Skip to main content Accessibility help
×
Hostname: page-component-586b7cd67f-rdxmf Total loading time: 0 Render date: 2024-11-23T07:38:40.191Z Has data issue: false hasContentIssue false

11 - Biomarkers for Alzheimer’s Disease

Published online by Cambridge University Press:  19 January 2024

Daniel Gibbs
Affiliation:
Emeritus of Oregon Health and Science University
Get access

Summary

Brain imaging tests such as CT and MRI scans can be helpful biomarkers for frontotemporal dementia because of the typical atrophy of the frontal and temporal lobes sparing more posterior parts of the brain. For other types of dementia, these imaging tests are not as helpful, although they may be important to rule out tumors, strokes, and hydrocephalus (excess fluid in the brain). Over the last ten years or so, PET scans that can image beta-amyloid plaques and tau-containing tangles have been developed and are now clinically available. These scans can be very useful in confirming a diagnosis of Alzheimer’s and staging the severity of the disease in research settings. However, they are very expensive and often not covered by insurance, presenting barriers for clinical use outside of research.

Type
Chapter
Information
Publisher: Cambridge University Press
Print publication year: 2024

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Mori, E, Ikeda, M, Nagai, R, et al. Long-term donepezil use for dementia with Lewy bodies: Results from an open-label extension of Phase III trial. Alzheimers Res Ther 2015; 7: 5. https://doi.org/10.1186/s13195-014-0081-2. PMID: 25713600; PMCID: PMC4338564 (open access).CrossRefGoogle ScholarPubMed
Milà-Alomà, M, Ashton, NJ, Shekari, Met alPlasma p-tau231 and p-tau217 as state markers of amyloid-β pathology in preclinical Alzheimer’s diseaseNat Med 2022; 28: 17971801. https://doi.org/10.1038/s41591-022-01925-w (open access).Google ScholarPubMed
Priemer, DS, Iacono, D, Rhodes, CH, et al. Chronic traumatic encephalopathy in the brains of military personnel. N Engl J Med 2022; 386: 21692177. https://doi.org/10.1056/NEJMoa2203199.CrossRefGoogle ScholarPubMed
Hansson, O, Edelmayer, RM, Boxer, AL, et al. The Alzheimer’s Association appropriate use recommendations for blood biomarkers in Alzheimer’s disease. Alzheimers Dement 2022; 18: 26692686. https://doi.org/10.1002/alz.12756. Epub 2022 Jul 31. PMID: 35908251 (open access).CrossRefGoogle ScholarPubMed

Save book to Kindle

To save this book to your Kindle, first ensure [email protected] is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Available formats
×

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

Available formats
×