Book contents
- Frontmatter
- Contents
- CONTRIBUTORS
- PREFACE
- Chap. 1 CELL INJURY AND CELL DEATH
- Chap. 2 CLEAN AND ASEPTIC TECHNIQUE AT THE BEDSIDE
- Chap. 3 NEW ANTIMICROBIALS
- Chap. 4 IMMUNOMODULATORS AND THE “BIOLOGICS” IN CUTANEOUS EMERGENCIES
- Chap. 5 CRITICAL CARE: STUFF YOU REALLY, REALLY NEED TO KNOW
- Chap. 6 ACUTE SKIN FAILURE: CONCEPT, CAUSES, CONSEQUENCES, AND CARE
- Chap. 7 CUTANEOUS SYMPTOMS AND NEONATAL EMERGENCIES
- Chap. 8 NECROTIZING SOFT-TISSUE INFECTIONS, INCLUDING NECROTIZING FASCIITIS
- Chap. 9 LIFE-THREATENING BACTERIAL SKIN INFECTIONS
- Chap. 10 BACTEREMIA, SEPSIS, SEPTIC SHOCK, AND TOXIC SHOCK SYNDROME
- Chap. 11 STAPHYLOCOCCAL SCALDED SKIN SYNDROME
- Chap. 12 LIFE-THREATENING CUTANEOUS VIRAL DISEASES
- Chap. 13 LIFE-THREATENING CUTANEOUS FUNGAL AND PARASITIC DISEASES
- Chap. 14 LIFE-THREATENING STINGS, BITES, AND MARINE ENVENOMATIONS
- Chap. 15 SEVERE, ACUTE ADVERSE CUTANEOUS DRUG REACTIONS I: STEVENS–JOHNSON SYNDROME AND TOXIC EPIDERMAL NECROLYSIS
- Chap. 16 SEVERE, ACUTE ADVERSE CUTANEOUS DRUG REACTIONS II: DRESS SYNDROME AND SERUM SICKNESS-LIKE REACTION
- Chap. 17 SEVERE, ACUTE COMPLICATIONS OF DERMATOLOGIC THERAPIES
- Chap. 18 SEVERE, ACUTE ALLERGIC AND IMMUNOLOGICAL REACTIONS I: URTICARIA, ANGIOEDEMA, MASTOCYTOSIS, AND ANAPHYLAXIS
- Chap. 19 SEVERE, ACUTE ALLERGIC AND IMMUNOLOGICAL REACTIONS II: OTHER HYPERSENSITIVITIES AND IMMUNE DEFECTS, INCLUDING HIV
- Chap. 20 GRAFT VERSUS HOST DISEASE
- Chap. 21 ERYTHRODERMA/EXFOLIATIVE DERMATITIS
- Chap. 22 ACUTE, SEVERE BULLOUS DERMATOSES
- Chap. 23 EMERGENCY MANAGEMENT OF PURPURA AND VASCULITIS, INCLUDING PURPURA FULMINANS
- Chap. 24 EMERGENCY MANAGEMENT OF CONNECTIVE TISSUE DISORDERS AND THEIR COMPLICATIONS
- Chap. 25 SKIN SIGNS OF SYSTEMIC INFECTIONS
- Chap. 26 SKIN SIGNS OF SYSTEMIC NEOPLASTIC DISEASES AND PARANEOPLASTIC CUTANEOUS SYNDROMES
- Chap. 27 BURN INJURY
- Chap. 28 EMERGENCY DERMATOSES OF THE ANORECTAL REGIONS
- Chap. 29 EMERGENCY MANAGEMENT OF SEXUALLY TRANSMITTED DISEASES AND OTHER GENITOURETHRAL DISORDERS
- Chap. 30 EMERGENCY MANAGEMENT OF ENVIRONMENTAL SKIN DISORDERS: HEAT, COLD, ULTRAVIOLET LIGHT INJURIES
- Chap. 31 ENDOCRINOLOGIC EMERGENCIES IN DERMATOLOGY
- Chap. 32 EMERGENCY MANAGEMENT OF SKIN TORTURE AND SELF-INFLICTED DERMATOSES
- Chap. 33 SKIN SIGNS OF POISONING
- Chap. 34 DISASTER PLANNING: MASS CASUALTY MANAGEMENT
- Chap. 35 CATASTROPHES IN COSMETIC PROCEDURES
- Chap. 36 LIFE-THREATENING DERMATOSES IN TRAVELERS
- Index
- References
Chap. 15 - SEVERE, ACUTE ADVERSE CUTANEOUS DRUG REACTIONS I: STEVENS–JOHNSON SYNDROME AND TOXIC EPIDERMAL NECROLYSIS
Published online by Cambridge University Press: 07 September 2011
- Frontmatter
- Contents
- CONTRIBUTORS
- PREFACE
- Chap. 1 CELL INJURY AND CELL DEATH
- Chap. 2 CLEAN AND ASEPTIC TECHNIQUE AT THE BEDSIDE
- Chap. 3 NEW ANTIMICROBIALS
- Chap. 4 IMMUNOMODULATORS AND THE “BIOLOGICS” IN CUTANEOUS EMERGENCIES
- Chap. 5 CRITICAL CARE: STUFF YOU REALLY, REALLY NEED TO KNOW
- Chap. 6 ACUTE SKIN FAILURE: CONCEPT, CAUSES, CONSEQUENCES, AND CARE
- Chap. 7 CUTANEOUS SYMPTOMS AND NEONATAL EMERGENCIES
- Chap. 8 NECROTIZING SOFT-TISSUE INFECTIONS, INCLUDING NECROTIZING FASCIITIS
- Chap. 9 LIFE-THREATENING BACTERIAL SKIN INFECTIONS
- Chap. 10 BACTEREMIA, SEPSIS, SEPTIC SHOCK, AND TOXIC SHOCK SYNDROME
- Chap. 11 STAPHYLOCOCCAL SCALDED SKIN SYNDROME
- Chap. 12 LIFE-THREATENING CUTANEOUS VIRAL DISEASES
- Chap. 13 LIFE-THREATENING CUTANEOUS FUNGAL AND PARASITIC DISEASES
- Chap. 14 LIFE-THREATENING STINGS, BITES, AND MARINE ENVENOMATIONS
- Chap. 15 SEVERE, ACUTE ADVERSE CUTANEOUS DRUG REACTIONS I: STEVENS–JOHNSON SYNDROME AND TOXIC EPIDERMAL NECROLYSIS
- Chap. 16 SEVERE, ACUTE ADVERSE CUTANEOUS DRUG REACTIONS II: DRESS SYNDROME AND SERUM SICKNESS-LIKE REACTION
- Chap. 17 SEVERE, ACUTE COMPLICATIONS OF DERMATOLOGIC THERAPIES
- Chap. 18 SEVERE, ACUTE ALLERGIC AND IMMUNOLOGICAL REACTIONS I: URTICARIA, ANGIOEDEMA, MASTOCYTOSIS, AND ANAPHYLAXIS
- Chap. 19 SEVERE, ACUTE ALLERGIC AND IMMUNOLOGICAL REACTIONS II: OTHER HYPERSENSITIVITIES AND IMMUNE DEFECTS, INCLUDING HIV
- Chap. 20 GRAFT VERSUS HOST DISEASE
- Chap. 21 ERYTHRODERMA/EXFOLIATIVE DERMATITIS
- Chap. 22 ACUTE, SEVERE BULLOUS DERMATOSES
- Chap. 23 EMERGENCY MANAGEMENT OF PURPURA AND VASCULITIS, INCLUDING PURPURA FULMINANS
- Chap. 24 EMERGENCY MANAGEMENT OF CONNECTIVE TISSUE DISORDERS AND THEIR COMPLICATIONS
- Chap. 25 SKIN SIGNS OF SYSTEMIC INFECTIONS
- Chap. 26 SKIN SIGNS OF SYSTEMIC NEOPLASTIC DISEASES AND PARANEOPLASTIC CUTANEOUS SYNDROMES
- Chap. 27 BURN INJURY
- Chap. 28 EMERGENCY DERMATOSES OF THE ANORECTAL REGIONS
- Chap. 29 EMERGENCY MANAGEMENT OF SEXUALLY TRANSMITTED DISEASES AND OTHER GENITOURETHRAL DISORDERS
- Chap. 30 EMERGENCY MANAGEMENT OF ENVIRONMENTAL SKIN DISORDERS: HEAT, COLD, ULTRAVIOLET LIGHT INJURIES
- Chap. 31 ENDOCRINOLOGIC EMERGENCIES IN DERMATOLOGY
- Chap. 32 EMERGENCY MANAGEMENT OF SKIN TORTURE AND SELF-INFLICTED DERMATOSES
- Chap. 33 SKIN SIGNS OF POISONING
- Chap. 34 DISASTER PLANNING: MASS CASUALTY MANAGEMENT
- Chap. 35 CATASTROPHES IN COSMETIC PROCEDURES
- Chap. 36 LIFE-THREATENING DERMATOSES IN TRAVELERS
- Index
- References
Summary
ADVERSE CUTANEOUS drug reactions (ADRs) are frequent, affecting 2%–3% of all hospitalized patients. Fortunately, only approximately 2% of ADRs are severe, and few are fatal.
Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are acute, severe, life-threatening diseases with a mortality rate reaching 30%. Only prompt recognition, diagnosis, and referral to an intensive care unit or burn care unit might improve the prognosis and save the patient's life.
HISTORICAL BACKGROUND
In his classic 1866 treatise “On Disease of the Skin,” Ferdinand von Hebra precisely described and gave the name to erythema multiforme (EM). In 1922, two American physicians, Stevens and Johnson, described two patients, boys 7 and 8 years old, who had “an extraordinary, generalized eruption with continued fever, inflamed buccal mucosa, and severe purulent conjunctivitis” that was later given the name “Stevens–Johnson syndrome.” In 1950, Thomas divided EM into two categories: erythema multiforme minor (von Hebra) and erythema multiforme major, also known as SJS. In 1956, Alan Lyell wrote the most highly cited article ever to appear in The British Journal of Dermatology: He described four patients with a scalding disease, which was later given the name toxic epidermal necrolysis (TEN), or the Lyell syndrome or Lyell disease. These severe, acute, life-threatening ADRs were not classified and defined according to their clinical appearance and/or linked to their etiology and prognosis until around 1993.
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- Emergency Dermatology , pp. 154 - 161Publisher: Cambridge University PressPrint publication year: 2011
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