This chapter will address contrasting ways in which Argentine literature has reflected on, and borrowed from, scientific theories and practices. Many nineteenth-century writers (such as José Mármol, Eugenio Cambaceres, and Lucio V. Mansilla) drew on (pseudo-)scientific discourses to lend legitimacy to their arguments, while others developed a critical approach to the legacies of positivism in Argentina. Dystopian visions of the imbrication of science, technology, and the politics of authoritarianism dominate the twentieth century, in texts that explore the experience of mass society or dictatorship. However, this chapter will also highlight cases of much greater ambivalence, such as that of Roberto Arlt, in whose work the pursuit of science and technology becomes both an instrument of violence and a fount of beauty and liberation. Furthermore, it will construct an important genealogy of authors – from Eduardo Holmberg in the final decades of the nineteenth century through to the contemporary writer Marcelo Cohen – who have conducted innovative metafictional explorations into the relationship between literature and science, and who have understood the porous boundary between them to be a source of great creativity.