In this chapter, we argue that if we are blinded by the constant stream of astrophysical and cosmological observations, we may forget that cosmology is the youngest of all the physical sciences. The 1965 discovery of the CMB radiation by Penzias and Wilson moved cosmology to the territory of firmly observational science from the domain of exclusively mathematical modeling, and the 1977 measurements of CMB’s anisotropies with detectors mounted on US spy aircraft opened its Big Science phase. A number of measurements of the CMB spectral shape by detectors mounted on rockets and balloons following the 1965 discovery led to fluctuating agreement with the values of the black body radiation spectrum. In particular, 1978–1979 measurements exhibited discrepancies that gave new impetus to the alternative explanations of the radiation. A series of satellite measurements since the early 1990s, with equipment similar to previous experiments but without atmospheric disturbances, led to the final phase of the convergence to the Hot Big Bang model.