Book contents
- Frontmatter
- Contents
- Preface
- Contributors
- Part I Clinical Syndromes – General
- 1 Fever of Unknown Origin
- 2 Sepsis and Septic Shock
- 3 Chronic Fatigue Syndrome
- Part II Clinical Syndromes – Head and Neck
- Part III Clinical Syndromes – Eye
- Part IV Clinical Syndromes – Skin and Lymph Nodes
- Part V Clinical Syndromes – Respiratory Tract
- Part VI Clinical Syndromes – Heart and Blood Vessels
- Part VII Clinical Syndromes – Gastrointestinal Tract, Liver, and Abdomen
- Part VIII Clinical Syndromes – Genitourinary Tract
- Part IX Clinical Syndromes – Musculoskeletal System
- Part X Clinical Syndromes – Neurologic System
- Part XI The Susceptible Host
- Part XII HIV
- Part XIII Nosocomial Infection
- Part XIV Infections Related to Surgery and Trauma
- Part XV Prevention of Infection
- Part XVI Travel and Recreation
- Part XVII Bioterrorism
- Part XVIII Specific Organisms – Bacteria
- Part XIX Specific Organisms – Spirochetes
- Part XX Specific Organisms – Mycoplasma and Chlamydia
- Part XXI Specific Organisms – Rickettsia, Ehrlichia, and Anaplasma
- Part XXII Specific Organisms – Fungi
- Part XXIII Specific Organisms – Viruses
- Part XXIV Specific Organisms – Parasites
- Part XXV Antimicrobial Therapy – General Considerations
- Index
2 - Sepsis and Septic Shock
from Part I - Clinical Syndromes – General
Published online by Cambridge University Press: 05 March 2013
- Frontmatter
- Contents
- Preface
- Contributors
- Part I Clinical Syndromes – General
- 1 Fever of Unknown Origin
- 2 Sepsis and Septic Shock
- 3 Chronic Fatigue Syndrome
- Part II Clinical Syndromes – Head and Neck
- Part III Clinical Syndromes – Eye
- Part IV Clinical Syndromes – Skin and Lymph Nodes
- Part V Clinical Syndromes – Respiratory Tract
- Part VI Clinical Syndromes – Heart and Blood Vessels
- Part VII Clinical Syndromes – Gastrointestinal Tract, Liver, and Abdomen
- Part VIII Clinical Syndromes – Genitourinary Tract
- Part IX Clinical Syndromes – Musculoskeletal System
- Part X Clinical Syndromes – Neurologic System
- Part XI The Susceptible Host
- Part XII HIV
- Part XIII Nosocomial Infection
- Part XIV Infections Related to Surgery and Trauma
- Part XV Prevention of Infection
- Part XVI Travel and Recreation
- Part XVII Bioterrorism
- Part XVIII Specific Organisms – Bacteria
- Part XIX Specific Organisms – Spirochetes
- Part XX Specific Organisms – Mycoplasma and Chlamydia
- Part XXI Specific Organisms – Rickettsia, Ehrlichia, and Anaplasma
- Part XXII Specific Organisms – Fungi
- Part XXIII Specific Organisms – Viruses
- Part XXIV Specific Organisms – Parasites
- Part XXV Antimicrobial Therapy – General Considerations
- Index
Summary
DEFINITIONS
Sepsis is a complex syndrome comprising a constellation of systemic symptoms and signs in response to infection, including inflammatory, pro-coagulant, and immunosuppressive events. Septic shock occurs when there is significant hypotension in the presence of sepsis. The definitions and diagnostic criteria for sepsis and related conditions were developed in 1991 at a consensus conference sponsored jointly by the American College of Chest Physicians and the Society for Critical Care Medicine and reviewed by the 2001 International Sepsis Definitions Conference (sponsored by the Society of Critical Care Medicine, European Society of Critical Care Medicine, American College of Chest Physicians, American Thoracic Society, and the Surgical Infections Society). Apart from expanding the list of signs and symptoms of sepsis to reflect clinical bedside experience, the definitions remained unchanged. The sepsis-related terminology and definitions are presented in Table 2.1; the diagnostic criteria for sepsis presented in Table 2.2 have been updated by the Conference to include a variety of signs of systemic inflammation in response to infection. This international group proposed a classification scheme for sepsis that stratifies patients based on their predisposing conditions, the nature and extent of the insult (infection), the host response, and the degree of concomitant organ dysfunction (acronym PIRO). This concept will have to be further tested and refined before it can be routinely applied in clinical practice.
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- Chapter
- Information
- Clinical Infectious Disease , pp. 9 - 20Publisher: Cambridge University PressPrint publication year: 2008