Fertility Preservation in Non-Cancer Patients

doi:10.1017/9781108784368.008

Chapter 7 - Fertility Preservation in Non-Cancer Patients

from Section 3 - Fertility Preservation in Cancer and Non-Cancer Patients

Published online by Cambridge University Press: 27 March 2021

Javier Domingo ,

Ana Cobo and

Antonio Pellicer

Edited by

Jacques Donnez and

S. Samuel Kim

Show author details

Jacques Donnez: Affiliation:
Catholic University of Louvain, Brussels
S. Samuel Kim: Affiliation:
University of Kansas School of Medicine

Book contents

Get access

Summary

The increasing survival rates of cancer patients [1] have encouraged many specialists to focus on the irreversible consequences of chemotherapy and radiotherapy. Chemotherapy and radiotherapy treatment for cancer or other pathologies have resulted in improved survival rates, but these treatments may also lead to sterility [2]. The increasing success of oncological treatments means it is now even more crucial to implement procedures aimed at preserving fertility.

Similar to cancer patients, there are some non-oncological conditions currently treated with gonadotoxic agents, such as patients with autoimmune disorders or some chromosomal abnormalities that can lead to ovarian failure. There are also other situations where a woman may benefit from fertility preservation procedures, such as women with severe or recurrent endometriosis or women who electively postpone conception [3].

Type: Chapter
Information: Fertility Preservation
Principles and Practice
, pp. 67 - 78

DOI: https://doi.org/10.1017/9781108784368.008 [Opens in a new window]

Publisher: Cambridge University Press

Print publication year: 2021

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Book purchase

Temporarily unavailable

References

Surveillance, Epidemiology and End Results Program, 1975–2015, Division of Cancer Control and Population Sciences, National Cancer Institute, 2018.Google Scholar

Larsen, EC, Müller, J, Schmiegelow, K et al. Reduced ovarian function in long-term survivors of radiation and chemotherapy-treated childhood cancer. J Clin Endocrinol Met, 2003;88:5307–5314.Google Scholar

Gidoni, Y, Holzer, H, Tulandi, T et al. Fertility preservation in patients with non-oncological conditions. Reprod Biomed Online, 2008;16:792–800.CrossRef Google Scholar PubMed

Cobo, A, Bellver, J, Domingo, J et al. New options in assisted reproduction technology: the Cryotop method of oocyte vitrification. Reprod Biomed Online, 2008;17:68–72.Google Scholar

Meseguer, M, Molina, N, García-Velasco, JA et al. Sperm cryopreservation in oncological patients: a 14-year follow-up study. Fertil Steril, 2006;85:640–645.CrossRef Google Scholar PubMed

Kuwayama, M, Vajta, G, Kato, O et al. Highly efficient vitrification method for cryopreservation of human oocytes. Reprod Biomed Online, 2005;11:300–308.Google Scholar

Silber, SJ, Derosa, M, Pineda, J et al. A series of monozygotic twins discordant for ovarian failure: ovary transplantation (cortical versus microvascular) and cryopreservation. Hum Reprod, 2008;23:1531–1537.Google Scholar

Elgindy, E, Sibai, H, Abdelghani, A et al. Protecting ovaries during chemotherapy through gonad suppression: A systematic review and metaanalysis. Obstet Gynecol, 2015;126:187–195.Google Scholar

De Vos, M, Smitz, J, Woodruff, T. Fertility preservation in women with cancer. Lancet, 2014;384:1302–1310.Google Scholar

Tulandi, T, Huang, JY, Tan, SL. Preservation of female fertility: an essential progress. Obstet Gynecol, 2008;112:1160–1172.Google Scholar

Bines, J, Oleske, DM, Cobleigh, MA. Ovarian function in premenopausal women treated with adjuvant chemotherapy for breast cancer. J Clin Oncol, 1996;14:1718–1729.Google Scholar

Poniatowski, BC, Grimm, P, Cohen, G. Chemotherapy-induced menopause: A literature review. Cancer Invest, 2001;19:641–648.Google Scholar

Meirow, D, Nugent, D. The effects of radiotherapy and chemotherapy on female reproduction. Hum Reprod Update, 2001;7:535–543.Google Scholar

Meirow, D, Epstein, M, Lewis, H et al. Administration of cyclophosphamide at different stages of follicular maturation in mice: effects on reproductive performance and fetal malformations. Hum Reprod, 2001;16:632–637.Google Scholar

Martinez, F. Update on fertility preservation from the Barcelona International Society for Fertility Preservation-ESHRE-ASRM 2015 expert meeting: indications, results and future perspectives. Fertil Steril, 2017;108:407–415.Google Scholar

Sonmezer, M, Oktay, K. Fertility preservation in young women undergoing breast cancer therapy. The Oncologist, 2006;11:422–434.CrossRef Google Scholar PubMed

Warne, GL, Fairley, KF, Hobbs, JB et al. Cyclophosphamide-induced ovarian failure. N Engl J Med, 1973;289:1159–1162.Google Scholar

Marcello, MF, Nuciforo, G, Romeo, R et al. Structural and ultrastructural study of the ovary in childhood leukemia after successful treatment. Cancer, 1990;66:2099–2104.Google Scholar

Familiari, G, Caggiati, A, Nottola, SA et al. Ultrastructure of human primordial follicles after combination chemotherapy for Hodgkin´s disease. Hum Reprod, 1993;8:2080–2087.Google Scholar

Meirow, D, Dor, J, Kaufman, B et al. Cortical fibrosis and blood-vessels damage in human ovaries exposed to chemotherapy. Potential mechanisms of ovarian injury. Hum Reprod, 2007;22:1626–1633.Google Scholar

Anderson, RA, Themmen, AP, Al-Qahtani, A et al. The effects of chemotherapy and long term gonadotrophin suppression on the ovarian reserve in premenopausal women with breast cancer. Hum Reprod, 2006;21:2583–2592.Google Scholar

Wallace, WH, Thomson, AB, Kelsey, TW. The radiosensitivity of human oocyte. Hum Reprod, 2003;18:117–121.Google Scholar

Howell, SJ, Shalet, S. Gonadal damage from chemotherapy and radiotherapy. Endocrinol Metab Clin, 1998;27:927–943.Google Scholar

Patrick, K, Wallace, WH, Critchley, H. Late reproductive effects of cancer treatment in female survivors of childhood malignancy. Curr Obstet Gynecol, 2003;13:369–372.Google Scholar

Goynumer, G, Kayabasoglu, F, Aydogdu, S et al. The effect of tubal sterilization through electrocoagulation on the ovarian reserve. Contraception, 2009;80:90–94.Google Scholar

Hernández-Díaz, S, Werler, MM, Walker, AM et al. Folic acid antagonists during pregnancy and the risk of birth defects. N Engl J Med, 2000;343:1608–1614.CrossRef Google Scholar PubMed

Alonso, V, Linares, V, Bellés, M et al. Sulfasalazine induced oxidative stress: a possible mechanism of male infertility. Reprod Toxicol, 2009;27:35–40.Google Scholar

Ostensen, , Khamashta, M, Lockshin, M et al. Anti-inflammatory and immunosuppressive drugs and reproduction. Arthritis Res Ther, 2006;8:209.Google Scholar

Gutierrez, JC, Hwang, K. The toxicity of methotrexate in male fertility and paternal eratogenicity. Expert Opin Drug Metab Toxicol, 2017;1:51–58.Google Scholar

Martini, AC, Molina, RI, Tissera, AD et al. Analysis of semen from patients chronically treated with low or moderate doses of aspirin like drugs. Fertil Steril, 2003;80:221–222.CrossRef Google Scholar PubMed

Huang, JY, Tulandi, T, Holzer, H et al. Combining ovarian tissue cryobanking with retrieval of immature oocytes followed by in vitro maturation and vitrification: an additional strategy of fertility preservation. Fertil Steril, 2008;89:567–572.Google Scholar

Tao, T, del Valle, A. Human oocyte and ovarian tissue cryopreservation and its application. J Assist Reprod Genet, 2008;25:287–296.Google Scholar

Cobo, A, Kuwayama, M, Pérez, S et al. Comparison of concomitant outcome achieved with fresh and cryopreserved oocytes vitrified by the Cryotop method. Fertil Steril, 2008;89:1657–1664.Google Scholar

Chian, RC, Huang, JY, Tan, SL et al. Obstetric and perinatal outcome in 200 infants conceived from vitrified oocytes. Reprod Biomed Online, 2008;16:608–610.Google Scholar

The Ethics Committee of the American Society for Reproductive Medicine. Fertility preservation and reproduction in cancer patients. Fertil Steril, 2005;83:1622–1628.Google Scholar

Nugent, D, Meirow, D, Brook, PF et al. Transplantation in reproductive medicine: previous experience, present knowledge and future prospects. Hum Reprod Update, 1997;3:267–280.Google Scholar

Donnez, J, Dolmans, MM. Ovarian cortex transplantation: 60 reported live births brings the success and worldwide expansion of the technique towards routine clinical practice. J Assist Reprod Genet, 2015;32:1167–1170.CrossRef Google Scholar PubMed

Van der Ven, H, Liebenthron, J, Beckmann, M et al. Ninety-five orthotropic transplantations in 74 women of ovarian tissue after cytotoxic treatment in a fertility preservation network: tissue activity, pregnancy and delivery rates. Hum Reprod, 2016;31:2031–2041.Google Scholar

Diaz-Garcia, C, Domingo, J, Garcia-Velasco, JA et al. Oocyte vitrification versus ovarian cortex transplantation in fertility preservation for adult women undergoing gonadotoxic treatments: a prospective cohort study. Fertil Steril, 2018;109:478–485.Google Scholar

Dolmans, MM, Luyckx, V, Donnez, J, Andersen, CY, Greve, T. Risk of transferring malignant cells with transplanted frozen-thawed ovarian tissue. Fertil Steril, 2013;99:1514–1522.Google Scholar

Shapira, M, Raanani, H, Barshack, I et al. First delivery in a leukemia survivor after transplantation of cryopreserved ovarian tissue, evaluated for leukemia cells contamination. Fertil Steril, 2018;109:48–53.Google Scholar

Committee, IP, Kim, SS, Donnez, J et al. Recommendations for fertility preservation in patients with lymphoma, leukemia, and breast cancer. J Assist Reprod Genet, 2012;29:465–468.Google Scholar

Robertson, JA. Ethical issues in ovarian transplantation and donation. Fertil Steril, 2000;73:443–446.Google Scholar

Blumenfeld, Z, Evron, A. Endocrine prevention of chemotherapy-induced ovarian failure. Curr Opin Obstet Gynecol, 2016;28:223–229.CrossRef Google Scholar PubMed

Del Mastro, L, Ceppi, M, Poggio, F et al. Gonadotropin-releasing hormone analogues for the prevention of chemotherapy-induced premature ovarian failure in cancer women: systematic review and meta-analysis of randomized trials. Cancer Treat Rev, 2014;40:675–683.Google Scholar

Srkalovic, G, Schally, AV, Wittliff, JL et al. Presence and characteristics of receptors for [D-Trp6] luteinizing hormone releasing hormone and epidermal growth factor in human ovarian cancer. Int J Oncol, 1998;12:489–498.Google Scholar

Emous, G, Grndker, C, Ganthert, AR et al. GnRH antagonists in the treatment of gynaecological and breast cancer. Endocr Relat Cancer, 2003;10:291–299.Google Scholar

Blumenfeld, Z, Shapiro, D, Shteinberg, M et al. Preservation of fertility and ovarian function and minimizing gonadotoxicity in young women with systemic lupus erythematosus treated by chemotherapy. Lupus, 2000;9:401–405.Google Scholar

Gougeon, A. Regulation of ovarian follicular development in primates: facts and hypotheses. Endocr Rev, 1996;17:121–155.CrossRef Google Scholar PubMed

Chian, RC, Huang, JY, Gilbert, L et al. Obstetric outcomes following vitrification of in vitro and in vivo matured oocytes. Fertil Steril, 2009;91:2391–2398.Google Scholar

Cohen, Y, St-Onge-St-Hilaire, A, Tannus, S et al. Decreased pregnancy and live birth rates after vitrification of in vitro matured oocytes. J Assist Reprod Genet. 2018;35(9):1683–1689.Google Scholar

Buckett, WM, Chian, RC, Dean, NL et al. Pregnancy loss in pregnancies conceived after in vitro oocyte maturation, conventional in vitro fertilization and intracytoplasmic sperm injection. Fertil Steril, 2008;90:546–550.Google Scholar

Bisharah, M, Tulandi, T. Laparoscopic preservation of ovarian function: an underused procedure. Am J Obstet Gynecol, 2003;188:367–370.Google Scholar

Chen, Y, Sun, J, Zou, K et al. Treatment for lupus nephritis: an overview of systematic reviews and meta-analyses. Rheumatol Int, 2017;37:1089–1099.Google Scholar

Bernatsky, S, Clarke, A, Suissa, S. Hematologic malignant neoplasms after drug exposure in rheumatoid arthritis. Arch Intern Med, 2008;168:378–381.Google Scholar

Langford, C. Wegener’s granulomatosis: current and upcoming therapies. Arthritis Res Ther, 2003;5:180–191.Google Scholar

Schroeder, JO, Euler, H, Loffler, H. Synchronization of plasmapheresis and pulse cyclophosphamide in severe systemic lupus erythematosus. Ann Intern Med, 1987;107:344–346.Google Scholar

Manger, K, Wildt, L, Kalden, JR et al. Prevention of gonadal toxicity and preservation of gonadal function and fertility in young women with systemic lupus erythematosus treated by cyclophosphamide: the PREGO-Study. Autoimmun Rev, 2006;5:269–272.Google Scholar

Buyon, JP, Petri, MA, Kim, MY et al. The effect of combined estrogen and progesterone hormone replacement therapy on disease activity in systemic lupus erythematosus: a randomized trial. Ann Intern Med, 2005;142:953–962.Google Scholar

Oktay, K, Hourvitz, A, Sahin, G et al. Letrozole reduces estrogen and gonadotropin exposure in women with breast cancer undergoing ovarian stimulation before chemotherapy. J Clin Endocrinol Metabol, 2006;91:3885–3890.Google Scholar

Ahlstrom, A, Westin, C, Wikland, M et al. Prediction of live birth in frozen-thawed single blastocyst transfer cycles by pre-freeze and post-thaw morphology. Hum Reprod, 2013;28:1199–1209.Google Scholar

Goldman, RH, Racowsky, C, Farland, LV et al. Predicting the likelihood of live birth for elective oocyte cryopreservation: a counseling tool for physicians and patients. Hum Reprod, 2017;32:853–859.Google Scholar

Dondorp, WJ, De Wert, GM. Fertility preservation for healthy women: ethical aspects. Hum Reprod, 2009;24:1779–1785.Google Scholar

Cobo, A, Garcia-Velasco, JA, Coello, A et al. Oocyte vitrification as an efficient option for elective fertility preservation. Fertil Steril, 2016;105:755–764.e8.Google Scholar

Cobo A, García-Velasco JA, Domingo J, Pellicer A, Remohí J. Elective and Onco-fertility preservation: factors related to IVF outcomes. Hum Reprod, 2018;33(12):2222–2231.CrossRef Google Scholar

Somigliana, E, Ragni, G, Benedetti, F et al. Does laparoscopic excision of endometriotic ovarian cysts significantly affect ovarian reserve? Insights from IVF cycles. Hum Reprod, 2003;18:2450–2453.Google Scholar

Carrillo, L, Seidman, D, Cittadini, E et al. The role of fertility preservation in patients with endometriosis. J Assist Reprod Genet, 2016;33:317–323.Google Scholar

García-Velasco, JA, Somigliana, E. Management of endometriomas in women requiring IVF: to touch or not to touch. Hum Reprod, 2009;24:496–501.Google Scholar

Busacca, M, Vignali, M. Endometrioma excision and ovarian reserve: a dangerous relation. J Minim Invasive Gynecol, 2009;16:142–148.Google Scholar

Rauck, AM, Grouas, AC. Bone marrow transplantation in adolescents. Adolesc Med, 1999;10:445–449.Google Scholar

Lau, NM, Huang, JY, MacDonald, S et al. Feasibility of fertility preservation in young females with Turner syndrome. Reprod Biomed Online, 2009;18:290–295.Google Scholar

Pienkowski, C, Menendez, M, Cartault, A et al. Turner’s syndrome and procreation. Ovarian function and Turner’s syndrome. Gynecol Obstet Fertil, 2008;36:1030–1034.Google Scholar

Sénéchal, C, Rousset-Jablonski, C. Should a systematic fertility preservation be proposed to healthy women carrying a BRCA1/2 mutation? Gynecol Obstet Fertil, 2015;43:800–805.Google Scholar

Derks-Smeets, IAP, van Tilborg, TC, van Montfoort, A et al. BRCA1 mutation carriers have a lower number of mature oocytes after ovarian stimulation for IVF/PGD. J Assist Reprod Genet, 2017;34:1475–1482.Google Scholar

Cobo, A, Bellver, J, Domingo, J et al. New options in assisted reproduction technology: the Cryotop method of oocyte vitrification. Reprod Biomed Online, 2008;17:68–72.Google Scholar

Bosch, E, Labarta, E, Crespo, J et al. Circulating progesterone levels and ongoing pregnancy rates in controlled ovarian stimulation cycles for in vitro fertilization: analysis of over 4000 cycles. Hum Reprod, 2010;25:2092–2100.Google Scholar