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Chapter 2 - Early Development of the Mammalian Lung-Branching Morphogenesis

Published online by Cambridge University Press:  05 April 2016

By
Kathleen M. Stewart  and
Edward E. Morrisey
Edited by
Alan H. Jobe ,
Jeffrey A. Whitsett  and
Steven H. Abman
Alan H. Jobe
Affiliation:
University of Cincinnati
Jeffrey A. Whitsett
Affiliation:
Cincinnati Children’s Hospital
Steven H. Abman
Affiliation:
University of Colorado School of Medicine
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Summary

Abstract

The lung is an essential organ for mammalian health throughout life and represents a critical interface with the external environment in the regulation of gas exchange. To achieve these goals the mammalian lung has evolved into a highly complex system of branching epithelial and vascular structures that connects to a vast network of alveolar gas-exchanging units. The generation of this complex organ involves multiple steps and encompasses events that span prenatal and postnatal life. This chapter focuses on the mechanisms that regulate early lung development and branching morphogenesis and the various signaling molecules, extracellular matrix proteins, and genetic changes that influence this process. These research areas are critical for understanding the various causes of respiratory disease, which are a major contributor to morbidity and mortality at all stages of life.

Type
Chapter
Information
Fetal and Neonatal Lung Development
Clinical Correlates and Technologies for the Future
 , pp. 22 - 33
Publisher: Cambridge University Press
Print publication year: 2016

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