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Chapter 47 - Neurocognitive Outcomes in Term Infants with Neonatal Encephalopathy

from Section 4 - Specific Conditions Associated with Fetal and Neonatal Brain Injury

Published online by Cambridge University Press:  13 December 2017

David K. Stevenson
Affiliation:
Stanford University, California
William E. Benitz
Affiliation:
Stanford University, California
Philip Sunshine
Affiliation:
Stanford University, California
Susan R. Hintz
Affiliation:
Stanford University, California
Maurice L. Druzin
Affiliation:
Stanford University, California
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Print publication year: 2017

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References

Volpe, J. Neurology of the Newborn, 4th edn. Philadelphia: Saunders, 2001.Google Scholar
Miller, SP, Latal, B, Clark, H, et al. Clinical signs predict 30-month neurodevelopmental outcome after neonatal encephalopathy. Am J Obstet Gynecol 2004; 190: 93–9.CrossRefGoogle ScholarPubMed
Ferriero, DM. Neonatal brain injury. N Engl J Med 2004; 351: 1985–95.Google Scholar
Vannucci, RC, Perlman, JM. Interventions for perinatal hypoxic-ischemic encephalopathy. Pediatrics 1997; 100: 1004–14.Google Scholar
Finer, NN, Robertson, CM, Richards, RT, et al. Hypoxic-ischemic encephalopathy in term neonates: perinatal factors and outcome. J Pediatr 1981; 98: 112–17.Google Scholar
Nelson, KB, Lynch, JK. Stroke in newborn infants. Lancet Neurol 2004; 3: 150–8.CrossRefGoogle ScholarPubMed
Edwards, AD, Brocklehurst, P, Gunn, AJ, et al. Neurological outcomes at 18 months of age after moderate hypothermia for perinatal hypoxic ischaemic encephalopathy: synthesis and meta-analysis of trial data. BMJ 2010; 340:c363.CrossRefGoogle ScholarPubMed
Jacobs, SE, Berg, M, Hunt, R, et al. Cooling for newborns with hypoxic ischaemic encephalopathy. Cochrane Database Syst Rev 2013; 1:CD003311.Google Scholar
Tagin, MA, Woolcott, CG, Vincer, MJ, et al. Hypothermia for neonatal hypoxic ischemic encephalopathy: an updated systematic review and meta-analysis. Arch Pediatr Adolesc Med 2012; 166: 558–66.CrossRefGoogle ScholarPubMed
Juul, SE, Ferriero, DM. Pharmacologic neuroprotective strategies in neonatal brain injury. Clin Perinatol 2014; 41: 119–31.CrossRefGoogle ScholarPubMed
Thoresen, M. Cooling after perinatal asphyxia. Semin Fetal Neonatal Med 2015; 20:65.Google Scholar
Dammann, O, Ferriero, D, Gressens, P. Neonatal encephalopathy or hypoxic-ischemic encephalopathy? Appropriate terminology matters. Pediatr Res 2011; 70:12.Google Scholar
Volpe, JJ. Neonatal encephalopathy: an inadequate term for hypoxic-ischemic encephalopathy. Ann Neurol 2012; 72: 156–66.CrossRefGoogle ScholarPubMed
Badawi, N, Kurinczuk, JJ, Keogh, JM, et al. Intrapartum risk factors for newborn encephalopathy: the Western Australian case-control study. BMJ 1998; 317: 1554–8.Google Scholar
Cowan, F, Rutherford, M, Groenendaal, F, et al. Origin and timing of brain lesions in term infants with neonatal encephalopathy. Lancet 2003; 361: 736–42.Google Scholar
Gano, D1, Chau, V, Poskitt, KJ, Hill, A, Roland, E, Brant, R, Chalmers, M, Miller, SP. Evolution of pattern of injury and quantitative MRI on days 1 and 3 in term newborns with hypoxic-ischemic encephalopathy. Pediatr Res 2013 Jul; 74(1): 82–7. doi: 10.1038/pr.2013.69. Epub 2013 Apr 25.Google Scholar
Barkovich, AJ, Miller, SP, Bartha, A, et al. MR imaging, MR spectroscopy, and diffusion tensor imaging of sequential studies in neonates with encephalopathy. AJNR Am J Neuroradiol 2006; 27: 533–47.Google Scholar
McKinstry, RC, Miller, JH, Snyder, AZ, et al. A prospective, longitudinal diffusion tensor imaging study of brain injury in newborns. Neurology 2002; 59: 824–33.Google Scholar
American College of Obstetricians and Gynecologists’ Task Force on Neonatal Encephalopathy. Executive summary: Neonatal encephalopathy and neurologic outcome, second edition. Report of the American College of Obstetricians and Gynecologists’ Task Force on Neonatal Encephalopathy. Obstet Gynecol 2014; 123:896901.CrossRefGoogle Scholar
Myers, RE. Four patterns of perinatal brain damage and their conditions of occurrence in primates. Adv Neurol 1975; 10: 223–34.Google ScholarPubMed
Myers, RE. Two patterns of perinatal brain damage and their conditions of occurrence. Am J Obstet Gynecol 1972; 112: 246–76.Google Scholar
Childs, AM, Cornette, L, Ramenghi, LA, et al. Magnetic resonance and cranial ultrasound characteristics of periventricular white matter abnormalities in newborn infants. Clin Radiol 2001; 56: 647–55.Google Scholar
Felderhoff-Mueser, U, Rutherford, MA, Squier, WV, et al. Relationship between MR imaging and histopathologic findings of the brain in extremely sick preterm infants. AJNR Am J Neuroradiol 1999; 20: 1349–57.Google Scholar
Hope, PL, Gould, SJ, Howard, S, et al. Precision of ultrasound diagnosis of pathologically verified lesions in the brains of very preterm infants. Dev Med Child Neurol 1988; 30: 457–71.CrossRefGoogle ScholarPubMed
Schouman-Claeys, E, Henry-Feugeas, MC, Roset, F, et al. Periventricular leukomalacia: correlation between MR imaging and autopsy findings during the first 2 months of life. Radiology 1993; 189:5964.Google Scholar
Barkovich, AJ, Hajnal, BL, Vigneron, D, et al. Prediction of neuromotor outcome in perinatal asphyxia: evaluation of MR scoring systems. AJNR Am J Neuroradiol 1998; 19: 143–9.Google Scholar
McQuillen, PS, Ferriero, DM. Selective vulnerability in the developing central nervous system. Pediatr Neurol 2004; 30: 227–35.Google Scholar
Sie, LT, van der Knaap, MS, Oosting, J, et al. MR patterns of hypoxic-ischemic brain damage after prenatal, perinatal or postnatal asphyxia. Neuropediatrics 2000; 31: 128–36.Google Scholar
Miller, SP, Ramaswamy, V, Michelson, D, et al. Patterns of brain injury in term neonatal encephalopathy. J Pediatr 2005; 146: 453–60.Google Scholar
Gadian, DG, Aicardi, J, Watkins, KE, et al. Developmental amnesia associated with early hypoxic-ischaemic injury. Brain 2000; 123(Pt 3):499507.Google Scholar
Ramaswamy, V, Miller, SP, Barkovich, AJ, et al. Perinatal stroke in term infants with neonatal encephalopathy. Neurology 2004; 62: 2088–91.CrossRefGoogle ScholarPubMed
Lee, J, Croen, LA, Backstrand, KH, et al. Maternal and infant characteristics associated with perinatal arterial stroke in the infant. JAMA 2005; 293: 723–9.Google Scholar
Perez, A, Ritter, S, Brotschi, B, et al. Long-term neurodevelopmental outcome with hypoxic-ischemic encephalopathy. J Pediatr 2013; 163: 454–9.CrossRefGoogle ScholarPubMed
Steinman, KJ, Gorno-Tempini, ML, Glidden, DV, et al. Neonatal watershed brain injury on magnetic resonance imaging correlates with verbal IQ at 4 years. Pediatrics 2009; 123: 1025–30.CrossRefGoogle ScholarPubMed
Miller, SP, Newton, N, Ferriero, DM, et al. Predictors of 30-month outcome after perinatal depression: role of proton MRS and socioeconomic factors. Pediatr Res 2002; 52: 71–7.Google Scholar
Gonzalez, FF, Miller, SP. Does perinatal asphyxia impair cognitive function without cerebral palsy? Arch Dis Child Fetal Neonatal Ed 2006; 91:F454–9.Google Scholar
Barnett, A, Mercuri, E, Rutherford, M, et al. Neurological and perceptual-motor outcome at 5–6 years of age in children with neonatal encephalopathy: relationship with neonatal brain MRI. Neuropediatrics 2002; 33: 242–8.CrossRefGoogle Scholar
Dixon, G, Badawi, N, Kurinczuk, JJ, et al. Early developmental outcomes after newborn encephalopathy. Pediatrics 2002; 109:2633.Google Scholar
Marlow, N, Rose, AS, Rands, CE, Draper, ES. Neuropsychological and educational problems at school age associated with neonatal encephalopathy. Arch Dis Child Fetal Neonatal Ed 2005; 90:F380–7.Google Scholar
Moster, D, Lie, RT, Markestad, T. Joint association of Apgar scores and early neonatal symptoms with minor disabilities at school age. Arch Dis Child Fetal Neonatal Ed 2002; 86:F1621.Google Scholar
Robertson, CM, Finer, NN, Grace, MG. School performance of survivors of neonatal encephalopathy associated with birth asphyxia at term. J Pediatr 1989; 114: 753–60.Google Scholar
Goodwin, TM, Belai, I, Hernandez, P, et al. Asphyxial complications in the term newborn with severe umbilical acidemia. Am J Obstet Gynecol 1992; 167: 1506–12.CrossRefGoogle ScholarPubMed
Nelson, KB, Ellenberg, JH. Apgar scores as predictors of chronic neurologic disability. Pediatrics 1981; 68:3644.Google Scholar
Sarnat, HB, Sarnat, MS. Neonatal encephalopathy following fetal distress: a clinical and electroencephalographic study. Arch Neurol 1976; 33:696705.CrossRefGoogle ScholarPubMed
Robertson, CM, Finer, NN. Long-term follow-up of term neonates with perinatal asphyxia. Clin Perinatol 1993; 20:483500.Google Scholar
Gunn, AJ, Wyatt, JS, Whitelaw, A, et al. Therapeutic hypothermia changes the prognostic value of clinical evaluation of neonatal encephalopathy. J Pediatr 2008; 152: 55–8.Google Scholar
de Vries, LS, Jongmans, MJ. Long-term outcome after neonatal hypoxic-ischaemic encephalopathy. Arch Dis Child Fetal Neonatal Ed 2010; 95:F220–4.Google Scholar
Diamond, A. Executive functions. Annu Rev Psychol 2013; 64: 135–68.Google Scholar
van Handel, M, Swaab, H, de Vries, LS, Jongmans, MJ. Long-term cognitive and behavioral consequences of neonatal encephalopathy following perinatal asphyxia: a review. Eur J Paediatr 2007; 166: 645–54.Google Scholar
Kjellmer, I, Beijer, E, Carlsson, G, et al. Follow-up into young adulthood after cardiopulmonary resuscitation in term and near-term newborn infants. I. Educational achievements and social adjustment. Acta Paediatr 2002; 91: 1212–17.Google Scholar
Lindstrom, K, Lagerroos, P, Gillberg, C, Fernell, E. Teenage outcome after being born at term with moderate neonatal encephalopathy. Pediatr Neurol 2006; 35: 268–74.Google Scholar
Viggedal, G, Lundalv, E, Carlsson, G, Kjellmer, I. Follow-up into young adulthood after cardiopulmonary resuscitation in term and near-term newborn infants. II. Neuropsychological consequences. Acta Paediatr 2002; 91: 1218–26.CrossRefGoogle ScholarPubMed
van Handel, M, de Sonneville, L, de Vries, LS, et al. Specific memory impairment following neonatal encephalopathy in term-born children. Dev Neuropsychol 2012; 37:3050.Google Scholar
Dilenge, ME, Majnemer, A, Shevell, MI. Long-term developmental outcome of asphyxiated term neonates. J Child Neurol 2001; 16: 781–92.Google Scholar
Badawi, N, Felix, JF, Kurinczuk, JJ, et al. Cerebral palsy following term newborn encephalopathy: a population-based study. Dev Med Child Neurol 2005; 47: 293–8.CrossRefGoogle ScholarPubMed
Volpe, JJ. Neonatal Neurology, 4th edn. Philadelphia: Saunders, 2001.Google Scholar
Handley-Derry, M, Low, JA, Burke, SO, et al. Intrapartum fetal asphyxia and the occurrence of minor deficits in 4- to 8-year-old children. Dev Med Child Neurol 1997; 39: 508–14.CrossRefGoogle ScholarPubMed
van Kooij, B, van Handel, M, Uiterwaal, C, et al. Corpus callosum size in relation to motor performance in 9- to 10- year-old children with neonatal encephalopathy. Pediatr Res 2008; 63:16.Google Scholar
van Schie, PE, Schijns, J, Becher, JG, et al. Long-term motor and behavioral outcome after perinatal hypoxic-ischemic encephalopathy. Eur J Paediatr Neurol. 2015; 19: 354–9.Google Scholar
Van Hof-van Duin, J, Mohn, G. Visual defects in children after cerebral hypoxia. Behav Brain Res 1984; 14: 147–55.Google Scholar
Mercuri, E, Atkinson, J, Braddick, O, et al. Basal ganglia damage and impaired visual function in the newborn infant. Arch Dis Child Fetal Neonatal Ed 1997; 77:F111–14.Google Scholar
Robertson, C, Finer, N. Term infants with hypoxic-ischemic encephalopathy: outcome at 3.5 years. Dev Med Child Neurol 1985; 27: 473–84.CrossRefGoogle ScholarPubMed
Shankaran, S, Woldt, E, Koepke, T, et al. Acute neonatal morbidity and long-term central nervous system sequelae of perinatal asphyxia in term infants. Early Hum Dev 1991; 25: 135–48.Google Scholar
Mercuri, E, Anker, S, Guzzetta, A, et al. Visual function at school age in children with neonatal encephalopathy and low Apgar scores. Arch Dis Child Fetal Neonatal Ed 2004; 89:F258–62.Google Scholar
D’Souza, SW, McCartney, E, Nolan, M, Taylor, IG. Hearing, speech, and language in survivors of severe perinatal asphyxia. Arch Dis Child 1981; 56: 245–52.Google Scholar
Roland, EH, Hill, A, Norman, MG, et al. Selective brainstem injury in an asphyxiated newborn. Ann Neurol 1988; 23:8992.Google Scholar
Brunquell, PJ, Glennon, CM, DiMario, FJ Jr, et al. Prediction of outcome based on clinical seizure type in newborn infants. J Pediatr 2002; 140: 707–12.Google Scholar
Clancy, RR, Legido, A. Postnatal epilepsy after EEG-confirmed neonatal seizures. Epilepsia 1991; 32:6976.Google Scholar
Hellstrom-Westas, L, Blennow, G, Lindroth, M, et al. Low risk of seizure recurrence after early withdrawal of antiepileptic treatment in the neonatal period. Arch Dis Child Fetal Neonatal Ed 1995; 72:F97101.Google Scholar
Toet, MC, Groenendaal, F, Osredkar, D, et al. Postneonatal epilepsy following amplitude-integrated EEG-detected neonatal seizures. Pediatr Neurol 2005; 32: 241–7.Google Scholar
Jung, DE, Ritacco, DG, Nordli, DR, et al. Early Anatomical Injury Patterns Predict Epilepsy in Head Cooled Neonates With Hypoxic-Ischemic Encephalopathy. Pediatr Neurol 2015; 53(2): 135–40.Google Scholar
Robertson, CM, Finer, NN. Educational readiness of survivors of neonatal encephalopathy associated with birth asphyxia at term. J Dev Behav Pediatr 1988; 9:298306.Google Scholar
Stuart, A, Otterblad Olausson, P, Kallen, K. Apgar scores at 5 minutes after birth in relation to school performance at 16 years of age. Obstet Gynecol 2011; 118: 201–8.Google Scholar
Koot, HM. The study of quality of life: concepts and methods. In: Koot, HM, Wallander, JL, eds., Quality of Life in Child and Adolescent Illness. Hove: Bunner-Routledge, 2001.Google Scholar
Azzopardi, DV, Strohm, B, Edwards, AD, et al. Moderate hypothermia to treat perinatal asphyxial encephalopathy. N Engl J Med 2009; 361: 1349–58.Google Scholar
Thornberg, E, Thiringer, K, Odeback, A, Milsom, I. Birth asphyxia: incidence, clinical course and outcome in a Swedish population. Acta Paediatr 1995; 84: 927–32.Google Scholar
Roland, EH, Poskitt, K, Rodriguez, E, et al. Perinatal hypoxic-ischemic thalamic injury: clinical features and neuroimaging. Ann Neurol 1998; 44: 161–6.Google Scholar
Rutherford, MA, Pennock, JM, Counsell, SJ, et al. Abnormal magnetic resonance signal in the internal capsule predicts poor neurodevelopmental outcome in infants with hypoxic-ischemic encephalopathy. Pediatrics 1998; 102: 323–8.Google Scholar
Krageloh-Mann, I, Helber, A, Mader, I, et al. Bilateral lesions of thalamus and basal ganglia: origin and outcome. Dev Med Child Neurol 2002; 44: 477–84.CrossRefGoogle ScholarPubMed
Le Strange, E, Saeed, N, Cowan, FM, et al. MR imaging quantification of cerebellar growth following hypoxic-ischemic injury to the neonatal brain. AJNR Am J Neuroradiol 2004; 25: 463–8.Google Scholar
Sargent, MA, Poskitt, KJ, Roland, EH, et al. Cerebellar vermian atrophy after neonatal hypoxic-ischemic encephalopathy. AJNR Am J Neuroradiol 2004; 25: 1008–15.Google Scholar
Bonifacio, SL, Saporta, A, Glass, HC, et al. Therapeutic hypothermia for neonatal encephalopathy results in improved microstructure and metabolism in the deep gray nuclei. AJNR Am J Neuroradiol 2012; 33: 2050–5.Google Scholar
Nagy, Z, Lindstrom, K, Westerberg, H, et al. Diffusion tensor imaging on teenagers, born at term with moderate hypoxic-ischemic encephalopathy. Pediatr Res 2005; 58: 936–40.Google Scholar
Rutherford, M, Counsell, S, Allsop, J, et al. Diffusion-weighted magnetic resonance imaging in term perinatal brain injury: a comparison with site of lesion and time from birth. Pediatrics 2004; 114: 1004–14.Google Scholar
Thayyil, S, Chandrasekaran, M, Taylor, A, et al. Cerebral magnetic resonance biomarkers in neonatal encephalopathy: a meta-analysis. Pediatrics 2010; 125:e382–95.Google Scholar
Alderliesten, T, de Vries, LS, Khalil, Y, et al. Therapeutic hypothermia modifies perinatal asphyxia-induced changes of the corpus callosum and outcome in neonates. PLoS One 2015; 10:e0123230.Google Scholar
Bonifacio, SL, deVries, LS, Groenendaal, F. Impact of hypothermia on predictors of poor outcome: how do we decide to redirect care? Semin Fetal Neonatal Med 2015; 20: 122–7.Google Scholar
Massaro, AN. MRI for neurodevelopmental prognostication in the high-risk term infant. Semin Perinatol 2015; 39: 159–67.Google Scholar
Merchant, N, Azzopardi, D. Early predictors of outcome in infants treated with hypothermia for hypoxic-ischaemic encephalopathy. Dev Med Child Neurol 2015; 57(Suppl 3):816.Google Scholar
Sabir, H, Cowan, FM. Prediction of outcome methods assessing short- and long-term outcome after therapeutic hypothermia. Semin Fetal Neonatal Med 2015; 20: 115–21.Google Scholar
Shankaran, S. Outcomes of hypoxic-ischemic encephalopathy in neonates treated with hypothermia. Clin Perinatol 2014; 41: 149–9.Google Scholar
Shankaran, S, Pappas, A, McDonald, SA, et al. Predictive value of an early amplitude integrated electroencephalogram and neurologic examination. Pediatrics 2011; 128:e112–20.Google Scholar
Simbruner, G, Mittal, RA, Rohlmann, F, Muche, R. Systemic hypothermia after neonatal encephalopathy: outcomes of neo.nEURO.network RCT. Pediatrics 2010; 126:e771–8.Google Scholar
Shankaran, S, Laptook, AR, Tyson, JE, et al. Evolution of encephalopathy during whole body hypothermia for neonatal hypoxic-ischemic encephalopathy. J Pediatr 2012; 160: 567–72.Google Scholar
Thoresen, M, Hellstrom-Westas, L, Liu, X, de Vries, LS. Effect of hypothermia on amplitude-integrated electroencephalogram in infants with asphyxia. Pediatrics 2010; 126:e131–9.CrossRefGoogle ScholarPubMed
Cheong, JL, Coleman, L, Hunt, RW, et al. Prognostic utility of magnetic resonance imaging in neonatal hypoxic-ischemic encephalopathy: substudy of a randomized trial. Arch Pediatr Adolesc Med 2012; 166: 634–40.CrossRefGoogle ScholarPubMed
Rutherford, M, Ramenghi, LA, Edwards, AD, et al. Assessment of brain tissue injury after moderate hypothermia in neonates with hypoxic-ischaemic encephalopathy: a nested substudy of a randomised controlled trial. Lancet Neurol 2010; 9:3945.Google Scholar

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