In this final chapter, a wide-angle perspective is provided on the major issues that arise when one thinks globally about literacy. Despite many important differences across the globe, literacy development suggests some general patterns that reflect nearly universal phases and shared operating principles. Although the “development” of literacy begins early through natural processes of language development and conceptual development, it is school experiences, explicitly designed to teach reading, that we expect to ensure the achievement of literacy. Each classroom within a school is its own literacy ecosystem, with one or more teachers, students, literacy curriculum materials, assesments, and regulated interactions. The classroom itself is embedded within other systems – the school, the community, the larger school administrative units, and local, regional, and national government control agents. A Global Literacy Framework is presented, showing that literacy development is embedded in language development and can be predicted by (a) system factors, referring to variations in the linguistic and writing systems, (b) child factors, associated with the neurobiological foundation of children’s learning capacity, and (c) support factors, associated with processes in the home and at school. All these influences exist within a sociopolitical context that exerts influence broadly across the system.