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33 - Oral Inflammation and Periodontitis

from PART VI - ANIMAL MODELS OF INFLAMMATION

Published online by Cambridge University Press:  05 April 2014

Alpdogan Kantarci
Affiliation:
Boston University
Hatice Hasturk
Affiliation:
Boston University
Thomas E. Van Dyke
Affiliation:
Boston University
Charles N. Serhan
Affiliation:
Harvard Medical School
Peter A. Ward
Affiliation:
University of Michigan, Ann Arbor
Derek W. Gilroy
Affiliation:
University College London
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Summary

INTRODUCTION

The oral cavity is a complex organ system composed of salivary glands, tongue, tonsils, and teeth. The tissues of the oral cavity are either mineralized-hard (e.g., enamel, dentin, cementum, and bone) or soft tissues (e.g., mucosa, periodontal ligament, and gingiva), which altogether maintain a complex system of function and esthetics. The oral cavity is the entrance to and a major component of the gastrointestinal tract as the first site in the body to break down the food due to its masticatory function; it is also the gateway for respiration. Oral systems are crucial for proper phonation; the alignment of the teeth affects how words are pronounced. Facial esthetics is also directly associated with the shapes of the teeth and soft tissues surrounding them. With this unique blend of components and functions, the health and the disease of the oral cavity, therefore, present an important area of research as well as a challenge to the maintenance of general health. As in many diseases common to humankind, oral pathologies are associated with alterations in tissue homeostasis. Oral pathological conditions and diseases have been recognized as important health problems since the dawn of the early civilizations. For example, golden toothpicks found in Mesopotamia have indicated that Sumerians were practicing oral hygiene as early as 3000 B.C. Various herbal medications were used by Babylonians and Assyrians to “treat” periodontal problems. Egyptians, Chinese, and Indians all have written documentation of treating dental and periodontal inflammation, ulcerations, and abscesses.

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Publisher: Cambridge University Press
Print publication year: 2010

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References

1. Shklar, G., and Carranza, F.A. 2006. The historical background of periodontology. In Carranzas Clinical Periodontology, Newman, M., Takei, H.H., Klokkevold, P., and Carranza, F.A. (eds.), pp. 1–10. St. Louis, MO: Elsevier.Google Scholar
2. Paster, B.J., Olsen, I., Aas, J., and Dewhirst, F.E. 2006. The breadth of bacterial diversity in the human periodontal pocket and other oral sites. Periodontol 2000 42:80–87.CrossRefGoogle ScholarPubMed
3. Pihlstrom, B.L., Michalowicz, B.S., and Johnson, N.W. 2005. Periodontal diseases. Lancet 366(9499):1809–1820.CrossRefGoogle ScholarPubMed
4. Socransky, S.S., and Haffajee, A.D. 2005. Periodontal microbial ecology. Periodontol 2000 38:135–187.CrossRefGoogle ScholarPubMed
5. Li, J., Helmerhorst, E.J., Troxler, R.F., and Oppenheim, F.G. 2004. Identification of in vivo pellicle constituents by analysis of serum immune responses. J Dent Res 83(1):60–64.CrossRefGoogle ScholarPubMed
6. Haffajee, A.D., and Socransky, S.S. 2005. Microbiology of periodontal diseases: introduction. Periodontol 2000 38:9–12.CrossRefGoogle ScholarPubMed
7. Danser, M.M., Timmerman, M.F., van Winkelhoff, A.J., and van der Velden., U. 1996. The effect of periodontal treatment on periodontal bacteria on the oral mucous membranes. J Periodontol 67(5):478–485.CrossRefGoogle ScholarPubMed
8. Mager, D.L., Ximenez-Fyvie, L. A., Haffajee, A.D., and Socransky, S.S. 2003. Distribution of selected bacterial species on intraoral surfaces. J Clin Periodontol 30(7):644–654.CrossRefGoogle ScholarPubMed
9. Sachdeo, A., Haffajee, A.D., and Socransky, S.S. 2008. Biofilms in the edentulous oral cavity. J Prosthodont 17(5):348–356.CrossRefGoogle ScholarPubMed
10. Ronstrom, A., Edwardsson, S., and Attstrom, R. 1977. Streptococcus sanguis and streptococcus salivarius in early plaque formation on plastic films. J Periodontal Res 12(5):331–339.CrossRefGoogle ScholarPubMed
11. Costerton, J.W., Stewart, P.S., and Greenberg, E.P. 1999. Bacterial biofilms: a common cause of persistent infections. Science 284(5418):1318–1322.CrossRefGoogle ScholarPubMed
12. Hajishengallis, G., Sojar, H., Genco, R.J., and Denardin, E. 2004. Intracellular signaling and cytokine induction upon interactions of Porphyromonas gingivalis fimbriae with pattern-recognition receptors. Immunol Invest 33(2):157–172.CrossRefGoogle ScholarPubMed
13. Yumoto, H., Chou, H.-H., Takahashi, Y., Davey, M., Gibson, F.C. III and Genco, C.A. 2005. Sensitization of human aortic endothelial cells to lipopolysaccharide via regulation of Toll-like receptor 4 by bacterial fimbria-dependent invasion. Infect Immun 73(12):8050–8059.CrossRefGoogle ScholarPubMed
14. Buhlin, K., Gustafsson, A., Pockley, A.G., Frostegård, J., and Klinge, B. 2003. Risk factors for cardiovascular disease in patients with periodontitis. Eur Heart J 24(23):2099–2107.CrossRefGoogle ScholarPubMed
15. Franek, E., Blaschyk, R., Kolonko, A., et al. 2006. Chronic periodontitis in hemodialysis patients with chronic kidney disease is associated with elevated serum C-reactive protein concentration and greater intima-media thickness of the carotid artery. J Nephrol 19(3):346–351.Google ScholarPubMed
16. Iwamoto, Y., et al., 2003. Antimicrobial periodontal treatment decreases serum C-reactive protein, tumor necrosis factor-alpha, but not adiponectin levels in patients with chronic periodontitis. J Periodontol 74(8):1231–1236.CrossRefGoogle Scholar
17. Kantarci, A., Oyaizu, K., and Van Dyke, T. E. 2003. Neutrophil-mediated tissue injury in periodontal disease pathogenesis: findings from localized aggressive periodontitis. J Periodontol 74(1):66–75.CrossRefGoogle ScholarPubMed
18. Löe, H., Anerud, A., Boysen, H., and Morrison, E. 1986. Natural history of periodontal disease in man. Rapid, moderate and no loss of attachment in Sri Lankan laborers 14 to 46 years of age. J Clin Periodontol 13(5):431–445.CrossRefGoogle ScholarPubMed
19. Benjamin, S.D., and Baer, P.N. 1967. Familial patterns of advanced alveolar bone loss in adolescence (periodontosis). Periodontics 5(2):82–88.Google Scholar
20. Boughman, J.A., Halloran, S.L., Roulston, D., et al., 1986. An autosomal-dominant form of juvenile perio-dontitis: its localization to chromosome 4 and linkage to dentinogenesis imperfecta and Gc. J Craniofac Genet Dev Biol 6(4):341–350.Google Scholar
21. Li, Y., Xu, L., Hasturk, H., Kantarci, A., DePalma, S.R., and Van Dyke, T.E. 2004. Localized aggressive periodontitis is linked to human chromosome 1q25. Hum Genet 114(3):291–297.CrossRefGoogle ScholarPubMed
22. Hart, T.C., Harta, P.S., Bowden, D.W., et al. 1999. Mutations of the cathepsin C gene are responsible for Papillon-Lefevre syndrome. J Med Genet 36(12):881–887.Google ScholarPubMed
23. Wilson, A.G. 2008. Epigenetic regulation of gene expression in the inflammatory response and relevance to common diseases. J Periodontol 79(8 Suppl):1514–1519.CrossRefGoogle ScholarPubMed
24. Mariotti, A. 1999. Dental plaque-induced gingival diseases. Ann Periodontol 4(1):7–19.CrossRefGoogle ScholarPubMed
25. Page, R.C., and Schroeder, H.E. 1976. Pathogenesis of inflammatory periodontal disease. A summary of current work. Lab Invest 34(3):235–249.Google ScholarPubMed
26. Loesche, W.J., and Syed, S.A. 1978. Bacteriology of human experimental gingivitis: effect of plaque and gingivitis score. Infect Immun 21(3):830–839.Google ScholarPubMed
27. Cohen, J. 2002. Therapies. Confronting the limits of success. Science 296(5577):2320–2324.Google Scholar
28. Kantarci, A., Hasturk, H., and Van Dyke, T.E. 2006. Host-mediated resolution of inflammation in periodontal diseases. Periodontol 2000 40:144–163.CrossRefGoogle ScholarPubMed
29. Serhan, C.N., Chiang, N., and Van Dyke, T.E. 2008. Resolving inflammation: dual anti-inflammatory and pro-resolution lipid mediators. Nat Rev Immunol 8(5):349–361.CrossRefGoogle ScholarPubMed
30. Serhan, C.N., Jain, A., Marleau, S., et al. 2003. Reduced inflammation and tissue damage in transgenic rabbits overexpressing 15-lipoxygenase and endogenous anti-inflammatory lipid mediators. J Immunol 171(12): 6856–6865.CrossRefGoogle ScholarPubMed
31. Hasturk, H., Kantarci, A., Ohira, T., et al. 2006. RvE1 protects from local inflammation and osteoclast-mediated bone destruction in periodontitis. FASEB J 20(2):401–403.CrossRefGoogle ScholarPubMed
32. Hasturk, H., Kantarci, A., Goguet-Surmenian, E., et al., 2007. Resolvin E1 regulates inflammation at the cellular and tissue level and restores tissue homeostasis in vivo. J Immunol 179(10):7021–7029.CrossRefGoogle ScholarPubMed
33. Sakamoto, M., Umeda, M., and Benno, Y. 2005. Molecular analysis of human oral microbiota. J Periodontal Res 40(3):277–285.CrossRefGoogle ScholarPubMed
34. Jain, A., Batista, E.L. Jr.Serhan, C., Stahl, G.L., and Van Dyke, T.E. 2003. Role for periodontitis in the progression of lipid deposition in an animal model. Infect Immun 71(10):6012–6018.CrossRefGoogle Scholar
35. Hickey, J.S., O'Neal, R.B., Scheidt, M.J., Strong, S.L., Turgeon, D., and Van Dyke, T.E. 1991. Microbiologic characterization of ligature-induced peri-implantitis in the microswine model. J Periodontol 62(9):548–553.CrossRefGoogle ScholarPubMed
36. Marks, S.C. Jr.McKee, M.D., Zalzal, S., and Nanci, A. 1994. The epithelial attachment and the dental junctional epithelium: ultrastructural features in porcine molars. Anat Rec 238(1):1–14.CrossRefGoogle ScholarPubMed
37. Sonoyama, W., Liu, Y., Fang, D., et al., 2006. Mesenchymal stem cell-mediated functional tooth regeneration in swine. PLoS ONE 1:e79.CrossRefGoogle ScholarPubMed
38. Liu, Y., Zheng, Y., Ding, G., et al., 2008. Periodontal ligament stem cell-mediated treatment for periodontitis in miniature swine. Stem Cells 26(4):1065–1073.CrossRefGoogle ScholarPubMed
39. Oliver, R.C., Brown, L.J., and Loe, H. 1998. Periodontal diseases in the United States population. J Periodontol 69(2):269–278.CrossRefGoogle ScholarPubMed
Kantarci, A., Hasturk, H., and Van Dyke, T.E. 2006. Host-mediated resolution of inflammation in periodontal diseases. Periodontol 2000 40:144–163.CrossRefGoogle ScholarPubMed
Serhan, C.N., Chiang, N., and Van Dyke, T.E. 2008. Resolving inflammation: dual anti-inflammatory and pro-resolution lipid mediators. Nat Rev Immunol 8(5):349–361.CrossRefGoogle ScholarPubMed

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