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6 - Depression and physical disability

from Part 2 - Depression and specific health problems

Published online by Cambridge University Press:  17 September 2009

By
Brenda W. J. H. Penninx
Edited by
Andrew Steptoe
Brenda W. J. H. Penninx
Affiliation:
Department of Psychiatry, VU University Medical Centre, Amsterdam, The Netherlands
Andrew Steptoe
Affiliation:
University College London
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Summary

This chapter describes the link between depression and disability. Disability can be defined as a restriction in or lack of ability to perform an activity because of impairment. These activities can include interpersonal relationships, work and school activities and physical activities; the latter is defined as ‘physical disability’. In this chapter, the main focus is on physical disability, since this is the type of disability that has often been examined in relation to depression, especially in old age. However, when appropriate the chapter also elaborates on other types of disability.

The first section of this chapter describes the concept of disability in more detail. The next section provides an overview of research that examines the link between depression and disability. It then goes on to discuss underlying mechanisms that could explain the link between depression and disability. Subsequently, results of intervention studies that try to break the link between depression and disability are described. The chapter ends with some concluding remarks.

Disability: a functional indicator of physical health

Various chapters of this book demonstrate that the importance of chronic conditions for mental health is undisputed. These chapters show that conditions such as cardiovascular disease, diabetes, cancer and chronic fatigue are included among the strongest risk factors for depression, and that the presence of depression influences the course and management of these chronic illnesses. Especially in old age, individuals often have multiple chronic conditions, which may vary in their severity.

Keywords

alcohol consumptionbehavioural riskdepressiondepressive symptomsphysical disabilitypsychosocial factorshealth statuspharmacotherapysmoking
Type
Chapter
Information
Depression and Physical Illness , pp. 125 - 144
Publisher: Cambridge University Press
Print publication year: 2006

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References

Verbrugge, L. M., Jette, A. M., The disablement process. Soc. Sci. Med. 38 (1994), 1–14.Google Scholar
World Health Organization. International Classification of Functioning, Disability and Health. (Geneva: WHO, 2001).
Kramarow, E., Lentzner, H., Rooks, R., Weeks, J., Saydah, S., Health, United States, 1999: Health and Aging Chartbook (Hyattsville, MD: National Center for Health Statistics, 1999).
Guralnik, J. M., Ferrucci, L., Simonsick, E. M., Salive, M. E., Wallace, R. B., Lower-extremity function in persons over the age of 70 years as a predictor of subsequent disability. N. Engl. J. Med. 332 (1995), 556–61.Google Scholar
Penninx, B. W., Ferrucci, L., Leveille, S. G., et al., Lower extremity performance in nondisabled older persons as a predictor of subsequent hospitalization. J. Gerontol. A Biol. Sci. Med. Sci. 55 (2000), M691–7.Google Scholar
Guralnik, J. M., Fried, L. P., Salive, M. E., Disability as a public health outcome in the aging population. Annu. Rev. Public Health 17 (1996), 25–46.Google Scholar
Fried, T. R., Bradley, E. H., Williams, C. S., Tinetti, M. E., Functional disability and health care expenditures for older persons. Arch. Intern. Med. 161 (2001), 2602–7.Google Scholar
Beekman, A. T., Deeg, D. J., Braam, A. W., Smit, J. H., Tilburg, W., Consequences of major and minor depression in later life: a study of disability, well-being and service utilization. Psychol. Med. 27 (1997), 1397–409.Google Scholar
Forsell, Y., Jorm, A. F., Winblad, B., Association of age, sex, cognitive dysfunction, and disability with major depressive symptoms in an elderly sample. Am. J. Psychiatry 151 (1994), 1600–604.Google Scholar
Koenig, H. G., George, L. K., Depression and physical disability outcomes in depressed medically ill hospitalized older adults. Am. J. Geriatr. Psychiatry 6 (1998), 230–47.Google Scholar
Lyness, J. M., King, D. A., Cox, C., Yoediono, Z., Caine, E. D., The importance of subsyndromal depression in older primary care patients: prevalence and associated functional disability. J. Am. Geriatr. Soc. 47 (2001), 647–52.Google Scholar
Sinclair, P. A., Lyness, J. M., King, D. A., Cox, C., Caine, E. D., Depression and self-reported functional status in older primary care patients. Am. J. Psychiatry 158 (2001), 416–19.Google Scholar
Wells, K. B., Stewart, A., Hays, R. D., et al., The functioning and well-being of depressed patients: results from the Medical Outcomes Study. J. Am. Med. Assoc. 262 (1989), 914–19.Google Scholar
Johnson, J., Weissman, M. M., Klerman, G. L., Service utilization and social morbidity associated with depressive symptoms in the community. J. Am. Med. Assoc. 267 (1992), 1478–83.Google Scholar
Ormel, J., Kempen, G. I., Deeg, D. J., et al., Functioning, well-being, and health perception in late middle-aged and older people: comparing the effects of depressive symptoms and chronic medical conditions. J. Am. Geriatr. Soc. 46 (1998), 39–48.Google Scholar
Druss, B. G., Marcus, S. C., Rosenheck, R. A., et al., Understanding disability in mental and general medical conditions. Am. J. Psychiatry 157 (2000), 1485–91.Google Scholar
Broadhead, W. E., Blazer, D. G., George, L. K., Tse, C. K., Depression, disability days, and days lost from work in a prospective epidemiologic survey. J. Am. Med. Assoc. 264 (1990), 2524–8.Google Scholar
Ormel, J., VonKorff, M., Ustun, T. B., et al., Common mental disorders and disability across cultures: results from the WHO Collaborative Study on Psychological Problems in General Health Care. J. Am. Med. Assoc. 272 (1994), 1741–8.Google Scholar
Wells, K. B., Sherbourne, C. D., Functioning and utility for current health of patients with depression or chronic medical conditions in managed, primary care practices. Arch. Gen. Psychiatry 56 (1999), 897–904.Google Scholar
Murray, C. J., Lopez, A. D., Alternative projections of mortality and disability by cause 1990–2020: Global Burden of Disease Study. Lancet 349 (1997), 1498–504.Google Scholar
Kennedy, G. J., Kelman, H. R., Thomas, C., The emergence of depressive symptoms in late life: the importance of declining health and increasing disability. J. Community Health. 15 (1990), 93–104.Google Scholar
Roberts, R. E., Kaplan, G. A., Shema, S. J., Strawbridge, W. J., Prevalence and correlates of depression in an aging cohort: the Alameda County Study. J. Gerontol. B. Psychol. Sci. Soc. Sci. 52 (1997), S252–8.Google Scholar
Zeiss, A. M., Lewinsohn, P. M., Rohde, P., Seeley, J. R., Relationship of physical disease and functional impairment to depression in older people. Psychol. Aging 11 (1996), 572–81.Google Scholar
Prince, M. J., Harwood, R. H., Thomas, A., Mann, A. H., A prospective population-based cohort study of the effects of disablement and social milieu on the onset and maintenance of late-life depression: the Gospel Oak Project VII. Psychol. Med. 28 (1998), 337–50.Google Scholar
Geerlings, S. W., Beekman, A. T., Deeg, D. J., Tilburg, W., Physical health and the onset and persistence of depression in older adults: an eight-wave prospective community-based study. Psychol. Med. 30 (2000), 369–80.Google Scholar
Berkman, L. F., Berkman, C. S., Kasl, S., et al., Depressive symptoms in relation to physical health and functioning in the elderly. Am. J. Epidemiol 124 (1986), 372–88.Google Scholar
Beekman, A. T., Deeg, D. J., Geerlings, S. W., et al., Emergence and persistence of late life depression: a 3-year follow-up of the Longitudinal Aging Study Amsterdam. J. Affect. Disord. 65 (2001), 131–8.Google Scholar
Ormel, J., Kempen, G. I., Penninx, B. W., et al., Chronic medical conditions and mental health in older people: disability and psychosocial resources mediate specific mental health effects. Psychol. Med. 27 (1997), 1065–77.Google Scholar
Turner, R. J., Noh, S., Physical disability and depression: a longitudinal analysis. J. Health. Soc. Behav. 29 (1988), 23–37.Google Scholar
Ormel, J., Oldehinkel, T., Brilman, E., Brink, W. vanden, Outcome of depression and anxiety in primary care: a three-wave 3 1/2-year study of psychopathology and disability. Arch. Gen. Psychiatry 50 (1993), 759–66.Google Scholar
Korff, M., Ormel, J., Katon, W., Lin, E. H., Disability and depression among high utilizers of health care: a longitudinal analysis. Arch. Gen. Psychiatry 49 (1992), 91–100.Google Scholar
Bruce, M. L., Seeman, T. E., Merrill, S. S., Blazer, D. G., The impact of depressive symptomatology on physical disability: MacArthur Studies of Successful Aging. Am. J. Public Health 84 (1994), 1796–9.Google Scholar
Gallo, J. J., Rabins, P. V., Lyketsos, C. G., Tien, A. Y., Anthony, J. C., Depression without sadness: functional outcomes of nondysphoric depression in later life. J. Am. Geriatr. Soc. 45 (1997), 570–78.Google Scholar
Penninx, B. W., Leveille, S., Ferrucci, L., Eijk, J. T., Guralnik, J. M., Exploring the effect of depression on physical disability: longitudinal evidence from the established populations for epidemiologic studies of the elderly. Am. J. Public Health 89 (1999), 1346–52.Google Scholar
Cronin-Stubbs, D., Leon, C. F., Beckett, L. A., et al., Six-year effect of depressive symptoms on the course of physical disability in community-living older adults. Arch. Intern. Med. 160 (2000), 3074–80.Google Scholar
Armenian, H. K., Pratt, L. A., Gallo, J., Eaton, W. W., Psychopathology as a predictor of disability: a population-based follow-up study in Baltimore, Maryland. Am. J. Epidemiol. 148 (1998), 269–75.Google Scholar
Lenze, E. J., Rogers, J. C., Martire, L. M., et al., The association of late-life depression and anxiety with physical disability: a review of the literature and prospectus for future research. Am. J. Geriatr. Psychiatry 9 (2001), 113–35.Google Scholar
Penninx, B. W., Guralnik, J. M., Ferrucci, L., et al., Depressive symptoms and physical decline in community-dwelling older persons. J. Am. Med. Assoc. 279 (1998), 1720–26.Google Scholar
Gool, C. H., Kempen, G. I., Penninx, B. W., et al., Impact of depression on disablement in late middle aged and older persons: results from the Longitudinal Aging Study Amsterdam. Soc. Sci. Med. 60 (2005), 25–36.Google Scholar
Penninx, B. W., Deeg, D. J., Eijk, J. T., Beekman, A. T., Guralnik, J. M., Changes in depression and physical decline in older adults: a longitudinal perspective. J. Affect. Disord. 61 (2000), 1–12.Google Scholar
Kennedy, G. J., Kelman, H. R., Thomas, C., Persistence and remission of depressive symptoms in late life. Am. J. Psychiatry 148 (1991), 174–8.Google Scholar
Ormel, J., Korff, M., , B. W., et al., Depression, anxiety, and social disability show synchrony of change in primary care patients. Am. J. Public Health 83 (1993), 385–90.Google Scholar
Kempen, G. I., Steverink, N., Ormel, J., Deeg, D. J., The assessment of ADL among frail elderly in an interview survey: self-report versus performance-based tests and determinants of discrepancies. J. Gerontol. B Psychol. Sci. Soc. Sci. 51 (1996), 254–60.Google Scholar
Judd, L. L., Akiskal, H. S., Zeller, P. J., et al., Psychosocial disability during the long-term course of unipolar major depressive disorder. Arch. Gen. Psychiatry 57 (2000), 375–80.Google Scholar
Ormel, J., Oldehinkel, A. J., Nolen, W. A., Vollebergh, W., Psychosocial disability before, during, and after a major depressive episode: a 3-wave population-based study of state, scar, and trait effects. Arch. Gen. Psychiatry 61 (2004), 387–92.Google Scholar
Anda, R. F., Williamson, D. F., Escobedo, L. G., et al., Depression and the dynamics of smoking: a national perspective. J. Am. Med. Assoc. 264 (1990), 1541–5.Google Scholar
Onyike, C. U., Crum, R. M., Lee, H. B., Lyketsos, C. G., Eaton, W. W., Is obesity associated with major depression? Results from the Third National Health and Nutrition Examination Survey. Am. J. Epidemiol. 158 (2003), 1139–47.Google Scholar
Penninx, B. W., Guralnik, J. M., Ferrucci, L., et al., Vitamin B(12) deficiency and depression in physically disabled older women: epidemiologic evidence from the Women's Health and Aging Study. Am. J. Psychiatry 157 (2000), 715–21.Google Scholar
Stephens, T., Physical activity and mental health in the United States and Canada: evidence from four population surveys. Prev. Med. 17 (1988), 35–47.Google Scholar
Penninx, B. W., Tilburg, T., Boeke, A. J., et al., Effects of social support and personal coping resources on depressive symptoms: different for various chronic diseases?Health Psychol. 17 (1998), 551–8.Google Scholar
Druss, B. G., Bradford, W. D., Rosenheck, R. A., Radford, M. J., Krumholz, H. M., Quality of medical care and excess mortality in older patients with mental disorders. Arch. Gen. Psychiatry 58 (2001), 565–72.Google Scholar
Penninx, B. W., Tilburg, T. G., Kriegsman, D. M., et al., Effects of social support and personal coping resources on mortality in older age: the Longitudinal Aging Study Amsterdam. Am. J. Epidemiol. 146 (1997), 510–19.Google Scholar
Nemeroff, C. B., Musselman, D. L., Evans, D. L., Depression and cardiac disease. Depress. Anxiety 8 Suppl 1 (1998), 71–9.Google Scholar
Musselman, D. L., Evans, D. L., Nemeroff, C. B., The relationship of depression to cardiovascular disease: epidemiology, biology, and treatment. Arch. Gen. Psychiatry 55 (1998), 580–92.Google Scholar
Rovere, M. T., Bigger, J. T. Jr, Marcus, F. I., Mortara, A., Schwartz, P. J., Baroreflex sensitivity and heart-rate variability in prediction of total cardiac mortality after myocardial infarction: ATRAMI (Autonomic Tone and Reflexes After Myocardial Infarction) investigators. Lancet 351 (1998), 478–84.Google Scholar
Vrijkotte, T. G., Doornen, L. J., Geus, E. J., Effects of work stress on ambulatory blood pressure, heart rate, and heart rate variability. Hypertension 35 (2000), 880–86.Google Scholar
Pasquali, R., Vicennati, V., Activity of the hypothalamic-pituitary-adrenal axis in different obesity phenotypes. Int. J. Obes. Relat. Metab. Disord. 24 Suppl 2 (2000), 47–9.Google Scholar
Abelson, J. L., Curtis, G. C., Hypothalamic-pituitary-adrenal axis activity in panic disorder: 24-hour secretion of corticotropin and cortisol. Arch. Gen. Psychiatry 53 (1996), 323–31.Google Scholar
Snick, J., Interleukin-6: an overview. Annu. Rev. Immunol. 8 (1990), 253–78.Google Scholar
Maes, M., Lin, A. H., Delmeire, L., et al., Elevated serum interleukin-6 (IL-6) and IL-6 receptor concentrations in posttraumatic stress disorder following accidental man-made traumatic events. Biol. Psychiatry 45 (1999), 833–9.Google Scholar
Sapolsky, R. M., Krey, L. C., McEwen, B. S., The neuroendocrinology of stress and aging: the glucocorticoid cascade hypothesis. Endocrinol. Rev. 7 (1986), 284–301.Google Scholar
Arimura, A., Takaki, A., Komaki, G., Interactions between cytokines and the hypothalamic-pituitary-adrenal axis during stress. Ann. N. Y. Acad. Sci. 739 (1994), 270–81.Google Scholar
Reichlin, S., Neuroendocrine-immune interactions. N. Engl. J. Med. 329 (1993), 1246–53.Google Scholar
Maes, M., Meltzer, H. Y., Bosmans, E., et al., Increased plasma concentrations of interleukin-6, soluble interleukin-6, soluble interleukin-2 and transferrin receptor in major depression. J. Affect. Disord. 34 (1995), 301–9.Google Scholar
Sluzewska, A., Rybakowski, J., Bosmans, E., et al., Indicators of immune activation in major depression. Psychiatry Res. 64 (1996), 161–7.Google Scholar
Berk, M., Wadee, A. A., Kuschke, R. H., O'Neill-Kerr, A., Acute phase proteins in major depression. J. Psychosom. Res. 43 (1997), 529–34.Google Scholar
Hornig, M., Goodman, D. B., Kamoun, M., Amsterdam, J. D., Positive and negative acute phase proteins in affective subtypes. J. Affect. Disord. 49 (1998), 9–18.Google Scholar
Penninx, B. W., Kritchevsky, S., Yaffe, K., et al., Inflammatory markers and depressed mood in older men and women: results from the Health ABC study. Biol Psychiatry 54 (2003), 566–72.Google Scholar
Tiemeier, H., Hofman, A., Tuijl, H. R., et al., Inflammatory proteins and depression in the elderly. Epidemiology 14 (2003), 103–7.Google Scholar
Steptoe, A., Kunz-Ebrecht, S. R., Owen, N., Lack of association between depressive symptoms and markers of immune and vascular inflammation in middle-aged men and women. Psychol. Med. 33 (2003), 667–74.Google Scholar
Penninx, B. W., Kritchevsky, S. B., Newman, A. B., et al., Inflammatory markers and incident mobility limitation in the elderly. J. Am. Geriatr. Soc. 52 (2004), 1105–13.Google Scholar
Ferrucci, L., Harris, T. B., Guralnik, J. M., et al., Serum IL-6 level and the development of disability in older persons. J. Am. Geriatr. Soc. 47 (1999), 639–46.Google Scholar
Lin, E. H., VonKorff, M., Russo, J., et al., Can depression treatment in primary care reduce disability? A stepped care approach. Arch. Fam. Med. 9 (2000), 1052–8.Google Scholar
Coulehan, J. L., Schulberg, H. C., Block, M. R., Madonia, M. J., Rodriguez, E., Treating depressed primary care patients improves their physical, mental, and social functioning. Arch. Intern. Med. 157 (1997), 1113–20.Google Scholar
Borson, S., McDonald, G. J., Gayle, T., et al., Improvement in mood, physical symptoms, and function with nortriptyline for depression in patients with chronic obstructive pulmonary disease. Psychosomatics 33 (1992), 190–201.Google Scholar
Heiligenstein, J. H., Ware, J. E. Jr, Beusterien, K. M., et al., Acute effects of fluoxetine versus placebo on functional health and well-being in late-life depression. Int. Psychogeriatr. 7: Suppl (1995), 125–37.Google Scholar
Robinson, R. G., Schultz, S. K., Castillo, C., et al., Nortriptyline versus fluoxetine in the treatment of depression and in short-term recovery after stroke: a placebo-controlled, double-blind study. Am. J. Psychiatry 157 (2000), 351–9.Google Scholar
Williams, J. W. Jr, Katon, W., Lin, E. H., et al., The effectiveness of depression care management on diabetes-related outcomes in older patients. Ann. Intern. Med. 140 (2004), 1015–24.Google Scholar
Carlson, J. E., Ostir, G. V., Black, S. A., et al., Disability in older adults: 2. Physical activity as prevention. Behav. Med. 24 (1999), 157–68.Google Scholar
Penninx, B. W., Messier, S. P., Rejeski, W. J., et al., Physical exercise and the prevention of disability in activities of daily living in older persons with osteoarthritis. Arch. Intern. Med. 161 (2001), 2309–16.Google Scholar
Ettinger, W. H. Jr, Burns, R., Messier, S. P., et al., A randomized trial comparing aerobic exercise and resistance exercise with a health education program in older adults with knee osteoarthritis: the Fitness Arthritis and Seniors Trial (FAST). J. Am. Med. Assoc. 277 (1997), 25–31.Google Scholar
Farmer, M. E., Locke, B. Z., Moscicki, E. K., et al., Physical activity and depressive symptoms: the NHANES I Epidemiologic Follow-up Study. Am. J. Epidemiol. 128 (1988), 1340–51.Google Scholar
Camacho, T. C., Roberts, R. E., Lazarus, N. B., Kaplan, G. A., Cohen, R. D., Physical activity and depression: evidence from the Alameda County Study. Am. J. Epidemiol. 134 (1991), 220–31.Google Scholar
North, T. C., McCullagh, P., Tran, Z. V., Effect of exercise on depression. Exerc. Sport. Sci. Rev. 18 (1990), 379–415.Google Scholar
Greist, J. H., Klein, M. H., Eischens, R. R., et al., Running as treatment for depression. Compr. Psychiatry 20 (1979), 41–54.Google Scholar
McCann, I. L., Holmes, D. S., Influence of aerobic exercise on depression. J. Pers. Soc. Psychol. 46 (1984), 1142–7.Google Scholar
Martinsen, E. W., Medhus, A., Sandvik, L., Effects of aerobic exercise on depression: a controlled study. Br. Med. J. (Clin. Res. Ed.) 291 (1985), 109.Google Scholar
Blumenthal, J. A., Babyak, M. A., Moore, K. A., et al., Effects of exercise training on older patients with major depression. Arch. Intern. Med. 159 (1999), 2349–56.Google Scholar
Babyak, M., Blumenthal, J. A., Herman, S., et al., Exercise treatment for major depression: maintenance of therapeutic benefit at 10 months. Psychosom. Med. 62 (2000), 633–8.Google Scholar
McNeil, J. K., LeBlanc, E. M., Joyner, M., The effect of exercise on depressive symptoms in the moderately depressed elderly. Psychol. Aging 6 (1991), 487–8.Google Scholar
Singh, N. A., Clements, K. M., Fiatarone, M. A., A randomized controlled trial of progressive resistance training in depressed elders. J. Gerontol. A Biol. Sci. Med. Sci. 52 (1997), M27–35.Google Scholar
Penninx, B. W., Rejeski, W. J., Pandya, J., et al., Exercise and depressive symptoms: a comparison of aerobic and resistance exercise effects on emotional and physical function in older persons with high and low depressive symptomatology. J. Gerontol. B Psychol. Sci. Soc. Sci. 57 (2002), 124–32.Google Scholar

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