Alcohol use disorder (AUD) is a prevalent medical condition characterized by the continuation of alcohol use despite negative consequences. AUD affects almost 15 million people over the age of 12 annually in the United States. Some of the major long-term negative health consequences of drinking alcohol include digestive problems, heart disease, stroke, liver disease, and cancer. Drinking alcohol can also result in emergency department visits for injuries or alcohol poisoning/overdose. In addition to these physical health consequences, AUD can have a negative impact on occupational performance, social relationships, and mental health. The good news is, there are guidelines to help health care providers identify who may be at risk to develop and who may be suffering from an AUD, and there are many evidence-based treatment options. In this chapter we outline the best practices for diagnosis, withdrawal management, long-term pharmacotherapy options, and resources for patients.