This chapter analyzes the technology of human genome editing with a focus on the ethical issues involved and offers guidance as how best to regulate this technology. First, this chapter explains several common types of gene editing technologies and then analyzes the ethical implications of the two primary therapeutic uses of gene editing: somatic and germline. Primary ethical analysis will focus on the bioethical principles of autonomy, beneficence, non-maleficence, and social justice; analysis will then provide a weighing of these principles and likely consequences–noting the biologic differences between somatic versus germline treatments. Somatic gene editing is generally more confined to the individual, while germline editing changes the genes of cells that are passed sexually to offspring, thus having the power to shape the human genome generationally--the ultimate consequence of which is the influence and shaping of human evolution. In conclusion, the chapter argues the consequences of somatic vs. germline genome editing demand that, when considering the proper emphasis of a regulatory paradigm, somatic editing should be regulated under a nationally guided framework and germline editing should be regulated under both a nationally and globally guided framework.