from Section 2 - Clinical applications
Published online by Cambridge University Press: 05 May 2013
Introduction
The MR perfusion techniques of dynamic susceptibility contrast (DSC; see Chapter 2) imaging and arterial spin labeling (ASL; see Chapter 3) imaging as applied to children will be discussed. While DSC perfusion is well established in the evaluation of adult neurological conditions, the use of both DSC and ASL perfusion imaging in pediatric neurological conditions remains in its infancy. While acute stroke imaging drove the adoption of DSC approaches in adults, the lack of demonstrated utility in children, the need for intravenous (IV) line placement, and the need for bolus injection has limited its adoption in children. While some groups extrapolate both DSC and ASL approaches and analysis from the adult literature in applying MR perfusion to pediatric disorders, there is still much unknown about pediatric cerebral perfusion and the changes that occur in pediatric diseases. For example, there are normal developmental changes in cerebral vasculature and cerebral perfusion as well as marked changes in body size, heart rate, vascular flow velocities, and capillary development which may impact optimization, quantification, and interpretation of both DSC and ASL. In addition, little is known about how these measures are affected by sedation, anesthesia, and hematocrit changes.
To save this book to your Kindle, first ensure [email protected] is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.
Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.
Find out more about the Kindle Personal Document Service.
To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.
To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.