This chapter addresses ocular inflammatory conditions such as conjunctivitis (allergic and infectious) and keratitis. For nearly all types of ocular inflammatory pain, ranging from traumatic inflammation to edema to allergic conjunctivitis, topical NSAIDs have proven useful. Topical NSAIDs also provide effective pain relief for allergic conjunctivitis. When corticosteroids are to be applied topically for infectious conjunctivitis, RCT evidence supports the use of dexamethasone. The historical role of cycloplegics in ocular conditions is based on their reduction of ciliary spasm-associated pain. Agents such as cyclopentolate are used in a variety of ocular inflammatory conditions, having been reported useful adjuncts for conditions ranging from keratoconjunctivitis-related ulcers to fungal iritis and plant sap-related conjunctivitis. The cycloplegics are particularly useful in traumatic or other etiologies of iritis, also contraindicated is the use of cycloplegics in patients with potential for angle-closure glaucoma.