This chapter traces Ottoman responses to the challenge of Europe’s rise and global hegemony – responses that engendered two emergent properties: religious disenchantment and growing resentment at the loss of Muslim primacy. These properties informed new political programs in the buildup to and during critical junctures. Milestones included the Tanzimat (1839) and subsequent, Young Ottoman reforms led by bureaucrats and intellectuals. The result was a framework for multicultural citizenship – an Islamo-liberal project. It bore fruit in the first Ottoman constitution (1878), but was soon suspended by Sultan Abdülhamid II (r.1876–1908/9) who instead developed (pan-)Islamism as a political program. His authoritarian rule, in turn, spurred a coalition of liberal and proto-nationalist Young Turks to revolt (1908), launching the “second constitutional period.” The revolution was then captured by an illiberal Triumvirate espousing a more unitary, proto-nationalist project. No linear or teleological process, the chapter reveals that contests were driven by the complex interplay of ideas, actors, and contextual pressures. These forces informed a new menu of programs for managing religion and diversity that would outlive the empire itself: Islamo-liberalism, liberalism, Islamism, and Turkism.