Book contents
- Developmental Origins of Health and Disease
- Developmental Origins of Health and Disease
- Copyright page
- Contents
- Contributors
- Preface
- Section I Overview
- Section II Exposures Driving Long-Term DOHaD Effects
- Section III Outcomes
- Section IV Mechanisms
- Section V Interventions
- Chapter 17 Interventions to Prevent DOHaD Effects in Pregnancy
- Chapter 18 Interventions to Prevent DOHaD Effects in Infancy and Early Childhood
- Section VI Public Health and Policy Implications of Interventions
- Index
- References
Chapter 17 - Interventions to Prevent DOHaD Effects in Pregnancy
from Section V - Interventions
Published online by Cambridge University Press: 01 December 2022
Book contents
- Developmental Origins of Health and Disease
- Developmental Origins of Health and Disease
- Copyright page
- Contents
- Contributors
- Preface
- Section I Overview
- Section II Exposures Driving Long-Term DOHaD Effects
- Section III Outcomes
- Section IV Mechanisms
- Section V Interventions
- Chapter 17 Interventions to Prevent DOHaD Effects in Pregnancy
- Chapter 18 Interventions to Prevent DOHaD Effects in Infancy and Early Childhood
- Section VI Public Health and Policy Implications of Interventions
- Index
- References
Summary
Numerous observational studies in mother-child cohorts have identified associations between adverse fetal exposures in utero and persistent consequences for the child in later life. These have prompted multiple randomized controlled trials (RCTs) in pregnant women to evaluate whether reversal of these exposures has the expected benefit for the health of the child. In this narrative review, the major categories of RCTs undertaken are introduced, and the outcomes addressed. In light of a preponderance of negative studies, reasons are explored including inadequacies in trial design and the rationale for intervening before conception, during pregnancy and after pregnancy.
- Type
- Chapter
- Information
- Developmental Origins of Health and Disease , pp. 177 - 188Publisher: Cambridge University PressPrint publication year: 2022
References
Nicholas, L. M. and Ozanne, S. E., Early life programming in mice by maternal overnutrition: mechanistic insights and interventional approaches. Philos Trans R Soc Lond B Biol Sci, 2019. 374(1770): p. 20180116.Google Scholar
Castro-Rodriguez, D. C., et al., Maternal interventions to prevent adverse fetal programming outcomes due to maternal malnutrition: evidence in animal models. Placenta, 2020. 102: pp. 49–54.CrossRefGoogle Scholar
Gatford, K. L., et al., Animal models of preeclampsia: causes, consequences, and interventions. Hypertension, 2020. 75(6): pp. 1363–1381.CrossRefGoogle Scholar
England, P. H. Health matters; Prevention- a life course approach. 2019; Available from:www.gov.uk/government/publications/health-matters-life-course-approach-to-prevention/health-matters-prevention-a-life-course-approach.Google Scholar
Kuruvilla, S., et al., A life-course approach to health: synergy with sustainable development goals. Bull World Health Organ, 2018. 96(1): pp. 42–50.CrossRefGoogle Scholar
Jones, N. L., et al., Life course approaches to the causes of health disparities. Am J Public Health, 2019. 109(S1): pp. S48–S55.CrossRefGoogle Scholar
Hetzel, P. A., et al., Genetic markers in Australian Caucasian subjects with coeliac disease. Tissue Antigens, 1987. 30(1): pp. 18–22.Google Scholar
Lowe, W. L., Jr., et al., Hyperglycemia and Adverse Pregnancy Outcome Follow-up Study (HAPO FUS): maternal gestational diabetes mellitus and childhood glucose metabolism. Diabetes Care, 2019. 42(3): pp. 372–380.Google Scholar
Raab, R., et al., Associations between lifestyle interventions during pregnancy and childhood weight and growth: a systematic review and meta-analysis. Int J Behav Nutr Phys Act, 2021. 18(1): p. 8.CrossRefGoogle Scholar
Rogozinska, E., et al., Effects of antenatal diet and physical activity on maternal and fetal outcomes: individual patient data meta-analysis and health economic evaluation. Health Technol Assess, 2017. 21(41): pp. 1–158.Google Scholar
Vincze, L., et al., Interventions including a nutrition component aimed at managing gestational weight gain or postpartum weight retention: a systematic review and meta-analysis. JBI Database System Rev Implement Rep, 2019. 17(3): pp. 297–364.Google Scholar
Poston, L., et al., Effect of a behavioural intervention in obese pregnant women (the UPBEAT study): a multicentre, randomised controlled trial. Lancet Diabetes Endocrinol, 2015. 3(10): pp. 767–777.CrossRefGoogle Scholar
Mills, H. L., et al., The effect of a lifestyle intervention in obese pregnant women on gestational metabolic profiles: findings from the UK Pregnancies Better Eating and Activity Trial (UPBEAT) randomised controlled trial. BMC Med, 2019. 17(1): p. 15.Google Scholar
Patel, N., et al., Mode of infant feeding, eating behaviour and anthropometry in infants at 6-months of age born to obese women – a secondary analysis of the UPBEAT trial. BMC Pregnancy Childbirth, 2018. 18(1): p. 355.Google Scholar
Dalrymple, K. V., et al., Adiposity and cardiovascular outcomes in three-year-old children of participants in UPBEAT, an RCT of a complex intervention in pregnant women with obesity. Pediatr Obes, 2021. 16(3): p. e12725.CrossRefGoogle Scholar
Bailey, C., et al., Are lifestyle interventions to reduce excessive gestational weight gain cost effective? A systematic review. Curr Diab Rep, 2020. 20(2): p. 6.Google Scholar
Chen, L. W., et al., Maternal dietary quality, inflammatory potential and childhood adiposity: an individual participant data pooled analysis of seven European cohorts in the ALPHABET consortium. BMC Med, 2021. 19(1): p. 33.Google Scholar
Moore, A. P., et al., Factors influencing pregnancy and postpartum weight management in women of African and Caribbean ancestry living in high income countries: systematic review and evidence synthesis using a behavioral change theoretical model. Front Public Health, 2021. 9: p. 637800.Google Scholar
Heslehurst, N., et al., Interventions to change maternity healthcare professionals’ behaviours to promote weight-related support for obese pregnant women: a systematic review. Implement Sci, 2014. 9: p. 97.Google Scholar
Mertens, L., Braeken, M., and Bogaerts, A., Effect of lifestyle coaching including telemonitoring and telecoaching on gestational weight gain and postnatal weight loss: A systematic review. Telemed J E Health, 2019. 25(10): pp. 889–901.Google Scholar
Garg, N., et al., Application of mobile technology for disease and treatment monitoring of gestational diabetes mellitus among pregnant women: a systematic review. J Diabetes Sci Technol, 2022 Mar; 16(2):491–497. doi: 10.1177/1932296820965577.Google Scholar
Saravanan, P., et al., Gestational diabetes: opportunities for improving maternal and child health. Lancet Diabetes Endocrinol, 2020. 8(9): pp. 793–800.Google Scholar
van Weelden, W., et al., Long-term effects of oral antidiabetic drugs during pregnancy on offspring: a systematic review and meta-analysis of follow-up studies of RCTs. Diabetes Ther, 2018. 9(5): pp. 1811–1829.CrossRefGoogle Scholar
Panagiotopoulou, O., et al., Metformin use in obese mothers is associated with improved cardiovascular profile in the offspring. Am J Obstet Gynecol, 2020. 223(2): pp. 246 e1–246 e10.Google Scholar
Oh, C., Keats, E. C., and Bhutta, Z. A., Vitamin and mineral supplementation during pregnancy on maternal, birth, child health and development outcomes in low- and middle-income countries: a systematic review and meta-analysis. Nutrients, 2020. 12(2); 491CrossRefGoogle Scholar
Jayasinghe, C., et al., The effect of universal maternal antenatal iron supplementation on neurodevelopment in offspring: a systematic review and meta-analysis. BMC Pediatr, 2018. 18(1): p. 150.Google Scholar
McCann, S., Perapoch Amado, M., and Moore, S. E., The role of iron in brain development: a systematic review. Nutrients, 2020. 12(7); 2001Google Scholar
Veena, S. R., et al., Association between maternal nutritional status in pregnancy and offspring cognitive function during childhood and adolescence; a systematic review. BMC Pregnancy Childbirth, 2016. 16: p. 220.Google Scholar
Larson, L. M. and Yousafzai, A. K., A meta-analysis of nutrition interventions on mental development of children under-two in low- and middle-income countries. Matern Child Nutr, 2017. 13(1);e12229Google Scholar
De-Regil, L. M., et al., Vitamin D supplementation for women during pregnancy. Cochrane Database Syst Rev, 2016(1): p. CD008873.Google Scholar
Larque, E., et al., Maternal and foetal health implications of vitamin D status during pregnancy. Ann Nutr Metab, 2018. 72(3): pp. 179–192.Google Scholar
Dawodu, A., et al., Randomized Controlled Trial (RCT) of vitamin D supplementation in pregnancy in a population with endemic vitamin D deficiency. J Clin Endocrinol Metab, 2013. 98(6): pp. 2337–2346.Google Scholar
Lawlor, D. A., et al., Association of maternal vitamin D status during pregnancy with bone-mineral content in offspring: a prospective cohort study. Lancet, 2013. 381(9884): pp. 2176–2183.Google Scholar
Woolford, S. J., et al., Prenatal influences on bone health in children. Expert Rev Endocrinol Metab, 2019. 14(3): pp. 193–202.CrossRefGoogle Scholar
Cooper, C., et al., Maternal gestational vitamin D supplementation and offspring bone health (MAVIDOS): a multicentre, double-blind, randomised placebo-controlled trial. Lancet Diabetes Endocrinol, 2016. 4(5): pp. 393–402.CrossRefGoogle Scholar
Brustad, N., et al., Effect of High-Dose vs Standard-Dose vitamin D supplementation in pregnancy on bone mineralization in offspring until age 6 years: a prespecified secondary analysis of a double-blinded, randomized clinical trial. JAMA Pediatr, 2020. 174(5): pp. 419–427.CrossRefGoogle Scholar
Kho, A. T., et al., Vitamin D related genes in lung development and asthma pathogenesis. BMC Med Genomics, 2013. 6: p. 47.Google Scholar
Tareke, A. A., et al., Prenatal vitamin D supplementation and child respiratory health: a systematic review and meta-analysis of randomized controlled trials. World Allergy Organ J, 2020. 13(12): p. 100486.Google Scholar
Best, K. P., Gomersall, J., and Makrides, M., Prenatal Nutritional Strategies to Reduce the Risk of Preterm Birth. Ann Nutr Metab, 2020. 76 Suppl 3: pp. 31–39.Google Scholar
Godhamgaonkar, A. A., Wadhwani, N. S., and Joshi, S. R., Exploring the role of LC-PUFA metabolism in pregnancy complications. Prostaglandins Leukot Essent Fatty Acids, 2020. 163: p. 102203.Google Scholar
Middleton, P., et al., Omega-3 fatty acid addition during pregnancy. Cochrane Database Syst Rev, 2018. 11: p. CD003402.Google Scholar
Sambra, V., et al., Docosahexaenoic and arachidonic acids as neuroprotective nutrients throughout the life cycle. Nutrients, 2021. 13(3).CrossRefGoogle Scholar
Vahdaninia, M., et al., omega-3 LCPUFA supplementation during pregnancy and risk of allergic outcomes or sensitization in offspring: a systematic review and meta-analysis. Ann Allergy Asthma Immunol, 2019. 122(3): pp. 302–313 e2.CrossRefGoogle Scholar
Best, K. P., et al., Prenatal omega-3 LCPUFA and symptoms of allergic disease and sensitization throughout early childhood – a longitudinal analysis of long-term follow-up of a randomized controlled trial. World Allergy Organ J, 2018. 11(1): p. 10.Google Scholar
Vahdaninia, M., et al., The effectiveness of omega-3 polyunsaturated fatty acid interventions during pregnancy on obesity measures in the offspring: an up-to-date systematic review and meta-analysis. Eur J Nutr, 2019. 58(7): pp. 2597–2613.Google Scholar
Herba, C. M., et al., Maternal depression and mental health in early childhood: an examination of underlying mechanisms in low-income and middle-income countries. Lancet Psychiatry, 2016. 3(10): pp. 983–992.Google Scholar
Plant, D. T., et al., Maternal depression during pregnancy and offspring depression in adulthood: role of child maltreatment. Br J Psychiatry, 2015. 207(3): pp. 213–220.Google Scholar
Eberle, C., et al., Impact of maternal prenatal stress by glucocorticoids on metabolic and cardiovascular outcomes in their offspring: a systematic scoping review. PLoS One, 2021. 16(1): p. e0245386.Google Scholar
Plant, D. T., et al., When one childhood meets another – maternal childhood trauma and offspring child psychopathology: A systematic review. Clin Child Psychol Psychiatry, 2018. 23(3): pp. 483–500.Google Scholar
Zhang, H., et al., Maternal adverse childhood experience and depression in relation with brain network development and behaviors in children: a longitudinal study. Cereb Cortex, 2021 Jul 29;31(9):4233-4244.Google Scholar
Kallak, T. K., et al., DNA methylation in cord blood in association with prenatal depressive symptoms. Clin Epigenetics, 2021. 13(1): p. 78.Google Scholar
Rahman, A., et al., Interventions for common perinatal mental disorders in women in low- and middle-income countries: a systematic review and meta-analysis. Bull World Health Organ, 2013. 91(8): pp. 593–601I.Google Scholar
Olmedo-Requena, R., et al., Variations in long-term outcome reporting among offspring followed up after lifestyle interventions in pregnancy: a systematic review. J Perinat Med, 2020. 48(2): pp. 89–95.Google Scholar
Baumfeld Andre, E., et al., Trial designs using real-world data: the changing landscape of the regulatory approval process. Pharmacoepidemiol Drug Saf, 2020. 29(10): pp. 1201–1212.CrossRefGoogle Scholar
Mc Cord, K. A., et al., Treatment effects in randomised trials using routinely collected data for outcome assessment versus traditional trials: meta-research study. BMJ, 2021. 372: p. n450.Google Scholar
Stephenson, J., et al., Before the beginning: nutrition and lifestyle in the preconception period and its importance for future health. Lancet, 2018. 391(10132): pp. 1830–1841.Google Scholar
van Dijk, M. R., et al., A mobile app lifestyle intervention to improve healthy nutrition in women before and during early pregnancy: single-center randomized controlled trial. J Med Internet Res, 2020. 22(5): p. e15773.Google Scholar
Dean, S. V., et al., Preconception care: nutritional risks and interventions. Reprod Health, 2014. 11 Suppl 3: p. S3.CrossRefGoogle Scholar
Ferguson, J. A., Daley, A. J., and Parretti, H. M., Behavioural weight management interventions for postnatal women: a systematic review of systematic reviews of randomized controlled trials. Obes Rev, 2019. 20(6): pp. 829–841.Google Scholar
Villamor, E. and Cnattingius, S., Interpregnancy weight change and risk of adverse pregnancy outcomes: a population-based study. Lancet, 2006. 368(9542): pp. 1164–1170.Google Scholar
Fernandes-Silva, H., et al., Retinoic acid: a key regulator of lung development. Biomolecules, 2020. 10(1): 152Google Scholar
Checkley, W., et al., Maternal vitamin A supplementation and lung function in offspring. N Engl J Med, 2010. 362(19): pp. 1784–1794.CrossRefGoogle Scholar
Robinson, K., et al., Risk factors and in-hospital course of first episode of myocardial infarction or acute coronary insufficiency in women. J Am Coll Cardiol, 1988. 11(5): pp. 932–936.Google Scholar
Wu, Y., et al., Study protocol for the Sino-Canadian Healthy Life Trajectories Initiative (SCHeLTI): a multicentre, cluster-randomised, parallel-group, superiority trial of a multifaceted community-family-mother-child intervention to prevent childhood overweight and obesity. BMJ Open, 2021. 11(4): p. e045192.Google Scholar
Bogaerts, A., et al., INTER-ACT: prevention of pregnancy complications through an e-health driven interpregnancy lifestyle intervention – study protocol of a multicentre randomised controlled trial. Pregnancy Childbirth, 2017. 17(1): p. 154.Google Scholar