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Chapter 60 - Radiotherapy for Gynaecological Cancer

from Section 12 - Miscellaneous

Published online by Cambridge University Press:  24 November 2021

By
Pedro B. Fernandes
Edited by
Tahir Mahmood ,
Charles Savona-Ventura ,
Ioannis Messinis  and
Sambit Mukhopadhyay
Tahir Mahmood
Affiliation:
Victoria Hospital, Kirkcaldy
Charles Savona-Ventura
Affiliation:
University of Malta, Malta
Ioannis Messinis
Affiliation:
University of Thessaly, Greece
Sambit Mukhopadhyay
Affiliation:
Norfolk & Norwich University Hospital, UK
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Summary

Radiation therapy is one of the major treatment modalities for gynaecological malignancies. It has been used for more than 100 years, since Pierre Becquerel first identified the potential medical uses of radiation. Some years later, in the twentieth century, Marie Curie, among others, introduced brachytherapy (BT) in treating gynaecological cancers. This treatment modality remains the most effective non-surgical treatment of cancer.

Keywords

radiotherapycancerbrachytherapyexternal beam radiation therapy
Type
Chapter
Information
The EBCOG Postgraduate Textbook of Obstetrics & Gynaecology
Gynaecology
 , pp. 513 - 523
Publisher: Cambridge University Press
Print publication year: 2021

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References

Further Reading

N.C.C. Network. Uterine neoplasms. NCCN Clinical Practice in Oncology. 2019Google Scholar
N.C.C. Network. Cervical cancer. NCCN Clinical Practice in Oncology. 2019Google Scholar
N.C.C. Network. Vulvar cancer. NCCN Clinical Practice in Oncology. 2019.Google Scholar
Colombo, N, Creutzberg, C, Amant, F, et al. ESMO–ESGO–ESTRO Consensus Conference on Endometrial Cancer: diagnosis, treatment and follow-up. Ann Oncol 2016;27:16–41.Google Scholar
Schwarz, J, Beriwall, S, Esthappan, J, et al. Consensus statement for brachytherapy for the treatment of medically inoperable endometrial cancer. Brachytherapy J 2015;14:587–599.Google Scholar
Albuquerque, K, Hrycushko, B, Harkenrider, M, et al. Compendium of fractionation choices for gynecologic HDR brachytherapy: An American Brachytherapy Society Task Group Report. Brachytherapy J (in press).Google Scholar
ACOG. Diagnosis and treatment of cervical carcinomas. Int J Gynaecol Obstet 2002;78:79–91.Google Scholar
Hansen, EC, Roach, M II. Handbook of Evidence-Based Radiation Oncology. New York: Springer.Google Scholar

References

Nout, RA, Smit, VT, Putter, H, et al. Vaginal brachytherapy versus pelvic external beam radiotherapy for patients with endometrial cancer of high-intermediate risk (PORTEC-2): an open-label, non-inferiority, randomised trial. Lancet 2010;375:816–823.Google Scholar
Creutzberg, CL, van Putten, WL, Koper, PC, et al. Surgery and postoperative radiotherapy versus surgery alone for patients with stage-1 endometrial carcinoma: multicentre randomised trial. PORTEC Study Group Post Operative Radiation Therapy in Endometrial Carcinoma. Lancet 2000;355:1404–1411.Google Scholar
Writing Committee on Behalf of the ASTEC Study Group. Efficacy of systematic pelvic lymphadenectomy in endometrial cancer (MRC ASTEC trial): a randomised study. Lancet 2009;373:125-136.Google Scholar
de Boer, SM, Powell, ME, Mileshkin, L., et al. Toxicity and quality of life after adjuvant chemoradiotherapy versus radiotherapy alone for women with high-risk endometrial cancer (PORTEC-3): an open-label, multicentre, randomised, phase 3 trial. Lancet Oncol 2016;17:1114–1126Google Scholar
N.C.C. Network. Uterine neoplasms. NCCN Clinical Practice in Oncology. 2019.Google Scholar
Colombo, N, Creutzberg, C, Amant, F., et al. ESMO-ESGO-ESTRO Consensus Conference on Endometrial Cancer: diagnosis, treatment and follow-up. Ann Oncol 27;2016:16–41Google Scholar
Reichardt, P. The treatment of uterine sarcomas. Ann Oncol 2012;23(Suppl. 10):x151–x157.Google Scholar
Moore, DH, Thomas, GM, Montana, GS, et al. Preoperative chemoradiation for advanced vulvar cancer: a phase II study of the Gynecologic Oncology Group. Int J Radiat Oncol Biol Phys 1998;42:79–85.Google Scholar
Moore, DH, Ali, S, Koh, W-J, et al. A phase II trial of radiation therapy and weekly cisplatin chemotherapy for the treatment of locally-advanced squamous cell carcinoma of the vulva: a gynecologic oncology group study. Gynecol Oncol 2012;124:529–533.Google Scholar

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