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Chapter 21 - Pharmacological Agents in Anaesthetic Practice

Published online by Cambridge University Press:  18 August 2022

By
Kathryn Newton ,
Peter Turton  and
Brian Corrin
Edited by
Daniel Rodger ,
Kevin Henshaw ,
Paul Rawling  and
Scott Miller
Daniel Rodger
Affiliation:
Senior Lecturer in Perioperative Practice, London South Bank University
Kevin Henshaw
Affiliation:
Associate Head of Allied Health Professions, Edge Hill University, Ormskirk
Paul Rawling
Affiliation:
Senior Lecturer in Perioperative Practice, Edge Hill University, Ormskirk
Scott Miller
Affiliation:
Consultant Anaesthetist, St Helens and Knowsley Hospitals NHS Trust
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Summary

The conduct of a general anaesthetic is more than just the administration of a drug to induce anaesthesia – a wide variety of agents are available, and they can be used pre-, intra-, and postoperatively. They will also be used for different purposes in different situations. This chapter discusses many of the common drugs used during a general anaesthetic, with a brief description of the effects, mechanism of action, and different routes of administration.

Keywords

AnaesthesiaLocal anaestheticIntravenousInhalationalVolatileMuscle relaxantAnalgesiaVasopressors,
Type
Chapter
Information
Fundamentals of Operating Department Practice , pp. 224 - 241
Publisher: Cambridge University Press
Print publication year: 2022

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References

Roberts, F. and Freshwater-Turner, D.. Pharmacokinetics and anaesthesia. Continuing Education in Anaesthesia Critical Care and Pain 2007; 7: 25–29.Google Scholar
Hocking, G. and Wildsmith, J. A. W.. Intrathecal drug spread. British Journal of Anaesthesia 2004; 93: 568–578.Google Scholar
Eger, E. I.. Characteristics of anaesthetic agents used for induction and maintenance of general anaesthesia. American Journal of Health System Pharmacy 2004; 61: S3–S10.Google Scholar
Khan, K. S., Hayes, I., and Buggy, D. J.. Pharmacology of anaesthetic agents I: intravenous anaesthetic agents. Continuing Education in Anaesthesia Critical Care and Pain 2014; 14: 100–105.Google Scholar
Al-Rifai, Z. and Mulvey, D.. Principles of total intravenous anaesthesia: practical aspects of using total intra-venous anaesthesia. BJA Education 2016; 16: 276–280.Google Scholar
Jacobi, J., Fraser, G. L., Coursin, D. B., et al. Clinical practice guidelines for the sustained use of sedatives and analgesics in the critically ill adult. Critical Care Medicine 2002; 30: 119–141.CrossRefGoogle ScholarPubMed
Hamer-Hodges, R. J., Bennett, J. R., Tunstall, M. E., and Knight, R. F.. General anaesthesia for operative obstetrics with special reference to the use of thiopentone and suxamethonium. British Journal of Anaesthesia 1959; 31: 152–163.CrossRefGoogle Scholar
Kurdi, M. S., Theerth, K. A., and Deva, R. S.. Ketamine: current applications in anaesthesia, pain and critical care. Anaesthesia Essays and Researches 2014; 8: 283–290.CrossRefGoogle ScholarPubMed
Hemmings, H. C.. The pharmacology of intravenous anaesthetic agents: a primer. Anaesthesiology News 2010; October: 9–16.Google Scholar
Khan, K. S., Hayes, I., and Buggy, D. J.. Pharmacology of anaesthetic agents II: inhalation anaesthetic agents. Continuing Education in Anaesthesia Critical Care and Pain 2014; 14: 106–111.CrossRefGoogle Scholar
El-Wahab, N. and Robinson, N.. Analgesia and anaesthesia in labour. Obstetrics Gynaecology and Reproductive Medicine 2011; 21: 137–141.CrossRefGoogle Scholar
Calderon, J. C., Bolanos, P., and Caputo, C.. The excitation–contraction coupling mechanism in skeletal muscle. Biophysical Reviews 2014; 6: 133–160.CrossRefGoogle ScholarPubMed
Appiah-Ankam, J. and Hunter, J. M.. Pharmacology of neuromuscular blocking drugs. Continuing Education in Anaesthesia Critical Care and Pain 2004; 4: 2–7.Google Scholar
Tripathi, S. S. and Hunter, J. M.. Neuromuscular blocking drugs in the critically ill. BJA Education 2006; 6: 119–123.Google Scholar
Gupta, P. K. and Hopkins, P. M.. Diagnosis and management of malignant hyperpyexia. BJA Education 2017; 17: 249–254.Google Scholar
Hunter, J. M.. Reversal of neuromuscular block. BJA Education 2020; 20: 259–265.Google Scholar
McGrath, C. D. and Hunter, J. M.. Monitoring of neuromuscular block. Continuing Education in Anaesthesia Critical Care and Pain 2006; 6: 7–12.Google Scholar
Butterworth, J. F. and Strichartz, G. R.. Clinical use of local anaesthetics in anaesthesia. Anaesthesiology 1990; 72: 711.Google Scholar
Becker, D. E. and Read, K. L.. Essentials of local anaesthetic pharmacology. Anaesthesia Progress 2006; 53: 98–109.Google Scholar
Becker, D. E. and Read, K. L.. Local anaesthetics: review of pharmacological considerations. Anaesthesia Progress 2012; 59: 90–102.Google Scholar
Christie, L. E., Picard, J., and Weinberg, G. L.. Local anaesthetic systemic toxicity. BJA Education 2015; 15: 136–142.CrossRefGoogle Scholar
Bangash, M. N., Kong, M., and Pearse, R. M.. Use of inotropes and vasopressor agents in critically ill patients. British Journal of Pharmacology 2012; 165: 2015–2033.Google Scholar
Stratton, L., Berlin, D. A. and Arbo, J. E.. Vasopressors and inotropes in sepsis. Emergency Medicine Clinics of North America 2017; 35: 75–91.Google Scholar
Nair, V. P. and Hunter, J. M.. Anticholinesterases and anticholinergic drugs. Continuing Education in Anaesthesia Critical Care and Pain 2004; 4: 164–168.CrossRefGoogle Scholar
Scott, D. B.. The use of labetalol in anaesthesia. British Journal of Clinical Pharmacology 1982; 13: S133–S135.CrossRefGoogle ScholarPubMed
Chatterjee, S., Rudra, A., and Sengupta, S.. Current concepts in the management of postoperative nausea and vomiting. Anaesthesiology Research and Practice 2011; 2011: 748031.Google Scholar
Cao, X., White, P. F., and Ma, H.. An update on the management of postoperative nausea and vomiting. Journal of Anaesthesia 2017; 31: 617–626.CrossRefGoogle ScholarPubMed
Pierre, S. and Whelan, R.. Nausea and vomiting after surgery. Continuing Education in Anaesthesia Critical Care and Pain 2013; 13: 28–32.Google Scholar
Sharma, C. V. and Mehta, V.. Paracetamol: mechanisms and updates. Continuing Education in Anaesthesia Critical Care and Pain 2014; 14: 153–158.CrossRefGoogle Scholar
Doleman, B., Loenardi-Bee, J., Heinink, T. P., Lund, J., and Williams, J. P.. Pre-emptive and preventive NSAIDs for postoperative pain in adults undergoing all types of surgery. Cochrane Database of Systematic Reviews 2018; 3: CD012978.Google Scholar
Kumar, K., Kirksey, M., Duong, S., and Wu, C.. A review of opioid-sparing modalities in perioperative pain management: methods to decrease opioid use postoperatively. Anaesthesia and Analgesia 2017; 125: 1749–1760.Google Scholar
Hug, C. C. Jr. Opioids: clinical use as anaesthetic agents. Journal of Pain Symptom Management 1992; 7: 350–355.Google Scholar
Lavand’homme, P. and Steyaert, A.. Opioid-free anaesthesia opioid side effects: tolerance and hyperalgesia. Best Practice and Research Clinical Anaesthesiology. 2017; 31: 487–498.CrossRefGoogle ScholarPubMed
Nimmo, A. F., Absalom, A. R., Bagshaw, O., et al. Guidelines for the safe practice of total intravenous anaesthesia (TIVA). Anaesthesia 2019; 72: 211–224.Google Scholar
Cook, T. and Harper, N.. Anaesthesia, surgery and life-threatening allergic reactions: report and findings of the Royal College of Anaesthetists’ 6th National Audit Project: perioperative anaphylaxis. Available from: www.nationalauditprojects.org.uk/downloads/NAP6%20Report%202018.pdf.Google Scholar

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