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Chapter 30 - Magnetic resonance spectroscopy in demyelination and inflammation

from Section 4 - Infection, inflammation and demyelination

Published online by Cambridge University Press:  05 March 2013

By
Gioacchino Tedeschi  and
Simona Bonavita
Edited by
Jonathan H. Gillard ,
Adam D. Waldman  and
Peter B. Barker
Jonathan H. Gillard
Affiliation:
University of Cambridge
Adam D. Waldman
Affiliation:
Imperial College London
Peter B. Barker
Affiliation:
The Johns Hopkins University School of Medicine
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Summary

Introduction

MR spectroscopy (MRS) furnishes in vivo metabolic information in central nervous system (CNS) diseases. This chapter addresses the application of proton MRS to the study of acquired demyelinating and inflammatory disorders of the CNS.

The major findings from single-voxel and MRS imaging (MRSI, also known as chemical shift imaging) studies are discussed. The choice of the technique depends on the disease being considered and on the questions being asked. Both MRS and MRSI have advantages and disadvantages. The former is easier to perform quantitatively, and is well suited to the study of focal lesions or single brain locations, but it provides limited anatomical coverage. In contrast, MRSI allows a more extensive regional sampling of diffuse CNS disorders, as well as of large and more heterogeneous lesions, but it mostly yields metabolite ratios and may have less biochemical sensitivity and specificity. In either case, it should be borne in mind that the maximum resolution of approximately 0.5 cm3 voxel size may often be too large to assess tiny lesions or small CNS structures.

Type
Chapter
Information
Clinical MR Neuroimaging
Physiological and Functional Techniques
 , pp. 475 - 487
Publisher: Cambridge University Press
Print publication year: 2009

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