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3 - Depression and the development of coronary heart disease

from Part 2 - Depression and specific health problems

Published online by Cambridge University Press:  17 September 2009

By
Andrew Steptoe
Edited by
Andrew Steptoe
Andrew Steptoe
Affiliation:
Department of Epidemiology and Public Health, University College London, London, UK
Andrew Steptoe
Affiliation:
University College London
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Summary

Introduction

This chapter is concerned with the role of depression in the development of coronary atherosclerosis and in the aetiology of coronary heart disease (CHD). Chapter 4 discusses the association between depression and prognosis in patients with existing CHD. The relationship of depression with cardiovascular disease has been a topic of intense research interest over the past 15 years and has driven much contemporary thinking about how physical illness and depression are linked. It has stimulated work on a variety of biological processes that potentially mediate the relationship, including platelet activation [1], vascular inflammation [2], endothelial dysfunction [3], reduced baroreceptor reflex sensitivity [4], sympathovagal imbalance [5] and neuroendocrine dysfunction [6].

The purpose of this chapter is to evaluate the strength and consistency of the association between depression and future CHD, to evaluate the specificity of the relationship, and to describe the biological processes that are probably involved. The chapter is divided into five sections. The first section provides a critical review of existing evidence from longitudinal observational studies that depression and depressive symptoms are associated prospectively with CHD in initially healthy adults. Studies of this topic have generated rather variable results, and so it is worth considering what accounts for the discrepancies. The chapter then questions whether there is a specific link between depression and CHD, or whether comparable associations are present for anxiety and more general psychological distress.

Keywords

acute haemostatic responsecomputed tomographycoronary artery calcificationcoronary atherosclerosisintima-medial layerpsychological stresscoronary heart diseasedepression
Type
Chapter
Information
Depression and Physical Illness , pp. 53 - 86
Publisher: Cambridge University Press
Print publication year: 2006

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References

Nemeroff, C. B., Musselman, D. L., Are platelets the link between depression and ischemic heart disease?Am. Heart J. 140 (2000), 57–62.Google Scholar
Black, P. H., Garbutt, L. D., Stress, inflammation and cardiovascular disease. J. Psychosom. Res. 52 (2002), 1–23.Google Scholar
Rajagopalan, S., Brook, R., Rubenfire, M., et al., Abnormal brachial artery flow-mediated vasodilation in young adults with major depression. Am. J. Cardiol. 88 (2001), 196–8, A7.Google Scholar
Watkins, L. L., Grossman, P., Association of depressive symptoms with reduced baroreflex cardiac control in coronary artery disease. Am. Heart J. 137 (1999), 453–7.Google Scholar
Carney, R. M., Blumenthal, J. A., Stein, P. K., et al., Depression, heart rate variability, and acute myocardial infarction. Circulation 104 (2001), 2024–8.Google Scholar
Brown, E. S., Varghese, F. P., McEwen, B. S., Association of depression with medical illness: does cortisol play a role?Biol. Psychiatry 55 (2004), 1–9.Google Scholar
Rosengren, A., Hawken, S., Ounpuu, S., et al., Association of psychosocial risk factors with risk of acute myocardial infarction in 11119 cases and 13648 controls from 52 countries (the INTERHEART study): case–control study. Lancet 364 (2004), 953–62.Google Scholar
Davidson, K., Jonas, B. S., Dixon, K. E., Markovitz, J. H., Do depression symptoms predict early hypertension incidence in young adults in the CARDIA study? Coronary Artery Risk Development in Young Adults. Arch. Intern. Med. 160 (2000), 1495–500.Google Scholar
Zieske, A. W., Malcom, G. T., Strong, J. P., Natural history and risk factors of atherosclerosis in children and youth: the PDAY study. Pediatr. Pathol. Mol. Med. 21 (2002), 213–37.Google Scholar
Rugulies, R., Depression as a predictor for coronary heart disease: a review and meta-analysis. Am. J. Prev. Med. 23 (2002), 51–61.Google Scholar
Lett, H. S., Blumenthal, J. A., Babyak, M. A., et al., Depression as a risk factor for coronary artery disease: evidence, mechanisms, and treatment. Psychosom. Med. 66 (2004), 305–15.Google Scholar
H. Hemingway, H. Kuper, M. Marmot, Psychosocial factors in the primary and secondary prevention of coronary heart disease: an updated systematic review of prospective cohort studies. In Evidence-Based Cardiology, 2nd edn, ed. Yusuf, S., Cairns, J. A., Camm, A. J., Fallen, E. L., Gersh, B. J. (London: BMJ Books, 2003), pp. 181–218.
Haines, A. P., Imeson, J. D., Meade, T. W., Phobic anxiety and ischaemic heart disease. Br. Med. J. 295 (1987), 297–9.Google Scholar
Leon, C. F. Mendes de, Krumholz, H. M., Seeman, T. S., et al., Depression and risk of coronary heart disease in elderly men and women: New Haven EPESE, 1982–1991. Established Populations for the Epidemiologic Studies of the Elderly. Arch. Intern. Med. 158 (1998), 2341–8.Google Scholar
Sesso, H. D., Kawachi, I., Vokonas, P. S., Sparrow, D., Depression and the risk of coronary heart disease in the Normative Aging Study. Am. J. Cardiol. 82 (1998), 851–6.Google Scholar
Anda, R., Williamson, D., Jones, D., et al., Depressed affect, hopelessness, and the risk of ischemic heart disease in a cohort of U. S. adults. Epidemiology 4 (1993), 285–94.Google Scholar
Luukinen, H., Laippala, P., Huikuri, H. V., Depressive symptoms and the risk of sudden cardiac death among the elderly. Eur. Heart J. 24 (2003), 2021–6.Google Scholar
Marzari, C., Maggi, S., Manzato, E., et al., Depressive symptoms and development of coronary heart disease events: the Italian longitudinal study on aging. J. Gerontol. A Biol. Sci. Med. Sci. 60 (2005), 85–92.Google Scholar
Empana, J. P., Sykes, D. H., Luc, G., et al., Contributions of depressive mood and circulating inflammatory markers to coronary heart disease in healthy European men: the Prospective Epidemiological Study of Myocardial Infarction (PRIME). Circulation 111 (2005), 2299–305.Google Scholar
Ariyo, A. A., Haan, M., Tangen, C. M., et al., Depressive symptoms and risks of coronary heart disease and mortality in elderly Americans: Cardiovascular Health Study Collaborative Research Group. Circulation 102 (2000), 1773–9.Google Scholar
Penninx, B. W., Guralnik, J. M., Mendes, C. F., de Leon, et al., Cardiovascular events and mortality in newly and chronically depressed persons > 70 years of age. Am. J. Cardiol. 81 (1998), 988–94.Google Scholar
Penninx, B. W., Beekman, A. T., Honig, A., et al., Depression and cardiac mortality: results from a community-based longitudinal study. Arch. Gen. Psychiatry 58 (2001), 221–7.Google Scholar
Wassertheil-Smoller, S., Applegate, W. B., Berge, K., et al., Change in depression as a precursor of cardiovascular events. SHEP Cooperative Research Group (Systolic Hypertension in the Elderly). Arch. Intern. Med. 156 (1996), 553–61.Google Scholar
Wassertheil-Smoller, S., Shumaker, S., Ockene, J., et al., Depression and cardiovascular sequelae in postmenopausal women: the Women's Health Initiative (WHI). Arch. Intern. Med. 164 (2004), 289–98.Google Scholar
Rowan, P. J., Haas, D., Campbell, J. A., Maclean, D. R., Davidson, K. W., Depressive symptoms have an independent, gradient risk for coronary heart disease incidence in a random, population-based sample. Ann. Epidemiol. 15 (2005), 316–20.Google Scholar
Haines, A., Cooper, J., Meade, T. W., Psychological characteristics and fatal ischaemic heart disease. Heart 85 (2001), 385–9.Google Scholar
Aromaa, A., Raitasalo, R., Reunanen, A., et al., Depression and cardiovascular diseases. Acta Psychiatr. Scand. Suppl. 377 (1994), 77–82.Google Scholar
Ford, D. E., Mead, L. A., Chang, P. P., et al., Depression is a risk factor for coronary artery disease in men: the precursors study. Arch Intern. Med. 158 (1998), 1422–6.Google Scholar
Pratt, L. A., Ford, D. E., Crum, R. M., Armenian, H. K., Gallo, J. J., Eaton, W. W., Depression, psychotropic medication, and risk of myocardial infarction: prospective data from the Baltimore ECA follow-up. Circulation 94 (1996), 3123–9.Google Scholar
Everson, S. A., Goldberg, D. E., Kaplan, G. A., et al., Hopelessness and risk of mortality and incidence of myocardial infarction and cancer. Psychosom. Med. 58 (1996), 113–21.Google Scholar
Appels, A., Mulder, P., Excess fatigue as a precursor of myocardial infarction. Eur. Heart J. 9 (1988), 758–64.Google Scholar
Prescott, E., Holst, C., Gronbaek, M., et al., Vital exhaustion as a risk factor for ischaemic heart disease and all-cause mortality in a community sample: a prospective study of 4084 men and 5479 women in the Copenhagen City Heart Study. Int. J. Epidemiol. 32 (2003), 990–97.Google Scholar
Norton, B., Whalley, L. J., Mortality of a lithium-treated population. Br. J. Psychiatry 145 (1984), 277–82.Google Scholar
Ahrens, B., Muller-Oerlinghausen, B., Schou, M., et al., Excess cardiovascular and suicide mortality of affective disorders may be reduced by lithium prophylaxis. J. Affect. Disord. 33 (1995), 67–75.Google Scholar
Black, D. W., Warrack, G., Winokur, G., Excess mortality among psychiatric patients: the Iowa Record-Linkage Study. J. Am. Med. Assoc. 253 (1985), 58–61.Google Scholar
Murphy, J. M., Monson, R. R., Olivier, D. C., Sobol, A. M., Leighton, A. H., Affective disorders and mortality: a general population study. Arch. Gen. Psychiatry 44 (1987), 473–80.Google Scholar
Allgulander, C., Suicide and mortality patterns in anxiety neurosis and depressive neurosis. Arch. Gen. Psychiatry 51 (1994), 708–12.Google Scholar
Coryell, W., Turvey, C., Leon, A., et al., Persistence of depressive symptoms and cardiovascular death among patients with affective disorder. Psychosom. Med. 61 (1999), 755–61.Google Scholar
Druss, B. G., Bradford, D. W., Rosenheck, R. A., Radford, M. J., Krumholz, H. M., Mental disorders and use of cardiovascular procedures after myocardial infarction. J. Am. Med. Assoc. 283 (2000), 506–11.Google Scholar
Hippisley-Cox, J., Pringle, M., Hammersley, V., et al., Antidepressants as risk factor for ischaemic heart disease: case–control study in primary care. Br. Med. J. 323 (2001), 666–9.Google Scholar
Cohen, H. W., Gibson, G., Alderman, M. H., Excess risk of myocardial infarction in patients treated with antidepressant medications: association with use of tricyclic agents. Am. J. Med. 108 (2000), 2–8.Google Scholar
Everson-Rose, S. A., Lewis, T. T., Psychological factors and cardiovascular diseases. Annu. Rev. Public Health 26 (2005), 469–500.Google Scholar
Ferketich, A. K., Binkley, P. F., Psychological distress and cardiovascular disease: results from the 2002 National Health Interview Survey. Eur. Heart J. 26 (2005), 1923–9.Google Scholar
Stansfeld, S. A., Fuhrer, R., Shipley, M. J., Marmot, M. G., Psychological distress as a risk factor for coronary heart disease in the Whitehall II study. Int. J. Epidemiol. 31 (2002), 248–55.Google Scholar
Robinson, K. L., McBeth, J., Macfarlane, G. J., Psychological distress and premature mortality in the general population: a prospective study. Ann. Epidemiol. 14 (2004), 467–72.Google Scholar
Kawachi, I., Colditz, G. A., Ascherio, A., et al., Prospective study of phobic anxiety and risk of coronary heart disease in men. Circulation 89 (1994), 1992–7.Google Scholar
Rasul, F., Stansfeld, S. A., Hart, C. L., Gillis, C. R., Smith, G. D., Psychological distress, physical illness and mortality risk. J. Psychosom. Res. 57 (2004), 231–6.Google Scholar
Albert, C. M., Chae, C. U., Rexrode, K. M., Manson, J. E., Kawachi, I., Phobic anxiety and risk of coronary heart disease and sudden cardiac death among women. Circulation 111 (2005), 480–87.Google Scholar
Rasul, F., Stansfeld, S. A., Hart, C. L., Smith, G. Davey, Psychological distress, physical illness, and risk of coronary heart disease. J. Epidemiol. Community Health 59 (2005), 140–45.Google Scholar
Kawachi, I., Sparrow, D., Vokonas, P. S., Weiss, S. T., Symptoms of anxiety and risk of coronary heart disease: the Normative Aging Study. Circulation 90 (1994), 2225–9.Google Scholar
Iso, H., Date, C., Yamamoto, A., et al., Perceived mental stress and mortality from cardiovascular disease among Japanese men and women: the Japan Collaborative Cohort Study for Evaluation of Cancer Risk Sponsored by Monbusho (JACC Study). Circulation 106 (2002), 1229–36.Google Scholar
Ohlin, B., Nilsson, P. M., Nilsson, J. A., Berglund, G., Chronic psychosocial stress predicts long-term cardiovascular morbidity and mortality in middle-aged men. Eur. Heart J. 25 (2004), 867–73.Google Scholar
Macleod, J., Davey Smith, G., Heslop, P., et al., Psychological stress and cardiovascular disease: empirical demonstration of bias in a prospective observational study of Scottish men. Br. Med. J. 324 (2002), 1247–51.Google Scholar
O'Leary, D. H., Polak, J. F., Kronmal, R. A., et al., Carotid-artery intima and media thickness as a risk factor for myocardial infarction and stroke in older adults: Cardiovascular Health Study Collaborative Research Group. N. Engl. J. Med. 340 (1999), 14–22.Google Scholar
Bots, M. L., Dijk, J. M., Oren, A., Grobbee, D. E., Carotid intima-media thickness, arterial stiffness and risk of cardiovascular disease: current evidence. J. Hypertens. 20 (2002), 2317–25.Google Scholar
Everson, S. A., Lynch, J. W., Chesney, M. A., et al., Interaction of workplace demands and cardiovascular reactivity in progression of carotid atherosclerosis: population based study. Br. Med. J. 314 (1997), 553–8.Google Scholar
Rosvall, M., Ostergren, P. O., Hedblad, B., et al., Occupational status, educational level, and the prevalence of carotid atherosclerosis in a general population sample of middle-aged Swedish men and women: results from the Malmo Diet and Cancer Study. Am. J. Epidemiol. 152 (2000), 334–46.Google Scholar
Jennings, J. R., Kamarck, T. W., Everson-Rose, S. A., et al., Exaggerated blood pressure responses during mental stress are prospectively related to enhanced carotid atherosclerosis in middle-aged Finnish men. Circulation 110 (2004), 2198–203.Google Scholar
Jones, D. J., Bromberger, J. T., Sutton-Tyrrell, K., Matthews, K. A., Lifetime history of depression and carotid atherosclerosis in middle-aged women. Arch. Gen. Psychiatry 60 (2003), 153–60.Google Scholar
Haas, D. C., Davidson, K. W., Schwartz, D. J., et al., Depressive symptoms are independently predictive of carotid atherosclerosis. Am. J. Cardiol. 95 (2005), 547–50.Google Scholar
Pletcher, M. J., Tice, J. A., Pignone, M., Browner, W. S., Using the coronary artery calcium score to predict coronary heart disease events: a systematic review and meta-analysis. Arch. Intern. Med. 164 (2004), 1285–92.Google Scholar
O'Malley, PG, Jones, D. L., Feuerstein, I. M., Taylor, A. J., Lack of correlation between psychological factors and subclinical coronary artery disease. N. Engl. J. Med. 343 (2000), 1298–304.Google Scholar
Tiemeier, H., W. van Dijck, Hofman, A., et al., Relationship between atherosclerosis and late-life depression: the Rotterdam Study. Arch. Gen. Psychiatry 61 (2004), 369–76.Google Scholar
Agatisa, P. K., Matthews, K. A., Bromberger, J. T., et al., Coronary and aortic calcification in women with a history of major depression. Arch. Intern. Med. 165 (2005), 1229–36.Google Scholar
Paterniti, S., Zureik, M., Ducimetiere, P., et al., Sustained anxiety and 4-year progression of carotid atherosclerosis. Arterioscler. Thromb. Vasc. Biol. 21 (2001), 136–41.Google Scholar
Wolff, B., Grabe, H. J., Volzke, H., et al., Relationship between psychological strain and carotid atherosclerosis in a general population. Heart 91 (2005), 460–64.Google Scholar
Matthews, K. A., Owens, J. F., Kuller, L. H., Sutton-Tyrrell, K., Jansen-McWilliams, L., Are hostility and anxiety associated with carotid atherosclerosis in healthy postmenopausal women?Psychosom. Med. 60 (1998), 633–8.Google Scholar
Lesperance, F., Frasure-Smith, N., Talajic, M., Major depression before and after myocardial infarction: its nature and consequences. Psychosom. Med. 58 (1996), 99–110.Google Scholar
Dickens, C. M., McGowan, L., Percival, C., et al., Lack of a close confidant, but not depression, predicts further cardiac events after myocardial infarction. Heart 90 (2004), 518–22.Google Scholar
Strike, P. C., Steptoe, A., Behavioral and emotional triggers of acute coronary syndromes: a systematic review and critique. Psychosom. Med. 67 (2005), 179–86.Google Scholar
Naghavi, M., Libby, P., Falk, E., et al., From vulnerable plaque to vulnerable patient: a call for new definitions and risk assessment strategies: part I. Circulation 108 (2003), 1664–72.Google Scholar
Maclure, M., Mittleman, M. A., Should we use a case-crossover design?Ann. Rev. Public Health 21 (2000), 193–221.Google Scholar
Mittleman, M. A., Maclure, M., Sherwood, J. B., et al., Triggering of acute myocardial infarction onset by episodes of anger. Circulation 92 (1995), 1720–25.Google Scholar
Willich, S. N., Lewis, M., Lowel, H., et al., Physical exertion as a trigger of acute myocardial infarction. N. Engl. J. Med. 329 (1993), 1684–90.Google Scholar
Steptoe, A., Whitehead, D. L., Depression, stress and coronary heart disease: the need for more complex models. Heart 91 (2005), 419–20.Google Scholar
Ferketich, A. K., Schwartzbaum, J. A., Frid, D. J., Moeschberger, M. L., Depression as an antecedent to heart disease among women and men in the NHANES I study. Arch. Intern. Med. 160 (2000), 1261–8.Google Scholar
Everson, S. A., Kaplan, G. A., Goldberg, D. E., Salonen, J. T., Hypertension incidence is predicted by high levels of hopelessness in Finnish men. Hypertension 35 (2000), 561–7.Google Scholar
Ross, R., Atherosclerosis: an inflammatory disease. N. Engl. J. Med. 340 (1999), 115–26.Google Scholar
Jarvisalo, M. J., Harmoinen, A., Hakanen, M., et al., Elevated serum C-reactive protein levels and early arterial changes in healthy children. Arterioscler. Thromb. Vasc. Biol. 22 (2002), 1323–8.Google Scholar
Raitakari, O. T., Juonala, M., Kahonen, M., et al., Cardiovascular risk factors in childhood and carotid artery intima-media thickness in adulthood: the Cardiovascular Risk in Young Finns Study. J. Am. Med. Assoc. 290 (2003), 2277–83.Google Scholar
Chrapko, W. E., Jurasz, P., Radomski, M. W., et al., Decreased platelet nitric oxide synthase activity and plasma nitric oxide metabolites in major depressive disorder. Biol. Psychiatry 56 (2004), 129–34.Google Scholar
Broadley, A. J., Korszun, A., Jones, C. J., Frenneaux, M. P., Arterial endothelial function is impaired in treated depression. Heart 88 (2002), 521–3.Google Scholar
Ghiadoni, L., Donald, A., Cropley, M., et al., Mental stress induces transient endothelial dysfunction in humans. Circulation 102 (2000), 2473–8.Google Scholar
Cesari, M., Penninx, B. W., Newman, A. B., et al., Inflammatory markers and onset of cardiovascular events: results from the Health ABC study. Circulation 108 (2003), 2317–22.Google Scholar
Lind, L., Circulating markers of inflammation and atherosclerosis. Atherosclerosis 169 (2003), 203–14.Google Scholar
Ridker, P. M., Hennekens, C. H., Buring, J. E., Rifai, N., C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women. N. Engl. J. Med. 342 (2000), 836–43.Google Scholar
Miller, G. E., Stetler, C. A., Carney, R. M., Freedland, K. E., Banks, W. A., Clinical depression and inflammatory risk markers for coronary heart disease. Am. J. Cardiol. 90 (2002), 1279–83.Google Scholar
Suarez, E. C., Joint effect of hostility and severity of depressive symptoms on plasma interleukin-6 concentration. Psychosom. Med. 65 (2003), 523–7.Google Scholar
Dentino, A. N., Pieper, C. F., Rao, M. K., et al., Association of interleukin-6 and other biologic variables with depression in older people living in the community. J. Am. Geriatr. Soc. 47 (1999), 6–11.Google Scholar
Penninx, B. W., Kritchevsky, S. B., Yaffe, K., et al., Inflammatory markers and depressed mood in older persons: results from the Health, Aging and Body Composition study. Biol. Psychiatry 54 (2003), 566–72.Google Scholar
Panagiotakos, D. B., Pitsavos, C., Chrysohoou, C., et al., Inflammation, coagulation, and depressive symptomatology in cardiovascular disease-free people: the ATTICA study. Eur. Heart J. 25 (2004), 492–9.Google Scholar
Kop, W. J., Gottdiener, J. S., Tangen, C. M., et al., Inflammation and coagulation factors in persons > 65 years of age with symptoms of depression but without evidence of myocardial ischemia. Am. J. Cardiol. 89 (2002), 419–24.Google Scholar
Steptoe, A., Kunz-Ebrecht, S. R., Owen, N., Lack of association between depressive symptoms and markers of immune and vascular inflammation in middle-aged men and women. Psychol. Med. 33 (2003), 667–74.Google Scholar
Tiemeier, H., Hofman, A., Tuijl, H. R., et al., Inflammatory proteins and depression in the elderly. Epidemiology 14 (2003), 103–7.Google Scholar
Davies, M. J., Stability and instability: two faces of coronary atherosclerosis. The Paul Dudley White Lecture 1995. Circulation 94 (1996), 2013–20.Google Scholar
Casscells, W., Naghavi, M., Willerson, J. T., Vulnerable atherosclerotic plaque: a multifocal disease. Circulation 107 (2003), 2072–5.Google Scholar
Danesh, J., Collins, R., Peto, R., Lowe, G. D., Haematocrit, viscosity, erythrocyte sedimentation rate: meta-analyses of prospective studies of coronary heart disease. Eur. Heart J. 21 (2000), 515–20.Google Scholar
Danesh, J., Whincup, P., Walker, M., et al., Fibrin D-dimer and coronary heart disease: prospective study and meta-analysis. Circulation 103 (2001), 2323–7.Google Scholar
Whincup, P. H., Danesh, J., Walker, M., et al., Von Willebrand factor and coronary heart disease: prospective study and meta-analysis. Eur. Heart. J. 23 (2002), 1764–70.Google Scholar
Monaco, C., Mathur, A., Martin, J. F., What causes acute coronary syndromes? Applying Koch's postulates. Atherosclerosis 179 (2005), 1–15.Google Scholar
Kanel, R., Mills, P. J., Fainman, C., Dimsdale, J. E., Effects of psychological stress and psychiatric disorders on blood coagulation and fibrinolysis: a biobehavioral pathway to coronary artery disease?Psychosom. Med. 63 (2001), 531–44.Google Scholar
Steptoe, A., Kunz-Ebrecht, S., Rumley, A., Lowe, G. D., Prolonged elevations in haemostatic and rheological responses following psychological stress in low socioeconomic status men and women. Thromb. Haemost. 89 (2003), 83–90.Google Scholar
Steptoe, A., Magid, K., Edwards, S., et al., The influence of psychological stress and socioeconomic status on platelet activation in men. Atherosclerosis 168 (2003), 57–63.Google Scholar
Kanel, R., Platelet hyperactivity in clinical depression and the beneficial effect of antidepressant drug treatment: how strong is the evidence?Acta Psychiatr. Scand. 110 (2004), 163–77.Google Scholar
Kanel, R., Dimsdale, J. E., Adler, K. A., et al., Effects of depressive symptoms and anxiety on hemostatic responses to acute mental stress and recovery in the elderly. Psychiatry Res. 126 (2004), 253–64.Google Scholar
Ljung, T., Andersson, B., Bengtsson, B. A., Bjorntorp, P., Marin, P., Inhibition of cortisol secretion by dexamethosone in relation to body fat distribution. Obes. Res. 4 (1996), 277–82.Google Scholar
Pasquali, R., Ambrosi, B., Armanini, D., et al., Cortisol and ACTH response to oral dexamethasone in obesity and effects of sex, body fat distribution, and dexamethasone concentrations: a dose–response study. J. Clin. Endocrinol. Metab. 87 (2002), 166–75.Google Scholar
Vicennati, V., Pasquali, R., Abnormalities of the hypothalamic-pituitary-adrenal axis in nondepressed women with abdominal obesity and relations with insulin resistance: evidence for a central and a peripheral alteration. J. Clin. Endocrinol. Metab. 85 (2000), 4093–8.Google Scholar
Seckl, J. R., Morton, N. M., Chapman, K. E., Walker, B. R., Glucocorticoids and 11beta-hydroxysteroid dehydrogenase in adipose tissue. Recent Prog. Horm. Res. 59 (2004), 359–93.Google Scholar
Epel, E. S., McEwen, B., Seeman, T., et al., Stress and body shape: stress-induced cortisol secretion is consistently greater among women with central fat. Psychosom. Med. 62 (2000), 623–32.Google Scholar
Steptoe, A., Kunz-Ebrecht, S. R., Brydon, L., Wardle, J., Central adiposity and cortisol responses to waking in middle-aged men and women. Int. J. Obes. Relat. Metab. Disord. 28 (2004), 1168–73.Google Scholar
Brunner, E. J., Hemingway, H., Walker, B. R., et al., Adrenocortical, autonomic, and inflammatory causes of the metabolic syndrome: nested case–control study. Circulation 106 (2002), 2659–65.Google Scholar
Hudson, J. I., Hudson, M. S., Rothschild, A. J., et al., Abnormal results of dexamethasone suppression tests in nondepressed patients with diabetes mellitus. Arch. Gen. Psychiatry 41 (1984), 1086–9.Google Scholar
Roy, M., Collier, B., Roy, A., Hypothalamic-pituitary-adrenal axis dysregulation among diabetic outpatients. Psychiatry Res. 31 (1990), 31–7.Google Scholar
Rosmond, R., Wallerius, S., Wanger, P., et al., A 5-year follow-up study of disease incidence in men with an abnormal hormone pattern. J. Intern. Med. 254 (2003), 386–90.Google Scholar
Phillips, D. I., Barker, D. J., Fall, C. H., et al., Elevated plasma cortisol concentrations: a link between low birth weight and the insulin resistance syndrome?J. Clin. Endocrinol. Metab. 83 (1998), 757–60.Google Scholar
Cohen, H. W., Madhavan, S., Alderman, M. H., History of treatment for depression: risk factor for myocardial infarction in hypertensive patients. Psychosom. Med. 63 (2001), 203–9.Google Scholar
Lawlor, D. A., Smith, G. D., Ebrahim, S., Association of insulin resistance with depression: cross sectional findings from the British Women's Heart and Health Study. Br. Med. J. 327 (2003), 1383–4.Google Scholar
Golomb, B. A., Tenkanen, L., Alikoski, T., et al., Insulin sensitivity markers: predictors of accidents and suicides in Helsinki Heart Study screenees. J. Clin. Epidemiol. 55 (2002), 767–73.Google Scholar
Everson-Rose, S. A., Meyer, P. M., Powell, L. H., et al., Depressive symptoms, insulin resistance, and risk of diabetes in women at midlife. Diabetes Care 27 (2004), 2856–62.Google Scholar
Timonen, M., Laakso, M., Jokelainen, J., et al., Insulin resistance and depression: cross sectional study. Br. Med. J. 330 (2005), 17–18.Google Scholar
Dunn, A. J., Swiergiel, A. H., Palamarchouk, V., Brain circuits involved in corticotropin-releasing factor–norepinephrine interactions during stress. Ann. N. Y. Acad. Sci. 1018 (2004), 25–34.Google Scholar
Lovallo, W. R.Stress and Health: Biological and Psychological Interactions, 2nd edn. (Thousand Oaks, CA: Sage, 2004).
Gimbrone, M. A. Jr, Topper, J. N., Nagel, T., Anderson, K. R., Garcia-Cardena, G., Endothelial dysfunction, hemodynamic forces, and atherogenesis. Ann. N. Y. Acad. Sci. 902 (2000), 230–39.Google Scholar
Cheng, C., R. de Crom, R. van Haperen, et al., The role of shear stress in atherosclerosis: action through gene expression and inflammation?Cell Biochem. Biophys. 41 (2004), 279–94.Google Scholar
Dyer, A. R., Persky, V., Stamler, J., et al., Heart rate as a prognostic factor for coronary heart disease and mortality: findings in three Chicago epidemiologic studies. Am. J. Epidemiol. 112 (1980), 736–49.Google Scholar
Kannel, W. B., Kannel, C., Paffenbarger, R. S. Jr, Cupples, L. A., Heart rate and cardiovascular mortality: the Framingham Study. Am. Heart J. 113 (1987), 1489–94.Google Scholar
Frenneaux, M. P., Autonomic changes in patients with heart failure and in post-myocardial infarction patients. Heart 90 (2004), 1248–55.Google Scholar
Liao, D., Cai, J., Rosamond, W. D., et al., Cardiac autonomic function and incident coronary heart disease: a population-based case–cohort study. Am. J. Epidemiol. 145 (1997), 696–706.Google Scholar
Rovere, M. T., Bigger, J. T. Jr, Marcus, F. I., Mortara, A., Schwartz, P. J., Baroreflex sensitivity and heart-rate variability in prediction of total cardiac mortality after myocardial infarction. Lancet 351 (1998), 478–84.Google Scholar
Lake, C. R., Pickar, D., Ziegler, M. G., et al., High plasma norepinephrine levels in patients with major affective disorder. Am. J. Psychiatry 139 (1982), 1315–18.Google Scholar
Veith, R. C., Lewis, N., Linares, O. A., et al., Sympathetic nervous system activity in major depression. Basal and desipramine-induced alterations in plasma norepinephrine kinetics. Arch. Gen. Psychiatry 51 (1994), 411–22.Google Scholar
Hughes, J. W., Watkins, L., Blumenthal, J. A., Kuhn, C., Sherwood, A., Depression and anxiety symptoms are related to increased 24-hour urinary norepinephrine excretion among healthy middle-aged women. J. Psychosom. Res. 57 (2004), 353–8.Google Scholar
Meredith, I. T., Broughton, A., Jennings, G. L., Esler, M. D., Evidence of a selective increase in cardiac sympathetic activity in patients with sustained ventricular arrhythmias. N. Engl. J. Med. 325 (1991), 618–24.Google Scholar
Moser, M., Lehofer, M., Hoehn-Saric, R., et al., Increased heart rate in depressed subjects in spite of unchanged autonomic balance?J. Affect. Disord. 48 (1998), 115–24.Google Scholar
Agelink, M. W., Boz, C., Ullrich, H., Andrich, J., Relationship between major depression and heart rate variability: clinical consequences and implications for antidepressive treatment. Psychiatry Res. 113 (2002), 139–49.Google Scholar
Volkers, A. C., Tulen, J. H., Broek, W. W., et al., Motor activity and autonomic cardiac functioning in major depressive disorder. J. Affect. Disord. 76 (2003), 23–30.Google Scholar
Yeragani, V. K., Pohl, R., Balon, R., et al., Heart rate variability in patients with major depression. Psychiatry Res. 37 (1991), 35–46.Google Scholar
Broadley, A. J., Frenneaux, M. P., Moskvina, V., Jones, C. J. H., Korszun, A., Baroreflex sensitivity is reduced in depression. Psychosom. Med. 67 (2005), 648–51.Google Scholar
Watkins, L. L., Grossman, P., Krishnan, R., Blumenthal, J. A., Anxiety reduces baroreflex cardiac control in older adults with major depression. Psychosom. Med. 61 (1999), 334–40.Google Scholar
Horsten, M., Ericson, M., Perski, A., et al., Psychosocial factors and heart rate variability in healthy women. Psychosom. Med. 61 (1999), 49–57.Google Scholar
Kim, C. K., McGorray, S. P., Bartholomew, B. A., et al., Depressive symptoms and heart rate variability in postmenopausal women. Arch. Intern. Med. 165 (2005), 1239–44.Google Scholar
Gehi, A., Mangano, D., Pipkin, S., Browner, W. S., Whooley, M. A., Depression and heart rate variability in patients with stable coronary heart disease: findings from the Heart and Soul Study. Arch. Gen. Psychiatry 62 (2005), 661–6.Google Scholar
Hemingway, H., Marmot, M., Evidence based cardiology: psychosocial factors in the aetiology and prognosis of coronary heart disease – systematic review of prospective cohort studies. Br. Med. J. 318 (1999), 1460–67.Google Scholar
Lynch, J. W., Kaplan, G. A., Cohen, R. D., Tuomilehto, J., Salonen, J., Do cardiovascular risk factors explain the relation between socio-economic status, risk of all-cause mortality, cardiovascular mortality, and acute myocardial infarction?Am. J. Epidemiol. 144 (1996), 934–42.Google Scholar
Lenthe, F. J., Gevers, E., Joung, I. M., Bosma, H., Mackenbach, J. P., Material and behavioral factors in the explanation of educational differences in incidence of acute myocardial infarction: the Globe study. Ann. Epidemiol. 12 (2002), 535–42.Google Scholar
Wamala, S. P., Mittleman, M. A., Schenck-Gustafsson, K., Orth-Gomer, K., Potential explanations for the educational gradient in coronary heart disease: a population-based case–control study of Swedish women. Am. J. Public Health 89 (1999), 315–21.Google Scholar
Juonala, M., Viikari, J. S., Laitinen, T., et al., Interrelations between brachial endothelial function and carotid intima-media thickness in young adults: the Cardiovascular Risk in Young Finns Study. Circulation 110 (2004), 2918–23.Google Scholar
Ostfeld, A. M., Lebovits, B. Z., Shekelle, R. B., Paul, O., A prospective study of the relationship between personality and coronary heart disease. J. Chronic Dis. 17 (1964), 265–76.Google Scholar
Hallstrom, T., Lapidus, L., Bengtsson, C., Edstrom, K., Psychosocial factors and risk of ischaemic heart disease and death in women: a twelve-year follow-up of participants in the population study of women in Gothenburg, Sweden. J. Psychosom. Res. 30 (1986), 451–9.Google Scholar
Barefoot, J. C., Schroll, M., Symptoms of depression, acute myocardial infarction, and total mortality in a community sample. Circulation 93 (1996), 1976–80.Google Scholar
Schwartz, S. W., Cornoni-Huntley, J., Cole, S. R., et al., Are sleep complaints an independent risk factor for myocardial infarction?Ann. Epidemiol. 8 (1998), 384–92.Google Scholar
Whooley, M. A., Browner, W. S., Association between depressive symptoms and mortality in older women. Arch. Intern. Med. 158 (1998), 2129–35.Google Scholar
Cole, S. R., Kawachi, I., Sesso, H. D., Paffenbarger, R. S., Lee, I. M., Sense of exhaustion and coronary heart disease among college alumni. Am. J. Cardiol. 84 (1999), 1401–5.Google Scholar
Chang, M., Hahn, R. A., Teutsch, S. M., Hutwagner, L. C., Multiple risk factors and population attributable risk for ischemic heart disease mortality in the United States, 1971–1992. J. Clin. Epidemiol. 54 (2001), 634–44.Google Scholar
Yasuda, N., Mino, Y., Koda, S., Ohara, H., The differential influence of distinct clusters of psychiatric symptoms, as assessed by the general health questionnaire, on cause of death in older persons living in a rural community of Japan. J. Am. Geriatr. Soc. 50 (2002), 313–20.Google Scholar
Everson-Rose, S. A., House, J. S., Mero, R. P., Depressive symptoms and mortality risk in a national sample: confounding effects of health status. Psychosom. Med. 66 (2004), 823–30.Google Scholar
Gump, B. B., Matthews, K. A., Eberly, L. E., Chang, Y. F., Depressive symptoms and mortality in men: results from the Multiple Risk Factor Intervention Trial. Stroke 36 (2005), 98–102.Google Scholar
Eaker, E. D., Pinsky, J., Castelli, W. P., Myocardial infarction and coronary death among women: psychosocial predictors from a 20-year follow-up of women in the Framingham Study. Am. J. Epidemiol. 135 (1992), 854–64.Google Scholar
Kubzansky, L. D., Kawachi, I., Spiro, A., et al., Is worrying bad for your heart? A prospective study of worry and coronary heart disease in the Normative Aging Study. Circulation 95 (1997), 818–24.Google Scholar

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