This chapter is devoted to a consideration of the role that three axioms such as causal containment axiom (CCA), conservation-is-creation axiom (C-I-CA), and universal causation axiom (UCA), play in the Meditations. It also explores the ways in which the axioms are indebted to, but also deviate from, early modern scholastic discussions of causation, emphasizing in particular the discussion in the Metaphysical Disputations of the early modern Jesuit Francisco Suárez. This text, which was known to Descartes, includes what is perhaps the most comprehensive treatment of causation in the early modern period. Descartes attempts to respond to scholastic objections to the implication of the UCA by denying that it requires that God is an efficient cause of his own existence. In contrast to the case of the first two axioms, this axiom is meant to expand the notion of causation beyond the paradigmatic case of efficient causality.