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Chapter 16 - Inflammation and Metabolic Issues in Mood Disorders

Published online by Cambridge University Press:  16 May 2024

By
Marsal Sanches  and
Jair C. Soares
Edited by
Allan Young ,
Marsal Sanches ,
Jair C. Soares  and
Mario Juruena
Allan Young
Affiliation:
Institute of Psychiatry, King's College London
Marsal Sanches
Affiliation:
Baylor College of Medicine, Texas
Jair C. Soares
Affiliation:
McGovern Medical School, The University of Texas
Mario Juruena
Affiliation:
King's College London
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Summary

Over the past few decades, the role of inflammation in the pathophysiology of depressive disorder and bipolar disorder has been the focus of considerable attention. In this chapter, we provide an update on the association between inflammatory processes and mood disorders, in light of available evidence. The pathophysiological and clinical implications of this association are critically discussed, as well as the interaction between inflammation, metabolic abnormalities, and medical comorbidities, which have important prognostic consequences for patients with mood disorders.

Keywords

inflammationdepressive disorderbipolar disordermetabolic syndrometraumacytokines
Type
Chapter
Information
Clinical Textbook of Mood Disorders , pp. 163 - 171
Publisher: Cambridge University Press
Print publication year: 2024

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