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Chapter 21 - Stem Cells and Brain Repair: Ethical Considerations

from Part III - Future Developments

Published online by Cambridge University Press:  29 May 2020

By
Ivar Mendez
Edited by
Stephen Honeybul
Stephen Honeybul
Affiliation:
Sir Charles Gairdner Hospital, Royal Perth and Fiona Stanley Hospitals
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Summary

The rapid advance of research in stem cells has opened the door for their potential use in cell-based therapies to treat neurological conditions some of them incurable to date. Encouraging studies in animal models are moving into early phase clinical trials that hold realistic promise for the future. However, important ethical challenges remain as stem cells are translated from preclinical research to the clinical realm.Translation of stem cell–based therapies must be framed within a rigorous scientific and ethical process. This framework extends to the continuum of basic science in the laboratory, subsequent animal studies to the execution of early and late phase clinical trials in humans.Neurosurgery will play a fundamental role in the stem cell therapies of the future. New neurosurgical techniques and instruments will be developed for the delivery of stem cells to single or multiple targets within the CNS. Neurosurgeon’s roles will expand as stem cells move from clinical trials to effective potential therapies. This chapter will review selected stem cell ethical issues, that may inform and guide the practicing neurosurgeon in a rapidly moving field of great scientific promise, as well as ethical challenges

Keywords

stem cellsbrain repairstem cell ethicsfunctional neurosurgeryreconstructive neurosurgeryneural transplantationneurosurgical ethicsstereotactic neurosurgery
Type
Chapter
Information
Ethics in Neurosurgical Practice , pp. 214 - 223
Publisher: Cambridge University Press
Print publication year: 2020

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References

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