Book contents
- Frontmatter
- Dedication
- Contents
- List of Contributors
- Preface
- Part I Clinical syndromes: general
- Part II Clinical syndromes: head and neck
- Part III Clinical syndromes: eye
- Part IV Clinical syndromes: skin and lymph nodes
- Part V Clinical syndromes: respiratory tract
- Part VI Clinical syndromes: heart and blood vessels
- Part VII Clinical syndromes: gastrointestinal tract, liver, and abdomen
- Part VIII Clinical syndromes: genitourinary tract
- Part IX Clinical syndromes: musculoskeletal system
- Part X Clinical syndromes: neurologic system
- Part XI The susceptible host
- Part XII HIV
- Part XIII Nosocomial infection
- Part XIV Infections related to surgery and trauma
- Part XV Prevention of infection
- Part XVI Travel and recreation
- Part XVII Bioterrorism
- Part XVIII Specific organisms: bacteria
- Part XIX Specific organisms: spirochetes
- Part XX Specific organisms: Mycoplasma and Chlamydia
- Part XXI Specific organisms: Rickettsia, Ehrlichia, and Anaplasma
- Part XXII Specific organisms: fungi
- 172 Candidiasis
- 173 Aspergillosis
- 174 Mucormycosis (and entomophthoramycosis)
- 175 Sporotrichum
- 176 Cryptococcus
- 177 Histoplasmosis
- 178 Blastomycosis
- 179 Coccidioidomycosis
- 180 Pneumocystis jirovecii (carinii)
- 181 Miscellaneous fungi and algae
- Part XXIII Specific organisms: viruses
- Part XXIV Specific organisms: parasites
- Part XXV Antimicrobial therapy: general considerations
- Index
- References
174 - Mucormycosis (and entomophthoramycosis)
from Part XXII - Specific organisms: fungi
Published online by Cambridge University Press: 05 April 2015
- Frontmatter
- Dedication
- Contents
- List of Contributors
- Preface
- Part I Clinical syndromes: general
- Part II Clinical syndromes: head and neck
- Part III Clinical syndromes: eye
- Part IV Clinical syndromes: skin and lymph nodes
- Part V Clinical syndromes: respiratory tract
- Part VI Clinical syndromes: heart and blood vessels
- Part VII Clinical syndromes: gastrointestinal tract, liver, and abdomen
- Part VIII Clinical syndromes: genitourinary tract
- Part IX Clinical syndromes: musculoskeletal system
- Part X Clinical syndromes: neurologic system
- Part XI The susceptible host
- Part XII HIV
- Part XIII Nosocomial infection
- Part XIV Infections related to surgery and trauma
- Part XV Prevention of infection
- Part XVI Travel and recreation
- Part XVII Bioterrorism
- Part XVIII Specific organisms: bacteria
- Part XIX Specific organisms: spirochetes
- Part XX Specific organisms: Mycoplasma and Chlamydia
- Part XXI Specific organisms: Rickettsia, Ehrlichia, and Anaplasma
- Part XXII Specific organisms: fungi
- 172 Candidiasis
- 173 Aspergillosis
- 174 Mucormycosis (and entomophthoramycosis)
- 175 Sporotrichum
- 176 Cryptococcus
- 177 Histoplasmosis
- 178 Blastomycosis
- 179 Coccidioidomycosis
- 180 Pneumocystis jirovecii (carinii)
- 181 Miscellaneous fungi and algae
- Part XXIII Specific organisms: viruses
- Part XXIV Specific organisms: parasites
- Part XXV Antimicrobial therapy: general considerations
- Index
- References
Summary
The term mucormycosis refers to a group of highly lethal angioinvasive fungal infections, mostly in immunocompromised hosts, caused by members of the order Mucorales, which include various species of the genera Rhizopus, Lichtheimia (formerly Absidia), Mucor, and Saksenaea. Other genera of Mucorales have also been implicated in human disease including Cunninghamella, Apophysomyces, and Rhizomucor. Most infections (50%–65% of total) are caused by Rhizopus species.
Classification is in flux because of extensive molecular phylogenetic analysis that has been ongoing for more than 10 years. Note that it is incorrect to use the term mucormycosis to refer only to infections caused by species of the genus Mucor, which are only a small minority of the total number of cases. Rather, mucormycosis refers to infection by any of the organisms within the seven genera of the order Mucorales as noted.
The term entomophthoramycosis refers to infections by members of the separate genera Conidiobolus and Basidiobolus. These organisms generally occur in tropics and cause chronic subcutaneous infection mostly in immunocompeten hosts. Only rarely (less than 15 reported cases) have they ever caused clinical syndromes overlapping with mucormycosis.
For the remainder of this chapter the term mucormycosis will be used to refer to the range of clinical infections caused by organisms in the seven genera of the order Mucorales. In recent usage this term is generally preferred over the term zygomycosis, because of elimination of Zycomycetes from the taxonomic structure and the very different clinical syndrome as compared to entomophthoramycosis with virtually no clinical overlap.
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- Information
- Clinical Infectious Disease , pp. 1119 - 1123Publisher: Cambridge University PressPrint publication year: 2015