Abnormalities of gait are commonly seen in the emergency department (ED) and often reflect some disorder of the nervous system. Station and gait is unique to each individual and reflects gender, age, body habitus, mood, and even culture. The goal of evaluation is to determine what part(s) of the nervous system are involved by the type of gait observed. The evaluation is individualized depending on the patient’s ability to ambulate safely. Patients may be observed standing with eyes open, eyes closed, and ambulating. They may be asked to walk on their toes, heels, or tandem walk, or hop on one foot at a time. The use of assistive devices may be indicated. Different types of gait disturbance are described with regard to neuroanatomical localization and specific neurological disorders.