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13 - Neurogenetic Disorders in Africa: Hereditary Spastic Paraplegia

A Case Study

Published online by Cambridge University Press:  02 December 2019

By
Liena E. O. Elsayed ,
Ammar E. M. Ahmed  and
Giovanni Stevanin
Edited by
Muntaser E. Ibrahim  and
Charles N. Rotimi
Muntaser E. Ibrahim
Affiliation:
University of Khartoum
Charles N. Rotimi
Affiliation:
National Human Genome Research Institute/NIH
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Summary

Many regions of Africa, the continent where the sun is always shining, are gradually becoming overwhelmed by genetic disorders, especially where consanguineous marriages are strongly favored over many generations. In this chapter we navigate through the genetic and phenotypic features observed in some African populations, using hereditary spastic paraplegia (HSP) as a model of neurogenetic disorders. Published data and unpublished studies on HSP are starting to disclose criteria that distinguish these populations due to an interesting mixture of environmental factors, traditions, and certain characteristics of African genomes.

Type
Chapter
Information
The Genetics of African Populations in Health and Disease , pp. 311 - 319
Publisher: Cambridge University Press
Print publication year: 2019

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