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13 - Role of α(1-3)-glucan in Aspergillus fumigatus and other human fungal pathogens

from IV - Pathogenic interactions in the environment

Published online by Cambridge University Press:  03 November 2009

By
Anne Beauvais ,
David S. Perlin  and
Jean Paul Latgé
Edited by
Geoffrey Gadd ,
Sarah C. Watkinson  and
Paul S. Dyer
Anne Beauvais
Affiliation:
Aspergillus Unit, Institut Pasteur, Paris
David S. Perlin
Affiliation:
Public Health Research Institute, Newark, New Jersey
Jean Paul Latgé
Affiliation:
Aspergillus Unit, Institut Pasteur, Paris
Geoffrey Gadd
Affiliation:
University of Dundee
Sarah C. Watkinson
Affiliation:
University of Oxford
Paul S. Dyer
Affiliation:
University of Nottingham
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Summary

Introduction

The fungal cell wall has been considered for a long time as an inert organelle but recent studies, mainly based on the analysis of the yeast cell wall, suggest that it is indeed a dynamic structure where constitutive polymers are continuously chemically modified and rearranged during morphogenesis. The cell wall plays an essential role in sensing adverse or favourable environments. In particular, it provides the fungus with adaptative responses to variable osmotic pressures and other stress factors including host defence reactions. The cell wall is continuously in contact with the host and acts also as a sieve and a reservoir for molecules such as enzymes, antigens, and elicitors or toxins that play an active role during infection (Mouyna & Latgé, 2001).

The major component of the cell wall is polysaccharide. It accounts for over 90% of the cell wall mass and and consists of three basic components: glucans, mannan and chitin (Fig. 13.1). The fibrillar skeleton of the cell wall is considered to be the alkali-insoluble fraction, whereas the material in which the fibrils are embedded is alkali-soluble (Fontaine et al., 2000). The central core of the cell wall is branched β1,3, β1,6 glucans that are linked to chitin via a β(1–4) linkage (Fontaine et al., 2000). This core is present in most fungi, and at least in all ascomycetes and basidiomycetes. The alkali-soluble amorphous cement varies with the fungal species; its composition has been analysed in few fungal species.

Type
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Fungi in the Environment , pp. 269 - 288
Publisher: Cambridge University Press
Print publication year: 2007

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References

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