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18 - The Basic Affective Circuits of Mammalian Brains: Implications for Healthy Human Development and the Cultural Landscapes of ADHD

Published online by Cambridge University Press:  26 May 2010

Carol M. Worthman
Affiliation:
Emory University, Atlanta
Paul M. Plotsky
Affiliation:
Emory University, Atlanta
Daniel S. Schechter
Affiliation:
Hôpitaux Universitaires de Genève
Constance A. Cummings
Affiliation:
Foundation for Psychocultural Research, California
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Summary

INTRODUCTION TO THE SCIENCE OF THE AFFECTIVE MIND

The first half of this essay summarizes the evidence-based affective neuroscience view of primary-process emotional systems in the mammalian brain, a basic plan of that brain (Panksepp, 1998, 2005a). The second half focuses on the psychological complexities that emerge when this plan, so similar in all animals, interacts with the relatively blank slate of the brain-mind's higher regions that need to be epigenetically created through developmental landscapes that vary dramatically among individuals and cultures. I will focus on this complexity through a single topic, gravid with cultural implications: namely, the possibility that our current epidemic of attention deficit hyperactivity disorders (ADHD), perhaps autism too, is being precipitated as much by cultural factors as any intrinsic genetically determined biological flaws. The thesis, already evaluated in animal models, is that our children may no longer get adequate amounts of natural physical-social play – play of their own choosing. Instead, their lives are excessively regimented by adult-guided activities. Such cultural changes, along with diminishing high quality interpersonal interactions with loving adults and peers, often replaced by a deluge of electronic “care-takers” and “companions” (TV, videogames, internet, and cell-phones), are not ideally suited for the epigenetic construction of deeply pro-social brains and minds.

The diminished ability of children to obtain neuro-developmental boosts from abundant self-initiated playful social-interchange with peers – a basic social and cultural meaning-making brain mechanism – may become manifest as impulse control problems.

Type
Chapter
Information
Formative Experiences
The Interaction of Caregiving, Culture, and Developmental Psychobiology
, pp. 470 - 502
Publisher: Cambridge University Press
Print publication year: 2010

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References

Alcaro, A., Huber, R. & Panksepp, J. (2007). Behavioral functions of the mesolimbic dopaminergic system: An affective neuroethological perspective. Brain Research Reviews, 56, 283–321.CrossRefGoogle ScholarPubMed
,American Psychiatric Association. (1994). Diagnostic and statistical manual of mental disorders. 4th ed. Washington, DC: Author.Google Scholar
Andersen, S. L., Arvanitogiannis, A., Pliakas, A. M., LeBlanc, C. & Carlezon, W. A.. (2002). Altered responsiveness to cocaine in rats exposed to methylphenidate during development. Nature Neuroscience, 5, 13–14.CrossRefGoogle ScholarPubMed
Barkley, R. A. (1997). ADHD and the nature of self-control. New York: Guilford Press.Google Scholar
Barrett, L. F. (2006). Emotions as natural kinds?Perspectives on Psychological Science, 1, 28–58.CrossRefGoogle ScholarPubMed
Beatty, W. W., Dodge, A. M., Dodge, L. J., White, K., & Panksepp, J. (1982). Psychomotor stimulants, social deprivation and play in juvenile rats. Pharmacology Biochemistry and Behavior, 16, 417–422.CrossRefGoogle ScholarPubMed
Bekoff, M. (2007). The emotional lives of animals. Novato, CA: New World Library.Google Scholar
Berridge, K. C., & Robinson, T. E. (1998). What is the role of dopamine in reward: Hedonic impact, reward learning, or incentive salience?Brain Research Reviews, 28, 309–369.CrossRefGoogle ScholarPubMed
Biederman, J., Wilens, T. E., Mick, E., Faraone, S. V., & Spencer, T. (1998). Does attention-deficit hyperactivity disorder impact the developmental course of drug and alcohol abuse and dependence?Biological Psychiatry, 15(44), 269–273.CrossRefGoogle Scholar
Biederman, J., Wilens, T., Mick, E., Spencer, T., & Faraone, S. V. (1999). Pharmacotherapy of attention-deficit/hyperactivity disorder reduces risk for substance use disorder. Pediatrics, 104(e20), 1–5.CrossRefGoogle ScholarPubMed
Brandon, C. L., Marinelli, M., Baker, L. K., & White, F. J. (2001). Enhanced reactivity and vulnerability to cocaine following methylphenidate treatment in adolescent rats. Neuropharmacology, 25, 651–661.Google ScholarPubMed
Brown, S. (1998). Play as an organizing principle: Clinical evidence and personal observations. In Bekoff, M. & Beyer, J. A. (Eds.), Animal play: Evolutionary, comparative, and ecological perspectives (pp. 242–251) Cambridge, UK: Cambridge University Press.Google Scholar
Burgdorf, J., Wood, P.L., Kroes, R. A., Moskal, J. R., & Panksepp, J. (2007). Neurobiology of 50-kHz ultrasonic vocalizations in rats: Electrode mapping, lesion, and pharmacology studies. Behavioral Brain Research, 182, 274–283.CrossRefGoogle ScholarPubMed
Burghardt, G. M. (2005). The genesis of animal play. Cambridge, MA: MIT Press.Google Scholar
Carlezon, W. A.., Mague, S. D., & Andersen, S. L. (2003). Enduring behavioral effects of early exposure to methylphenidate in rats. Biological Psychiatry, 54, 1330–1337.CrossRefGoogle ScholarPubMed
Castellanos, F. X., & Tannock, R. (2002). Neuroscience of attention-deficit/hyperactivity disorder: The search for endophenotypes. Nature Reviews Neuroscience, 3, 617–628.CrossRef
Champagne, F., & Meaney, M. J. (2001). Like mother, like daughter: Evidence for non-genomic transmission of parental behavior and stress responsivity. Progress in Brain Research, 133, 287–302.CrossRefGoogle ScholarPubMed
Champagne, F., & Meaney, M. J. (2007). Transgenerational effects of social environment on variations in maternal care and behavioral response to novelty. Behavioral Neuroscience, 121, 1353–1363.CrossRefGoogle ScholarPubMed
Darwin, C. (1872/1965). The expession of the emotions in man and animals. Chicago: University of Chicago Press.CrossRefGoogle Scholar
Dolinoy, D. C., & Jirtle, R. L. (2008). Environmental epigenomics in human health and disease. Environmental and Molecular Mutagenesis. 49, 4–8.CrossRefGoogle ScholarPubMed
Dolinoy, D. C., Weidman, J. R., & Jirtle, R. L. (2007). Epigenetic gene regulation: Linking early developmental environment to adult disease. Reproductive Toxicology, 23, 297–307.CrossRefGoogle ScholarPubMed
Dunbar, R., & Barrett, L. (Eds.) (2007). Oxford handbook of evolutionary psychology. Oxford: Oxford University Press.
Fosha, D., Siegel, D. J., & Solomon, M. F. (Eds.). (2009). The healing power of emotion: Affective neuroscience, development and clinical practice. New York: Norton.Google Scholar
Freed, P. J., & Mann, J. J. (2007). Sadness and loss: Toward a neurobiopsychosocial model. American Journal of Psychiatry, 164, 28–34.CrossRefGoogle Scholar
Gordon, N. S., Burke, S., Akil, H., Watson, J., & Panksepp, J. (2003). Socially induced brain fertilization: Play promotes brain derived neurotrophic factor expression. Neuroscience Letters, 341, 17–20.CrossRefGoogle Scholar
Grandin, T. & Johnson, C. (2005). Animals in translation. New York: Scribner.Google Scholar
Harlow, H. F. (1971). Learning to love. San Francisco: Albion.Google Scholar
Harlow, H. F., & Suomi, S. J. (1974). Induced depression in monkeys. Behavioral Biology, 12, 273–296.CrossRefGoogle ScholarPubMed
Hess, W. R. (1957). The functional organization of the diencephalons. New York: Grune and Statton.Google Scholar
Izard, C. E. (2007). Basic emotions, natural kinds, emotion schemas, and a new paradigm. Perspectives on Psychological Science, 2, 260–280.CrossRefGoogle Scholar
Kirkpatrick, E. A. (1903). Fundamental of child study: A discussion of instincts and other factors in human development with practical application. New York: MacMillan Co.CrossRefGoogle Scholar
Kroes, R. A., Burgdorf, J. S., Schmidt, M. E., Panksepp, J., Beinfeld, M. C. & Moskal, J. R (2008). Uncovering the moledualr basis of positive affect using rough-and-tumble play in rats: A role for Insulin-Like Growth Factor 1. Neuroscience Abstracts, 393.2.Google Scholar
Laviola, G., Adriani, W., Terranova, M. L., & Gerra, G. (1999). Psychobiological risk factors for vulnerability to psychostimulants in human adolescents and animal models. Neuroscience and Biobehavioral Reviews, 23, 993–1010.CrossRefGoogle ScholarPubMed
Fever, G. B., Dawson, K. V., & Morrow, A. L. (1999). The extent of drug therapy for attention deficit-hyperactivity disorder among children in public schools. American Journal of Public Health, 89, 1359–1364.Google Scholar
Lickliter, R., & Honeycutt, H. (2003). Developmental dynamics: Toward a biologically plausible evolutionary psychology. Psychological Bulletin, 129, 819–835.CrossRefGoogle Scholar
Mague, S. D., Andersen, , Carlezon, S. L., Jr, W. A.. (2005). Early developmental exposure to methylphenidate reduces cocaine-induced potentiation of brain stimulation reward in rats. Biological Psychiatry, 57, 120–125.CrossRefGoogle ScholarPubMed
Mannuzza, S., Klein, R. G., & Moulton, J. L. (2003). Does stimulant treatment place children at risk for adult substance abuse? A controlled, prospective follow-up study. Journal of Child and Adolescent Psychopharmacology, 13(3), 273–282.CrossRefGoogle ScholarPubMed
Meaney, M. J. (2001). Maternal care, gene expression, and the transmission of individual differences in stress reactivity across generations. Annual Review of Neuroscience, 24, 1161–1192.CrossRefGoogle Scholar
Mol Lous, A., Wit, C. A., Bruyn, E. E., & Riksen-Walraven, J. M. (2002). Depression markers in young children's play: A comparison between depressed and nondepressed 3- to 6-year-olds in various play situations. Journal of Child Psychology and Psychiatry, 43, 1029–1038.CrossRefGoogle ScholarPubMed
Moll, G. H., Hause, S., Rüther, E.Rothenberger, A., & Huether, G. (2001). Early methylphenidate administration to young rats causes a persistent reduction in the density of striatal dopamine transporters. Journal of Child and Adolescent Psychopharmacology, 11, 15–24.CrossRefGoogle ScholarPubMed
Nocjar, C., & Panksepp, J. (2002). Chronic intermittent amphetamine pretreatment enhances future appetitive behavior for drug- and natural-reward: Interaction with environmental variables. Behavioural Brain Research, 128, 189–203.CrossRefGoogle Scholar
Northoff, G., & Panksepp, J. (2008). The trans-species concept of self and the subcortical-cortical midline system. Trends in Cognitive Sciences, 12(7), 259–264.CrossRefGoogle ScholarPubMed
Numan, M., & Insel, T. R. (2003). The neurobiology of parental behavior. New York: Springer.Google Scholar
Panksepp, J. (1971). Aggression elicited by electrical stimulation of the hypothalamus in albino rats. Physiology & Behavior, 6, 311–316.CrossRefGoogle ScholarPubMed
Panksepp, J. (1998). Affective neuroscience, The foundations of human and animal emotions. New York: Oxford University Press.Google Scholar
Panksepp, J. (2001). The long-term psychobiological consequences of infant emotions: Prescriptions for the twenty-first century. Infant Mental Health Journal, 22, 132–173.3.0.CO;2-9>CrossRefGoogle Scholar
Panksepp, J. (2003). At the interface of affective, behavioral and cognitive neurosciences: Decoding the emotional feelings of the brain. Brain and Cognition, 52, 4–14.CrossRefGoogle Scholar
Panksepp, J (Ed.) (2004). Textbook of biological psychiatry. Hoboken, NJ: Wiley.Google Scholar
Panksepp, J. (2005a). Affective consciousness: Core emotional feelings in animals and humans. Consciousness & Cognition, 14, 30–80.CrossRefGoogle ScholarPubMed
Panksepp, J. (2005b). On the embodied neural nature of core emotional affects. Journal of Consciousness Studies, 12, 161–187.Google Scholar
Panksepp, J. (2006). Emotional endophenotypes in evolutionary psychiatry. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 30, 774–784.CrossRefGoogle ScholarPubMed
Panksepp, J. (2007a). Neuroevolutionary sources of laughter and social joy: Modeling primal human laughter in laboratory rats. Behavioral Brain Research, 182, 231–244.CrossRefGoogle ScholarPubMed
Panksepp, J. (2007b). Affective consciousness. In Velmans, M. & Schneider, S. (Eds.), The Blackwell companion to consciousness (pp. 114–129). Malden, MA: Blackwell Publishing.CrossRefGoogle Scholar
Panksepp, J. (2007c). The neuroevolutionary and neuroaffective psychobiology of the prosocial brain. In Dunbar, R. I. M. & Barrett, L. (Eds.), The Oxford handbook of evolutionary psychology (pp. 145–162). Oxford, UK: Oxford University Press.Google Scholar
Panksepp, J. (2007d). Neurologizing the psychology of affects: How appraisal-based constructivism and basic emotion theory can coexist. Perspectives on Psychological Science, 2, 281–296.CrossRefGoogle Scholar
Panksepp, J. (2008). The affective brain and core-consciousness: How does neural activity generate emotional feelings. In Lewis, M., Haviland, J. M., & Barrett, L. F. (Eds.), Handbook of emotions (pp. 47–67). New York: Guilford Press.Google Scholar
Panksepp, J. (2010). The evolutionary sources of jealousy: Cross-species approaches to fundamental issues. In Hart, S. L. & Legerstee, M. (Eds.), Handbook of jealousy: Theory, research, and multidisciplinary approaches (in press). Hoboken, NJ: Wiley-Blackwell.Google Scholar
Panksepp, J., Burgdorf, J., Gordon, N., & Turner, C. (2002). Treatment of ADHD with methylphenidate may sensitize brain substrates for desire. Consciousness & Emotion, 3, 7–19.CrossRefGoogle Scholar
Panksepp, J., & Burgdorf, J. (2003). “Laughing” rats and the evolutionary antecedents of human joy? Physiology & Behavior, 79, 533–547.CrossRefGoogle ScholarPubMed
Panksepp, J., Burgdorf, J., Turner, C., & Gordon, N. (2003). Modeling ADHD-type arousal with unilateral frontal cortex damage in rats and beneficial effects of play therapy. Brain and Cognition, 52, 97–105.CrossRefGoogle ScholarPubMed
Panksepp, J., Jalowiec, J., DeEskinazi, F.G., Bishop, P. (1985). Opiates and play dominance in juvenile rats. Behavioral Neuroscience, 99, 441–453.CrossRefGoogle ScholarPubMed
Panksepp, J., & Moskal, J. (2008). Dopamine and SEEKING: Subcortical “reward” systems and appetitive urges. In Elliot, A. (Ed.), Handbook of approach and avoidance motivation (pp. 67–87). Mahwah, NJ: Lawrence Erlbaum Associates.Google Scholar
Panksepp, J., & Northoff, G. (2009). The trans–species core self: The emergence of active cultural and neuro-ecological agents through self related processing within subcortical-cortical midline networks. Consciousness & Cognition, 18, 193–215.CrossRefGoogle ScholarPubMed
Panksepp, J., & Panksepp, J. B. (2000). A continuing critique of evolutionary psychology: Seven sins for seven sinners, plus or minus two. Evolution & Cognition, 7, 56–80.Google Scholar
Pfaff, D. W. (1999). Drive: Neurobiological and molecular mechanisms of sexual behavior. Cambridge, MA: MIT Press.Google Scholar
Potegal, M., & Einon, D. (1989). Aggressive behaviors in adult rats deprived of playfighting experiences as juveniles. Developmental Psychobiology, 22, 159–172.CrossRefGoogle Scholar
Power, T. G. (2000). Play and exploration in children and animals. Hillsdale, NJ: Lawrence Erlbaum Associates.Google Scholar
Robinson, T. E., & Berridge, K. C. (1993). The neural basis of drug craving: An incentive-sensitization theory of addiction. Brain Research Reviews, 18, 247–291.CrossRefGoogle Scholar
Robinson, T. E., & Kolb, B. (2004). Structural plasticity associated with exposure to drugs of abuse. Neuropharmacology, 47(Suppl. 1), 33–46.CrossRefGoogle ScholarPubMed
Schore, A. N. (2001). The effects of relational trauma on right brain development, affect regulation, and infant mental health. Infant Mental Health Journal, 22, 201–269.3.0.CO;2-9>CrossRefGoogle Scholar
Scott, E. (2001). Toward a play program to benefit children's attention in the classroom. (Unpublished doctoral dissertation). Bowling Green State University, Bowling Green, Ohio.
Scott, E., & Panksepp, J. (2003). Rough-and-tumble play in human children. Aggressive Behavior, 29(6), 539–551.CrossRefGoogle Scholar
Shahbazian, M. D., & Zoghbi, H. Y. (2002). Rett syndrome and MeCP2: Linking epigenetics and neuronal function. American Journal of Human Genetics, 71, 1259–1272.CrossRefGoogle ScholarPubMed
Siegel, A. (2005). The neurobiology of aggression and rage. Boca Raton, FL: CRC Press.Google Scholar
Solanto, M. V. (2000). Clinical psychopharmacology of AD/HD: Implications for animal models. Neuroscience and Biobehavioral Reviews, 24, 27–30.CrossRefGoogle ScholarPubMed
Spinka, M., Newberry, R. C., & Bekoff, M. (2001). Mammalian play: Training for the unexpected. Quarterly Review of Biology, 76, 141–68.CrossRefGoogle ScholarPubMed
Suomi, S. J., Delizio, R., & Harlow, H. F. (1976). Social rehabilitation of separation-induced depressive disorders in monkeys. American Journal of Psychiatry, 133, 1279–1285.Google ScholarPubMed
Sunderland, M. (2006). The science of parenting. London: DK Publishing Inc.Google Scholar
Sur, M., & Leamey, C. A. (2001). Development and plasticity of cortical areas and networks. Nature Reviews Neuroscience, 2, 251–262.CrossRefGoogle ScholarPubMed
Sur, M., & Rubenstein, J. L. (2005). Patterning and plasticity of the cerebral cortex. Science, 310, 805–810.CrossRefGoogle ScholarPubMed
Swain, J. E., Lorberbaum, J. P., Kose, S., & Strathearn, L. (2007). Brain basis of early parent-infant interactions: psychology, physiology, and in vivo functional neuroimaging studies. Journal of Child Psychology and Psychiatry, 48, 262–287.CrossRefGoogle ScholarPubMed
Szyf, M., McGowan, P., & Meaney, M. J. (2008). The social environment and the epigenome. Environmental and Molecular Mutagenesis, 49, 46–60.CrossRefGoogle ScholarPubMed
Tremolizzo, L., Doueiri, M. S., Dong, E., Grayson, D. R., Davis, J., Pinna, G., et al. (2005). Valproate corrects the schizophrenia-like epigenetic behavioral modifications induced by methionine in mice. Biological Psychiatry, 57, 500–509.CrossRefGoogle ScholarPubMed
Tronick, E. (2007). The neurobehavioral and social emotional development of infants and children. New York: Norton.Google Scholar
Berg, C. L., Hol, T., Everts, H., Koolhaas, J. M., Ree, J. M., Spruijt, B. M. (1999). Play is indispensable for an adequate development of coping with social challenges in the rat. Developmental Psychobiology, 34, 129–138.3.0.CO;2-L>CrossRefGoogle ScholarPubMed
Vanderschuren, L. J., & Kalivas, P. W. (2000). Alterations in dopaminergic and glutamatergic transmission in the induction and expression of behavioral sensitization, a critical review of preclinical studies. Psychopharmacology, 151, 99–120.CrossRefGoogle ScholarPubMed
Watt, D. F. & Panksepp, J. (2009). Depression: An evolutionarily conserved mechanism to terminate separation-distress? A review of aminergic, peptidergic, and neural network perspectives. Neuropsychoanalysis, 11, in press.CrossRefGoogle Scholar
Wilens, T. E. (2004). Impact of ADHD and its treatment on substance abuse in adults. Journal of Clinical Psychiatry, 65(Suppl. 3), 38–45.Google ScholarPubMed
Wilens, T. E., & Biederman, J. (2006). Alcohol, drugs, and attention-deficit/ hyperactivity disorder: A model for the study of addictions in youth. Journal of Psychopharmacology, 20(4), 580–588.CrossRefGoogle Scholar

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