Skip to main content Accessibility help
×
Hostname: page-component-78c5997874-s2hrs Total loading time: 0 Render date: 2024-11-05T06:41:43.117Z Has data issue: false hasContentIssue false

Chapter 28 - Linkage and candidate gene studies of obstructive sleep apnea

from Section 6 - Sleep-related breathing disorders

Published online by Cambridge University Press:  05 November 2013

Paul Shaw
Affiliation:
University of Washington, St Louis
Mehdi Tafti
Affiliation:
University of Lausanne
Michael J. Thorpy
Affiliation:
Sleep-Wake Disorders Center, Albert Einstein College of Medicine, New York
Get access

Summary

This chapter describes the different approaches that might be taken to elucidate the genes conferring risk for obstructive sleep apnea (OSA) and for its downstream consequences. Linkage studies are useful for investigating patterns of genetic marker and phenotype co-transmission in affected families. Overall, linkage analysis has not proven, to date, to be a successful approach for discovery of sequence variants that contribute to risk of OSA or severity of the condition. Many association studies of OSA-associated traits, such as obesity, have been undertaken and several association studies of OSA have been performed. OSA is most likely very polygenetic with many gene-gene interactions given what we know already about many different risk factors. Current approaches have been largely limited to linkage studies and candidate gene association studies. Genome-wide association studies (GWAS) will likely and only lead to identifying a limited part of the heritability of OSA.
Type
Chapter
Information
Publisher: Cambridge University Press
Print publication year: 2013

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Save book to Kindle

To save this book to your Kindle, first ensure [email protected] is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Available formats
×

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

Available formats
×