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Chapter 10 - Breast Cancer Therapy and Fertility

from Section 3 - Fertility Preservation in Cancer and Non-Cancer Patients

Published online by Cambridge University Press:  27 March 2021

By
Kenny A Rodriguez-Wallberg
Edited by
Jacques Donnez  and
S. Samuel Kim
Jacques Donnez
Affiliation:
Catholic University of Louvain, Brussels
S. Samuel Kim
Affiliation:
University of Kansas School of Medicine
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Summary

Breast cancer is the most common cancer disease in women worldwide, being also the third most common incident cancer overall, with a global estimated of 1.7 million new diagnosed cases per year during 2016 [1]. Fortunately, modern breast cancer treatment achieves a high rate of cure and long-term survival today and improved survival has been continuously observed over the last 50 years, from a 50% 10-year survival in the 1960s up to 80% during the 2010s []. In general, survival of women with a breast cancer treated at early stages 0–1 reaches nearly 100%, whereas it approaches about 80%, 60%, or 20% when the disease is treated in a stages 2, 3, or 4, respectively [2].

Although breast cancer is the most common cancer presenting in women of reproductive age, only 2% of all breast cancers occur in young adult women between 20 and 34 years of age and 11% in women between 35 and 44 years of age [3].

Type
Chapter
Information
Fertility Preservation
Principles and Practice
 , pp. 106 - 115
Publisher: Cambridge University Press
Print publication year: 2021

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References

Fitzmaurice, C, Akinyemiju, TF, Al Lami, FH et al. for the Global Burden of Disease Cancer Collaboration. Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-Years for 29 Cancer Groups, 1990 to 2016: A Systematic Analysis for the Global Burden of Disease Study. JAMA Oncol, 2018 June 2. DOI:10.1001/jamaoncol.2018.2706. [Epub ahead of print]Google Scholar
Engholm, G, Ferlay, J, Christensen, N et al. NORDCAN: Cancer Incidence, Mortality, Prevalence and Survival in the Nordic Countries. Association of the Nordic Cancer Registries. Danish Cancer Society 2014.Google Scholar
Surveillance, Epidemiology, and End Results (SEER) 5-year relative survival by site. SEER cancer statistics review 1975–2008. www.seer.cancer.govGoogle Scholar
Oktay, K, Harvey, BE, Partridge, AH et al. Fertility preservation in patients with cancer: ASCO clinical practice guideline update. J Clin Oncol, 2018 July 1;36(19):1994–2001.Google Scholar
Armuand, GM, Rodriguez-Wallberg, KA, Wettergren, L et al. Sex differences in fertility-related information received by young adult cancer survivors. J Clin Oncol, 2012;30(17):2147–2153.Google Scholar
Armuand, GM, Wettergren, L, Rodriguez-Wallberg, KA, Lampic, C. Women more vulnerable than men when facing risk for treatment-induced infertility: a qualitative study of young adults newly diagnosed with cancer. Acta Oncol, 2015 February;54(2):243–552.CrossRefGoogle ScholarPubMed
Fredholm, H, Eaker, S, Frisell, J et al. Breast cancer in young women: poor survival despite intensive treatment. PLoS One, 2009;4:e76957.Google Scholar
Curigliano, G, Burstein, HJ, Winer, EP et al.; Panel Members of the St. Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2017. Ann Oncol, 2018 May 3. DOI:10.1093/annonc/mdx806.[Epub ahead of print]CrossRefGoogle Scholar
Rodriguez-Wallberg, KA. Principles of cancer treatment: impact on reproduction. Adv Exp Med Biol, 2012;732:1–8.Google Scholar
Sonmezer, M, Oktay, K. Fertility preservation in young women undergoing breast cancer therapy. Oncologist, 2006;11(5):422–434.CrossRefGoogle ScholarPubMed
Rodriguez-Wallberg, KA, Oktay, K. Fertility preservation and pregnancy in women with and without BRCA mutation-positive breast cancer. Oncologist, 2012;17:1409–1417.Google Scholar
Ethics Committee of the American Society for Reproductive Medicine. Fertility preservation and reproduction in patients facing gonadotoxic therapies: an Ethics Committee opinion. Fertil Steril, 2018 August;110(3):380–386.CrossRefGoogle Scholar
Lambertini, M, Fontana, V, Massarotti, C et al. Prospective study to optimize care and improve knowledge on ovarian function and/or fertility preservation in young breast cancer patients: results of the pilot phase of the PREgnancy and FERtility (PREFER) study. Breast, 2018 June 22;41:51–56.CrossRefGoogle ScholarPubMed
Rodriguez-Wallberg, KA, Tanbo, T, Tinkanen, H et al. Ovarian tissue cryopreservation and transplantation among alternatives for fertility preservation in the Nordic countries – compilation of 20 years of multicenter experience. Acta Obstet Gynecol Scand, 2016 September;95(9):1015–1026.Google Scholar
Oktay, K, Buyuk, E, Davis, O et al. Fertility preservation in breast cancer patients: IVF and embryo cryopreservation after ovarian stimulation with tamoxifen. Hum Reprod, 2003;18(1):90–95.CrossRefGoogle ScholarPubMed
Meirow, D, Raanani, H, Maman, E et al. Tamoxifen co-administration during controlled ovarian hyperstimulation for in vitro fertilization in breast cancer patients increases the safety of fertility-preservation treatment strategies. Fertil Steril, 2014 August;102(2):488–495.Google Scholar
Fisk, NM, Templeton, AA, Papadopoulos, GC, Matlin, SA, Wu, ZY. Lack of effect of high-dose antioestrogen on the maturation and in-vitro fertilization of human oocytes. Hum Reprod, 1989 July;4(5):584–587.CrossRefGoogle ScholarPubMed
Tulandi, T, Martin, J, Al-Fadhli, R et al. Congenital malformations among 911 newborns conceived after infertility treatment with letrozole or clomiphene citrate. Fertil Steril, 2006;85(6):1761–1765.CrossRefGoogle ScholarPubMed
Ata, B, Tulandi, T. Reassurance of safety of letrozole and suggested approaches in controlled ovarian hyperstimulation. Fertil Steril, 2009 July;92(1):e6.Google Scholar
Oktay, K, Hourvitz, A, Sahin, G et al. Letrozole reduces estrogen and gonadotropin exposure in women with breast cancer undergoing ovarian stimulation before chemotherapy. J Clin Endocrinol Metab, 2006;91(10):3885–3890.Google Scholar
Azim, AA, Costantini-Ferrando, M, Lostritto, K, Oktay, K. Relative potencies of anastrozole and letrozole to suppress estradiol in breast cancer patients undergoing ovarian stimulation before in vitro fertilization. J Clin Endocrinol Metab, 2007;92(6):2197–2200.CrossRefGoogle ScholarPubMed
Oktay, K, Hourvitz, A, Sahin, G et al. Letrozole reduces estrogen and gonadotropin exposure in women with breast cancer undergoing ovarian stimulation before chemotherapy. J Clin Endocrinol Metab, 2006 October;91(10):3885–3890.Google Scholar
Oktay, K, Türkçüoglu, I, Rodriguez-Wallberg, KA. GnRH agonist trigger for women with breast cancer undergoing fertility preservation by aromatase inhibitor/FSH stimulation. Reprod Biomed Online, 2010;20(6):783–788.Google Scholar
Sönmezer, M1, Türkçüoğlu, I, Coşkun, U, Oktay, K. Random-start controlled ovarian hyperstimulation for emergency fertility preservation in letrozole cycles. Fertil Steril, 2011 May;95(6):2125.e9–11.CrossRefGoogle ScholarPubMed
Oktay, K, Buyuk, E, Rodriguez-Wallberg, KA, Sahin, G. In vitro maturation improves oocyte or embryo cryopreservation outcome in breast cancer patients undergoing ovarian stimulation for fertility preservation. Reprod Biomed Online, 2010 May;20(5):634–638.Google Scholar
Gellert, SE, Pors, SE, Kristensen, SG et al. Transplantation of frozen-thawed ovarian tissue: an update on worldwide activity published in peer-reviewed papers and on the Danish cohort. J Assist Reprod Genet, 2018 April;35(4):561–570.Google Scholar
Azim, AA, Costantini-Ferrando, M, Oktay, K. Safety of fertility preservation by ovarian stimulation with letrozole and gonadotropins in patients with breast cancer: a prospective controlled study. J Clin Oncol, 2008;26:2630–2635.CrossRefGoogle ScholarPubMed
Kim, J, Turan, V, Oktay, K. Long-term safety of letrozone and gonadotropin stimulation for fertility preservation in women with breast cancer. J Clin Endocrinol Metab, 2016;101(4):1364–1371, jc20153878.Google Scholar
Rodriguez-Wallberg, KA, Eloranta, S, Krawiec, K et al. Safety of fertility preservation in breast cancer patients in a register-based matched cohort study. Breast Cancer Res Treat 2018 February;167 (3):761–769.Google Scholar
Kroman, N, Jensen, MB, Wohlfahrt, J, Ejlertsen, B; Danish Breast Cancer Cooperative Group. Pregnancy after treatment of breast cancer–a population-based study on behalf of Danish Breast Cancer Cooperative Group. Acta Oncol, 2008;47(4):545–549.Google Scholar
Azim, HA Jr, Santoro, L, Pavlidis, N et al. Safety of pregnancy following breast cancer diagnosis: a meta-analysis of 14 studies. Eur J Cancer, 2011 January;47(1):74–83.Google Scholar
Hartman, EK, Eslick, GD. The prognosis of women diagnosed with breast cancer before, during and after pregnancy: a meta-analysis. Breast Cancer Res Treat, 2016 November;160(2):347–360.CrossRefGoogle ScholarPubMed
Sankila, R, Heinävaara, S, Hakulinen, T. Survival of breast cancer patients after subsequent term pregnancy: “healthy mother effect”. Am J Obstet Gynecol, 1994 March;170(3):818–823.CrossRefGoogle ScholarPubMed
Dalberg, K, Eriksson, J, Holmberg, L. Birth outcome in women with previously treated breast cancer–a population-based cohort study from Sweden. PLoS Med, 2006;3(9):e336.Google Scholar
Marklund, A, Nasiell, J, Berger, AS, Fagerberg, A, Rodriguez-Wallberg, KA. Pregnancy achieved using donor eggs in cancer survivors with treatment-induced ovarian failure: obstetric and perinatal outcome. J Womens Health (Larchmt), 2018 July;27(7):939–945.Google Scholar

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