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Chapter 32 - Vulvar Malignancies

from Section 6 - Vulva and Vagina

Published online by Cambridge University Press:  24 November 2021

Tahir Mahmood
Affiliation:
Victoria Hospital, Kirkcaldy
Charles Savona-Ventura
Affiliation:
University of Malta, Malta
Ioannis Messinis
Affiliation:
University of Thessaly, Greece
Sambit Mukhopadhyay
Affiliation:
Norfolk & Norwich University Hospital, UK
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Summary

Vulvar carcinoma is a relatively rare cancer entity. However, this disease, in contrast to other gynaecological cancers, recently showed an increasing incidence, including young women. Despite showing a poor response on the administration of chemotherapeutics, vulvar carcinomas have excellent response to surgical treatment when detected in early stages. More than other cancer entities and especially in young females, treatment of vulvar cancer effects body image, sexuality, quality of life and sexual activity. Interdisciplinary decision making, a stage-conforming therapy accompanied with low invasiveness (e.g. lymphadenectomy using the sentinel technique) and further treatment regimens (e.g. radiation) are important steps to preserve the sensitivity and function of the vulva and adjacent organs. Surgical treatment procedures for vulvar cancers have changed during recent years towards tissue-sparing oncoplastic and reconstructive surgery. Previously applied radical surgical approaches, such as en-bloc resection, are often associated with high postoperative morbidity, vulvar deformity and sexual dissatisfaction.

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Publisher: Cambridge University Press
Print publication year: 2021

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References

Gatta, G, Capocaccia, R, Botta, L, et al. Burden and centralised treatment in Europe of rare tumours: results of RARECAREnet – a population-based study. Lancet Oncol 2017;18:10221039.CrossRefGoogle ScholarPubMed
Noone, AM, Howlader, N, Krapcho, M, et al. SEER Cancer Statistics Review, 1975–2015. Bethesda, MD: National Cancer Institute.Google Scholar
Hampel, M, Deckers-Figiel, S, Hapl, JA, Rein, D, Bender, HG. New aspects of vulvar cancer: changes in localization and age of onset. Gynecol Oncol 2008;109:340345.Google Scholar
Al-Ghamdi, A, Freedman, D, Miller, D, et al. Vulvar squamous cell carcinoma in young women: a clinicopathologic study of 21 cases. Gynecol Oncol 2002;84:94101.Google Scholar
Jones, RW, Baranyai, J, Stables, S. Trends in squamous cell carcinoma of the vulva: the influence of vulva intraepithelial neoplasia. Obstet Gynecol 1997;90:448452.Google Scholar
Skapa, P, Zamecnik, J, Hamsikova, E, et al. Human papillomavirus (HPV) profiles of vulvar lesions: possible implications for the classification of vulvar squamous cell carcinoma precursors and for the efficacy of prophylactic HPV vaccination. Am J Surg Pathol 2007;31:18341843.Google Scholar
Hoevenaars, BM, van der Avoort, IA, de Wilde, PC, et al. A panel of p16(INK4A), MIB1 and p53 proteins can distinguish between the 2 pathways leading to vulvar squamous cell carcinoma. Int J Cancer 2008;123:27672773.Google Scholar
Del Pino, M, Rodriguez-Carunchio, L, Ordi, J. Pathways of vulvar intraepithelial neoplasia and squamous cell carcinoma. Histopathology 2013;62:161175.Google Scholar
Wilkinson, EJ. Premalignant and malignant tumors of the vulva. In: Blaustein’s Pathology of the Female Genital Tract. New York: Springer; 2011, pp. 106154.Google Scholar
Ansink, A, van der Velden, J. Surgical interventions for early squamous cell carcinoma of the vulva. Cochrane Database Syst Rev 2000;2:CD002036.Google Scholar
Micheletti, L, Preti, M, Zola, P, et al. A proposed glossary of terminology related to the surgical treatment of vulvar carcinoma. Cancer 1998;83:13691375.3.0.CO;2-2>CrossRefGoogle Scholar
Heaps, JM, Fu, YS, Montz, FJ, Hacker, NF, Berek, JS. Surgical-pathologic variables predictive of local recurrence in squamous cell carcinoma of the vulva. Gynecol Oncol 1990;38:309314.Google Scholar
Burke, TW, Levenback, C, Coleman, RL, et al. Surgical therapy of T1 and T2 vulvar carcinoma: further experience with radical wide excision and selective inguinal lymphadenectomy. Gynecol Oncol 1995;57:215220.Google Scholar
Van Doorn, HC, Ansink, A, Verhaar-Langereis, M, Stalpers, L. Neoadjuvant chemoradiation for advanced primary vulvar cancer. Cochrane Database Syst Rev 2006;3:CD003752.Google Scholar
Pleunis, N, Leermakers, MEJ, van der Wurff, AA, et al. Surgical margins in squamous cell carcinoma, different for the vulva? Eur J Surg Oncol 2018;44:15551560.Google Scholar
Van der Zee, AG, Oonk, MH, De Hullu, JA, et al. Sentinel node dissection is safe in the treatment of early-stage vulvar cancer. J Clin Oncol 2008;26:884889.CrossRefGoogle ScholarPubMed
Oonk, MH, van Hemel, BM, Hollema, H, et al. Size of sentinel-node metastasis and chances of non-sentinel-node involvement and survival in early stage vulvar cancer: results from GROINSS-V, a multicentre observational study. Lancet Oncol 2010;11:646652.Google Scholar
Schnürch, HG, Ackermann, S, Alt, CD, et al. Diagnosis, therapy and follow-up care of vulvar cancer and its precursors. Guideline of the DGGG and DKG (S2 k-Level, AWMF Registry Number 015/059, November 2015). Geburtshilfe Frauenheilkd 2016;76:10351049.Google Scholar
Höckel, M, Schmidt, K, Bornmann, K, Horn, LC, Dornhöfer, N. Vulvar field resection: novel approach to the surgical treatment of vulvar cancer based on ontogenetic anatomy. Gynecol Oncol 2010;119:106113.Google Scholar
Godoy, H, Vaddadi, P, Cooper, M, et al. Photodynamic therapy effectively palliates gynecologic malignancies. Eur J Gynaecol Oncol 2013;34:300302.Google Scholar
Edey, KA, Allan, E, Murdoch, JB, Cooper, S, Bryant, A. Interventions for the treatment of Paget’s disease of the vulva. Cochrane Database Syst Rev 2013;10:CD009245.Google Scholar
Weiss, M, Stope, MB. Physical plasma: a new treatment option in gynecological oncology. Arch Gynecol Obstet 2018. doi:10.1007/s00404-018-4889-z.Google Scholar
Barnes, EA, Thomas, G. Integrating radiation into the management of vulvar cancer. Semin Radiat Oncol 2006;16:168176.Google Scholar
Cunningham, MJ. Primary radiation, cisplatin, and 5-fluorouracil for advanced squamous carcinoma of the vulva. Gynecol Oncol 1997;66:258261.Google Scholar
Gerszten, K, Selvaraj, RN, Kelley, J, Faul, C. Preoperative chemoradiation for locally advanced carcinoma of the vulva. Gynecol Oncol 2005;99:640644.Google Scholar
Montana, GS, Thomas, GM, Moore, DH, et al. Preoperative chemo-radiation for carcinoma of the vulva with N2/N3 nodes: a gynecologic oncology group study. Int J Radiat Oncol Biol Phys 2000;48:10071013.Google Scholar
Mahner, S, Jueckstock, J, Hilpert, F, et al. Adjuvant therapy in lymph node positive vulvar cancer: the AGO-CaRE-1 study. J Natl Cancer Inst 2015;107. doi:10.1093/jnci/dju426.Google Scholar
Wahlen, SA, Slater, JD, Wagner, RJ, et al. Concurrent radiation therapy and chemotherapy in the treatment of primary squamous cell carcinoma of the vulva. Cancer 1995;75:22892294.Google Scholar
Thomas, GM. Gynaecologic tumors overview. In: Clinical Radiation Oncology. Philadelphia, PA: Elsevier; 2016.Google Scholar
Homesley, HD, Bundy, BN, Sedlis, A, Adcock, L. Radiation therapy versus pelvic node resection for carcinoma of the vulva with positive groin nodes. Obstet Gynecol 1986;68:733740.Google Scholar
Benedetti-Panici, P, Greggi, S, Scambia, G, Salerno, G, Mancuso, S. Cisplatin (P), bleomycin (B), and methotrexate (M) preoperative chemotherapy in locally advanced vulvar carcinoma. Gynecol Oncol 1993;50:4953.Google Scholar
Domingues, AP, Mota, F, Durão, M, et al. Neoadjuvant chemotherapy in advanced vulvar cancer. Int J Gynecol Cancer 2010;20:294298.Google Scholar
Bellati, F, Angioli, R, Manci, N, et al. Single agent cisplatin chemotherapy in surgically resected vulvar cancer patients with multiple inguinal lymph node metastases. Gynecol Oncol 2005;96:227231.Google Scholar
Cormio, G, Loizzi, V, Gissi, F, et al. Cisplatin and vinorelbine chemotherapy in recurrent vulvar carcinoma. Oncology 2009;77:281284.Google Scholar
Witteveen, PO, van der Velden, J, Vergote, I, et al. Phase II study on paclitaxel in patients with recurrent, metastatic or locally advanced vulvar cancer not amenable to surgery or radiotherapy: a study of the EORTC-GCG (European Organisation for Research and Treatment of Cancer–Gynaecological Cancer Group). Ann Oncol 2009;20:15111516.Google Scholar
Wagenaar, HC, Colombo, N, Vergote, I, et al. Bleomycin, methotrexate, and CCNU in locally advanced or recurrent, inoperable, squamous-cell carcinoma of the vulva: an EORTC Gynaecological Cancer Cooperative Group Study. European Organization for Research and Treatment of Cancer. Gynecol Oncol 2001;81:348354.Google Scholar

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