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Published online by Cambridge University Press: 19 January 2024
In 2015 and again in 2018, I traveled to San Francisco to be a volunteer in a study of a then experimental PET scan for abnormal tau protein in the brain using a radioactive ligand called [18F]-AV1451. This radioactive ligand binds with high affinity to insoluble, paired-helical filaments of hyperphosphorylated tau, the principal component of neurofibrillary tangles. Although my three-year follow up scans were delayed by the Covid-19 pandemic, I returned with Lois in September, 2022 for third set of studies spread over two days. What made this visit different, other than having to wear masks throughout the visit, was the presence of the film crew that is making a documentary film based on my first book, A Tattoo on my Brain: A Neurologist’s Personal Battle against Alzheimer’s Disease.
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