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Chapter 2 - Quantification and analysis in MR spectroscopy

from Section 1 - Physiological MR techniques

Published online by Cambridge University Press:  05 March 2013

By
Ernst Thomas
Edited by
Jonathan H. Gillard ,
Adam D. Waldman  and
Peter B. Barker
Jonathan H. Gillard
Affiliation:
University of Cambridge
Adam D. Waldman
Affiliation:
Imperial College London
Peter B. Barker
Affiliation:
The Johns Hopkins University School of Medicine
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Summary

Why quantification and not visual interpretation?

The quantification of spectral peaks plays an important role in MRS, and pure visual readings of spectra are less common compared with MRI. The reason for this difference is that MRI relies on the detection of spatial abnormalities as a result of disease conditions, whereas MRS interpretation commonly relies on the interpretation of differences in relative proportions of metabolite peaks at a given location. Furthermore, spectroscopic peaks reflect the concentrations of metabolites in the tissue; however, it is impossible to determine these concentrations visually.

These points are illustrated in Fig. 2.1, which shows proton spectra from a lymphoma and a contralateral voxel in a patient with AIDS. Since the spectra can be plotted with arbitrary vertical scaling, it is unclear if a given metabolite peak, and its associated concentration, in the lesion is higher or lower compared with the healthy brain tissue. It is even more difficult to estimate the relative heights of the metabolite peaks within each voxel. Therefore, the ultimate goal of spectral analysis is to determine accurate values for metabolite peak areas and, ultimately, for metabolite concentrations.

Type
Chapter
Information
Clinical MR Neuroimaging
Physiological and Functional Techniques
 , pp. 21 - 29
Publisher: Cambridge University Press
Print publication year: 2009

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