Book contents
- Fundamentals of Nanomedicine
- Fundamentals of Nanomedicine
- Copyright page
- Dedication
- Contents
- Preface
- Acknowledgments
- 1 The Need for New Perspectives in Medicine
- 2 Nanomedicine: Single-Cell Medicine
- 3 Targeted Drug Delivery
- 4 Drug Delivery Cell Entry Mechanisms
- 5 Nanomaterial Cores for Noninvasive Imaging
- 6 Attaching Biomolecules to Nanoparticles
- 7 Characterizing Nanoparticles
- 8 Nanomedicine Drug Dosing
- 9 Nanodelivery of Therapeutic Genes
- 10 Assessing Nanomedical Therapies at the Single-Cell Level
- 11 Nanotoxicity at the Single-Cell Level
- 12 Designing Nanodelivery Systems for In Vivo Use
- 13 Designing and Testing Nanomedical Devices
- 14 Quality Assurance and Regulatory Issues of Nanomedicine for the Pharmaceutical Industry
- References
- Index
10 - Assessing Nanomedical Therapies at the Single-Cell Level
Published online by Cambridge University Press: 08 March 2022
Book contents
- Fundamentals of Nanomedicine
- Fundamentals of Nanomedicine
- Copyright page
- Dedication
- Contents
- Preface
- Acknowledgments
- 1 The Need for New Perspectives in Medicine
- 2 Nanomedicine: Single-Cell Medicine
- 3 Targeted Drug Delivery
- 4 Drug Delivery Cell Entry Mechanisms
- 5 Nanomaterial Cores for Noninvasive Imaging
- 6 Attaching Biomolecules to Nanoparticles
- 7 Characterizing Nanoparticles
- 8 Nanomedicine Drug Dosing
- 9 Nanodelivery of Therapeutic Genes
- 10 Assessing Nanomedical Therapies at the Single-Cell Level
- 11 Nanotoxicity at the Single-Cell Level
- 12 Designing Nanodelivery Systems for In Vivo Use
- 13 Designing and Testing Nanomedical Devices
- 14 Quality Assurance and Regulatory Issues of Nanomedicine for the Pharmaceutical Industry
- References
- Index
Summary
It is necessary to make quantitative single-cell measurements of efficacy. Efficacy is broadly defined as anything that is helpful or is providing some kind of a positive therapeutic effect, either directly or indirectly, that can be done on a single-cell level. While traditional medical measures of efficacy remain relevant and useful, it is important for a nanomedical approach to remain focused mostly on what is happening at the single-cell level. These measurements may be structural or functional, but they allow us to determine the efficacy of nanomedical treatments at the single-cell level.
Keywords
disease at the single-cell levelassessing therapy at single-cell leveldoes structure reveal functionwhy single-cell measurementspower of multiple correlated measurements per cellcell-sorting purification of cellscell surface biomarkersphospho-specific antibodies to determine active genesgene array technologies, gene expression profiles (GEP)gene silencing
- Type
- Chapter
- Information
- Fundamentals of Nanomedicine , pp. 186 - 202Publisher: Cambridge University PressPrint publication year: 2022