This clinical guide describes an innovative, individualized approach to the treatment of body focused repetitive behaviors (BFRBs), including hair pulling disorder (HPD) (also called trichotillomania) and skin picking disorder (SPD) (also called excoriation disorder). This treatment is derived from the Comprehensive Behavioral (ComB) conceptual model described more than two decades ago (Mansueto et al., 1997). In addition to the conceptual model, ComB treatment was first introduced in 1990 (Mansueto, 1990; Mansueto & Goldfinger, 1990), and has been refined by Mansueto and his colleagues at the Behavior Therapy Center of Greater Washington in the ensuing years (Mansueto et al., 1999; Mansueto, 2013, 2021; Mansueto, Vavrichek, & Golomb, 2019; Stemberger, Thomas, MacGlashan & Mansueto, 2000). Today, ComB is regarded as an established conceptual framework and as an assessment and treatment approach employed by scores of clinicians. ComB has served as the basis for the clinical training by the TLC Foundation for Body Focused Repetitive Behaviors’ Professional Training Institute for over two decades; it was established as a favored treatment modality by that organization’s Scientific Advisory Board; and it has influenced contemporary cognitive behavioral treatments of HPD, SPD, and other BFRBs since its introduction.