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Chapter K

from Drugs: An A–Z Guide

Henry G. W. Paw  and
Rob Shulman
Henry G. W. Paw
Affiliation:
York Hospital, York
Rob Shulman
Affiliation:
University College London Hospitals, London
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Summary

Ketamine is a non-competitive antagonist of N-methyl-D-aspartate (NMDA) receptors and also binds to mu and kappa opioid receptors. It is licensed as an anaesthetic agent for diagnostic and surgical procedures and is best suited to shorter procedures. It has a role in the ICU as a co-analgesic, with opioid-sparing properties. It has good analgesic properties in subanaesthetic doses. Use of midazolam or another benzodiazepine as an adjunct to ketamine reduces the incidence of emergence reactions.

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Handbook of Drugs in Intensive Care
An A-Z Guide
 , pp. 171 - 173
Publisher: Cambridge University Press
Print publication year: 2025

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  • Chapter K
  • Henry G. W. Paw, York Hospital, York, Rob Shulman, University College London Hospitals, London
  • Book: Handbook of Drugs in Intensive Care
  • Online publication: 15 January 2025
  • Chapter DOI: https://doi.org/10.1017/9781009429702.013
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  • Chapter K
  • Henry G. W. Paw, York Hospital, York, Rob Shulman, University College London Hospitals, London
  • Book: Handbook of Drugs in Intensive Care
  • Online publication: 15 January 2025
  • Chapter DOI: https://doi.org/10.1017/9781009429702.013
Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

  • Chapter K
  • Henry G. W. Paw, York Hospital, York, Rob Shulman, University College London Hospitals, London
  • Book: Handbook of Drugs in Intensive Care
  • Online publication: 15 January 2025
  • Chapter DOI: https://doi.org/10.1017/9781009429702.013
Available formats
×