Vannuccini, S, Bocchi, C, Severi, FM, et al. Endocrinology of human parturition. Ann Endocrinol (Paris). 2016, 77(2):105–113.Google Scholar

Voltolini, C, and Petraglia, F. Neuroendocrinology of pregnancy and parturition. In: Handbook of Clinical Neurology. 2014.CrossRefGoogle Scholar

Behura, SK, Dhakal, P, Kelleher, AM, et al. The brain-placental axis: Therapeutic and pharmacological relevancy to pregnancy. Pharmacological Research. 2019.Google Scholar

Petraglia, F, Imperatore, A, and Challis, JRG. Neuroendocrine mechanisms in pregnancy and parturition. Endocrine Reviews. 2010, 31: 783–816.CrossRefGoogle ScholarPubMed

Iliodromiti, Z, Antonakopoulos, N, Sifakis, S, et al. Endocrine, paracrine, and autocrine placental mediators in labor. Hormones. 2012.Google Scholar

Petraglia, F, Florio, P, Nappi, C, et al. Peptide signaling in human placenta and membranes: Autocrine, paracrine, and endocrine mechanisms. Vol., Endocrine Reviews. 1996, 17: 156–186.Google Scholar

Petraglia, F, Florio, P, and Torricelli, M. Placental endocrine function. In: Knobil and Neill’s Physiology of Reproduction. 2006.Google Scholar

Brunton, PJ, and Russell, JA. Endocrine induced changes in brain function during pregnancy. Brain Research. 2010.Google Scholar

Warren, WB, and Silverman, AJ. Cellular localization of corticotrophin releasing hormone in the human placenta, fetal membranes and decidua. Placenta. 1995.Google Scholar

Vaughan, J, Donaldson, C, Bittencourt, J, et al. Urocortin, a mammalian neuropeptide related to fish urotensin I and to corticotropin-releasing factor. Nature. 1995.Google Scholar

Zoumakis, E, Kalantaridou, S, and Makrigiannakis, A. CRH-like peptides in human reproduction. Curr Med Chem. 2009.Google Scholar

Welberg, LAM, and Seckl, JR. Prenatal stress, glucocorticoids and the programming of the brain. Journal of Neuroendocrinology. 2001.Google Scholar

Waddell, BJ. The placenta as hypothalamus and pituitary: Possible impact on maternal and fetal adrenal function. Reproduction, Fertility and Development. 1993.Google Scholar

Florio, P, Severi, FM, Ciarmela, P, et al. Placental stress factors and maternal-fetal adaptive response: The corticotropin-releasing factor family. Endocrine. 2002.Google Scholar

Challis, JRG, Bloomfield, FH, Booking, AD, et al. Fetal signals and parturition. Journal of Obstetrics and Gynaecology Research. 2005.Google Scholar

Ochȩdalski, T, Zylinńska, K, Laudański, T, et al. Corticotrophin-releasing hormone and ACTH levels in maternal and fetal blood during spontaneous and oxytocin-induced labour. European Journal of Endocrinology. 2001;Google Scholar

Vitoratos, N, Papatheodorou, DC, Kalantaridou, SN, et al. “Reproductive” corticotropin-releasing hormone. In: Annals of the New York Academy of Sciences. 2006.Google Scholar

Challis, JRG, Matthews, SG, Gibb, W, et al. Endocrine and paracrine regulation of birth at term and preterm. Endocrine Reviews. 2000.Google Scholar

McLean, M, Bisits, A, Davies, J, et al. A placental clock controlling the length of human pregnancy. Nature Medicine. 1995, 1(5):460–463.CrossRefGoogle ScholarPubMed

Torricelli, M, Ignacchiti, E, Giovannelli, A, et al. Maternal plasma corticotrophin-releasing factor and urocortin levels in post-term pregnancies. European Journal of Endocrinology. 2006.Google Scholar

Rainey, WE, Rehman, KS, and Carr, BR. The human fetal adrenal: Making adrenal androgens for placental estrogens. Seminars in Reproductive Medicine. 2004.CrossRefGoogle Scholar

Smith, R, Smith, JI, Shen, X, et al. Patterns of plasma corticotropin-releasing hormone, progesterone, estradiol, and estriol change and the onset of human labor. Journal of Clinical Endocrinology & Metabolism. 2009, 94(6):2066–2074.Google Scholar

Grammatopoulos, DK. Placental corticotrophin-releasing hormone and its receptors in human pregnancy and labour: Still a scientific enigma. In: Journal of Neuroendocrinology. 2008.Google Scholar

McKeown, KJ, and Challis, JRG. Regulation of 15-hydroxy prostaglandin dehydrogenase by corticotrophin-releasing hormone through a calcium-dependent pathway in human chorion trophoblast cells. Journal of Clinical Endocrinology & Metabolism. 2003.Google Scholar

Grammatopoulos, DK, and Hillhouse, EW. Role of corticotropin-releasing hormone in onset of labour. Vol. 354, Lancet. 1999, 1546–1549.Google Scholar

Simpkin, JC, Kermani, F, Palmer, AM, et al. Effects of corticotrophin releasing hormone on contractile activity of myometrium from pregnant women. BJOG: An International Journal of Obstetrics & Gynaecology. 1999.Google Scholar

Jeschke, U, Mylonas, I, Richter, DU, et al. Regulation of progesterone production in human term trophoblasts in vitro by CRH, ACTH and cortisol (prednisolone). Archives of Gynecology and Obstetrics. 2005.CrossRefGoogle Scholar

Zhao, XJ, Hoheisel, C, Schauer, J, et al. Corticotropin-releasing hormone-binding protein and its possible role in neuroendocrinological research. Hormone and Metabolic Research. 1997.Google Scholar

Florio, P, Woods, RJ, Genazzani, AR, et al. Changes in amniotic fluid immunoreactive Corticotropin-Releasing Factor (CRF) and CRF-binding protein levels in pregnant women at term and during labor 1. Journal of Clinical Endocrinology & Metabolism. 1997.Google Scholar

Gitau, R, Fisk, NM, Teixeira, JMA, et al. Fetal hypothalamic-pituitary-adrenal stress responses to invasive procedures are independent of maternal responses. Journal of Clinical Endocrinology & Metabolism. 2001.Google Scholar

Mesiano, S, DeFranco, E, Muglia, LJ. Parturition. In: Knobil and Neill’s Physiology of Reproduction: Two-Volume Set. 2015.Google Scholar

Nepomnaschy, PA, Welch, KB, McConnell, DS, et al. Cortisol levels and very early pregnancy loss in humans. Proceedings of the National Academy of Sciences of the United States of America. 2006.Google Scholar

Hobel, CJ, Dunkel-Schetter, C, Roesch, SC, et al. Maternal plasma corticotropin-releasing hormone associated with stress at 20 weeks’ gestation in pregnancies ending in preterm delivery. American Journal of Obstetrics and Gynecology. 1999.Google Scholar

Torricelli, M, Novembri, R, Bloise, E, et al Changes in placental CRH, urocortins, and CRH-receptor mRNA expression associated with preterm delivery and chorioamnionitis. Journal of Clinical Endocrinology & Metabolism. 2011.Google Scholar

Florio, P, Imperatore, A, Sanseverino, F, et al. The measurement of maternal plasma corticotropin-releasing factor (CRF) and CRF-binding protein improves the early prediction of preeclampsia. Journal of Clinical Endocrinology & Metabolism. 2004.Google Scholar

Glynn, BP, Welton, A, Rodriguez-Linares, B, et al. Urocortin in pregnancy. American Journal of Obstetrics and Gynecology. 1998.Google Scholar

Petraglia, F, Florio, P, Benedetto, C, et al. Urocortin stimulates placental adrenocorticotropin and prostaglandin release and myometrial contractility in vitro. Journal of Clinical Endocrinology & Metabolism. 1999, 84(4):1420–1423.Google Scholar

Clifton, VL, Qing, G, Murphy, VE, et al. Localization and characterization of urocortin during human pregnancy. Placenta. 2000, 21(8):782–788.CrossRefGoogle ScholarPubMed

Imperatore, A, Florio, P, Torres, PB, et al. Urocortin 2 and urocortin 3 are expressed by the human placenta, deciduas, and fetal membranes. Am Journal of Obstetrics and Gynaecology. 2006.CrossRefGoogle Scholar

Hashimoto, K, Nishiyama, M, Tanaka, Y, et al. Urocortins and corticotropin releasing factor type 2 receptors in the hypothalamus and the cardiovascular system. Peptides. 2004.Google Scholar

Karteris, E, Hillhouse, EW, and Grammatopoulos, D. Urocortin II Is expressed in human pregnant myometrial cells and regulates myosin light chain phosphorylation: Potential role of the type-2 Corticotropin-Releasing Hormone receptor in the control of myometrial contractility. Endocrinology. 2004;145(2):890–900.Google Scholar

Florio, P, Torricelli, M, Galleri, L, et al. High fetal urocortin levels at term and preterm labor. Journal of Clinical Endocrinology & Metabolism. 2005.Google Scholar

Florio, P, Torricelli, M, De Falco, G, et al. High maternal and fetal plasma urocortin levels in pregnancies complicated by hypertension. Journal of Hypertension. 2006.Google Scholar

Imperatore, A, Rolfo, A, Petraglia, F, et al. Hypoxia and preeclampsia: Increased expression of urocortin 2 and urocortin 3. Reproductive Sciences. 2010.Google Scholar

Giovannelli, A, Greenwood, SL, Desforges, M, et al. Corticotrophin-releasing factor and urocortin inhibit system a activity in term human placental villous explants. Placenta. 2011.Google Scholar

Sasaki, K, and Norwitz, ER. Gonadotropin-releasing hormone/gonadotropin-releasing hormone receptor signaling in the placenta. Current Opinion in Endocrinology, Diabetes and Obesity. 2011.CrossRefGoogle Scholar

Lee, HJ, Snegovskikh, VV, Park, JS, et al. Role of GnRH-GnRH receptor signaling at the maternal-fetal interface. Fertility and Sterility. 2010.Google Scholar

Sassolas, G. Growth hormone-releasing hormone: Past and present. Hormone Research. 2000.Google Scholar

Frankenne, F, Scippo, ML, Van, BJ, et al. Identification of placental human growth hormone as the growth hormone-v gene expression product. Journal of Clinical Endocrinology & Metabolism. 1990.Google Scholar

Alsat, E, Guibourdenche, J, Couturier, A, et al. Physiological role of human placental growth hormone. Molecular and Cellular Endocrinology. 1998.Google Scholar

Davies, S, Byrn, F, and Cole, LA. Human chorionic gonadotropin testing for early pregnancy viability and complications. Clinics in Laboratory Medicine. 2003.Google Scholar

Williams, GR. Neurodevelopmental and neurophysiological actions of thyroid hormone. Journal of Neuroendocrinology. 2008.Google Scholar

Arrowsmith, S, and Wray, S. Oxytocin: Its mechanism of action and receptor signalling in the myometrium. Journal of Neuroendocrinology. 2014.Google Scholar

Uvnäs-Moberg, K, Ekström-Bergström, A, Berg, M, et al. Maternal plasma levels of oxytocin during physiological childbirth - A systematic review with implications for uterine contractions and central actions of oxytocin. BMC Pregnancy Childbirth. 2019.Google Scholar

Bossmar, T, Osman, N, Zilahi, E, et al. Expression of the oxytocin gene, but not the vasopressin gene, in the rat uterus during pregnancy: Influence of oestradiol and progesterone. Journal of Endocrinology. 2007.CrossRefGoogle Scholar

Fuchs, A‐R, and Fuchs, F. Endocrinology of human parturition: A review. BJOG An International Journal of Gynecology & Obstetrics. 1984.Google Scholar

Keverne, EB. Central mechanisms underlying the neural and neuroendocrine determinants of maternal behaviour. Psychoneuroendocrinology. 1988.Google Scholar

Freeman, ME, Kanyicska, B, Lerant, A, et al. Prolactin: Structure, function, and regulation of secretion. Physiological Reviews. 2000.Google Scholar

Ben-Jonathan, N, LaPensee, CR, and LaPensee, EW. What can we learn from rodents about prolactin in humans? Endocrine Reviews. 2008.Google Scholar

Grattan, DR, and Kokay, IC. Prolactin: A pleiotropic neuroendocrine hormone. Journal of Neuroendocrinology. 2008.Google Scholar

Walker, WH, Fitzpatrick, SL, Saunders, GF, et al. The human placental lactogen genes: Structure, function, evolution and transcriptional regulation. Endocrine Reviews. 1991.Google Scholar

Newbern, D, and Freemark, M. Placental hormones and the control of maternal metabolism and fetal growth. Current Opinion in Endocrinology, Diabetes and Obesity. 2011.Google Scholar

Sørensen, S, Von Tabouillot, D, Schiøler, V, et al. Serial measurements of serum human placental lactogen (hPL) and serial ultrasound examinations in the evaluation of fetal growth. Early Human Development. 2000.Google Scholar

Shingo, T, Gregg, C, Enwere, E, et al. Pregnancy-stimulated neurogenesis in the adult female forebrain mediated by prolactin. Science (80- ). 2003.Google Scholar

Torner, L, and Neumann, ID. The brain prolactin system: Involvement in stress response adaptations in lactation. Stress. 2002.Google Scholar

Sahay, A, Kale, A, and Joshi, S. Role of neurotrophins in pregnancy and offspring brain development. Neuropeptides. 2020.Google Scholar

Petraglia, F, Coukos, G, Battaglia, C, et al. Plasma and amniotic fluid immunoreactive neuropeptide-Y level changes during pregnancy, labor, and at parturition. Journal of Clinical Endocrinology & Metabolism. 1989.Google Scholar

Khatun, S, Kanayama, N, Belayet, HM, et al. Increased concentrations of plasma neuropeptide Y in patients with eclampsia and preeclampsia. American Journal of Obstetrics & Gynecology. 2000.Google Scholar

Marshall, SA, Senadheera, SN, Parry, LJ, et al. The role of relaxin in normal and abnormal uterine function during the menstrual cycle and early pregnancy. Reproductive Sciences. 2017.Google Scholar

Goldsmith, LT, Weiss, G, and Steinetz, BG. Relaxin and its role in pregnancy. Endocrinology and Metabolism Clinics of North America. 1995.Google Scholar

Clemens, TL, Cormier, S, Eichinger, A, et al. Parathyroid hormone-related protein and its receptors: Nuclear functions and roles in the renal and cardiovascular systems, the placental trophoblasts and the pancreatic islets. British Journal of Pharmacology. 2001.Google Scholar

Ferguson, JE, Gorman, JV, Bruns, DE, et al. Abundant expression of parathyroid hormone-related protein in human amnion and its association with labor. Proceedings of the National Academy of Sciences of the United States of America. 1992.Google Scholar

Ahmed, MS, Cemerikic, B, and Agbas, A. Properties and functions of human placental opioid system. Life Sciences. 1992.Google Scholar

Le Goascogne, C, Eychenne, B, Tonon, MC, et al. Neurosteroid progesterone is up-regulated in the brain of jimpy and shiverer mice. Glia. 2000.Google Scholar

Dombroski, RA, Casey, ML, and MacDonald, PC. 5α-dihydroprogesterone formation in human placenta from 5α-pregnan-3β/α-ol-20-ones and 5-pregnan-3β-yl-20-one sulfate. Journal of Steroid Biochemistry and Molecular Biology. 1997.Google Scholar

Luisi, S, Petraglia, F, Benedetto, C, et al. Serum allopregnanolone levels in pregnant women: Changes during pregnancy, at delivery, and in hypertensive patients. Journal of Clinical Endocrinology & Metabolism. 2000.Google Scholar

Manyonda, IT, Slater, DM, Fenske, C, et al. A role for noradrenaline in pre-eclampsia: Towards a unifying hypothesis for the pathophysiology. BJOG: An International Journal of Obstetrics & Gynaecology. 1998.Google Scholar

Nappi, RE, Petraglia, F, Luisi, S, et al. Serum allopregnanolone in women with postpartum “blues.” Obstetrics & Gynecology. 2001.Google Scholar

Pluchino, N, Ansaldi, Y, and Genazzani, AR. Brain intracrinology of allopregnanolone during pregnancy and hormonal contraception. Hormone Molecular Biology and Clinical Investigation. 2019.CrossRefGoogle Scholar

Smith, R, Paul, JW, and Tolosa, JM. Sharpey-Schafer Lecture 2019: From retroviruses to human birth. Exp Physiol. 2020, 105(4):555–561.Google Scholar

Sultana, Z, Maiti, K, Aitken, J, et al. Oxidative stress, placental ageing-related pathologies and adverse pregnancy outcomes. Am J Reprod Immunol. 2017, 77(5).Google Scholar

Jin, J, and Menon, R. Placental exosomes: A proxy to understand pregnancy complications. Am J Reprod Immunol. 2018, 79(5):e12788.Google Scholar

Zeng, Y, and Chen, T. DNA methylation reprogramming during mammalian development. Genes (Basel). 2019, 10(4).Google Scholar

Tolosa, JM, Schjenken, JE, Clifton, VL, et al. The endogenous retroviral envelope protein syncytin-1 inhibits LPS/PHA-stimulated cytokine responses in human blood and is sorted into placental exosomes. Placenta. 2012, 33(11):933–941.Google Scholar

Cheng, YH, and Handwerger, S. A placenta-specific enhancer of the human syncytin gene. Biol Reprod. 2005, 73(3):500–509.Google Scholar

Makrigiannakis, A, Vrekoussis, T, Zoumakis, E, et al. The role of HCG in implantation: A mini-review of molecular and clinical evidence. Int J Mol Sci. 2017, 18(6).Google Scholar

Fisher, JJ, Bartho, LA, Perkins, AV, et al. Placental mitochondria and reactive oxygen species in the physiology and pathophysiology of pregnancy. Clin Exp Pharmacol Physiol. 2020, 47(1):176–184.Google Scholar

Gomez-Concha, C, Flores-Herrera, O, Olvera-Sanchez, S, et al. Progesterone synthesis by human placental mitochondria is sensitive to PKA inhibition by H89. Int. J. Biochem. Cell Biol. 2011, 43(9):1402–1411.Google Scholar

Martinez, F, Olvera-Sanchez, S, Esparza-Perusquia, M, et al. Multiple functions of syncytiotrophoblast mitochondria. Steroids. 2015, 103:11–22.Google Scholar

Berkane, N, Liere, P, Oudinet, JP, et al. From pregnancy to preeclampsia: A key role for estrogens. Endocr Rev. 2017, 38(2):123–144.Google Scholar

Smith, R, Mesiano, S, Chan, EC, et al. Corticotropin-releasing hormone directly and preferentially stimulates dehydroepiandrosterone sulfate secretion by human fetal adrenal cortical cells. J Clin Endocrinol Metab. 1998, 83(8):2916–2920.Google Scholar

Nagashima, K, Yagi, H, Yunoki, H, et al. Cord blood levels of corticotropin-releasing factor. Biol Neonate. 1987, 51(1):1–4.Google Scholar

Clark, D, Thody, AJ, Shuster, S, et al. Immunoreactive alpha-MSH in human plasma in pregnancy. Nature. 1978, 273(5658):163–164.CrossRefGoogle ScholarPubMed

Sasaki, A, Shinkawa, O, and Yoshinaga, K. Placental corticotropin-releasing hormone may be a stimulator of maternal pituitary adrenocorticotropic hormone secretion in humans. J Clin Invest. 1989;84(6), 1997–2001.Google Scholar

Steine, IM, LeWinn, KZ, Lisha, N, et al. Maternal exposure to childhood traumatic events, but not multi-domain psychosocial stressors, predict placental corticotrophin releasing hormone across pregnancy. Soc Sci Med. 2020, 266:113461.Google Scholar

Smith, R, Smith, JI, Shen, X, et al. Patterns of plasma corticotropin-releasing hormone, progesterone, estradiol, and estriol change and the onset of human labor. J Clin Endocrinol Metab. 2009, 94(6):2066–2074.Google Scholar

Melamed, M, Castano, E, Notides, AC, et al. Molecular and kinetic basis for the mixed agonist/antagonist activity of estriol. Mol Endocrinol. 1997, 11(12):1868–1878.Google Scholar

Lappano, R, Rosano, C, De Marco, P, et al. Estriol acts as a GPR30 antagonist in estrogen receptor-negative breast cancer cells. Mol Cell Endocrinol. 2010, 320(1-2):162–170.Google Scholar

King, BR, Smith, R, and Nicholson, RC. Novel glucocorticoid and cAMP interactions on the CRH gene promoter. Mol Cell Endocrinol. 2002, 194(1–2), 19–28.Google Scholar

Matsuo, H, Maruo, T, Hoshina, M, et al. [Selective inhibition of synthesis and secretion of hCG by progesterone and its correlation with hCG (alpha, beta) mRNA levels]. Nihon Naibunpi Gakkai Zasshi. 1985, 61(9):882–892.Google Scholar

Morrish, DW, Marusyk, H, and Siy, O. Demonstration of specific secretory granules for human chorionic gonadotropin in placenta. J Histochem Cytochem. 1987, 35(1):93–101.Google Scholar

Gellersen, B, Brosens, IA, and Brosens, JJ. Decidualization of the human endometrium: mechanisms, functions, and clinical perspectives. Semin Reprod Med. 2007, 25(6):445–453.Google Scholar

Burton, GJ, Jauniaux, E, and Charnock-Jones, DS. Human early placental development: potential roles of the endometrial glands. Placenta. 2007, 28 Suppl A:S64–9.Google Scholar

Doheny, HC, Houlihan, DD, Ravikumar, N, et al. Human chorionic gonadotrophin relaxation of human pregnant myometrium and activation of the BKCa channel. J Clin Endocrinol Metab. 2003, 88(9):4310–4315.Google Scholar

Karolczak-Bayatti, M, Loughney, AD, Robson, SC, et al. Epigenetic modulation of the protein kinase A RIIalpha (PRKAR2A) gene by histone deacetylases 1 and 2 in human smooth muscle cells. J Cell Mol Med. 2011, 15(1):94–108.Google Scholar

Anamthathmakula, P, Kyathanahalli, C, Ingles, J, et al. Estrogen receptor alpha isoform ERdelta7 in myometrium modulates uterine quiescence during pregnancy. EBioMedicine. 2019, 39:520–530.Google Scholar

Jones, SA, and Challis, JR. Effects of corticotropin-releasing hormone and adrenocorticotropin on prostaglandin output by human placenta and fetal membranes. Gynecol Obstet Invest. 1990, 29(3):165–168.Google Scholar

Mesiano, S, Chan, EC, Fitter, JT, et al. Progesterone withdrawal and estrogen activation in human parturition are coordinated by progesterone receptor A expression in the myometrium. J Clin Endocrinol Metab. 2002, 87(6):2924–2930.Google Scholar

Nadeem, L, Balendran, R, Dorogin, A, et al. Pro-inflammatory signals induce 20alpha-HSD expression in myometrial cells: A key mechanism for local progesterone withdrawal. J Cell Mol Med. 2021.Google Scholar

Brizzi, P, Tonolo, G, Esposito, F, et al. Lipoprotein metabolism during normal pregnancy. Am J Obstet Gynecol. 1999, 181(2):430–434.Google Scholar

Angelin, B, Olivecrona, H, Reihner, E, et al. Hepatic cholesterol metabolism in estrogen-treated men. Gastroenterology. 1992, 103(5):1657–1663.Google Scholar

Faggiano, A, Pivonello, R, Melis, D, et al. Evaluation of circulating levels and renal clearance of natural amino acids in patients with Cushing’s disease. J Endocrinol Invest. 2002, 25(2):142–151.Google Scholar

Bridges, RS, Robertson, MC, Shiu, RP, et al. Endocrine communication between conceptus and mother: placental lactogen stimulation of maternal behavior. Neuroendocrinology. 1996, 64(1):57–64.Google Scholar

Bridges, RS. Neuroendocrine regulation of maternal behavior. Front Neuroendocrinol. 2015, 36:178–196.Google Scholar

Schiller, CE, Meltzer-Brody, S, and Rubinow, DR. The role of reproductive hormones in postpartum depression. CNS Spectr. 2015, 20(1):48–59.Google Scholar

Macias, H, and Hinck, L. Mammary gland development. Wiley Interdiscip Rev Dev Biol. 2012, 1(4):533–557.Google Scholar

Ivell, R, Ludwig, M, Tribe, RM, et al. Oxytocin. In Skinner, M. K. (Ed.), Encyclopedia of Reproduction. vol. 2, 2018; 597–606. Academic Press: Elsevier.Google Scholar

Arrowsmith, S, and Wray, S. Oxytocin: Its mechanism of action and receptor signalling in the myometrium. J Neuroendocrinol. 2014, 26: 356–369.Google Scholar

Borrow, AP, and Cameron, NM. The role of oxytocin in mating and pregnancy. Horm Behav. 2012, 61 :266–276.Google Scholar

Giraldi, A, Marson, L, Nappi, R, et al. Physiology of female sexual function: Animal models. J Sexual Med. 2004, 1: 237–253.Google Scholar

Nishimori, K, Young, LJ, Guo, Q et al. Oxytocin is required for nursing but is not essential for parturition or reproductive behavior. Proc Natl Acad Sci USA. 1996, 93: 11699–11704.Google Scholar

Salonia, A, Nappi, RE, Pontillo, M, et al. Menstrual cycle-related changes in plasma oxytocin are relevant to normal sexual function in healthy women. Horm Behav. 2005, 47: 164–169.Google Scholar

Veening, JG, de Jong, TR, Waldinger, MD, et al. The role of oxytocin in male and female reproductive behavior. Eur J Pharmacol. 2015, 753: 209–228.Google Scholar

Carmichael, MS, Warburton, VL, Dixen, J, et al. Relationships among cardiovascular, muscular, and oxytocin responses during human sexual activity. Arch Sexual Behav. 1994, 23: 59–79.Google Scholar

Einspanier, A, Ivell, R, and Hodges, JK. Oxytocin: A follicular luteinisation factor in the marmoset monkey. Adv Exp Med Biol. 1995, 395: 517–522.Google Scholar

Furuya, K, Mizumoto, Y, Makimura, N, et al. A novel biological aspect of ovarian oxytocin: Gene expression of oxytocin and oxytocin receptor in cumulus/luteal cells and the effect of oxytocin on embryogenesis in fertilized oocytes. Adv Exp Med Biol. 1995, 395: 523–528.Google Scholar

Fuchs, AR, Romero, R, Keefe, D, et al. Oxytocin secretion and human parturition: pulse frequency and duration increase during spontaneous labor in women. Am J Obstet Gynecol. 1991, 165: 1515–1523.Google Scholar

Wathes, DC, Borwick, SC, Timmons, PM, et al. Oxytocin receptor expression in human term and preterm gestational tissues prior to and following the onset of labour. J Endocrinol. 1999, 161: 143–151.Google Scholar

Kimura, T, Takemura, M, Nomura, S, et al. Expression of oxytocin receptor in human pregnant myometrium. Endocrinology. 1996, 137: 780–785.Google Scholar

Soloff, MS, Alexandrova, M, and Fernstrom, MJ. Oxytocin receptors: Triggers for parturition and lactation? Science. 1979, 204: 1313–1315.Google Scholar

Fuchs, AR, Fuchs, F, Husslein, P, et al. Oxytocin receptors in the human uterus during pregnancy and parturition. Am J Obstet Gynecol. 1984, 150: 734–741.Google Scholar

Pieber, D, Allport, VC, Hills, F, et al. Interactions between progesterone receptor isoforms in myometrial cells in human labour. Mol Hum Reprod 2001, 7: 875–879.Google Scholar

Mesiano, S, Chan, EC, Fitter, JT, et al. Progesterone withdrawal and estrogen activation in human parturition are coordinated by progesterone receptor A expression in the myometrium. J Clin Endocrinol Metab. 2002, 87: 2924–2930.Google Scholar

McNeilly, AS, Robinson, IC, Houston, MJ, et al. Release of oxytocin and prolactin in response to suckling. Br Med J. 1983, 286: 257–259.Google Scholar

Uvnäs-Moberg, K, Widström, AM, Werner, S, et al. Oxytocin and prolactin levels in breast-feeding women. Correlation with milk yield and duration of breast-feeding. Acta Obstet Gynecol Scand. 1990, 69: 301–306.Google Scholar

Fuchs, AR, Ivell, R, Ganz, N, et al. Secretion of oxytocin in pregnant and parturient cows: Corpus luteum may contribute to plasma oxytocin at term. Biol. Reprod. 2001, 65: 1135–1141.Google Scholar

Christensson, K, Nilsson, BA, Stock, S, et al. Effect of nipple stimulation on uterine activity and on plasma levels of oxytocin in full term, healthy, pregnant women. Acta Obstet Gynecol Scand. 1989, 68: 205–210.Google Scholar

Jonas, W, Johansson, LM, Nissen, E, et al. Effects of intrapartum oxytocin administration and epidural analgesia on the concentration of plasma oxytocin and prolactin, in response to suckling during the second day postpartum. Breastfeeding Med. 2009, 4: 71–82.Google Scholar

Nissen, E, Uvnäs-Moberg, K, Svensson, K, et al. Different patterns of oxytocin, prolactin but not cortisol release during breastfeeding in women delivered by caesarean section or by the vaginal route. Early Hum Devel. 1996, 45: 103–118.Google Scholar

Yokoyama, Y, Ueda, T, Irahara, M, et al. Releases of oxytocin and prolactin during breast massage and suckling in puerperal women. Eur J Obstet Gynecol Reprod Biol. 1994, 53: 17–20.Google Scholar

Uvnas Moberg, K, Ekstrom-Bergstrom, A, Buckley, S, et al. Maternal plasma levels of oxytocin during breastfeeding – A systematic review. PLoS ONE 2020, 15: e0235806.Google Scholar

Bell, AF, Erickson, EN, and Carter, CS: Beyond labor: The role of natural and synthetic oxytocin in the transition to motherhood. J Midwifery Womens Health. 2014, 59: 35–42.Google Scholar

Odent, MR. Synthetic oxytocin and breastfeeding: Reasons for testing an hypothesis. Med Hypotheses. 2013, 81: 889–891.Google Scholar

Williams, GL, Gazal, OS, Leshin, LS, et al. Physiological regulation of maternal behavior in heifers: roles of genital stimulation, intracerebral oxytocin release, and ovarian steroids. Biol Reprod. 2001, 65: 295–300.Google Scholar

Carter, CS, Altemus, M, and Chrousos, GP. Neuroendocrine and emotional changes in the post-partum period. Prog Brain Res. 2001, 133: 241–249.Google Scholar

Boccia, ML, Goursaud, AP, Bachevalier, J, et al. Peripherally administered non-peptide oxytocin antagonist, L368,899, accumulates in limbic brain areas: a new pharmacological tool for the study of social motivation in non-human primates. Horm Behav. 2007, 52: 344–351.Google Scholar

Gordon, I, Zagoory-Sharon, O, Leckman, JF, et al. Oxytocin and the development of parenting in humans. Biol Psychiatry. 2010, 68: 377–382.Google Scholar

Budden, A, Chen, LJ, and Henry, A. High-dose versus low-dose oxytocin infusion regimens for induction of labour at term. Cochrane Database Syst Rev. 2014, Cd009701.Google Scholar

Saccone, G, Ciardulli, A, Baxter, JK, et al. Discontinuing oxytocin infusion in the active phase of labor: A systematic review and meta-analysis. Obstet Gynec. 2017, 130: 1090–1096.Google Scholar

Tribe, RM, Crawshaw, SE, Seed, P, et al. Pulsatile versus continuous administration of oxytocin for induction and augmentation of labor: Two randomized controlled trials. Am J Obstet Gynecol. 2012, 206(230):e231–238.Google Scholar

ACOG Practice Bulletin No. 107: Induction of labor. Obstet Gynecol. 2009, 114: 386–397.CrossRefGoogle Scholar

Smyth, RM, Markham, C, and Dowswell, T. Amniotomy for shortening spontaneous labour. Cochrane Database Syst Rev. 2013, Cd006167.Google Scholar

Grobman, WA, Rice, MM, Reddy, UM, et al. Labor induction versus expectant management in low-risk nulliparous women. N Engl J Med. 2018, 379: 513–523.Google Scholar

Winterfeld, U, Meyer, Y, Panchaud, A, et al. Management of deficient lactation in Switzerland and Canada: A survey of midwives’ current practices. Breastfeeding Med. 2012, 7: 317–318.Google Scholar

Cazorla-Ortiz, G, Obregón-Guitérrez, N, Rozas-Garcia, MR, et al. Methods and success factors of induced lactation: A scoping review. J Hum Lact. 2020, 36: 739–749.Google Scholar

Mangesi, L, and Zakarija-Grkovic, I. Treatments for breast engorgement during lactation. Cochrane Database Syst Rev. 2016, Cd006946.Google Scholar

Fewtrell, MS, Loh, KL, Blake, A, et al. Randomised, double blind trial of oxytocin nasal spray in mothers expressing breast milk for preterm infants. Arch Dis Child Fetal Neonatal Ed. 2006, 91: F169–174.Google Scholar

Practice Bulletin No. 183: Postpartum Hemorrhage. Obstet Gynecol. 2017, 130: e168–e186.Google Scholar

Salati, JA, Leathersich, SJ, Williams, MJ, et al. Prophylactic oxytocin for the third stage of labour to prevent postpartum haemorrhage. Cochrane Database Syst Rev. 2019, Cd001808.Google Scholar

Westhoff, G, Cotter, AM, and Tolosa, JE. Prophylactic oxytocin for the third stage of labour to prevent postpartum haemorrhage. Cochrane Database Syst Rev. 2013, Cd001808.Google Scholar

Durocher, J, Dzuba, IG, Carroli, G, et al. Does route matter? Impact of route of oxytocin administration on postpartum bleeding: A double-blind, randomized controlled trial. PLoS ONE. 2019, 14: e0222981.Google Scholar

Windle, RJ, Shanks, N, Lightman, SL, et al. Central oxytocin administration reduces stress-induced corticosterone release and anxiety behavior in rats. Endocrinology. 1997, 138: 2829–2834.Google Scholar

Petersson, M, Wiberg, U, Lundeberg, T, et al. Oxytocin decreases carrageenan induced inflammation in rats. Peptides. 2001, 22: 1479–1484.Google Scholar

Neumann, ID. Brain oxytocin: A key regulator of emotional and social behaviours in both females and males. J Neuroendocrinol. 2008, 20: 858–865.Google Scholar

Churchland, PS, and Winkielman, P. Modulating social behavior with oxytocin: how does it work? What does it mean? Horm Behav. 2012, 61: 392–399.Google Scholar

Cyranowski, JM, Hofkens, TL, Frank, E, et al. Evidence of dysregulated peripheral oxytocin release among depressed women. Psychosom Med. 2008, 70: 967–975.Google Scholar

Leng, G, and Ludwig, M. Intranasal oxytocin: Myths and delusions. Biol Psychiatry. 2016, 79: 243–250.Google Scholar

Saxbe, D, Khaled, M, Horton, KT, et al. Maternal prenatal plasma oxytocin is positively associated with prenatal psychological symptoms, but method of immunoassay extraction may affect results. Biol Psychol 2019. 147: 107718.Google Scholar

Bosch, OJ, Meddle, SL, Beiderbeck, DI, et al. Brain oxytocin correlates with maternal aggression: Link to anxiety. J Neurosci. 2005, 25: 6807–6815.Google Scholar

Craciunas, L, Kollmann, M, Tsampras, N, et al. Oxytocin antagonists for assisted reproduction. Cochrane Database Syst Rev. 2016, Cd012375.Google Scholar

Moraloglu, O, Tonguc, E, Var, T, et al. Treatment with oxytocin antagonists before embryo transfer may increase implantation rates after IVF. Reprod Biomed Online. 2010, 21: 338–343.Google Scholar

Kam, KY, and Lamont, RF. Developments in the pharmacotherapeutic management of spontaneous preterm labor. Expert Opin Pharmacother. 2008, 9: 1153–1168.Google Scholar

van Vliet, EOG, Nijman, TAJ, Schuit, E, et al. Nifedipine versus atosiban for threatened preterm birth (APOSTEL III): A multicentre, randomised controlled trial. Lancet. 2016, 387: 2117–2124.Google Scholar

Thornton, S, Goodwin, TM, Greisen, G, et al. The effect of barusiban, a selective oxytocin antagonist, in threatened preterm labor at late gestational age: A randomized, double-blind, placebo-controlled trial. Am J Obstet Gynecol. 2009, 200(627): e621–610.Google Scholar

Thornton, S, Miller, H, Valenzuela, G, et al. Treatment of spontaneous preterm labour with retosiban: A phase 2 proof-of-concept study. Br J Clin Pharmacol. 2015, 80: 740–749.Google Scholar

Ogawa, S, Kudo, S, Kitsunai, Y, et al. Increase in oxytocin secretion at ejaculation in male. Clin Endocrinol. 1980, 13: 95–97.Google Scholar

Carmichael, MS, Humbert, R, Dixen, J, et al. Plasma oxytocin increases in the human sexual response. J Clin Endocrinol Metab. 1987, 64: 27–31.Google Scholar

Melis, MR, Argiolas, A, andGessa, GL. Oxytocin-induced penile erection and yawning: site of action in the brain. Brain Res. 1986, 398: 259–265.Google Scholar

Filippi, S, Vannelli, GB, Granchi, S, et al. Identification, localization and functional activity of oxytocin receptors in epididymis. Mol Cell Endocrinol. 2002, 193: 89–100.Google Scholar

Ivell, R, Balvers, M, Rust, W, et al. Oxytocin and male reproductive function. Adv Exp Med Biol. 1997, 424: 253–264.Google Scholar

Thackare, H, Nicholson, HD, and Whittington, K. Oxytocin - Its role in male reproduction and new potential therapeutic uses. Hum Reprod Update. 2006, 12: 437–448.Google Scholar

Neumann, ID, Wigger, A, Torner, L, et al. Brain oxytocin inhibits basal and stress-induced activity of the hypothalamo-pituitary-adrenal axis in male and female rats: Partial action within the paraventricular nucleus. J Neuroendocrinol. 2000, 12: 235–243.Google Scholar

Goodin, BR, Anderson, AJB, Freeman, EL, et al. Intranasal oxytocin administration is associated with enhanced endogenous pain inhibition and reduced negative mood states. Clin J Pain. 2015, 31: 757–767.Google Scholar

Boll, S, Almeida de Minas, AC, Raftogianni, A, et al. Oxytocin and pain perception: From animal models to human research. Neuroscience. 2018, 387: 149–161.Google Scholar

Tracy, LM, Georgiou-Karistianis, N, Gibson, SJ, et al. Oxytocin and the modulation of pain experience: Implications for chronic pain management. Neurosci Biobehav Rev. 2015, 55: 53–67.Google Scholar

Onaka, T, and Takayanagi, Y. Role of oxytocin in the control of stress and food intake. J Neuroendocrinol. 2019, e12700.Google Scholar

Pierce, JG, and Parsons, TF. Glycoprotein hormones: Structure and function. Annu Rev Biochem. 1981, 50: 465–495.Google Scholar

Stockell Hartree, A, and Renwick, AG. Molecular structures of glycoprotein hormones and functions of their carbohydrate components. Biochem J. 1992, 287(Pt 3): 665–679.Google Scholar

Godine, JE, Chin, WW, and Habener, JF. Alpha Subunit of rat pituitary glycoprotein hormones. Primary structure of the precursor determined from the nucleotide sequence of cloned cDNAs. J Biol Chem. 1982, 257, 8368–8371,Google Scholar

Golos, TG, Durning, M, and Fisher, JM. Molecular cloning of the rhesus glycoprotein hormone alpha-subunit gene. DNA Cell Biol. 1991, 10, 367–380.Google Scholar

McGregor, WG, Kuhn, RW, and Jaffe, RB. Biologically active chorionic gonadotropin: Synthesis by the human fetus. Science. 1983, 220, 306–308.Google Scholar

Miller-Lindholm, AK, LaBenz, CJ, Ramey, J, et al. Human chorionic gonadotropin-beta gene expression in first trimester placenta. Endocrinology. 1997, 138, 5459–5465.Google Scholar

Morrish, DW, Manickavel, V, Jewell, LD, et al. Immunolocalization of alpha and beta chains of human chorionic gonadotropin, placental lactogen and pregnancy-specific beta-glycoprotein in term placenta by a touch preparation method. Histochemistry. 1987, 88, 57–60.Google Scholar

Hoshina, M, Ashitake, Y, and Tojo, S. Immunohistochemical interaction on antisera to HCG and its subunits with chorionic tissue of early gestation. Endocrinol Jpn. 1979, 26, 175–184.Google Scholar

Maruo, T, Ladines-Llave, CA, Matsuo, H, et al. A novel change in cytologic localization of human chorionic gonadotropin and human placental lactogen in first-trimester placenta in the course of gestation. Am J Obstet Gynecol. 1992, 167, 217–222.Google Scholar

Beck, T, Schweikhart, G, and Stolz, E. Immunohistochemical location of HPL, SP1 and beta-HCG in normal placentas of varying gestational age. Arch Gynecol. 1986, 239, 63–74.Google Scholar

Hoshina, M, Boothby, M, and Boime, I. Cytological localization of chorionic gonadotropin alpha and placental lactogen mRNAs during development of the human placenta. J Cell Biol. 1982, 93, 190–198Google Scholar

Cole, LA. Immunoassay of human chorionic gonadotropin, its free subunits, and metabolites. Clin Chem. 1997, 43, 2233–2243.Google Scholar

Wolfahrt, S, Kleine, B, and Rossmanith, WG. Detection of gonadotrophin releasing hormone and its receptor mRNA in human placental trophoblasts using in-situ reverse transcription-polymerase chain reaction. Mol Hum Reprod. 1998, 4, 999–1006.Google Scholar

Petraglia, F, Vaughan, J, and Vale, W. Inhibin and activin modulate the release of gonadotropin-releasing hormone, human chorionic gonadotropin, and progesterone from cultured human placental cells. Proc Natl Acad Sci USA. 1989, 86, 5114–5117.Google Scholar

Wehmann, RE, and Nisula, BC. Renal clearance rates of the subunits of human chorionic gonadotropin in man. J Clin Endocrinol Metab. 1980, 50, 674–679.Google Scholar

Zirkin, BR, and Papadopoulos, V. Leydig cells: Formation, function, and regulation. Biol Reprod. 2018, 99, 101–111.Google Scholar

Clements, JA, Reyes, FI, Winter, JS, et al. Studies on human sexual development. III. Fetal pituitary and serum, and amniotic fluid concentrations of LH, CG, and FSH. J Clin Endocrinol Metab. 1976, 42, 9–19.Google Scholar

Molsberry, RL, Carr, BR, Mendelson, CR, et al. Human chorionic gonadotropin binding to human fetal testes as a function of gestational age. J Clin Endocrinol Metab. 1982, 55, 791–794.Google Scholar

Tapanainen, J, Kellokumpu-Lehtinen, P, Pelliniemi, L, et al. Age-related changes in endogenous steroids of human fetal testis during early and midpregnancy. J Clin Endocrinol Metab. 1981, 52, 98–102.Google Scholar

Leinonen, PJ, and Jaffe, RB. Leydig cell desensitization by human chorionic gonadotropin does not occur in the human fetal testis. J Clin Endocrinol Metab. 1985, 61, 234–238.Google Scholar

Hershman, JM. Human chorionic gonadotropin and the thyroid: Hyperemesis gravidarum and trophoblastic tumors. Thyroid. 1999, 9, 653–657.Google Scholar

Kraiem, Z, Sadeh, O, Blithe, DL, et al. Human chorionic gonadotropin stimulates thyroid hormone secretion, iodide uptake, organification, and adenosine 3’,5’-monophosphate formation in cultured human thyrocytes. J Clin Endocrinol Metab. 1994, 79, 595–599.Google Scholar

Tomer, Y, Huber, GK, and Davies, TF. Human chorionic gonadotropin (hCG) interacts directly with recombinant human TSH receptors. J Clin Endocrinol Metab. 1992, 74, 1477–1479.Google Scholar

Fitzpatrick, DL, and Russell, MA. Diagnosis and management of thyroid disease in pregnancy. Obstet Gynecol Clin North Am. 2010, 37, 173–193.Google Scholar

Nathan, N, and Sullivan, SD. Thyroid disorders during pregnancy. Endocrinol Metab Clin North Am. 2014, 43, 573–597.Google Scholar

Oppenheimer, JH, and Schwartz, HL. Molecular basis of thyroid hormone-dependent brain development. Endocr Rev, 1997, 18, 462–475.Google Scholar

Noten, AM, Loomans, EM, Vrijkotte, TG, et al. Maternal hypothyroxinaemia in early pregnancy and school performance in 5-year-old offspring. Eur J Endocrinol. 2015, 173, 563–571.Google Scholar

Nelson, SM, Haig, C, McConnachie, A, et al. Maternal thyroid function and child educational attainment: Prospective cohort study. BMJ. 2018, 360, k452.Google Scholar

Remaud, S, Gothie, JD, Morvan-Dubois, G, et al. Thyroid hormone signaling and adult neurogenesis in mammals. Front Endocrinol (Lausanne). 2014, 5, 62.Google Scholar

Kurtzman, JT, Wilson, H, and Rao, CV. A proposed role for hCG in clinical obstetrics. Semin Reprod Med. 2001, 19, 63–68.Google Scholar

Kane, N, Kelly, R, Saunders, PT, et al. Proliferation of uterine natural killer cells is induced by human chorionic gonadotropin and mediated via the mannose receptor. Endocrinology. 2009, 150, 2882–2888.Google Scholar

Han, T. Inhibitory effect of human chorionic gonadotrophin on lymphocyte blastogenic response to mitogen, antigen and allogeneic cells. Clin Exp Immunol. 1974, 18, 529–535.Google Scholar

Braunstein, GD. The long gestation of the modern home pregnancy test. Clin Chem. 2014, 60, 18–21.Google Scholar

Wilcox, AJ, Baird, DD, Dunson, D, et al. Natural limits of pregnancy testing in relation to the expected menstrual period. JAMA. 2001, 286, 1759–1761.Google Scholar

Braunstein, GD. False-positive serum human chorionic gonadotropin results: Causes, characteristics, and recognition. Am J Obstet Gynecol. 2002, 187, 217–224.Google Scholar

Montagnana, M, Trenti, T, Aloe, R, et al. Human chorionic gonadotropin in pregnancy diagnostics. Clin Chim Acta. 2011, 412, 1515–1520.Google Scholar

Grenache, DG. Variable accuracy of home pregnancy tests: Truth in advertising? Clin Chem Lab Med. 2015, 53, 339–341.Google Scholar

Johnson, S, Cushion, M, Bond, S, et al. Comparison of analytical sensitivity and women’s interpretation of home pregnancy tests. Clin Chem Lab Med. 2015, 53, 391–402.Google Scholar

Cole, LA. The utility of six over-the-counter (home) pregnancy tests. Clin Chem Lab Med. 2011, 49, 1317–1322.Google Scholar

Banerjee, S, Smallwood, A, Chambers, AE, et al. A link between high serum levels of human chorionic gonadotrophin and chorionic expression of its mature functional receptor (LHCGR) in Down’s syndrome pregnancies. Reprod Biol Endocrinol. 2005, 3, 25.Google Scholar

Stenman, UH, Alfthan, H, and Hotakainen, K. Human chorionic gonadotropin in cancer. Clin Biochem. 2004, 37, 549–561.Google Scholar

Bedi, DG, Moeller, D, Fagan, CJ, et al. Chronic ectopic pregnancy. A comparison with acute ectopic pregnancy. Eur J Radiol. 1987, 7, 46–48.Google Scholar

Brennan, DF, Kwatra, S, Kelly, M, et al. Chronic ectopic pregnancy – Two cases of acute rupture despite negative beta hCG. J Emerg Med. 2000, 19, 249–254.Google Scholar

Smith, HO, Kohorn, E, and Cole, LA. Choriocarcinoma and gestational trophoblastic disease. Obstet Gynecol Clin North Am. 2005, 32, 661–684.Google Scholar

Barnhart, K, Mennuti, MT, Benjamin, I, et al. Prompt diagnosis of ectopic pregnancy in an emergency department setting. Obstet Gynecol. 1994, 84, 1010–1015.Google Scholar

Barnhart, K, Sammel, MD, Chung, K, et al. Decline of serum human chorionic gonadotropin and spontaneous complete abortion: Defining the normal curve. Obstet Gynecol. 2004, 104, 975–981.Google Scholar

Seeber, BE, Sammel, MD, Guo, W, et al. Application of redefined human chorionic gonadotropin curves for the diagnosis of women at risk for ectopic pregnancy. Fertil Steril. 2006, 86, 454–459.Google Scholar

Chung, K, Sammel, MD, Coutifaris, C, et al. Defining the rise of serum HCG in viable pregnancies achieved through use of IVF. Hum Reprod. 2006, 21, 823–828.Google Scholar

Silva, C, Sammel, MD, Zhou, L, et al. Human chorionic gonadotropin profile for women with ectopic pregnancy. Obstet Gynecol. 2006, 107, 605–610.Google Scholar

Zee, J, Sammel, MD, Chung, K, et al. Ectopic pregnancy prediction in women with a pregnancy of unknown location: Data beyond 48 h are necessary. Hum Reprod. 2014, 29, 441–447.Google Scholar

Abbassi-Ghanavati, M, Greer, LG, and Cunningham, FG. Pregnancy and laboratory studies: A reference table for clinicians. Obstet Gynecol. 2009, 114(6):1326–1331.Google Scholar

Devroey, P, Camus, M, Palermo, G, et al. Placental production of estradiol and progesterone after oocyte donation in patients with primary ovarian failure. Am J Obstet Gynecol. 1990, 162(1): 66–70.Google Scholar

Berkane, N, Liere, P, Oudinet, JP, et al. From pregnancy to preeclampsia: A key role for estrogens. Endocr Rev. 2017, 38:123–144.Google Scholar

Osawa, N Y. Purification of human placental aromatase cytochrome P-450 with monoclonal antibody and its characterization. Biochemistry. 1991, 30(12):3003–3010.Google Scholar

Pepe, GJ, and Albrecht, ED. Actions of placental and fetal adrenal steroid hormones in primate pregnancy. Endocr Rev. 1995, 16(5): 608–648.Google Scholar

Siiteri, PK. The continuing saga of dehydroepiandrosterone (DHEA). J Clin Endocrinol Metab. 2005, 90(6):3795–3796.Google Scholar

Kragie, L. Aromatase in primate pregnancy: A review. Endocr Res. 2002, 28(3):121–128.Google Scholar

Fournet-Dulguerov, N, MacLusky, NJ, Leranth, CZ, et al. Immunohistochemical localization of aromatase cytochrome P-450 and estradiol dehydrogenase in the syncytiotrophoblast of the human placenta. J Clin Endocrinol Metab. 1987, 65(4):757–764.Google Scholar

Kumar, P, Kamat, A, and Mendelson, CR. Estrogen receptor alpha (Eralpha) mediates stimulatory effects of estrogen on aromatase (CYP19) gene expression in human placenta. Mol Endocrinol. 2009, 23(6):784–793.Google Scholar

Calzada-Mendoza, CC, Sa´nchez, EC, Campos, RR, et al. Differential aromatase (CYP19) expression in human arteries from normal and neoplasic uterus: An immuno-histochemical and in situ hybridization study. Front Biosci. 2006, 11:389–393.Google Scholar

Zbella, EA, Ilekis, J, Scommegna, A, et al. Competitive studies with dehydroepiandrosterone sulfate and 16 alpha- hydroxydehydroepiandrosterone sulfate in cultured human cho- riocarcinoma JEG-3 cells: Effect on estrone, 17 beta-estradiol, and estriol secretion. J Clin Endocrinol Metab. 1986, 63(3):751–757.Google Scholar

Milewich, L, MacDonald, PC, and Carr, BR. Estrogen 16 alpha-hydroxylase activity in human fetal tissues. J Clin Endocrinol Metab. 1986, 63(2):404–406.Google Scholar

Jobe, SO, Tyler, CT, and Magness, RR. Aberrant synthesis, metabolism, and plasma accumulation of circulating estrogens and estrogen metabolites in preeclampsia implications for vascular dysfunction. Hypertension. 2013, 61(2):480–487.Google Scholar

Holinka, CF, Diczfalusy, E, and Coelingh Bennink, HJT. Estetrol: A unique steroid in human pregnancy. J Steroid Biochem Mol Biol. 2008, 110(1–2):138–143.Google Scholar

Pluchino, N, Santoro, AN, Casarosa, E, et al. Effect of estetrol administration on brain and serum allopregnanolone in intact and ovariectomized rats. J Steroid Biochem Mol Biol. 2014, 143: 285–290.Google Scholar

Jobe, SO, Ramadoss, J, Koch, JM, et al. Estradiol-17beta and its cytochrome P450- and catechol-O-methyltransferase-derived metabolites stimulate proliferation in uterine artery endothelial cells: Role of estrogen receptor-alpha versus estrogen receptor-beta. Hypertension. 2010, 55(4): 1005–1011.Google Scholar

Aitio, A. UDPglucuronosyltransferase of the human placenta. Biochem Pharmacol. 1974, 23(15):2203–2205.Google Scholar

Gamage, N, Barnett, A, Hempel, N, et al. Human sulfotransferases and their role in chemical metabolism. Toxicol Sci. 2006, 90(1):5–22.Google Scholar

Falany, CN, Wheeler, J, Oh, TS, et al. Steroid sulfation by expressed human cytosolic sulfotransferases. J Steroid Biochem Mol Biol. 1994, 48(4):369–375.Google Scholar

Tong, MH, Jiang, H, Liu, P, et al. Spontaneous fetal loss caused by placental thrombosis in estrogen sulfotransferase-deficient mice. Nat Med. 2005, 11(2):153–159.Google Scholar

Pepe, GJ, Burch, MG,and Albrecht, E. Estroge regulates 11ß-hydroxysteroid dehydrogenase-1 and -2 localization in placental syncytiotrophoblast in the second half of primate pregnancy. Endocrinology. 2001, 142.4496–4503.Google Scholar

Hu, W, Weng, X, Dong, M, et al. Alteration in methylation level at 11ß-hydroxysteroid dehydrogenase type 2 gene promoter in infants born to preeclamptic women. BMC Genetics. 2014, 15:96.Google Scholar

Dao, B, Vanageg, MA, Bardin, CW, et al. Anti-implantation activity of antiestrogens and mifepristone. Contraception. 1996, 54: 253–258.Google Scholar

Bukovsky, A, Cekanova, M, Caudle, MR, et al. Expression and localization of estrogen receptor-alpha protein in normal and abnormal term placentae and stimulation of trophoblast differentiation by estradiol. Reprod Biol Endocrinol. 2003, 1:13.Google Scholar

Bukovsky, A, Caudle, MR, Cekanova, M, et al. Placental expression of estrogen receptor beta and its hormone binding variant – Comparison with estrogen receptor alpha and a role for estrogen receptors in asymmetric division and differentiation of estrogen-dependent cells. Reprod Biol Endocrinol. 2003, 1:36.Google Scholar

Pijnenborg, R, Vercruysse, L, and Hanssens, M. The uterine spiral arteries in human pregnancy: Facts and controversies. Placenta. 2006, 27(9–10):939–958.Google Scholar

Liu, LX, Lu, H, Luo, Y, et al. Stabilization of vascular endothelial growth factor mRNA by hypoxia-inducible factor 1. Biochem Biophys Res Commun. 2002, 291(4):908–914.Google Scholar

Losordo, DW, and Isner, JM. Estrogen and angiogenesis: A review. Arterioscler Thromb Vasc Biol. 2001, 21(1):6–12.Google Scholar

Ce, ZM, Bucak, K, Chu, S, et al. 17Beta-estradiol up-regulates vascular endothelial growth factor receptor-2 expression in human myometrial microvascular endothelial cells: Role of estrogen receptor-alpha and -beta. J Clin Endocrinol Metab. 2002, 87(9):4341–4349.Google Scholar

Fotsis, T, Zhang, Y, Pepper, MS, et al. The endogenous oestrogen metabolite 2-methoxyoestradiol inhibits angiogenesis and suppresses tumour growth. Nature. 1994, 368(6468):237–239.Google Scholar

Thaler, I, Manor, D, Itskovitz, J, et al. Changes in uterine blood flow during human pregnancy. Am J Obstet Gynecol. 1990, 162(1):121–125.Google Scholar

Mabie, WC, DiSessa, TG, Crocker, LG, et al. A longitudinal study of cardiac output in normal human pregnancy. Am J Obstet Gynecol. 1994, 170(3):849–856.Google Scholar

Dubey, RK, and Jackson, EK. Potential vascular actions of 2-methoxyestradiol. Trends Endocrinol Metab. 2009,20(8):374–379.Google Scholar

Rupnow, HL, Phernetton, TM, Shaw, CE, et al. Endothelial vasodilator production by uterine and systemic arteries. VII. Estrogen and progesterone effects on eNOS. Am J Physiol Heart Circ Physiol. 2001, 280(4):H1699–H1705.Google Scholar

Miller, SL, Jenkin, G, and Walker, DW. Effect of nitric oxide synthase inhibition on the uterine vasculature of the late-pregnant ewe. Am J Obstet Gynecol. 1999, 180(5):1138–1145.Google Scholar

Baggia, S, Albrecht, ED, and Pepe, GJ. Regulation of 11 beta-hydroxysteroid dehydrogenase activity in the baboon placenta by estrogen. Endocrinology. 1990, 126(5):2742–2748.Google Scholar

Almey, A, Milner, TA, and Brake, W. Estrogen receptors in the central nervous system and their implication for dopamine-dependent cognition in females. Horm Behav. 2015, 74:125–138.Google Scholar

Baud, O, Berkane, N. Hormonal changes associated with intra-uterine growth restriction: Impact on the developing brain and future neurodevelopment. Front Endocrinol. 2019, 10:179.Google Scholar

Hertig, A, Liere, P, Chabbert-Buffet, N, et al. Steroid profiling in preeclamptic women: Evidence for aromatase deficiency. Am J Obstet Gynecol. 2010, 203(5):477.e1–477.e9.Google Scholar

Perez-Sepulveda, A, Monteiro, LJ, Dobierzewska, A, et al. Placental aromatase is deficient in placental ischemia and preeclampsia. PLoS ONE. 2015, 10(10):e0139682.Google Scholar

Kumar, P, Luo, Y, Tudela, C, et al. The c-Myc-regulated microRNA-17~92 (miR-17~92) and miR- 106a~363 clusters target hCYP19A1 and hGCM1 to inhibit human trophoblast differentiation. Mol Cell Biol. 2013, 33(9): 1782–1796.Google Scholar

Ma, CX, Adjei, AA, Salavaggione, OE, et al. Human aromatase: Gene resequencing and functional genomics. Cancer Res. 2005, 65(23):11071–11082.Google Scholar

Charles, SM, Julian, CG, Vargas, E, et al. Higher estrogen levels during pregnancy in Andean than European residents of high altitude suggest differences in aromatase activity. J Clin Endocrinol Metab. 2014, 99(8):2908–2916.Google Scholar

Berkane, N, Liere, P, Lefevre, G, et al. Abnormal steroidogenesis and aromatase activity and the risk of preeclampsia. Placenta. 2018, 69:40–49.Google Scholar

Kanasaki, K, Palmsten, K, Sugimoto, H, et al. Deficiency in catechol-O-methyltransferase and 2-methoxyoestradiol is associated with pre-eclampsia. Nature. 2008, 453(7198):1117–1121.Google Scholar

Ishibashi, O, Ohkuchi, A, Ali, MM, et al. Hydroxysteroid (17-b) dehydrogenase 1 is dysregulated by miR-210 and miR-518c that are aberrantly expressed in preeclamptic placentas: a novel marker for predicting pre-eclampsia. Hypertension. 2012, 59(2):265–273.Google Scholar

Ohkuchi, A, Ishibashi, O, Hirashima, C, et al. Plasma level of hydroxysteroid (17-b) dehydrogenase 1 in the second trimester is an independent risk factor for predicting preeclampsia after adjusting for the effects of mean blood pressure, bilateral notching and plasma level of soluble fms-like tyrosine kinase 1/placental growth factor ratio. Hypertens Res. 2012, 35(12):1152–1158.Google Scholar

Ludwikowski, B, Heger, S, Datz, N, et al. Aromatase deficiency: Rare cause of virilization. Eur J Pediatr Surg. 2013, 23(5):418–422.Google Scholar

Maliqueo, M, Echiburú, B, and Crisosto, N. Sex steroids modulate uterine-placental vasculature: Implications for obstetrics and neonatal outcomes. Front Physiol. 2016, 7:152.Google Scholar

Salih, SM, Salama, SA, Fadl, AA, et al. Expression and cyclic variations of catechol-O-methyl transferase in human endometrial stroma. Fertil Steril. 2008, 90(3):789–797.Google Scholar

Rabe, T, Hösch, R, and Runnebaum, B. Sulfatase deficiency in the human placenta: Clinical findings. Biol Res Pregnancy Perinatol. 1983, 4(3):95–102.Google Scholar

Young, I, Renfree, M, Mesiano, S, et al. The comparative physiology of parturition in mammals: Hormones and parturition in mammals. 2011, 5:95–116.Google Scholar

Renthal, NE, Williams, KC, Montalbano, AP, et al. Molecular regulation of parturition: A myometrial perspective. Cold Spring Harb Perspect Med. 2015, 5:a023069.Google Scholar

Weiss, G. Clinical review 118. Endocrinology of parturition. J Clin Endocrinol Metab. 2000, 85:4421–4425.Google Scholar

Callard, IP, Fileti, LA, Perez, LE, et al. Role of the corpus luteum and progesterone in the evolution of vertebrate viviparity. Am. Zool. 1992, 32:264–275.Google Scholar

Hisaw, FL. Endocrine adaptations of the mammalian estrous cycle and gestation. In: Gorbman, A, ed. Comparative Endocrinology. 1959; 533–552. New York.: John Wiley & Sons.Google Scholar

Wilson, SC, andSharp, PJ. The effects of progesterone on oviposition and ovulation in the domestic fowl (Gallus domesticus). Br Poult Sci. 1976, 17:163–173.Google Scholar

Thornton, JW. Evolution of vertebrate steroid receptors from an ancestral estrogen receptor by ligand exploitation and serial genome expansions. Proc Natl Acad Sci USA. 2001, 98:5671–5676.Google Scholar

Corner, GW. The Hormones in Human Reproduction. London: Princeton University Press.Google Scholar

Allen, WM. Recollections of my life with progesterone. Gynecol Invest. 1974, 5:142–182.Google Scholar

Corner, GW, Sr. The early history of progesterone. Gynecol Invest. 1974, 5:106–112.Google Scholar

Medvei, VC. A History of Clinical Endocrinology. New York: The Parthenon Publishing Group.Google Scholar

Frobenius, W. Ludwig Fraenkel: ‘Spiritus rector’ of the early progesterone research. Eur J Obstet Gynecol Reprod Biol. 1999, 83:115–119.Google Scholar

Allen, WM, and Wintersteiner, O. Crystalline progestin. Science. 1934, 80:190–191.Google Scholar

Butenandt, A, andWestphal, U. Zur Isolierung und Characterisierung des Corpus-luteum-Hormons. Ber Chem Ges. 1934, 67:1440–1442.Google Scholar

Hartmann, M, and Wettstein, A. Ein krystallisiertes Hormon aus Corpus luteum. Helv Chim Acta. 1934, 17:878–882.Google Scholar

Slotta, K, Ruschig, H, and Fels, E. Reindarstellung der Hormone aus dem Corpus luteum. Ber Chem Ges. 1934, 67:1270–1273.Google Scholar

Allen, WM, Butenandt, A, Corner, GW, et al. Nomenclature of corpus luteum hormone. Science. 1935, 82:153.Google Scholar

Davis, ME, and Wied, GL. 17-alpha-hydroxyprogesterone-caproate: A new substance with prolonged progestational activity: A comparison with chemically pure progesterone. J Clin Endocrinol Metabol. 1955, 15:923–930.Google Scholar

Venning, EH, and Browne, JSL. Isolation of a water-soluble pregnandiol complex from human pregnancy urine. Proc Soc Exper Biol and Med. 1936, 34:729.Google Scholar

Venning, EH. Gravimetric method for the determination of sodium pregnandiol glucuronidate (an excretion product of progesterone). J Biol Chem. 1937, 119:473.Google Scholar

Wilson, KM, and Rochester, NY. Pregnancy complicated by ovarian and paraovarian tumors. Am J Ob/Gyn. 1937, 34:977–986.Google Scholar

Csapo, AI, Pulkkinen, MO, Ruttner, B, et al. The significance of the human corpus luteum in pregnancy maintenance. I. Preliminary studies. Am J Obstet Gynecol. 1972, 112:1061–1067.Google Scholar

Csapo, A. The luteo-placental shift, the guardian of pre-natal life. Postgrad Med J. 1969, 45:57–64.Google Scholar

O’Malley, BW. In vitro hormonal induction of a specific protein (avidin) in chick oviduct. Biochemistry. 1967, 6:2546–2551.Google Scholar

O’Malley, BW, and Korenman, SG. Studies on the mechanism of hormone induction of a specific protein. Immunological identity and kinetic studies of avidin synthesized in vitro by the chick oviduct. Life Sci. 1967, 6:1953–1959.Google Scholar

Milgrom, E, Atger, M, and Baulieu, EE. Progesterone in uterus and plasma. IV. Progesterone receptor(s) in guinea pig uterus cytosol. Steroids. 1970, 16:741–754.Google Scholar

Smith, RG, Iramain, CA, Buttram, VC, Jr., et al. Purification of human uterine progesterone receptor. Nature. 1975, 253:271–272.Google Scholar

Heikinheimo, O, Kontula, K, Croxatto, H, et al. Plasma concentrations and receptor binding of RU 486 and its metabolites in humans. J Steroid Biochem. 1987, 26:279–284.Google Scholar

Gellersen, B, Brosens, IA, and Brosens, JJ. Decidualization of the human endometrium: mechanisms, functions, and clinical perspectives. Sem Reprod Med. 2007, 25:445–453.Google Scholar

Mao, G, Wang, J, Kang, Y, et al. Progesterone increases systemic and local uterine proportions of CD4+CD25+ Treg cells during midterm pregnancy in mice. Endocrinology. 2010, 151:5477–5488.Google Scholar

Renthal, NE, Chen, CC, Williams, KC, et al. miR-200 family and targets, ZEB1 and ZEB2, modulate uterine quiescence and contractility during pregnancy and labor. Proc Natl Acad Sci USA. 2010, 107:20828–20833.Google Scholar

Siiteri, PK, Febres, F, Clemens, LE, et al. Progesterone and maintenance of pregnancy: is progesterone nature’s immunosuppressant? Ann NY Acad Sci. 1977, 286:384–397.Google Scholar

Hardy, DB, Janowski, BA, Corey, DR, et al. Progesterone receptor plays a major antiinflammatory role in human myometrial cells by antagonism of nuclear factor-kappaB activation of cyclooxygenase 2 expression. Mol Endocrinol. 2006, 20:2724–2733.Google Scholar

Thomson, AJ, Telfer, JF, Young, A, et al. Leukocytes infiltrate the myometrium during human parturition: further evidence that labour is an inflammatory process. Hum Reproduct. 1999, 14:229–236.Google Scholar

Osman, I, Young, A, Jordan, F, et al. Leukocyte density and proinflammatory mediator expression in regional human fetal membranes and decidua before and during labor at term. J Soc Gynecol Invest. 2006, 13:97–103.Google Scholar

Mesiano, S, Chan, EC, Fitter, JT, et al. Progesterone withdrawal and estrogen activation in human parturition are coordinated by progesterone receptor A expression in the myometrium. J Clin Endocrinol Metabol. 2002, 87:2924–2930.Google Scholar

Tan, H, Yi, L, Rote, NS, et al. Progesterone receptor-A and -B have opposite effects on proinflammatory gene expression in human myometrial cells: Implications for progesterone actions in human pregnancy and parturition. J Clin Endocrinol Metabol. 2012, 97:E719–730.Google Scholar

Merlino, AA, Welsh, TN, Tan, H, et al. Nuclear progesterone receptors in the human pregnancy myometrium: evidence that parturition involves functional progesterone withdrawal mediated by increased expression of progesterone receptor-A. J Clin Endocrinol Metabol. 2007, 92:1927–1933.Google Scholar

Chai, SY, Smith, R, Fitter, JT, et al. Increased progesterone receptor A expression in labouring human myometrium is associated with decreased promoter occupancy by the histone demethylase JARID1A. Mol Hum Reprod. 2014, 20:442–453.Google Scholar

Amini, P, Michniuk, D, Kuo, K, et al. Human parturition involves phosphorylation of progesterone receptor-A at serine-345 in myometrial cells. Endocrinology. 2016, 157:4434–4445.Google Scholar

Condon, JC, Jeyasuria, P, Faust, JM, et al. A decline in the levels of progesterone receptor coactivators in the pregnant uterus at term may antagonize progesterone receptor function and contribute to the initiation of parturition. Proc Natl Acad Sci USA. 2003, 100:9518–9523.Google Scholar

Mahendroo, MS, Porter, A, Russell, DW, et al. The parturition defect in steroid 5alpha-reductase type 1 knockout mice is due to impaired cervical ripening. Mol Endocrinol. 1999, 13:981–992.Google Scholar

Nadeem, L, Shynlova, O, Matysiak-Zablocki, E, et al. Molecular evidence of functional progesterone withdrawal in human myometrium. Nat Commun. 2016, 7:11565.Google Scholar

Nadeem, L, Shynlova, O, Mesiano, S, et al. Progesterone via its type-A receptor promotes myometrial gap junction coupling. Sci Rep. 2017, 7:13357.Google Scholar

Bengtsson, LP. The Effect of Progesterone on the Maintenance of Early Pregnancy. Paper presented at: Brook Lodge Symposium: Progesterone 1961; Augusta, MI.Google Scholar

Pinto, RM, Montuori, E, Lerner, U, et al. Effect of progesterone on the oxytocic action of estradiol-17-beta. Am J Obstet Gynecol. 1965, 91:1084–1089.Google Scholar

Keirse, MJ. Progestogen administration in pregnancy may prevent preterm delivery. Br J Obstet Gynaecol. 1990, 97:149–154.Google Scholar

da Fonseca, EB, Bittar, RE, Carvalho, MH, et al. Prophylactic administration of progesterone by vaginal suppository to reduce the incidence of spontaneous preterm birth in women at increased risk: a randomized placebo-controlled double-blind study. Am J Obstet Gynecol. 2003, 188:419–424.Google Scholar

Meis, PJ, Klebanoff, M, Thom, E, et al. Prevention of recurrent preterm delivery by 17 alpha-hydroxyprogesterone caproate. N Engl J Med. 2003, 348:2379–2385.Google Scholar

Norman, JE, Marlow, N, Messow, CM, et al. Vaginal progesterone prophylaxis for preterm birth (the OPPTIMUM study): A multicentre, randomised, double-blind trial. Lancet. 2016, 387:2106–2116.Google Scholar

Blackwell, SC, Gyamfi-Bannerman, C, Biggio, JR, Jr., et al. 17-OHPC to prevent recurrent preterm birth in singleton gestations (PROLONG Study): A multicenter, international. Randomized Double-Blind Trial. Am J Perinatol. 2020, 37:127–136.Google Scholar

Weatherborn, M, and Mesiano, S. Rationale for current and future progestin-based therapies to prevent preterm birth. Best Prac Res Clin Obstet Gynaecol. 2018, 52:114–125.Google Scholar

Spaanderman, M, and Staelens, A (2018). Plasma volume changes in pregnancy. In: C. Lees & W. Gyselaers (Eds.), Mater Hemodyn. Cambridge: Cambridge University Press. https://doi.org/10.1017/9781316661925.Google Scholar

Scholten, RR, Oyen, WJ, Van der Vlugt, MJ, et al. Impaired fetal growth and low plasma volume in adult life. Obstet Gynecol. 2011, 118(6):1314–1322. https://doi.org/10.1097/AOG.0b013e3182383781. PMID: 22105261.Google Scholar

Sanghavi, M, and Rutherford, JD. Cardiovascular physiology of pregnancy. Circulation. 2014, 130(12):1003–1008. https://doi.org/10.1161/CIRCULATIONAHA.114.009029. PMID: 25223771.Google Scholar

Ouzounian, JG, and Elkayam, U. Physiologic changes during normal pregnancy and delivery. Cardiol Clin. 2012, 30(3):317–329. https://doi.org/10.1016/j.ccl.2012.05.004. Epub 2012. PMID: 22813360.Google Scholar

Chung, E, and Leinwand, LA. Pregnancy as a cardiac stress model. Cardiovasc Res. 2014, 101(4):561–570. https://doi.org/10.1093/cvr/cvu013. Epub 201. PMID: 24448313; PMCID: PMC3941597.Google Scholar

Peeters, L. Cardiovascular and volume regulatory functions in pregnancy: An overview. In C. Lees & W. Gyselaers (Eds.), Maternal Hemodynamics. 2018; 13–23. Cambridge: Cambridge University Press. https://doi.org/10.1017/9781316661925.002.Google Scholar

Tal, R, Taylor, HS, Burney, RO, et al. Endocrinology of Pregnancy. In Feingold, KR, Anawalt, B, Boyce, A, Chrousos, G, de Herder, WW, Dungan, K, Grossman, A, Hershman, JM, Hofland, J, Kaltsas, G, Koch, C, Kopp, P, Korbonits, M, McLachlan, R, Morley, JE, New, M, Purnell, J, Singer, F, Stratakis, CA, Trence, DL, Wilson, DP, (Eds). 2000. South Dartmouth, MA: MDText.com, Inc..Google Scholar

Kodogo, V, Azibani, F, and Sliwa, K. Role of pregnancy hormones and hormonal interaction on the maternal cardiovascular system: A literature review. Clin Res Cardiol. 2019, 108(8):831–846. https://doi.org/10.1007/s00392-019-01441-x. Epub 2019. PMID: 30806769.Google Scholar

Napso, T, Yong, HEJ, Lopez-Tello, J, et al. The role of placental hormones in mediating maternal adaptations to support pregnancy and lactation. Front Physiol. 2018, 9:1091. https://doi.org/10.3389/fphys.2018.01091. PMID: 30174608; PMCID: PMC6108594.Google Scholar

Das, A, Mantena, SR, Kannan, A, et al. De novo synthesis of estrogen in pregnant uterus is critical for stromal decidualization and angiogenesis. Proc Natl Acad Sci USA. 2009, 106(30):12542–12547. https://doi.org/10.1073/pnas.0901647106.Google Scholar

Takahashi, K, Ohmichi, M, Yoshida, M, et al. Both estrogen and raloxifene cause G1 arrest of vascular smooth muscle cells. J Endocrinol. 2003, 178(2):319–329. https://doi.org/10.1677/joe.0.1780319. PMID: 12904179.Google Scholar

Castardo-de-Paula, JC, de Campos, BH, Amorim, EDT, et al. Cardiovascular risk and the effect of nitric oxide synthase inhibition in female rats: The role of estrogen. Exp Gerontol. 2017, 97:38–48. https://doi.org/10.1016/j.exger.2017.07.016. Epub 2017. PMID: 28757113.Google Scholar

Favre, J, Gao, J, Henry, J-P, et al. Endothelial estrogen receptor {alpha} plays an essential role in the coronary and myocardial protective effects of estradiol in ischemia/reperfusion. Arterioscler Thromb Vasc Biol. 2010, 30:2562–2567.Google Scholar

Fortini, F, Dalla Sega, FV, Caliceti, C, et al. Estrogen receptor β-dependent Notch1 activation protects vascular endothelium against tumor necrosis factor α (TNFα)-induced apoptosis. J Biol Chem. 2017, 292:18178–18191.Google Scholar

Jobe, SO, Ramadoss, J, Koch, JM, et al. Estradiol-17beta and its cytochrome P450- and catechol-O-methyltransferase-derived metabolites stimulate proliferation in uterine artery endothelial cells: Role of estrogen receptor-alpha versus estrogen receptor-beta. Hypertension. 2010, 55(4):1005–1011. https://doi.org/10.1161/HYPERTENSIONAHA.109.146399. Epub 2010. PMID: 20212268; PMCID: PMC2876348.Google Scholar

Storment, JM, Meyer, M, and Osol, G. Estrogen augments the vasodilatory effects of vascular endothelial growth factor in the uterine circulation of the rat. Am J Obstet Gynecol. 2000, 183(2):449–453. https://doi.org/10.1067/mob.2000.105910. PMID: 10942485.Google Scholar

van Eickels, M, Grohé, C, Cleutjens, JP, et al. 17beta-estradiol attenuates the development of pressure-overload hypertrophy. Circulation. 2001, 104(12):1419–1423. https://doi.org/10.1161/hc3601.095577. PMID: 11560859.Google Scholar

Bueno, OF, De Windt, LJ, Lim, HW, et al. The dual-specificity phosphatase MKP-1 limits the cardiac hypertrophic response in vitro and in vivo. Circ Res. 2001, 88(1):88–96. https://doi.org/10.1161/01.res.88.1.88. PMID: 11139479.Google Scholar

Fliegner, D, Schubert, C, Penkalla, A, et al. Female sex and estrogen receptor-beta attenuate cardiac remodeling and apoptosis in pressure overload. Am J Physiol Regul Integr Comp Physiol. 2010, 298(6):R1597–606. https://doi.org/10.1152/ajpregu.00825. 2009. Epub 2010.Google Scholar

Liou, C-M, Yang, A-L, Kuo, C-H, et al. E ects of 17 Beta- estradiol on cardiac apoptosis in overiectomized rats. Cell Biochem Funct. 2010, 28:521–528. https://doi.org/10.1016/j.numecd.2011.11.002.Google Scholar

Zhu, Y, Bian, Z, Lu, P, et al. Abnormal vascular function and hypertension in mice deficient in estrogen receptor beta. Science. 2002, 295(5554):505–508. https://doi.org/10.1126/science.1065250. PMID: 11799247.Google Scholar

Eghbali, M, Deva, R, Alioua, A, et al. Molecular and functional signature of heart hypertrophy during pregnancy. Circ Res. 2005, 96(11):1208–1216. https://doi.org/10.1161/01.RES.0000170652.71414.16. Epub 2005. PMID: 15905459.Google Scholar

Karpanou, EA, Vyssoulis, GP, Georgoudi, DG, et al. Ambulatory blood pressure changes in the menstrual cycle of hypertensive women. Significance of plasma renin activity values. Am J Hypertens. 1993, 6(8):654–659. https://doi.org/10.1093/ajh/6.8.654. PMID: 8217027.Google Scholar

Simoncini, T, Fu, XD, Caruso, A, et al. Drospirenone increases endothelial nitric oxide synthesis via a combined action on progesterone and mineralocorticoid receptors. Hum Reprod. 2007, 22(8):2325–2334. https://doi.org/10.1093/humrep/dem109. Epub 2007. PMID: 17545686.Google Scholar

Simoncini, T, Mannella, P, Fornari, L, et al. Differential signal transduction of progesterone and medroxyprogesterone acetate in human endothelial cells. Endocrinology. 2004, 145(12):5745–5756. https://doi.org/10.1210/en.2004-0510. Epub 2004. PMID: 15358673.Google Scholar

Zhang, L, Fishman, MC, and Huang, PL. Estrogen mediates the protective effects of pregnancy and chorionic gonadotropin in a mouse model of vascular injury. Arterioscler Thromb Vasc Biol. 1999, 19(9):2059–2065. https://doi.org/10.1161/01.atv.19.9.2059. PMID: 10479646.Google Scholar

Thomas, P, and Pang, Y. Protective actions of progesterone in the cardiovascular system: potential role of membrane progesterone receptors (mPRs) in mediating rapid effects. Steroids. 2013, 78(6):583–588. https://doi.org/10.1016/j.steroids.2013.01.003. Epub 2013. PMID: 23357432.Google Scholar

Liu, LX, Rowe, GC, Yang, S, et al. PDK4 Inhibits Cardiac Pyruvate Oxidation in Late Pregnancy. Circ Res. 2017, 121(12):1370–1378. https://doi.org/10.1161/CIRCRESAHA.117.311456. Epub 2017. PMID: 28928113; PMCID: PMC5722682.Google Scholar

Chung, E, Yeung, F, and Leinwand, LA. Calcineurin activity is required for cardiac remodelling in pregnancy. Cardiovasc Res. 2013, 100(3):402–410. https://doi.org/10.1093/cvr/cvt208. Epub 2013. PMID: 23985902; PMCID: PMC3826703.Google Scholar

Morrissy, S, Xu, B, Aguilar, D, et al. Inhibition of apoptosis by progesterone in cardiomyocytes. Aging Cell. 2010, 9(5):799–809. https://doi.org/10.1111/j.1474-9726.2010.00619.x. PMID: 20726854; PMCID: PMC4133411.Google Scholar

Hsieh, DJ, Huang, CY, Pai, P, et al. Prolactin protects cardiomyocytes against intermittent hypoxia-induced cell damage by the modulation of signaling pathways related to cardiac hypertrophy and proliferation. Int J Cardiol. 2015, 181:255–266. https://doi.org/10.1016/j.ijcard.2014.11.154. Epub 2014. PMID: 25531577.Google Scholar

Gonzalez, C, Rosas-Hernandez, H, Jurado-Manzano, B, et al. The prolactin family hormones regulate vascular tone through NO and prostacyclin production in isolated rat aortic rings. Acta Pharmacol Sin. 2015, 36(5):572–586. https://doi.org/10.1038/aps.2014.159. Epub 2015. PMID: 25891087; PMCID: PMC4422941.Google Scholar

Zamani, P, and Greenberg, BH. Novel vasodilators in heart failure. Curr Heart Fail Rep. 2013, 10(1):1–11. https://doi.org/10.1007/s11897-012-0126-4. PMID: 23299783.Google Scholar

Kristiansson, P, and Wang, JX. Reproductive hormones and blood pressure during pregnancy. Hum Reprod. 2001, 16(1):13–17. https://doi.org/10.1093/humrep/16.1.13. PMID: 11139529.Google Scholar

Smith, MC, Danielson, LA, Conrad, KP, et al. Influence of recombinant human relaxin on renal hemodynamics in healthy volunteers. J Am Soc Nephrol. 2006, 17(11):3192–3197. https://doi.org/10.1681/ASN.2005090950. Epub 2006. PMID: 17035617.Google Scholar

Leo, CH, Ng, HH, Marshall, SA, et al. Relaxin reduces endothelium-derived vasoconstriction in hypertension: Revealing new therapeutic insights. Br J Pharmacol. 2020, 177(1):217–233. https://doi.org/10.1111/bph.14858. Epub 2019. PMID: 31479151; PMCID: PMC6976785.Google Scholar

Soma-Pillay, P, Nelson-Piercy, C, Tolppanen, H, et al. Physiological changes in pregnancy. Cardiovasc J Afr. 2016, 27(2):89–94. https://doi.org/10.5830/CVJA-2016-021. PMID: 27213856; PMCID: PMC4928162.Google Scholar

Gennari-Moser, C, Khankin, EV, Schüller, S, et al. Regulation of placental growth by aldosterone and cortisol. Endocrinology. 2011, 152(1):263–271. https://doi.org/10.1210/en.2010-0525. Epub 2010. PMID: 21068161.Google Scholar