazardous Materials 61: 91–98.CrossRefGoogle Scholar
Rabl, A. 2003. Interpretation of air pollution mortality: number of deaths or years of life lost?J Air and Waste Management 53(1): 41–50.CrossRefGoogle ScholarPubMed
Rabl, A., Curtiss, P. S., Spadaro, J. V. et al. 1996. Environmental Impacts and Costs: the Nuclear and the Fossil Fuel Cycles. Report to EC, DG XII, Version 3.0 June 1996. ARMINES (Ecole des Mines), 60 boul. St.-Michel, 75272 Paris CEDEX 06.
Rabl, A., Thach, T. Q., Chau, P. Y. K. and Wong, C. M. 2011. How to determine life expectancy change of air pollution mortality: a time series study. Environmental Health 10: 25.CrossRefGoogle ScholarPubMed
Reiss, R., Anderson, E. L., Cross, C. E. et al. 2007. Evidence of health impacts of sulfate- and nitrate-containing particles in ambient air. Inhalation Toxicology 19: 419–449.CrossRefGoogle ScholarPubMed
Rice, G. and Hammitt, J. K. 2005. Economic Valuation of Human Health Benefits of Controlling Mercury Emissions from US Coal-Fired Power Plants. Northeast States for Coordinated Air Use Management (NESCAUM). Boston, MA. February 2005.
Rowe, R. D., Lang, C. M., Chestnut, L. G., Latimer, D., Rae, D., Bernow, S. M. and White, D. 1995. The New York Electricity Externality Study. Oceana Publications, Dobbs Ferry, New York.Google Scholar
Samet, J. M., Dominici, F., Zeger, S. L., Schwartz, J. and Dockery, D. W. 2000. The National Morbidity, Mortality and Air Pollution Study, Part I: Methods and Methodologic Issues. Research Report 94, Part I. Health Effects Institute, Cambridge MA. Available at
Samoli, E., Aga, E., Touloumi, G. et al. 2006. Short-term effects of nitrogen dioxide on mortality: an analysis within the APHEA project. Eur Respir J 27: 1129–1137CrossRefGoogle ScholarPubMed
Samoli, E., Schwartz, J., Wojtyniak, B. et al. 2001. Investigating regional differences in short-term effects of air pollution on daily mortality in the APHEA project: a sensitivity analysis for controlling long-term trends and seasonality. Environ Health Perspect, 109(4): 349–53.CrossRefGoogle ScholarPubMed
Schindler, C., Keidel, D., Gerbase, M. W. et al. 2009. Improvements in PM10-exposure and reduced rates of respiratory symptoms in a cohort of Swiss adults (SAPALDIA-study). Am J Respir Crit Care Med 179: 579–587.CrossRefGoogle Scholar
Schwartz, J., Coull, B., Laden, F. and Ryan, L. 2008. The effect of dose and timing of dose on the association between airborne particles and survival. Environmental Health Perspective 116(1): 64–69.CrossRefGoogle Scholar
Schwartz, J., Norris, G., Larson, T. et al. 1999. Episodes of high coarse particle concentrations are not associated with increased mortality. Environmental Health Perspectives 107(5): 339–342.CrossRefGoogle Scholar
Schwartz, J. 1994. Low-level lead exposure and children’s IQ: a meta-analysis and search for a threshold. Environmental Research 65: 42–55.CrossRefGoogle ScholarPubMed
Stern, A. 2005. A revised estimate of the maternal methyl mercury intake dose corresponding to a measured cord blood mercury concentration. Environmental Health Perspectives 113(2): 155–163.CrossRefGoogle ScholarPubMed
Stern, A. H. and Smith, A. E. 2003. An assessment of the cord blood: maternal blood methylmercury ratio: Implications for risk assessment. Environmental Health Perspectives 111(12): 1465–1470.CrossRefGoogle ScholarPubMed
Thun, M. J., Peto, R., Lopez, A. D. et al. 1997. Alcohol consumption and mortality among middle-aged and elderly U.S. adults. New England Journal of Medicine 337(24): 1705–1714.CrossRefGoogle ScholarPubMed
Trasande, L., Landrigan, T. J. and Schechtes, C. 2005. Public health and economic consequences of methyl mercury toxicity to the developing brain. Environmental Health Perspectives 113: 590–596.CrossRefGoogle ScholarPubMed
Trasande, L., Schechter, C., Haynes, K. A. and Landrigan, P. J. 2006. Applying cost analyses to drive policy that protects children. Ann NY Acad Sci 1076: 911–923.CrossRefGoogle ScholarPubMed
Tschirley, F. H. 1986. Dioxin. Scientific American 254, 29. Feb.1986.CrossRefGoogle ScholarPubMed
UNEP 2002. United Nations Environment Programme. Global Mercury Assessment. UNEP Chemicals, Geneva, Switzerland.
UNSCEAR (2000) Report Vol. II Sources and effects of ionizing radiation United Nations Scientific Committee on the Effects of Atomic Radiation UNSCEAR 2000 Report to the General Assembly, with scientific annexes Volume II: Effects, Annex G Biological effects at low radiation doses.
van der Zee, S., Hoek, G., Boezen, H. M. et al. 2000. Acute effects of urban air pollution on respiratory health of 50–70 yr old adults. Eur Respir J 15: 700–709CrossRefGoogle ScholarPubMed
Virtanen, J. K., Rissanen, T. H., Voutilainen, S. and Tuomainen, T-P. 2007. Mercury as a risk factor for cardiovascular diseases. Journal of Nutritional Biochemistry 18: 75–85.CrossRefGoogle ScholarPubMed
Ward, D. J. and Ayres, J. G. 2004. Particulate air pollution and panel studies in children: a systematic review. Occup Environ Med. 61(4): e13CrossRefGoogle ScholarPubMed
Weil, M., Bressler, J., Parsons, P. et al. 2005. Blood mercury levels and neurobehavioral function. JAMA 293(15): 1875–1882.CrossRefGoogle ScholarPubMed
WHO 1987. Air Quality Guidelines for Europe, European Series No.23. World Health Organization, Regional Publications, Copenhagen.
WHO 1988–2001. WHO 1988, Chromium. Environmental Health Criteria 61. WHO 1990, Methyl Mercury. Environmental Health Criteria 101. WHO 1991, Inorganic Mercury. Environmental Health Criteria 118. WHO 1991, Nickel. Environmental Health Criteria 108. WHO 1992, Cadmium. Environmental Health Criteria 134. WHO 1995, Inorganic Lead. Environmental Health Criteria 165. WHO 2001, Arsenic and arsenic compounds. Environmental Health Criteria 224. World Health Organization, Geneva, Switzerland.
WHO. 2003. Health aspects of air pollution with particulate matter, ozone and nitrogen dioxide, Report on a WHO Working Group, Bonn, Germany, 13–15 January 2003. World Health Organization: Available at ; accessed November 2004.
WHO 2005. WHO Air quality guidelines for particulate matter, ozone, nitrogen dioxide and sulfur dioxide – Global update 2005 – Summary of risk assessment. World Health Organization report WHO/SDE/PHE/OEH/06.02.
Wilson, R. and Crouch, E. A. C. 2001. Risk-Benefit Analysis. Harvard University Press, Cambridge, MA.Google Scholar
Wilson, R. and Spengler, J. D. eds 1996. Particles in Our Air: Concentrations and Health Effects. Harvard University Press, Cambridge, MA.
Woodruff, T. J., Grillo, J., and Schoendorf, K. C. 1997. The relationship between selected causes of postneonatal infant mortality and particulate air pollution in the United States. Environ Health Perspect 105(6): 608–612.CrossRefGoogle ScholarPubMed
Zanobetti, A. and Schwartz, J. 2008. Mortality displacement in the association of ozone with mortality: an analysis of 48 cities in the United States. Am J Respir Crit Care Med 177(2): 184–9.CrossRefGoogle ScholarPubMed
Zeghnoun, A., Eilstein, D., Saviuc, P. et al. 2001. Surveillance of short-term effects of urban air pollution on mortality. Results of a feasibility study in 9 French cities. Rev Epidemiol Sante Publique 49(1): 3–12.Google ScholarPubMed
Zmirou, D., Balducci, F., Dechenaux, J. et al. 1997. Méta-analyse et fonctions dose-réponse des effets respiratoires de la pollution atmosphérique (Meta-analysis and dose–response functions of air pollution respiratory effects). Rev Epidemiol Sante Publique 45(4): 293–304.Google Scholar

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To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

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